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Integrated genomic and transcriptomic analysis reveals unique mechanisms for high osmotolerance and halotolerance in Hyphopichia yeast.

Environ Microbiol 2021 Apr 8. Epub 2021 Apr 8.

Molecular Systems Biology Laboratory of Life Science, Chung-Ang University, Seoul, 06974, South Korea.

The yeast species Hyphopichia is common in nature and strongly competitive under harsh environmental conditions. Here, we characterized Hyphopichia burtonii KJJ43 and H. pseudoburtonii KJS14, which exhibit strong halotolerance, using genomic and transcriptomic analyses. Read More

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Genome-wide association mapping for resistance to bacterial blight and bacterial leaf streak in rice.

Planta 2021 Apr 8;253(5):94. Epub 2021 Apr 8.

Southern Regional Collaborative Innovation Center for Grain and Oil Crops and College of Agronomy, Hunan Agricultural University, Changsha, China.

Main Conclusion: Using genome-wide SNP association mapping, a total of 77 and 7 loci were identified for rice bacterial blight and bacterial leaf streak resistance, respectively, which may facilitate rice resistance improvement. Bacterial blight (BB) and bacterial leaf streak (BLS) caused by Gram-negative bacteria Xanthomonas oryzae pv. oryzae (Xoo) and X. Read More

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Molecular and phenotypic characterization of efflux pump and biofilm in multi-drug resistant non-typhoidal Serovars isolated from food animals and handlers in Lagos Nigeria.

One Health Outlook 2021 9;3. Epub 2021 Feb 9.

Molecular Biology and Biotechnology Department, Nigerian Institute of Medical Research Lagos, Lagos, Nigeria.

Background: Multidrug resistance efflux pumps and biofilm formation are mechanisms by which bacteria can evade the actions of many antimicrobials. Antibiotic resistant non-typhoidal serovars have become wide spread causing infections that result in high morbidity and mortality globally. The aim of this study was to evaluate the efflux pump activity and biofilm forming capability of multidrug resistant non-typhoidal (NTS) serovars isolated from food handlers and animals (cattle, chicken and sheep) in Lagos. Read More

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February 2021

Enhanced Fenton-like catalytic activity and stability of g-CN nanosheet-wrapped copper phosphide with strong anti-interference ability: Kinetics and mechanistic study.

J Colloid Interface Sci 2021 Mar 24;595:129-141. Epub 2021 Mar 24.

School of Materials Science and Engineering, Shandong University of Technology, Zibo 255049, China.

Metal-based Fenton-like catalysts usually activate HO to produce free radicals (OH and O) for the degradation of organic pollutants. However, a catalytic reaction dominated by free radicals is easily interfered with by various inorganic anions and water matrices. Herein, g-CN-wrapped copper phosphide (CuP), as a highly efficient Fenton-like catalyst, was successfully synthesized by a simple low-temperature phosphidation method. Read More

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Antibacterial activity of positively charged carbon quantum dots without detectable resistance for wound healing with mixed bacteria infection.

Mater Sci Eng C Mater Biol Appl 2021 Apr 18;123:111971. Epub 2021 Feb 18.

Department of Pharmaceutical Analysis, School of Pharmacy, Fujian Medical University, Fuzhou, 350122, China. Electronic address:

Widespread bacterial infection and the spread of antibiotic resistance exhibit increasing threat to the public and thus require new antibacterial strategies. Carbon quantum dots (CQDs) have been extensively investigated to play fluorescent, catalytic roles and even potential biomedical functions containing sterilization. However, synthetic understanding of the interaction of CQDs and bacteria, the exhibition of antibacterial ability, and the risk of resistance evolution remain lacking. Read More

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Highly sensitive and selective fluorescence sensing of nitrofurantoin based on water-soluble copper nanoclusters.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Mar 23;255:119737. Epub 2021 Mar 23.

Department of Chemistry, Taiyuan Normal University, Jinzhong 030619, PR China.

In this contribution, dopamine-protected copper nanoclusters as a novel fluorescent nanosensor was employed to detect nitrofurantoin (NFT) for the first time, which were prepared by using dopamine as the stabilizing agent and sodium borohydride (NaBH) and hydrazine hydrate (NH·HO) as the reducing agents. A series of methods were used to analyze the structure and optical properties of as-prepared Cu NCs, such as UV-Vis absorption spectroscopy, fluorescence spectroscopy, Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). It possessed high dispersion, excellent water solubility, good photostability and strong green fluorescence under UV lamp (365 nm). Read More

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Antioxidant and Antiproliferative Potentials of and Its Bioactive Polyphenol Metabolites.

Pharmaceuticals (Basel) 2021 Mar 15;14(3). Epub 2021 Mar 15.

CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China.

Delile (Moraceae), a reputed plant that is used in herbal medicine, is of high medicinal and nutritional value in local communities primarily ascribed to its phytochemical profile. Currently, there are hardly any fine details on the chemical profiling and pharmacological evaluation of this species. In this study, the flavonoids and phenolics contents of the ethanol extracts and four extracted fractions (petroleum ether (PE), ethyl acetate (EA), -butanol, and water) of the stem bark of were firstly quantified. Read More

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Quantitative Analysis of Rutin by HPTLC and In Vitro Antioxidant and Antibacterial Activities of Phenolic-Rich Extracts from .

Plants (Basel) 2021 Mar 3;10(3). Epub 2021 Mar 3.

CONACYT-Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional Unidad Michoacán, Instituto Politécnico Nacional, Jiquilpan 59510, Michoacan, Mexico.

A. Gray, like other wild plants of the genus , has been used in herbal medicine. There is information for other species of the genus related to their phenolic content, antioxidant capacity, and isolation of bioactive compounds with antimicrobial activity. Read More

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Mitochondrial genome characterization of (Orthoptera: Gryllidae) and its phylogenetic implications.

Mitochondrial DNA B Resour 2021 Mar 19;6(3):1056-1058. Epub 2021 Mar 19.

School of Preclinical Medicine, Wannan Medical College, Wuhu, China.

is a cricket widely distributed throughout the world. In this study, we reported the first complete mitogenome sequence of Genus and inferred its phylogeny. The mitogenome of was 16,369 bp and consisted of a control region and a typical set of 37 genes. Read More

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Coaxial electrospun PVA/PCL nanofibers with dual release of tea polyphenols and ε-poly (L-lysine) as antioxidant and antibacterial wound dressing materials.

Int J Pharm 2021 Mar 26:120525. Epub 2021 Mar 26.

School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, 510006, China; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, China. Electronic address:

Preparing wound dressing with dual-delivery of antioxidant and antibacterial agents is highly desirable in clinical wound treatment. Herein, a series of coaxial nanofiber membranes loaded with antioxidant tea polyphenols (TP) in the core and antibacterial ε-poly (L-lysine) (ε-PL) in the shell layer were successfully fabricated by coaxial electrospinning. The physicochemical characterizations by transmission electron microscopy, inverted fluorescence microscopy and fourier transform infrared spectroscopy confirmed the formation of core-shell structure. Read More

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Novel 4,5-dihydrospiro[benzo[c]azepine-1,1'-cyclohexan]-3(2H)-one derivatives as PARP-1 inhibitors: Design, synthesis and biological evaluation.

Bioorg Chem 2021 Mar 22;111:104840. Epub 2021 Mar 22.

School of Pharmacy, China Medical University, 77 Puhe Road, North New Area, Shenyang 110122, China. Electronic address:

To further explore the research of novel PARP-1 inhibitors, we designed and synthesized a series of novel amide PARP-1 inhibitors based on our previous research. Most compounds displayed certain antitumor activities against four tumor cell lines (A549, HepG2, HCT-116, and MCF-7). Specifically, the candidate compound R8e possessed strong anti-proliferative potency toward A549 cells with the IC value of 2. Read More

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Characterization of a Deep Sea Isolate: Genomic and Pathogenic Features.

Front Cell Infect Microbiol 2021 10;11:629116. Epub 2021 Mar 10.

CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, China.

is a group of Gram-positive bacteria belonging to the group and used in some cases as probiotics or biocontrol agents. To our knowledge, from the deep sea (depth >1,000 m) has not been documented. Here, we report the isolation and characterization of a strain, P18, from a deep sea hydrothermal field. Read More

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Physiological, biochemical, and transcriptional regulation in a leguminous forage Trifolium pratense L. responding to silver ions.

Plant Physiol Biochem 2021 Mar 11;162:531-546. Epub 2021 Mar 11.

School of Resources and Civil Engineering, Northeastern University, 11 Wenhua Road, Heping District, Shenyang, 110819, China. Electronic address:

Trifolium pratense L. (red clover) is an important leguminous crop with great potential for Ag-contaminated environment remediation. Whereas, the molecular mechanisms of Ag tolerance in red clover are largely unknown. Read More

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Identification of novel androgen receptor degrading agents to treat advanced prostate cancer.

Eur J Med Chem 2021 Mar 16;217:113376. Epub 2021 Mar 16.

Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China. Electronic address:

Prostate cancer (PCa) is one of the most common malignancies affecting men worldwide. Androgen receptor (AR) has been a target of PCa treatment for nearly six decades. AR antagonists/degraders can effectively treat PCa caused by increased AR overexpression. Read More

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The relationship between cardiac injury, inflammation and coagulation in predicting COVID-19 outcome.

Sci Rep 2021 03 22;11(1):6515. Epub 2021 Mar 22.

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

High sensitivity troponin T (hsTnT) is a strong predictor of adverse outcome during SARS-CoV-2 infection. However, its determinants remain partially unknown. We aimed to assess the relationship between severity of inflammatory response/coagulation abnormalities and hsTnT in Coronavirus Disease 2019 (COVID-19). Read More

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Agricultural land-use change and rotation system exert considerable influences on the soil antibiotic resistome in Lake Tai Basin.

Sci Total Environ 2021 Jun 19;771:144848. Epub 2021 Jan 19.

State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China.

In this study, we use high-throughput quantitative polymerase chain reaction approaches to comprehensively assess the effects of agricultural land-use change on the antibiotic resistome of agricultural runoffs after rainfalls in Lake Tai Basin. For the first time in this region, our findings show that orchard runoffs harbored more diverse and abundant antibiotic resistance genes (ARGs) than traditional cropland runoffs. Network analysis demonstrated that orchard runoffs possessed a strong ability for ARG dissemination via horizontal gene transfer. Read More

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Carbon nitride grafted waste-derived carbon as sustainable materials for lithium-sulfur batteries.

Nanotechnology 2021 Mar 18. Epub 2021 Mar 18.

State Key Laboratory of Clean and Efficient Coal Utilization, Taiyuan University of Technology, Taiyuan, Shanxi , CHINA.

The syntheses of carbon materials by carbonizing coal, melamine-urea-formaldehyde resin, and luffa cylindrical sponge precursors were demonstrated, respectively. The lithium-sulfur battery performances of C3N4 grafted carbon materials were investigated. The lithium-sulfur cell assembled by cathodes of the composites from coal-derived carbon possessed specific capacity of 1269. Read More

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Regulation of Ce (Ⅲ) / Ce (Ⅳ) ratio of cerium oxide for antibacterial application.

iScience 2021 Mar 24;24(3):102226. Epub 2021 Feb 24.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.

Antibiotics have been considered as effective weapons against bacterial infections since they were discovered. However, antibiotic resistance caused by overuse and abuse of antibiotics is an emerging public health threat nowadays. Fully defeating bacterial infections has become a tough challenge. Read More

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Accelerating ESD-induced gastric ulcer healing using a pH-responsive polyurethane/small intestinal submucosa hydrogel delivered by endoscopic catheter.

Regen Biomater 2021 Feb 4;8(1):rbaa056. Epub 2021 Jan 4.

Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Keyuan Road 4, Gaopeng Street, Chengdu, Sichuan 610041, China.

Endoscopic submucosal dissection (ESD) is the standard treatment for early-stage gastric cancer, but the large post-operative ulcers caused by ESD often lead to serious side effects. Post-ESD mucosal repair materials provide a new option for the treatment of post-ESD ulcers. In this study, we developed a polyurethane/small intestinal submucosa (PU/SIS) hydrogel and investigated its efficacy for accelerating ESD-induced ulcer healing in a canine model. Read More

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February 2021

Emodin suppresses the migration and invasion of melanoma cells.

Biol Pharm Bull 2021 Mar 17. Epub 2021 Mar 17.

Department of Plastic and Reconstructive Surgery, Hua Dong Hospital Affiliated to Fu Dan University.

Emodin(1,3,8-trihydroxy-6-methylanthraquinone), as an active ingredient in rhubarb roots and rhizomes, has been reported to possess various pharmacological properties including anti-tumor effects. Recent studies have confirmed that emodin inhibited cell proliferation and induced apoptosis of cancer cells. However, the inhibitory effect of emodin on the migration and invasion of melanoma cells and its underlying mechanism are still unclear. Read More

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Poly(amino acid)s-based star AIEgens for cell uptake with pH-response and chiral difference.

Colloids Surf B Biointerfaces 2021 Mar 9;202:111687. Epub 2021 Mar 9.

Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address:

Chiral aggregation-induced emission luminogens (AIEgens) are the new-generation chiral sensors that regulate chiral signals from the molecular level to the macroscopic assembly. Expanding applications of chiral AIEgens and in-depth understanding of their chiral recognition in biological systems are meaningful. Herein, two star chiral AIEgens, consisting of tetraphenylethene (TPE) as core and poly(N-acryloyl-L(D) valine) (PLV or PDV) as arms, were precisely synthesized via atom transfer radical polymerization (ATRP) technique and named TPE-PLV and TPE-PDV. Read More

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Conversion of Multicyclic Hydrocarbons to Mono-Aromatic Hydrocarbons Over CoMo/Zeolite Socony Mobil-5 Catalysts.

J Nanosci Nanotechnol 2021 Jul;21(7):3819-3823

Department of Chemical Engineering, Kongju National University, Cheonan 31080, Republic of Korea.

This study focuses on analyzing the effects of the SiO₂/Al₂O₃ ratio of a support on the physico-chemical properties of bead-type CoMo/HZSM-5 catalysts and on the catalytic performance during the hydrocracking reaction of PFO. CoMo/HZSM-5 catalysts were prepared by an incipient wetness method. Subsequently, binder-added catalysts were molded into the bead type catalysts. Read More

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Evaluation of preventive, supportive and awareness building measures among international students in China in response to COVID-19: a structural equation modeling approach.

Glob Health Res Policy 2021 03 13;6(1):10. Epub 2021 Mar 13.

Centre for Global Health, University of Oslo, Kirkeveien 166, Frederik Holsts hus, 0450, Oslo, Norway.

Background: Education institutions promptly implemented a set of steps to prevent the spread of COVID-19 among international Chinese students, such as restrictive physical exercise, mask wear, daily health reporting, etc. Success of such behavioral change campaigns largely depends on awareness building, satisfaction and trust on the authorities. The purpose of this current study is to assess the preventive, supportive and awareness-building steps taken during the COVID-19 pandemic for international students in China, that will be useful for planning such a behavioral change campaign in the potential pandemic situation in other parts of the world. Read More

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Th17, rather than Th1 cell proportion, is closely correlated with elevated disease severity, higher inflammation level, and worse prognosis in sepsis patients.

J Clin Lab Anal 2021 Mar 11:e23753. Epub 2021 Mar 11.

Department of Intensive Care Unit, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: The current study aimed to investigate the prognostic value of T helper (Th) 1 and Th17 proportions in sepsis patients.

Methods: Th1 and Th17 cells in blood CD4 T cells were detected by flow cytometry in 210 sepsis patients and 100 healthy controls (HCs). Besides, serum interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and interleukin-17 (IL-17) levels in the enrolled sepsis patients were determined with enzyme-linked immunosorbent assay. Read More

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An autophagy-related prognostic signature associated with immune microenvironment features of uveal melanoma.

Biosci Rep 2021 Mar;41(3)

Department of Pediatric Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Autophagy is involved in cancer initiation and progression but its role in uveal melanoma (UM) was rarely investigated. Herein, we built an autophagy-related gene (ARG) risk model of UM patients by univariate Cox regression and least absolute shrinkage and selection operator (Lasso) regression model and filtrated out nine prognostic ARGs in The Cancer Genome Atlas (TCGA) cohort. Survival and Receiver Operating Characteristic (ROC) Curve analysis in the TCGA and other four independent UM cohorts (GSE22138, GSE27831, GSE44295 and GSE84976) proved that the ARG-signature possessed robust and steady prognosis predictive ability. Read More

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Discovery of Acyl-sulfonamide Na1.7 Inhibitors GDC-0276 and GDC-0310.

J Med Chem 2021 Mar 8;64(6):2953-2966. Epub 2021 Mar 8.

Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.

Na1.7 is an extensively investigated target for pain with a strong genetic link in humans, yet in spite of this effort, it remains challenging to identify efficacious, selective, and safe inhibitors. Here, we disclose the discovery and preclinical profile of GDC-0276 () and GDC-0310 (), selective Na1. Read More

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Carboxylated PEG-Functionalized MnFeO Nanocubes Synthesized in a Mixed Solvent: Morphology, Magnetic Properties, and Biomedical Applications.

ACS Omega 2021 Mar 18;6(8):5266-5275. Epub 2021 Feb 18.

Centre for Nanotechnology Research, Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India.

Ferrites are one of the most studied materials around the globe due to their distinctive biological and magnetic properties. In the same line, anisotropic MnFeO nanoparticles have been explored as a potential candidate possessing excellent magnetic properties, biocompatibility, and strong magnetic resonance imaging (MRI) properties such as 2 relaxivity for magnetic field-guided biomedical applications. The current work reports the synthesis and morphological evolution of MnFeO nanocubes (MNCs) in a hydrothermal process using different volume ratios of water and ethanol. Read More

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The inhibitory effect of 225 frequently-used traditional Chinese medicines for CYP3A4 metabolic enzyme by isoform-specific probe.

Fitoterapia 2021 Mar 4:104858. Epub 2021 Mar 4.

Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Traditional Chinese medicines (TCMs), have been widely used for the prevention, treatment, and cure of various diseases for thousands of years in China and Asian countries. It is usually applied either alone or in combination with synthetic drugs or other herbs to be more effective. However, the evaluation of TCMs against the main phase I metabolic enzyme CYP3A4 in vitro was limited. Read More

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A Long-Term Stable Sensor Based on Fe@PCN-224 for Rapid and Quantitative Detection of HO in Fishery Products.

Foods 2021 Feb 14;10(2). Epub 2021 Feb 14.

Ocean College, Zhejiang University, Zhoushan 316021, China.

Hydrogen peroxide (HO) has been reported to be used for the illegal treatment of fishery products in order to obtain "fake" freshness. Residues of HO in food may be of toxicology concern. In this study, a nonenzymatic sensor was developed based on Fe@PCN-224 metal-organic frameworks wrapped by Nafion to detect HO concentration. Read More

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February 2021

Preparation of a Novel Cellulose-Styrene Copolymer Adsorbent and Its Adsorption of Nitrobenzene from Aqueous Solutions.

Polymers (Basel) 2021 Feb 18;13(4). Epub 2021 Feb 18.

College of Chemical Engineering, Fuzhou University, Fuzhou 350116, China.

A novel cellulose-styrene copolymer adsorbent (cellulose-St) was prepared using free radical polymerization. Successful polymerization was confirmed through Fourier Transform Infrared Spectroscopy (FTIR), Carbon 13 Solid Nuclear Magnetic Resonance (C NMR) Spectroscopy, Scanning Electron Microscopy (SEM), etc. Cellulose-St possessed good hydrophobicity, and the best water contact angle of cellulose-St samples could reach 146°. Read More

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February 2021