J Bone Joint Surg Am 2021 Mar 23. Epub 2021 Mar 23.
Departments of Orthopaedic Surgery (C.Y., M.S.H., S.J., M.A.O., A.J.D., K.Y.C., J.Y., J.P., R.J.L., W.K.H., and E.L.H.) and Cell and Molecular Biology (S.R.S.), Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Background: After spinal surgery and other orthopaedic procedures, most patients receive opioids for pain, leading to potential complications such as pseudarthrosis and opioid abuse associated with long-term use. As an alternative, the endocannabinoid system has been shown to have antinociceptive activity, while contributing to bone homeostasis via the CB1 and CB2 cannabinoid receptors. This study evaluates the impact of the cannabinoid receptor agonist WIN55,212-2 (WIN55) on osteogenic differentiation in vitro as well as bone regeneration and spinal fusion in a preclinical rat model. Read More