1,559 results match your criteria post-stroke depression


Depressive-, Cognitive- or Stroke-Related Risk Factors of Post-Stroke Depression: Which One Could Better Help Clinicians and Patients?

Neuropsychiatr Dis Treat 2021 29;17:1243-1251. Epub 2021 Apr 29.

GHU Paris Psychiatrie et Neurosciences, CMME, Hôpital Sainte-Anne, Paris, France.

Purpose: Post-stroke depression (PSD) affects one third of stroke survivors, with multiple severe negative consequences. We aim to assess the weight of four different types of clinical risk factors for PSD.

Patients And Methods: We conducted a prospective cohort study in a stroke centre. Read More

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Temporal evolution and predictors of subjective cognitive complaints up to 4 years after stroke.

J Rehabil Med 2021 May 5. Epub 2021 May 5.

Neurology, Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands.

Objective: To examine the temporal evolution of subjective cognitive complaints in the long-term after stroke, and to identify predictors of long-term subjective cognitive complaints.

Methods: Prospective cohort study including 395 stroke patients. Subjective cognitive complaints were assessed at 2 months, 6 months and 4 years post-stroke, using the Checklist for Cognitive and Emotional consequences following stroke (CLCE-24). Read More

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The efficacy and safety of agomelatine, sertraline, and escitalopram for senile post-stroke depression: A randomized double-blind placebo-controlled trial.

Clin Neurol Neurosurg 2021 Apr 16;205:106651. Epub 2021 Apr 16.

Department of General Medicine, Wu Zhongpei Memorial Hospital, Foshan 528300, China.

Objectives: This study aims to investigate the efficacy and safety of agomelatine, sertraline, and escitalopram for patients with senile post-stroke depression (SPSD, aged over 65 years).

Patients And Methods: A total of 165 patients (aged over 65 years) with post-stroke depression (PSD) were recruited. These patients were randomly assigned to one of four groups and given an anti-depressant or a placebo as follows: group A (agomelatine in combination with conventional cerebrovascular disease medication) 48 patients; group B (sertraline in combination with conventional cerebrovascular disease medication) 47 patients; group C (escitalopram in combination with conventional cerebrovascular disease medication) 50 patients; and, a control group (conventional treatment alone) 20 patients. Read More

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Telehealth Interventions to Support Self-Management in Stroke Survivors: A Systematic Review.

Healthcare (Basel) 2021 Apr 15;9(4). Epub 2021 Apr 15.

Department of Occupational Therapy, Inje University, 197 Inje-ro, Gimhae 50834, Korea.

Telehealth (TH) intervention is a method to optimize self-management (SM) support in stroke survivors. Objectives of this study included identifying the TH-SM intervention's focus and SM support components, the TH delivery type, and the TH-SM support effects on stroke survivors. Five databases were searched for the years 2005-2020 to identify TH-SM support interventions for stroke survivors. Read More

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Understanding Why Post-Stroke Depression May Be the Norm Rather Than the Exception: The Anatomical and Neuroinflammatory Correlates of Post-Stroke Depression.

J Clin Med 2021 Apr 14;10(8). Epub 2021 Apr 14.

Department of Neurology, Western Health & University Melbourne, AIMSS, Level Three, WHCRE, Sunshine Hospital, St Albans 3021, Australia.

Ischemic Stroke precedes depression. Post-stroke depression (PSD) is a major driver for poor recovery, negative quality of life, poor rehabilitation outcomes and poor functional ability. In this systematic review, we analysed the inflammatory basis of post-stroke depression, which involves bioenergetic failure, deranged iron homeostasis (calcium influx, Na influx, potassium efflux etc), excitotoxicity, acidotoxicity, disruption of the blood brain barrier, cytokine-mediated cytotoxicity, reactive oxygen mediated toxicity, activation of cyclooxygenase pathway and generation of toxic products. Read More

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Toll-like receptor 4-mediated cytokine synthesis and post-stroke depressive symptoms.

Transl Psychiatry 2021 Apr 26;11(1):246. Epub 2021 Apr 26.

Department of Neurology, Jagiellonian University Medical College, Krakow, Poland.

Altered cytokine synthesis thought to contribute to the pathophysiology of post-stroke depression (PSD). Toll-like receptor 4 (TLR4) is a master regulator of innate immunity. The aim of this study was to explore the putative association between TLR4-mediated cytokine synthesis and subsequent symptoms of PSD. Read More

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[Combined application of classical acupuncture, su-jok and craniopuncture in the acute period of ischemic stroke].

Vopr Kurortol Fizioter Lech Fiz Kult 2021 ;98(2):5-9

Novosibirsk State Medical University, Novosibirsk, Russia.

The disability of post-stroke patients is one of the most important problems of the modern medical community requiring the improvement of existing rehabilitation technologies through the wider use of non-drug treatment methods among which the most accessible are various modifications of reflexotherapy.

Objective: To evaluate the effectiveness of the combined reflexology technique, including the combined use of classical acupuncture, su-jok and cranial acupuncture in the early rehabilitation of patients after ischemic stroke.

Material And Methods: Examination and course of early neurorehabilitation were carried out in 80 patients aged 47-78 years. Read More

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[Pseudobulbar affect in stroke patients in Argentina].

Vertex 2020 Apr;XXX(148):1-5

Sección de Enfermedades Cerebrovasculares, Servicio de Neurología. Hospital J.M. Ramos Mejía, Ciudad de Buenos Aires, Argentina. E-mail:

Background: Pseudobulbar affect is defined by involuntary or exaggerated episodes of laughter or crying, subsequent to a specific disease. After-stroke pseudobulbar affect is reported in 11%-34% of patients. In our population is underdiagnosed. Read More

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Electroacupuncture Ameliorates Depressive-Like Behaviors in Poststroke Rats via Activating the tPA/BDNF/TrkB Pathway.

Neuropsychiatr Dis Treat 2021 13;17:1057-1067. Epub 2021 Apr 13.

Beijing Bo'ai Hospital, China Rehabilitation Research Center, China Rehabilitation Science Institute, Beijing, People's Republic of China.

Background: Electroacupuncture (EA) is a form of physical therapy that has been widely used in clinical practice in China. Post-stroke depression (PSD) is the most common neuropsychiatric complication after stroke. EA has been shown to have beneficial effects on PSD patients. Read More

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Effect of NEUROG3 polymorphism rs144643855 on regional spontaneous brain activity in major depressive disorder.

Behav Brain Res 2021 Apr 18;409:113310. Epub 2021 Apr 18.

Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medical, Southeast University, Nanjing, China; The Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, China. Electronic address:

Purpose: Our previous study identified a significant association between a single nucleotide polymorphism (SNP) located in the neurogenin3 (NEUROG3) gene and post-stroke depression (PSD) in Chinese populations. The present work explores whether polymorphism rs144643855 affects regional brain activity and clinical phenotypes in major depressive disorder (MDD).

Method: A total of 182 participants were included: 116 MDD patients and 66 normal controls. Read More

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Prevalence and predictors of new onset depression in the acute phase of stroke.

Asian J Psychiatr 2021 May 6;59:102636. Epub 2021 Apr 6.

Department of Medicine, University of Sri Lanka, Sri Lanka.

Introduction: Post-stroke depression (PSD) is known to be associated with poor functional outcome and high mortality. There is limited data on the prevalence and associated factors of depression in the acute phase after stroke.

Objectives: To determine the prevalence of PSD in the acute phase and its correlates among patients with stroke in a tertiary care hospital in Sri Lanka. Read More

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Impact of Sleep Duration on Depression and Anxiety After Acute Ischemic Stroke.

Front Neurol 2021 26;12:630638. Epub 2021 Mar 26.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Abnormal sleep duration predicts depression and anxiety. We seek to evaluate the impact of sleep duration before stroke on the occurrence of depression and anxiety at 3 months after acute ischemic stroke (AIS). Nationally representative samples from the Third China National Stroke Registry were used to examine cognition and sleep impairment after AIS (CNSR-III-ICONS). Read More

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Conversion of Reactive Astrocytes to Induced Neurons Enhances Neuronal Repair and Functional Recovery After Ischemic Stroke.

Front Aging Neurosci 2021 26;13:612856. Epub 2021 Mar 26.

Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA, United States.

The master neuronal transcription factor NeuroD1 can directly reprogram astrocytes into induced neurons (iNeurons) after stroke. Using viral vectors to drive ectopic ND1 expression in gliotic astrocytes after brain injury presents an autologous form of cell therapy for neurodegenerative disease. Cultured astrocytes transfected with ND1 exhibited reduced proliferation and adopted neuronal morphology within 2-3 weeks later, expressed neuronal/synaptic markers, and extended processes. Read More

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Effect of traditional Chinese medicine emotional therapy on post-stroke depression: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(14):e25386

Jinan People's Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China.

Background: Post-stroke depression has seriously affected the rehabilitation and quality of life of patients, and there is no reliable treatment plan at present. Nursing plays an important role in the recovery of patients, some studies have pointed out that traditional Chinese medicine emotional therapy has advantages in improving post-stroke depression and promoting rehabilitation, but it is lack of evidence-based basis. The purpose of this study is to systematically evaluate the effect of traditional Chinese medicine emotional therapy on the improvement of post-stroke depression. Read More

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Is Fluoxetine Good for Subacute Stroke? A Meta-Analysis Evidenced From Randomized Controlled Trials.

Front Neurol 2021 22;12:633781. Epub 2021 Mar 22.

Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China.

Fluoxetine is a drug commonly used to treat mental disorders, such as depression and obsessive-compulsive disorder, and some studies have shown that fluoxetine can improve motor and function recovery after stroke. Therefore, we performed a meta-analysis to investigate the efficacy and safety of fluoxetine in the treatment of post-stroke neurological recovery. PubMed, Embase, and Cochrane Library were searched for randomized controlled trials (RCTs) that were performed to assess the efficacy and safety of fluoxetine for functional and motor recovery in subacute stroke patients up to October 2020. Read More

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'Emotion is of the essence. … Number one priority': A nested qualitative study exploring psychosocial adjustment to stroke and aphasia.

Int J Lang Commun Disord 2021 Apr 7. Epub 2021 Apr 7.

Centre for Language and Communication Science Research, School of Health Sciences, City, University of London, London, UK.

Background: Stroke and aphasia can have a profound impact on people's lives, and depression is a common, frequently persistent consequence. Social networks also suffer, with poor social support associated with worse recovery. It is essential to support psychosocial well-being post-stroke, and examine which factors facilitate successful adjustment to living with aphasia. Read More

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A sudden and severe depressive episode after a left cingulate gyrus stroke: a case report of post-stroke depression and review of literature.

J Neural Transm (Vienna) 2021 Apr 7. Epub 2021 Apr 7.

Department of Psychiatry and Mental Health, Setúbal Hospital Center, Rua Camilo Castelo Branco, 2910-446, Setúbal, Portugal.

Post-stroke depression is a frequent complication of cerebrovascular lesions and mainly occurs within the first 6 months after stroke. Stroke patients who develop depression have slower recovery, greater disability, and higher mortality rates. The pathophysiology of post-stroke depression is not yet clearly defined, but studies suggest contributions from both psychosocial factors and stroke-related factors, such as lesions affecting the frontal-subcortical circuits. Read More

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Sleep Disorders in Stroke: An Update on Management.

Aging Dis 2021 Apr 1;12(2):570-585. Epub 2021 Apr 1.

2Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Stroke is a leading cause of disability and mortality all over the world. Due to an aging population, the incidence of stroke is rising significantly, which has led to devastating consequences for patients. In addition to traditional risk factors such as age, hypertension, hyperlipidemia, diabetes and atrial fibrillation, sleep disorders, as independent modifiable risk factors for stroke, have been highlighted increasingly. Read More

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Stroke Rehabilitation Use and Caregiver Psychosocial Health Profiles in Singapore: A Latent Profile Transition Analysis.

J Am Med Dir Assoc 2021 Apr 2. Epub 2021 Apr 2.

Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, Singapore.

Objectives: To identify and describe caregiver profiles based on their psychosocial health characteristics over a 12-month period and transitions among these profiles, to determine if stroke rehabilitation use at 12 months post-stroke differed by caregiver profile transition patterns, and to investigate if caregiver profiles at 3 months post-stroke moderate the association of stroke rehabilitation use at 3 months and 12 months post-stroke after accounting for covariates.

Design: Latent profile transition analysis of caregiver psychosocial health with stroke rehabilitation use at 12 month post-stroke as outcome.

Setting And Participants: A total of 149 stroke patient-caregiver dyads from the Singapore Stroke Study. Read More

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Prevalence of Balance Impairment and Factors Associated with Balance among Patients with Stroke. A Cross Sectional Retrospective Case Control Study.

Healthcare (Basel) 2021 Mar 13;9(3). Epub 2021 Mar 13.

Department of Physical Therapy, Faculty of Medical Rehabilitation Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Stroke is a major cause of disability worldwide, and balance impairments are common disabling factors in patients with stroke, leading to falls. Thus, the study objectives were as follows: (i) To find the prevalence of balance impairment among patients with stroke. (ii) To find out the factors associated with balance impairment in patients with stroke. Read More

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Acupuncture for post-stroke depression: a systematic review and meta-analysis.

BMC Complement Med Ther 2021 Apr 1;21(1):109. Epub 2021 Apr 1.

Department of Acupuncture, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Background: Acupuncture for post-stroke depression (PSD) has been evolving, but uncertainty remains. To assess the existing evidence from randomized clinical trials (RCTs) of acupuncture for PSD, we sought to draw conclusions by synthesizing RCTs.

Methods: An exhaustive literature search was conducted in seven electronic databases from their inception dates to April 19, 2020, to identify systematic reviews (SRs) and meta-analyses (MAs) on this topic. Read More

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Urinary Metabolite Signatures for Predicting Elderly Stroke Survivors with Depression.

Neuropsychiatr Dis Treat 2021 25;17:925-933. Epub 2021 Mar 25.

Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330006, People's Republic of China.

Background: Post-stroke depression (PSD) is a major complication in stroke survivors, especially in elderly stroke survivors. But there are still no objective methods to diagnose depression in elderly stroke survivors. Thus, this study was conducted to identify potential biomarkers for diagnosing elderly PSD subjects. Read More

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[Effect of acupuncture on PI3K/Akt/mTOR signaling pathway and autophagy-related proteins of hippocampus in rats with post-stroke depression].

Zhongguo Zhen Jiu 2020 Nov;40(11):1205-10

Department of Encephalopathy, Second Affiliated Hospital of Anhui University of CM, Hefei 230061, China.

Objective: To observe the improvement of acupuncture on depression-like behavior in rats with post-stroke depression (PSD), and to explore its possible mechanism.

Methods: A total of 48 SD rats were randomized into a sham-operation group, a model group, a Tongdu Tiaoshen group and a non-meridian-non-acupoint group, 12 rats in each group. In the the model group, the Tongdu Tiaoshen group and the non-meridian-non-acupoint group, PSD model was established by the compound method of cerebral medial arterial occlusion, chronic unpredictable mild stress and isolation. Read More

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November 2020

The Relationship of Psychiatric Symptoms with Performance-Based and Self-Reported Cognitive Function After Ischemic Stroke.

J Int Neuropsychol Soc 2021 Mar 31:1-13. Epub 2021 Mar 31.

Department of Psychology, Norwegian Institute of Science and Technology, Trondheim, Norway.

Objective: Findings on the relationship of psychiatric symptoms with performance-based and self-reported cognitive function post-stroke are inconclusive. We aimed to (1) study the relation of depression and anxiety to performance-based cognitive function and (2) explore a broader spectrum of psychiatric symptoms and their association with performance-based versus self-reported cognitive function.

Method: Individuals with supratentorial ischemic stroke performed neuropsychological examination 3 months after stroke. Read More

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Gadd45b is a novel mediator of depression-like behaviors and neuroinflammation after cerebral ischemia.

Biochem Biophys Res Commun 2021 May 27;554:107-113. Epub 2021 Mar 27.

Department of Neurology, The First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, China. Electronic address:

Background: Poststroke depression (PSD) is an important consequence after stroke, with a negative impact on stroke outcome. Recent evidence points to a modulatory role of Growth arrest and DNA-damage-inducible protein 45 beta (Gadd45b) in depression. Herein, we evaluated the antidepressant efficacy and mechanism underlying the potent therapeutic effects of Gadd45b after cerebral ischemia. Read More

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Post-stroke depression: Can intravenous thrombolysis be effective?

Eur J Neurol 2021 Mar 29. Epub 2021 Mar 29.

Stroke Center, Department of Systems Medicine, University of Rome Tor Vergata, Viale Oxford, 81, Rome, 00133, Italy.

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Monocyte-to-Lymphocyte Ratio is Associated with Depression 3 Months After Stroke.

Neuropsychiatr Dis Treat 2021 19;17:835-845. Epub 2021 Mar 19.

Department of Neurology and Institute of Neurology, Ruijin Hospital/Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Purpose: To explore the relationship between the monocyte-to-lymphocyte ratio (MLR) and depression three months after acute ischemic stroke.

Patients And Methods: From May 2013 to September 2014, 203 patients with acute ischemic stroke were recruited within 7 days post-stroke from Shanghai Ruijin Hospital and blood samples were collected after admission. The Hamilton Depression Scale and Clinical Review were evaluated at 3 months after stroke. Read More

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Serum ceramide concentrations are associated with depression in patients after ischemic stroke-A two-center case-controlled study.

Clin Chim Acta 2021 Mar 26;518:110-115. Epub 2021 Mar 26.

Clinical Diagnosis Department of Beijing Tiantan Hospital & Capital Medical University, China; NMPA Key Laboratory for Quality Control of In Vitro Diagnostics, Fengtai district, Beijing, 100076, China; Beijing Engineering Research Center of Immunological Reagents Clinical Research, Fengtai district, Beijing, 100076, China. Electronic address:

Background And Aims: The present study aims to correlate the severity of post-stroke depression (PSD) and serum ceramide concentration.

Materials And Methods: In this two-center case-control study, we prospectively collected clinical and demographical information from age and gender-matched 51 PSD patients, 56 non-post-stroke depression (Non-PSD) patients, and 39 patients with major depression (MD) to perform the suitable biochemical analysis to bring a correlation in causing depression in patients soon after the stroke. The ROC curve method was used to evaluate ceramide's diagnostic efficacy in all three groups of patients. Read More

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Effectiveness and safety of music-supported therapy on mood in post-stroke rehabilitation patients: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Mar;100(12):e25077

The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China.

Background: Music-supported therapy has been widely used clinically to relieve post-stroke rehabilitation. However, the efficacy of Music-supported therapy in the treatment of Mood in post-stroke rehabilitation Patients is uncertain. The purpose of this study is to determine the effectiveness and safety of Music-supported therapy in the treatment of Mood in post-stroke rehabilitation Patients. Read More

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Study on quantitative diagnosis model of TCM syndromes of post-stroke depression based on combination of disease and syndrome.

Medicine (Baltimore) 2021 Mar;100(12):e25041

Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Background: Post-stroke depression (PSD) is one of the most common stroke complications with high morbidity. Researchers have done much clinical research on Traditional Chinese Medicine (TCM) treatment, but very little research on diagnosis. Based on the thought of combination of disease and syndrome, this study will establish a unified and objective quantitative diagnosis model of TCM syndromes of PSD, so as to improve the clinical diagnosis and treatment of PSD. Read More

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