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Transitional care experiences of caregivers of preterm infants hospitalized in a neonatal intensive care unit: A qualitative descriptive study.

Nurs Open 2021 May 5. Epub 2021 May 5.

Neonatal Intensive Care Unit, Children's Hospital of Soochow University, Suzhou, China.

Aim: To describe the transitional care experiences and nursing needs of caregivers of preterm infants hospitalized in neonatal intensive care units (NICUs).

Design: A qualitative descriptive study.

Methods: We conducted semi-structured interviews with the 24 caregivers of preterm infants admitted to Children's Hospital, Soochow University. Read More

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What is a compassionate response in the emergency department? Learner evaluation of an End-of-Life Essentials online education module.

Emerg Med Australas 2021 May 5. Epub 2021 May 5.

Palliative and Supportive Services, Flinders University, Adelaide, South Australia, Australia.

Objective: To evaluate the End-of-Life Essentials education module 'Emergency Department End-of-Life Care' and explore learners' views on what constitutes a compassionate response in the ED.

Methods: The present study used a multi-methods approach. Learners comprised a mix of nurses, doctors and allied health professionals. Read More

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The association of estimated cardiorespiratory fitness with COVID-19 incidence and mortality: A cohort study.

PLoS One 2021 5;16(5):e0250508. Epub 2021 May 5.

Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

Background: It has been suggested that cardiorespiratory fitness (CRF) may be used to identify those at greatest risk for severe COVID-19 illness. However, no study to date has examined the association between CRF and COVID-19. The objectives of this study were to determine whether CRF is independently associated with testing positive with or dying from COVID-19. Read More

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Nutritional markers of undiagnosed type 2 diabetes in adults: Findings of a machine learning analysis with external validation and benchmarking.

PLoS One 2021 5;16(5):e0250832. Epub 2021 May 5.

Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing, and Health Sciences, Monash University, Clayton, Australia.

Objectives: Using a nationally-representative, cross-sectional cohort, we examined nutritional markers of undiagnosed type 2 diabetes in adults via machine learning.

Methods: A total of 16429 men and non-pregnant women ≥ 20 years of age were analysed from five consecutive cycles of the National Health and Nutrition Examination Survey. Cohorts from years 2013-2016 (n = 6673) was used for external validation. Read More

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Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region.

PLoS One 2021 5;16(5):e0250586. Epub 2021 May 5.

Division of Pulmonary and Critical Care Medicine and UCSF Center for Tuberculosis, University of California San Francisco, San Francisco, California, United States of America.

Introduction: Contemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus non-African regions, the reasons for which remain unclear. Understanding host and disease phenotypes that may vary by region is important for optimizing curative treatments.

Methods: We characterized clinical features and the serum proteome of phase 2 TB clinical trial participants undergoing treatment for smear positive, culture-confirmed TB, comparing host serum protein expression in clinical trial participants enrolled in African and Non-African regions. Read More

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Surgical Features after Neoadjuvant Treatment for Breast Cancer.

Chirurgia (Bucur) 2021 Mar-Apr;116(2):193-200

Patients with breast cancer may receive neoadjuvant cancer treatment in order to benefit from radical surgery or to turn an indication for extensive surgery into a conservatory or oncoplastic operation.

Aim: To establish the main implications of therapeutic management of the cases of breast cancer treated initially with chemotherapy followed by surgery.

Material And Method: 35 breast cancer patients operated in 2020 after NACT (neoadjuvant chemotherapy) in Surgery Clinic of Coltea Hospital are analyzed, and the response after treatment is pathologicaly evaluated using the Residual Cancer Burden method The results of the analysis of the group of patients showed that most patients presented downstaging of the disease after neoadjuvant treatment with a proportion of 17,14% with complete pathologic response. Read More

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Sentinel Lymph Node Biopsy after Neoadjuvant Treatment for Breast Cancer. The Validation Protocol.

Chirurgia (Bucur) 2021 Mar-Apr;116(2):178-185

The identification and biopsy of the sentinel lymph node (SLNB) in breast cancer patients requiring neoadjuvant cytostatic treatment (NAC), with clinically negative lymph nodes following treatment, may be an effective method of de-escalation of axillary surgery. Materials and methods: This prospective study includes 47 cases of breast cancer stage IIB-IIIA, with NAC treatment and complete axillary clinical and imaging response, surgeries performed at Prof. Dr. Read More

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Mechanisms of exercise as a preventative measure to muscle wasting.

Am J Physiol Cell Physiol 2021 May 5. Epub 2021 May 5.

Florida Institute for Human & Machine Cognition, Pensacola, FL; Department of Cell, Developmental, and Integrative Biology; UAB Center for Exercise Medicine; Division of Gerontology, Geriatrics and Palliative Care, Department of Medicine, United States.

Skeletal muscle is the most abundant tissue in healthy individuals and it has important roles in health beyond voluntary movement. The overall mass and energy requirements of skeletal muscle require it to be metabolically active and flexible to multiple energy substrates. The tissue has evolved to be largely load-dependent and it readily adapts in a number of positive ways to repetitive overload, such as various forms of exercise training. Read More

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Breast cancer organoids from malignant pleural effusion-derived tumor cells as an individualized medicine platform.

In Vitro Cell Dev Biol Anim 2021 May 5. Epub 2021 May 5.

Department of Oncology & Department of Breast Surgery, The Second Hospital of Dalian Medical University, Dalian, 116023, China.

Malignant pleural effusion (MPE) presents a severe medical condition in patients with advanced breast cancer (BC). We applied organoid culture technology to culture preoperative puncture specimen and corresponding surgical specimen-derived tumor cells from early BC patients and pleural effusion-derived tumor cells from advanced BC patients with MPE to study whether in vitro models could predict therapies of clinical patients. We successfully expanded pleural effusion-derived tumor organoids from 1 advanced triple-negative breast cancer (TNBC) patient with MPE which had been continuously propagated for more than 3 months. Read More

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Histomorphological patterns of regional lymph nodes in COVID-19 lungs.

Pathologe 2021 May 5. Epub 2021 May 5.

Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.

Background: A dysregulated immune response is considered one of the major factors leading to severe COVID-19. Previously described mechanisms include the development of a cytokine storm, missing immunoglobulin class switch, antibody-mediated enhancement, and aberrant antigen presentation.

Objectives: To understand the heterogeneity of immune response in COVID-19, a thorough investigation of histomorphological patterns in regional lymph nodes was performed. Read More

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Long-term Physical and Psychological Outcomes of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.

JAMA Dermatol 2021 May 5. Epub 2021 May 5.

Hennepin Healthcare, University of Minnesota Medical School, Minneapolis.

Importance: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is known to cause multiple end-organ complications in its acute phase, but less is known about the long-term association with patients' mental health and quality of life.

Objective: To examine the chronic physical and psychological sequelae affecting patients with SJS/TEN.

Design, Setting, And Participants: A survey study conducted at 11 academic health centers in the US evaluated 121 adults diagnosed with SJS/TEN by inpatient consultive dermatologists between January 1, 2009, and September 30, 2019. Read More

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Psychometric analysis of the comfort scale for family members of people in critical health condition.

Rev Bras Enferm 2021 3;74(2):e20200170. Epub 2021 May 3.

Universidade Estadual Paulista Júlio de Mesquita Filho. Botucatu, São Paulo, Brazil.

Objectives: to assess the reliability and validity of the 46 items version of the comfort scale for family members of people in critical condition.

Methods: a methodological study, carried out with 278 family members of critically ill patients, admitted to adult and pediatric intensive care units, in a city in the interior of the state of São Paulo, in Brazil. The analyzes were based on the Classical Test Theory and Item Response Theory. Read More

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Soil respiration analysis using a mid-infrared quantum cascade laser and calibration-free WMS-based dual-gas sensor.

Analyst 2021 May 5. Epub 2021 May 5.

Laser Spectroscopy and Sensing Laboratory, Anhui University, 230601 Hefei, China.

A high response and sensitive dual-gas sensor based on calibration-free wavelength modulation spectroscopy (CF-WMS) has been developed for the simultaneous detection of carbon monoxide (CO) and nitrous oxide (N2O) to eliminate the detection errors caused by light intensity variations. A multi-pass cell (MPC) was employed to lengthen the optical path to improve the precision of the sensing system by combining with a 4.56 μm mid-infrared quantum cascade laser (MIR-QCL). Read More

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In patients with heart failure, enhanced ventilatory response to exercise is associated with severe obstructive sleep apnea.

J Clin Sleep Med 2021 May 5. Epub 2021 May 5.

Departamento de Psicobiologia, Universidade Federal de São Paulo, São Paulo, Brazil.

Study Objectives: Patients with chronic heart failure (CHF) while undergoing exercise test, frequently exhibit elevated ratio of minute ventilation over CO₂ output (VE/VCO₂ slope). One of the factors contributing to this elevated slope is increased chemosensitivity to CO₂, as this slope significantly correlates with the slope of the ventilatory response to CO₂ rebreathing at rest. A previous study in patients with CHF and central sleep apnea (CSA) has shown the highest VE/VCO2 slope during exercise was associated with the most severe CSA. Read More

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Patient personalized translational tools in Cystic fibrosis to transform data from bench to bed-side and back.

Am J Physiol Gastrointest Liver Physiol 2021 May 5. Epub 2021 May 5.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, United Statesgrid.239573.9.

Cystic fibrosis is a deadly multi-organ disorder caused by loss of function mutations in the gene that encodes for the cystic fibrosis transmembrane conductance regulator (CFTR) chloride/bicarbonate ion channel. More than 1700 CFTR genetic variants exist that can cause CF, and, majority of these are extremely rare. Due to genetic and environmental influences, CF patients exhibit large phenotypic variation. Read More

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Quantile modeling through multivariate log-normal/independent linear regression models with application to newborn data.

Biom J 2021 May 5. Epub 2021 May 5.

Departamento de Estatística, Universidade de São Paulo, São Paulo, Brazil.

In this article, we propose and study the class of multivariate log-normal/independent distributions and linear regression models based on this class. The class of multivariate log-normal/independent distributions is very attractive for robust statistical modeling because it includes several heavy-tailed distributions suitable for modeling correlated multivariate positive data that are skewed and possibly heavy-tailed. Besides, expectation-maximization (EM)-type algorithms can be easily implemented for maximum likelihood estimation. Read More

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Burkitt lymphoma with granulomatous reaction: A M1/TH1-polarized microenvironment associates with controlled growth and spontaneous regression.

Histopathology 2021 May 5. Epub 2021 May 5.

Department of Medical Biotechnologies, University of Siena, Siena, Italy.

Aims: Burkitt lymphoma (BL) is an aggressive B-cell lymphoma, which in some instances, may show a granulomatous reaction associated with a favourable prognosis and occasional spontaneous regression. In the present study, we aimed to define the tumour microenvironment (TME) in four of such cases, two of which regressed spontaneously.

Methods And Results: All cases showed aggregates of tumour cells with the typical morphology, molecular cytogenetics and immunophenotype of BL surrounded by a florid epithelioid granulomatous reaction. Read More

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3D-printing-assisted fabrication of chitosan scaffolds from different sources and cross-linkers for dental tissue engineering.

Eur Cell Mater 2021 05 5;41:485-501. Epub 2021 May 5.

The aim of the present study was to fabricate and characterise chitosan scaffolds from animal and fungal sources, with or without gelatine as a co-polymer, and cross-linked to 3-glycidyloxyproply trimethoxysilane (GPTMS) or genipin for application in dental root tissue engineering. Chitosan-based scaffolds were prepared by the emulsion freeze-drying technique. Scanning electron microscopy (SEM) and nano-focus computed tomography (nano-CT) were used to characterise scaffold microstructure. Read More

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Retinal Morpho-Functional Changes Following 0.19 mg Fluocinolone Acetonide Intravitreal Implant for Chronic Diabetic Macular Edema.

Adv Ther 2021 May 4. Epub 2021 May 4.

Università Cattolica del Sacro Cuore, Rome, Italy.

Purpose: To evaluate morpho-functional outcomes of the intravitreal fluocinolone acetonide (FAc) implant.

Methods: Retrospective, observational, single-center study. Primary endpoint was the mean change in central macular thickness (CMT) from baseline to month 1-3. Read More

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Comparisons of Serologic Responses of Early Syphilis to Treatment with a Single-Dose Benzathine Penicillin G Between HIV-Positive and HIV-Negative Patients.

Infect Dis Ther 2021 May 4. Epub 2021 May 4.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung-Shan South Road, Taipei, Taiwan.

Introduction: Poorer serologic responses of early syphilis to treatment have been inconsistently reported in HIV-positive patients compared with HIV-negative patients, but the interpretation of previous studies is limited by discrepant study designs. The present study aimed to evaluate the effect of HIV infection on the treatment response to a single dose of benzathine penicillin G (BPG) for early syphilis.

Methods: From January 2015 to March 2020, adult patients with early syphilis who received a single dose of BPG were enrolled and rapid plasma reagin (RPR) titers were periodically determined. Read More

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Usefulness of ultrasound in sub-Saharan patients with a serological diagnosis of schistosomiasis.

Infection 2021 May 4. Epub 2021 May 4.

Tropical Medicine Unit, Hospital de Poniente, Ctra de Almerimar 31, 04700, El Ejido, Almería, Spain.

Objective: To evaluate the usefulness of ultrasound examination in patients with just a serological diagnosis of schistosomiasis but no other evidence of active infection.

Methods: 346 sub-Saharan patients with possible schistosomiasis that presented at a Tropical Medicine Unit between 2008 and 2019 were retrospectively selected. Possible schistosomiasis was considered in those patients with a positive serology for schistosomasis in the absence of direct microbiological isolates, hematuria and/or eosinophilia. Read More

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Wild robust capuchin monkey interactions with sympatric primates.

Primates 2021 May 4. Epub 2021 May 4.

Neotropical Primates Research Group, São Paulo, Brazil.

Examining interactions among sympatric primate species can provide interesting information about competition, cooperation, and avoidance between those species. Those interactions can be neutral, positive, or negative for the species involved. Capuchin monkeys are medium-sized primates that can encounter both larger and smaller primates in their varied habitats. Read More

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Acute Limb Ischemia as the Initial Severe Presentation in COVID-19.

Cureus 2021 Mar 31;13(3):e14226. Epub 2021 Mar 31.

Cardiology, St. Joseph's University Medical Center, Paterson, USA.

Coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is characterized by an overwhelming inflammatory response in a subset of patients, resulting in respiratory compromise, multiorgan failure, and death. A common complication seen in patients hospitalized with COVID-19 infections is the development of venous and arterial thromboemboli. This occurs especially in patients who suffer from severe respiratory or systemic manifestations on the COVID-19 spectrum of disease. Read More

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Outlook into the future of front-line immune checkpoint inhibition in metastatic urothelial carcinoma.

Ther Adv Urol 2021 Jan-Dec;13:17562872211004797. Epub 2021 Apr 15.

Deming Department of Medicine, Section of Hematology/Medical Oncology, Tulane University Medical School, 1430 Tulane Avenue, New Orleans, LA, USA.

Immune checkpoint inhibition has been approved for front-line treatment of metastatic bladder cancer in patients who are cisplatin-ineligible and demonstrate programmed death-ligand 1 (PD-L1) positivity. This approval followed the positive results of IMvigor210 and KEYNOTE-052 studies. Immunotherapy has also demonstrated efficacy as maintenance therapy patients for patients who initially respond to platinum-based chemotherapy. Read More

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In times of trouble: Higher education lecturers' emotional reaction to online instruction during COVID-19 outbreak.

Educ Inf Technol (Dordr) 2021 Apr 30:1-17. Epub 2021 Apr 30.

Innovation in Education, Gordon Academic College of Education, M.Ed. program, Haifa, Israel.

The disruption of 'normal' academic studies in the wake of the COVID-19 pandemic outbreak was embodied mainly in a rapid transition from in-class teaching to online synchronous instruction. The purpose of this study was to examine the lecturer's emotions towards the change they experienced with the sudden shift to online instruction during the COVID-19 pandemic and the effect of those emotions on their willingness to teach online in the future. In the present study, 239 academic lecturers answered an online questionnaire. Read More

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Patients' perception of the outpatient pharmaceutical service quality in hospital pharmacies with auditable pharmaceutical transactions and services in Ethiopia: a cross-sectional study.

BMJ Open 2021 May 4;11(5):e042853. Epub 2021 May 4.

Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xi'an Jiaotong University, Xi'an, China

Objective: To ensure the availability of quality pharmaceutical products and effective pharmaceutical services, a package of interventions named auditable pharmaceutical transactions and services (APTS), was implemented in the tertiary and secondary hospitals across Ethiopia since 2014. This study aimed to evaluate outpatients' perception of pharmaceutical service quality in hospitals with APTS in Ethiopia.

Design: Cross-sectional study. Read More

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A Phase I study of alpelisib in combination with trastuzumab and LJM716 in patients with -mutated HER2-positive metastatic breast cancer.

Clin Cancer Res 2021 May 4. Epub 2021 May 4.

Medicine, Memorial Sloan-Kettering Cancer Center/Weill Cornell Medical College

Purpose: Activating mutations in PIK3CA promote resistance to HER2-targeted therapy in breast cancer, however inhibition of PI3K alone leads to escape via feedback upregulation of HER3. Combined inhibition of HER2, HER3 and PI3K overcomes this mechanism preclinically.

Experimental Design: This phase I study investigated the maximum tolerated dose (MTD) of alpelisib given in combination with trastuzumab and LJM716 (a HER3-targeted antibody) in patients with PIK3CA-mutant HER2-positive metastatic breast cancer (MBC) using the continual reassessment method. Read More

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Semiquantitative analysis of interim F-FDG PET is superior in predicting outcome in Hodgkin lymphoma patients compared to visual analysis.

Rev Esp Med Nucl Imagen Mol 2021 May 1. Epub 2021 May 1.

Onco-Hematology Department, Instituto Português de Oncologia do Porto FG, Portugal.

Purpose: To investigate the prognostic value of interim PET (PETi) in adult HL patients, comparing visual with semiquantitative analysis.

Material And Methods: Retrospective analysis of Hodgkin's Lymphoma (HL) patients diagnosed between 2012 and 2016 in the Onco-Hematology Department of Instituto Português de Oncologia - Porto (median follow-up: 46.5 months [2,6-66,4]). Read More

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Role of interferon gamma in SARS-CoV-2-positive patients with parasitic infections.

Gut Pathog 2021 May 4;13(1):29. Epub 2021 May 4.

Haematology and Transfusion Medicine, King Abdulaziz University, Jeddah, 21577, Saudi Arabia.

Background: By 27 June 2020, almost half a million people had died due to COVID-19 infections. The susceptibility and severity of infection vary significantly across nations. The contribution of chronic viral and parasitic infections to immune homeostasis remains a concern. Read More

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Cognitive control and emotional response in attention-deficit/ hyperactivity disorder comorbidity with disruptive, impulse-control, and conduct disorders.

BMC Psychiatry 2021 05 4;21(1):232. Epub 2021 May 4.

Clinical Research Center, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.

Background: This study investigated cognitive and emotional functioning in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and disruptive, impulse-control, and conduct disorders (DICCD).

Methods: Thirty patients with ADHD, 26 with DICCD, 22 with ADHD+DICCD were recruited from the outpatient department of Shanghai Changning Mental Health Center, plus 20 healthy controls (HC). Differences between the groups in cognitive and emotional functioning were examined using Golden's Stroop and Emotional Stroop tests. Read More

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