Pathology 2018 Aug 23;50(5):554-561. Epub 2018 Jun 23.
Department of Immunology, PathWest, Fiona Stanley Hospital, Murdoch, WA, Australia; Institute for Immunology and Infectious Diseases (IIID), Murdoch University, WA, Australia; Department of Clinical Immunology, Royal Perth Hospital, Perth, WA, Australia.
Prevention of cytomegalovirus (CMV) infection remains an important aspect of improving long term outcomes of solid organ transplantation and currently relies on prophylactic antiviral medication and early detection of viraemia or disease. Uptake of diagnostic tools to personalise assessment of CMV immunity and guide interpretation of viral testing remains low. We assessed the QuantiFERON-CMV assay in 54 Western Australian recipients of renal, heart, lung or liver allografts to determine the relationship between CMV-specific immunity, viraemia and disease following cessation of antiviral prophylaxis. Read More