2,681 results match your criteria post-thrombotic syndrome


Catheter directed thrombolysis and mechanical intervention in deep venous thrombosis: What is the status after the ATTRACT Trial?

Postgrad Med 2021 Apr 16. Epub 2021 Apr 16.

Division of Interventional Radiology, Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California.

Deep venous thrombosis (DVT) is a major cause of acute and chronic morbidity, mortality, and increased healthcare costs. Endovascular methods of thrombus removal and re-establishing venous patency are increasing in both scope and usage. The most commonly used method of endovascular thrombectomy is catheter directed thrombolysis (CDT). Read More

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Thrombolytic therapy for pulmonary embolism.

Cochrane Database Syst Rev 2021 Apr 15;4:CD004437. Epub 2021 Apr 15.

The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, China.

Background: Thrombolytic therapy is usually reserved for people with clinically serious or massive pulmonary embolism (PE). Evidence suggests that thrombolytic agents may dissolve blood clots more rapidly than heparin and may reduce the death rate associated with PE. However, there are still concerns about the possible risk of adverse effects of thrombolytic therapy, such as major or minor haemorrhage. Read More

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Bilateral Pulmonary Embolism in Patients Recovered From Asymptomatic COVID-19 Infection.

Cureus 2021 Mar 12;13(3):e13848. Epub 2021 Mar 12.

Cardiology, Mohammed VI University Hospital, Mohammed I University, Oujda, MAR.

Hypercoagulability state is common in patients with coronavirus disease 2019 (COVID-19), especially those requiring intensive care. Indeed, anticoagulation therapy is recommended for all hospitalized COVID-19-patients. Despite well-conducted thromboprophylaxis, so many patients have developed these life-threatening complications. Read More

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Comparing the efficacy of endovascular treatment for iliac vein compression syndrome with or without acute deep venous thrombosis: A single-center retrospective study.

Vascular 2021 Apr 14:17085381211003776. Epub 2021 Apr 14.

Department of Gastroenterology, University-Town Hospital of Chongqing Medical University, Chongqing, China.

Background: To compare the efficacy of endovascular treatment for iliac vein compression syndrome (IVCS) with or without acute deep venous thrombosis of lower extremity.

Methods: This study retrospectively analyzed the clinical data of 300 IVCS patients, who received endovascular treatment between January 2013 and December 2017. According to whether IVCS was complicated by deep venous thrombosis or not, these patients were divided into non-thrombotic iliac vein lesion group (NIVL group,  = 127) and post-thrombotic iliac vein lesion group (PIVL group,  = 173). Read More

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What, if anything, should replace the Villalta score for post thrombotic syndrome?

Phlebology 2021 Apr 15:2683555211008774. Epub 2021 Apr 15.

Imperial College Healthcare NHS Trust, South Wharf Road, London, UK.

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Compression hosiery to avoid post-thrombotic syndrome (CHAPS) protocol for a randomised controlled trial (ISRCTN73041168).

BMJ Open 2021 Apr 12;11(4):e044285. Epub 2021 Apr 12.

Academic Section of Vascular Surgery, Imperial College London, London, UK.

Introduction: Up to 50% of patients develop post-thrombotic syndrome (PTS) after an above knee deep vein thrombosis (DVT). The aim of the study was to determine the effect of graduated compression stockings in preventing PTS after DVT.

Methods And Analysis: Pragmatic, UK multicentre randomised trial in adults with first above knee DVT. Read More

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Reversal of cardiopulmonary exercise intolerance in patients with post-thrombotic obstruction of the inferior vena cava.

Thromb Res 2021 Apr 8. Epub 2021 Apr 8.

Clinic for Angiology, University Hospital Zurich, Switzerland. Electronic address:

Background: It is unclear whether cardiopulmonary exercise intolerance in patients with chronic obstruction of the inferior vena cava (IVC) is reversible following endovascular IVC reconstruction.

Methods: In 17 patients (mean age 45 ± 15 years, 71% men) with post-thrombotic syndrome due to IVC obstruction and preserved left ventricular ejection fraction (mean 58 ± 3%), we performed cardiopulmonary exercise testing before and 3 months after IVC reconstruction (mean 4.1 ± 1. Read More

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Histological Assessment of Lower Extremity Deep Vein Thrombi from Patients Undergoing Percutaneous Mechanical Thrombectomy.

J Vasc Surg Venous Lymphat Disord 2021 Apr 6. Epub 2021 Apr 6.

Division of Vascular Surgery, Department of Surgery, NYU Langone Health, New York, NY 10016, USA. Electronic address:

Background: Histological analyses of deep vein thrombi (DVT) are based on autopsy samples and animal models. No prior study has reported on thrombus composition following percutaneous mechanical extraction. As elements of chronicity and organization render thrombus resistant to anticoagulation and thrombolysis, a better understanding of clot evolution may inform therapies. Read More

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Clinical outcomes of Stenting extending below the Inguinal Ligament for Treatment of Chronic Iliofemoral Venous Obstruction.

Ann Vasc Surg 2021 Apr 3. Epub 2021 Apr 3.

Department of Vascular Surgery, Fujian Medical University Union Hospital, Fuzhou, China, NO.29, Xinquan Road, Fuzhou City, Fujian Province, China. Electronic address:

Background: Patients with chronic iliofemoral venous obstructive lesions that often require stenting extending below the inguinal ligament. However, the issue of stents crossing the inguinal ligament is currently controversial. Some guidelines suggest that it should be avoided, and some guidelines suggest that in order to ensure adequate flow, the inguinal ligament can be crossed if necessary. Read More

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Clinical outcomes and overview of dedicated venous stents for management of chronic iliocaval and femoral deep venous disease.

Vascular 2021 Apr 4:1708538121989860. Epub 2021 Apr 4.

Academic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, Charing Cross Hospital, London, UK.

Objectives: Venous stenting of the lower extremities has grown in popularity and is now considered a key component of the primary treatment strategy for the management of pathologically obstructive or stenotic lesions of the deep venous system. This review aims to provide an overview of the role of venous stenting in the management of chronic conditions affecting the deep venous system of the lower limbs.

Methods: An overview of venous stents design and current role of stenting procedure in individuals presenting with Chronic Venous Insufficiency (CVI) and presenting the current trials of dedicated venous stenting in management of chronic deep venous lesions. Read More

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Challenges and Advances in Managing Thrombocytopenic Cancer Patients.

J Clin Med 2021 Mar 11;10(6). Epub 2021 Mar 11.

Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Petah Tikva 4941492, Israel.

Cancer patients have varying incidence, depth and duration of thrombocytopenia. The mainstay of managing severe chemotherapy-induced thrombocytopenia (CIT) in cancer is the use of platelet transfusions. While prophylactic platelet transfusions reduce the bleeding rate, multiple unmet needs remain, such as high residual rates of bleeding, and anticancer treatment dose reductions/delays. Read More

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Successful treatment of acquired arteriovenous fistula following iliac vein thrombosis.

Vascular 2021 Mar 24:1708538121995298. Epub 2021 Mar 24.

Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objectives: Cases of arteriovenous fistula following iliac vein thrombosis are uncommon. The pathogenesis of its formation remains unclear. We present the efficacy of left common iliac vein recanalization in acquired arteriovenous fistula treatment. Read More

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Improving Outcomes in Cardiovascular Diseases: A Review on Vorapaxar.

Cardiol Rev 2021 Mar 19. Epub 2021 Mar 19.

Mayo Clinic, Rochester, MN Division of Cardiology, University of Pittsburgh Medical Centre Heart and Vascular Institute, Pittsburgh, PA Garden City Hospital, Garden City, MI Sinai Hospital of Baltimore, Baltimore, MD Johns Hopkins University School of Medicine, Baltimore, MD.

Antiplatelet agents are the standard of practice in the management of atherosclerosis and acute coronary syndrome (ACS). In contrast to the available antiplatelet agents, vorapaxar represents a novel mechanism of action. It is an antagonist of the platelet protease-activated receptor-1 (PAR-1) and inhibits thrombin-induced and thrombin receptor agonist peptide (TRAP)- induced platelet aggregation. Read More

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Endovascular and medical therapy of May-Thurner syndrome: Case series and scoping literature review.

J Med Vasc 2021 Apr 5;46(2):80-89. Epub 2021 Mar 5.

Surgery Department, Vascular Surgery Service, Hospital Fundación Valle del Lili, Cali, CO, Colombia. Electronic address:

Introduction: May-Thurner syndrome has been recognized as a cause of chronic venous insufficiency and a trigger for venous thromboembolism. There is no consensus about the definition, diagnosis, and therapeutic approach. We are aiming to describe its characteristics and a scoping literature review. Read More

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The Open Vein Hypothesis and Postthrombotic Syndrome: Not Dead Yet.

Circulation 2021 Mar 22;143(12):1239-1241. Epub 2021 Mar 22.

Vanderbilt Translational and Clinical Cardiovascular Research Center, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN.

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Paget-Schroetter Syndrome in a Young Female.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211003263

Ashland Bellefonte Cancer Center, Ashland, KY, USA.

Paget-Schroetter syndrome or effort thrombosis is a relatively rare primary spontaneous thrombosis of upper extremity deep veins secondary to entrapment of axillary subclavian veins from an abnormality of the thoracic outlet. It is commonly seen in young adults who lift heavy weights or strenuous use of the upper extremities during athletic activities. Repetitive microtrauma to the subclavian vein secondary to narrow costoclavicular space and strenuous activities leads to intimal layer inflammation, hypertrophy, fibrosis, and coagulation cascade activation. Read More

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Compression treatment in acute symptomatic proximal deep venous thrombosis - Results of a worldwide survey.

Phlebology 2021 Mar 21:2683555211003801. Epub 2021 Mar 21.

Private Practice Phlebology & Dermatology, Bonn, Germany and Department of Dermatology, University of Cologne, Köln, Germany.

Objectives: The aim of this study was to illustrate how compression is performed worldwide in proximal DVT and if compression management has changed recently.

Methods: A global online survey, consisting of 36 questions, was used. The survey was solicited from membership lists of Union Internationale de Phlébologie (UIP) membership societies. Read More

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Mid-term patency of iliac venous stenting for post-thrombotic syndrome: systematic review and meta-analysis.

Int Angiol 2021 Mar 19. Epub 2021 Mar 19.

Faculty of Medicine, University of Porto, Porto, Portugal.

Introduction: Post-thrombotic syndrome (PTS) is the most common chronic complication of deep vein thrombosis. Recent studies suggested that iliac stenting in chronic obstructive venous disease is safe and effective. However, systematic reviews focusing on mid-term efficacy of iliac stenting in post-thrombotic syndrome are lacking. Read More

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Glomerulonephritis in AKI: From Pathogenesis to Therapeutic Intervention.

Front Med (Lausanne) 2020 2;7:582272. Epub 2021 Mar 2.

Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.

Acute kidney injury (AKI) is increasingly emerging as a global emergency. Sepsis, major surgery, and nephrotoxic drugs are the main causes of AKI in hospitalized patients. However, glomerulonephritis accounts for about 10% of AKI episodes in adults, mainly related to rapidly progressive glomerulonephritis resulting from granulomatous polyangiitis (GPA, Wegener granulomatosis), microscopic polyangiitis (MPA), and anti-glomerular basement membrane (GBM) disease. Read More

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Acute Severe Thrombocytopenia Event Associated with Trimethoprim/Sulfamethoxazole Use.

Am J Med Case Rep 2021 13;9(3):155-157. Epub 2021 Jan 13.

Department of Internal Medicine, State University of New York: Downstate- Health Science University, Brooklyn, New York, United States- 11203.

Objective: To report a case of life-threatening thrombocytopenia associated with the use of trimethoprim/sulfamethoxazole (TMP/SMX) therapy.

Report Of The Case: 50-year-old woman with no significant past medical history who presented with one day of petechial rash on her arms, chest and legs. Patient reports that she had just completed a 7- day course of TMP/SMX (1-double strength tablet twice a day) for uncomplicated UTI by her PMD. Read More

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January 2021

Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging Predicts Vein Wall Scarring and Statin Benefit in Murine Venous Thrombosis.

Circ Cardiovasc Imaging 2021 Mar 16:CIRCIMAGING120011898. Epub 2021 Mar 16.

Cardiology Division, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA (C.W.K., G.Q., F.A.J.).

Background: The postthrombotic syndrome is a common, often morbid sequela of venous thrombosis (VT) that arises from thrombus persistence and inflammatory scarring of juxtaposed vein walls and valves. Noninvasive F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) imaging can measure neutrophil inflammation in VT. Here, we hypothesized (1) early fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) VT inflammation can predict subsequent vein wall scarring (VWS) and (2) statin therapy can reduce FDG-PET VT inflammation and subsequent VWS. Read More

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Intravascular Ultrasound for Pulmonary Vein Stenosis Interventions in Congenital Heart Disease.

J Invasive Cardiol 2021 Apr 3;33(4):E259-E262. Epub 2021 Mar 3.

University of Arizona, Department of Pediatrics (Cardiology), 1501 N. Campbell Ave, P.O. Box 245073, Tucson AZ, 85724 USA.

Objective: Pulmonary vein stenosis (PVS) is aggressive, with high morbidity and mortality. Surgical and catheter interventions yield modest success, at best. Refinements in catheter interventions could potentially improve outcomes in this patient population. Read More

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Post-thrombotic syndrome - a position paper from European Society of Vascular Medicine.

Vasa 2021 Mar 15:1-10. Epub 2021 Mar 15.

Arianna Foundation, Bologna, Italy.

Post-thrombotic syndrome (PTS) is a chronic venous insufficiency manifestation following an episode of deep-vein thrombosis (DVT). It is an important and frequent long-term adverse event of proximal DVT affecting 20-50% of patients. This position paper integrates data guiding clinicians in deciding PTS diagnosis, treatment and follow-up. Read More

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The risk of thrombosis after acute-COVID-19 infection.

QJM 2021 Mar 15. Epub 2021 Mar 15.

Department of Specialistic Medicine, Division of Cardiology, Santa Maria della Misericordia Hospital, Rovigo, Italy.

Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) has been associated with coagulation dysfunction which predisposes patients to an increased risk of both venous and arterial thromboembolism, increasing the short-term morbidity and mortality. Current data evidenced that the rate of post discharge thrombotic events in COVID-19 patients is lower compared to that observed during hospitalization. Rather than "true thrombotic events", these complications seem more probably "immunothrombosis" consequent to the recent infection. Read More

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Leukocyte gene expression in post-thrombotic syndrome.

Thromb Res 2021 Mar 8;202:40-42. Epub 2021 Mar 8.

Thrombosis Expertise Center, Heart+Vascular Center, Maastricht University Medical Center (MUMC), Maastricht, the Netherlands; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.

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Validation of Outcome Instruments for Pediatric Postthrombotic Syndrome: Introducing the Peds-VEINES-QOL, a New Health-Related Quality of Life Instrument.

Thromb Haemost 2021 Mar 11. Epub 2021 Mar 11.

Hemophilia and Thrombosis Center, Department of Pediatrics, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.

Background:  There is need for validated outcome measures for postthrombotic syndrome (PTS) following pediatric venous thromboembolism (VTE), with a focus on quality of life (QoL).

Aims:  This article assesses reliability and validity of two PTS and two QoL scales for children following lower extremity VTE.

Methods:  Pediatric patients following lower extremity VTE were recruited from three thrombosis clinics. Read More

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Activated Prothrombin Complex Concentrate-Induced Atypical Hemolytic Uremic Syndrome Treated with Eculizumab.

Am J Case Rep 2021 Mar 8;22:e929616. Epub 2021 Mar 8.

Department of Hematology and Oncology, Veterans Affairs Loma Linda Healthcare System, Loma Linda, CA, USA.

BACKGROUND Atypical hemolytic uremic syndrome (aHUS) is a set of heterogenous disorders of thrombotic microangiopathy defined by thrombocytopenia, hemolytic anemia, and acute renal failure that is not mediated by shiga toxin. Factor Eight Inhibitor Bypassing Activity (FEIBA) is a concentrate of inactivated and activated coagulation factors that is approved for use to establish hemostasis in patients with hemophilia or acquired factor inhibitors. However, it has recently been used off-label as an anticoagulant reversal therapy among the general population. Read More

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Endovascular Treatment for Lower Extremity Deep Vein Thrombosis: An Overview.

Korean J Radiol 2021 Feb 2. Epub 2021 Feb 2.

Department of Radiology and Medical Research Institute, School of Medicine, Ewha Womans University, Seoul, Korea.

Lower extremity deep vein thrombosis (DVT) is a serious medical condition that can result in local pain and gait disturbance. DVT progression can also lead to death or major disability as a result of pulmonary embolism, postthrombotic syndrome, or limb amputation. However, early thrombus removal can rapidly relieve symptoms and prevent disease progression. Read More

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February 2021

Pediatric May-Thurner Syndrome-Systematic review and individual patient data meta-analysis.

J Thromb Haemost 2021 Mar 2. Epub 2021 Mar 2.

The Hospital for Sick Children, Toronto, Ontario, Canada.

Background: The outcomes of deep vein thrombosis (DVT) in children with May-Thurner Syndrome (MTS) remain unclear.

Objectives: This systematic review and patient-level meta-analysis aims to describe the outcomes of children with MTS presenting with DVT.

Methods: A systematic review of the published literature was performed. Read More

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Clinical characteristics and outcomes of combined thrombolysis and anticoagulation for pediatric and young adult lower extremity and inferior vena cava thrombosis.

Pediatr Hematol Oncol 2021 Mar 1:1-16. Epub 2021 Mar 1.

Department of Radiology, Section of Interventional Radiology, Texas, Children's Hospital, Baylor College of Medicine, Houston, Texas, USA.

Effective treatment for acute, extensive, symptomatic lower extremity (LE) thrombosis involves thrombolysis in addition to anticoagulation. There is limited available data on the outcomes and safety of thrombolysis to help guide its use in pediatrics and young adults. A retrospective study of children and young adults (<21 years of age) that received catheter directed thrombolysis (CDT) for LE and inferior vena cava (IVC) thrombosis was performed over a 5-year span at a pediatric tertiary care center. Read More

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