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Treatment components in behavioral versus nondirective telephone-assisted self-help interventions for parents of children with externalizing behavior problems.

J Clin Psychol 2021 Sep 24. Epub 2021 Sep 24.

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Background: The aim of this study was to analyze treatment differentiation in a behavioral and a nondirective telephone-assisted self-help intervention for parents of children with externalizing behavior problems, including the development and evaluation of a rating scale.

Methods: In a randomized controlled trial, 149 parents of children aged 4-11 years with externalizing behavior problems were allocated to a behavioral or a nondirective guided self-help intervention. Parents in both conditions received eight self-help booklets and ten telephone consultations. Read More

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September 2021

Effects of a Written Expression-Based Positive Psychological Intervention on the Psychological Status of Patients With Inflammatory Bowel Disease: A Randomized Controlled Trial.

Gastroenterol Nurs 2021 Sep 20. Epub 2021 Sep 20.

Xingchen Shang, MSN, is Nursing Faculty, School of Nursing, Yangzhou University, Yangzhou, Jiangsu, China. Fangchen Gu, BSN, is Under Postgraduate Student, School of Nursing, Nanjing Medical University, Nanjing, Jiangsu, China. Qiugui Bian, MSN, is Head Nurse, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. Meifeng Wang, BSN, is Specialist Nurse, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. Zheng Lin, MSN, is Professor and Deputy Director of Nursing Department, School of Nursing, Nanjing Medical University, Nanjing, Jiangsu, China; the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

This prospective parallel-group controlled trial explored the effects of a written expression-based positive psychological intervention on the psychological status of patients with inflammatory bowel disease. Primary outcomes were anxiety, depression, hope, optimism, and subjective well-being, assessed at 8 weeks. Secondary outcomes were coping mode, quality of life at 8 weeks, and patient feedback. Read More

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September 2021

The performance of COBRA, a decision rule to predict the need for intensive care interventions in intentional drug overdose.

Eur J Emerg Med 2021 Sep 21. Epub 2021 Sep 21.

Department of Emergency Medicine Department of Intensive care, Deventer Hospital, Deventer Department of Emergency Medicine, Rijnstate Teaching Hospital, Arnhem Department of Research and Development Department of Clinical Pharmacy, Deventer Hospital, Deventer Unit of PharmacoTherapy, Epidemiology & Economics, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, The Netherlands.

Background: COBRA was developed as a decision rule to predict which patients visiting the emergency department (ED) following intentional drug overdose will not require intensive care unit (ICU) interventions. COBRA uses parameters from five vital systems (cardiac conduction, oxygenation, blood pressure, respiration, and awareness) that are readily available in the ED. COBRA recommends against ICU admission when all these parameters are normal. Read More

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September 2021

Utility of D2-40, Cytokeratin 5/6, and High-Molecular-weight Cytokeratin (Clone 34βE12) in Distinguishing Intraductal Spread of Urothelial Carcinoma From Prostatic Stromal Invasion.

Am J Surg Pathol 2021 Sep 23. Epub 2021 Sep 23.

Departments of Pathology and Laboratory Medicine Urology Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL.

Intraductal spread of urothelial carcinoma (UC) is not an uncommon finding in bladder cancer that requires appropriate clinical management. The presence of prostatic stromal invasion in non-muscle-invasive bladder cancer upstages the disease, necessitating cisplatin-based neoadjuvant chemotherapy and subsequent cystroprostatectomy. However, the identification of prostatic stromal invasion can be challenging, especially in biopsy and transurethral resection specimens. Read More

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September 2021

The added value of cerebrospinal fluid analysis in patients with subarachnoid hemorrhage after negative noncontrast CT.

J Neurosurg 2021 Sep 24:1-5. Epub 2021 Sep 24.

2Neurosurgery, and.

Objective: In patients presenting within 6 hours after signs and symptoms of suspected subarachnoid hemorrhage (SAH), CSF examination is judged to be no longer necessary if a noncontrast CT (NCCT) scan rules out SAH. In this study, the authors evaluated the performance of NCCT to rule out SAH in patients with positive CSF findings.

Methods: Between January 2006 and April 2018, 1657 patients were admitted with a nontraumatic SAH. Read More

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September 2021

Laryngeal disorders in people living with HIV.

Am J Otolaryngol 2021 Sep 20;43(1):103234. Epub 2021 Sep 20.

Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States of America.

Objectives: Several studies have shown that HIV infected individuals are at higher risk compared to the general population of developing non-AIDS defining conditions such as some types of cancer, kidney disease, liver disease and others. In this case-control study, we compared the incidence of laryngeal disorders between a treatment-seeking HIV-positive population and uninfected controls. We aimed to investigate whether there are any laryngeal disorders that are overrepresented in HIV-positive individuals. Read More

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September 2021

Ambient noise limits efficacy of smartphone-based screening for hearing loss in children at risk.

Am J Otolaryngol 2021 Sep 11;43(1):103223. Epub 2021 Sep 11.

Tufts University School of Medicine, Boston, MA, United States of America; Department of Otolaryngology-Head & Neck Surgery, Tufts Medical Center, Boston, MA, United States of America; Division of Pediatric Otolaryngology and Facial Plastic Surgery, Tufts Children's Hospital, Boston, MA, United States of America. Electronic address:

Objective: To determine if hearScreen®, a smartphone-based pure tone audiometric screen, serves as an effective hearing screen for identifying hearing loss in children at risk, such as those with chronic otitis media and/or craniofacial anomalies.

Methods: A cross-sectional, single-center, prospective study at an urban tertiary care hospital was completed. From June to October 2019, a total of 208 pediatric ears at risk for hearing loss were evaluated by both hearScreen® and conventional pure tone audiometry. Read More

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September 2021

Rapid screening of depression and anxiety in cancer patients: Interview validation of emotion thermometers.

Asian J Psychiatr 2021 Sep 10;65:102827. Epub 2021 Sep 10.

Department of Nursing, Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czechia; Department of Clinical Psychology, University Hospital Kralovske Vinohrady, Prague, Czechia. Electronic address:

Background And Objective: This study aimed to determine the degree of depression and anxiety in cancer patients using the Emotion Thermometers (ET) and confirming their clinical usefulness compared to the gold standard interview, as well as determining optimal cut-off values for the appropriate identification of cancer patients' distress.

Methods: We included 238 cancer patients and we used ET (Emotion Thermometers) to screen depression and anxiety and the Beck depression inventory for adults (BDI-II), the Generalized Anxiety Disorder 7-item scale (GAD-7) and the Mini-International Neuropsychiatric Interview (M.I. Read More

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September 2021

Myrrhanone B and Myrrhanol B from resin of Commipohora mukul exhibit hepatoprotective effects in-vivo.

Biomed Pharmacother 2021 Sep 21;143:112131. Epub 2021 Sep 21.

Natural and Medical Sciences Research Center, University of Nizwa, P.O. Box 33, Birkat Al Mauz, Nizwa 616, Oman. Electronic address:

Despite a large number of liver disorders, clinically useful drugs are scarce. Moreover, the available therapies are facing the challenges of efficacy and safety. Commipohora mukul has been used in folk medicine globally for millennia for the treatment of several ailments. Read More

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September 2021

A prospective cohort evaluation of the sensitivity and specificity of the chest X-ray for the detection of lung cancer in symptomatic adults.

Eur J Radiol 2021 Sep 20;144:109953. Epub 2021 Sep 20.

Department of Respiratory Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK.

Background: The accuracy of the chest x-ray (CXR) in the identification of lung cancer amongst symptomatic individuals is uncertain.

Purpose: To determine the diagnostic accuracy of the CXR for the detection of non-small cell carcinomas (NSCLC) and all primary intrathoracic malignancies.

Methods: A prospective cohort study of consecutive CXR reports obtained within a primary care open access initiative. Read More

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September 2021

Pre-game drinking among young adults and its association with positive and negative alcohol consequences.

Addict Behav 2021 Sep 15;124:107120. Epub 2021 Sep 15.

Pennsylvania State University, Edna Bennett Pierce Prevention Research Center, 320E Biobehavioral Health Building, University Park, PA 16802, United States.

Background: Pre-gaming, or drinking before going out, is common among young adults and associated with heavier drinking and negative consequences. However, findings have been mixed as to whether a unique, day-level association between pre-gaming and negative consequences exists independent of alcohol intake. It is also unknown whether young adults experience more positive consequences of alcohol use on days they engage in pre-gaming. Read More

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September 2021

14-3-3ζ promoted invasion and lymph node metastasis of breast invasive ductal carcinoma with HER2 overexpression.

Pathol Res Pract 2021 Sep 21;227:153619. Epub 2021 Sep 21.

Department of Pathology, The First People's Hospital of Zigong, shang yi hao yi zhi lu 42#, Zigong 643099, Sichuan Province, China.

Background: HER2 was a recognized oncogene that promoted the development and metastasis of breast cancer, but its positive expression rate in invasive ductal carcinoma (IDC) was much lower than that in ductal carcinoma in situ (DCIS). The correlation between the occurrence and development of breast cancer and the amplification and overexpression of HER2 gene alone was still controversial. 14-3-3ζ had a strong protein binding ability and a variety of functions, mainly through the interaction with other proteins to exert its unique biological activities. Read More

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September 2021

Gender differences in prevalence and clinical correlates of anxiety symptoms in first-episode and drug-naïve patients with major depressive disorder.

Compr Psychiatry 2021 Sep 17;111:152275. Epub 2021 Sep 17.

CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China. Electronic address:

Aim: Gender differences in major depressive disorder (MDD) are commonly reported; however, gender differences in first-episode and drug-naïve (FEDN) patients with major depressive disorder remain unclear. This study aimed to examine potential gender differences in the prevalence and clinical correlates of comorbid anxiety in FEDN patients with MDD.

Methods: A cross-sectional study was conducted with1718 FEDN patients with MDD. Read More

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September 2021

Regulation of neurotoxicity in the striatum and colon of MPTP-induced Parkinson's disease mice by gut microbiome.

Brain Res Bull 2021 Sep 21. Epub 2021 Sep 21.

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260-8670, Japan. Electronic address:

Increasing evidence suggests the role of gut-microbiota-brain axis in the pathogenesis of Parkinson's disease (PD). The objective of this study was to examine whether repeated administration of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) can influence the neurotoxicity in the striatum and colon, and the composition of gut microbiota and short-chain fatty acids (SCFAs) in feces of adult mice. MPTP caused the reduction of dopamine transporter (DAT) and tyrosine hydroxylase (TH) in the striatum, and increases in phosphorylated α-synuclein (p-α-Syn) in the striatum and colon. Read More

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September 2021

CD19-targeted chimeric antigen receptor T-cell therapy for CNS relapsed or refractory acute lymphocytic leukaemia: a post-hoc analysis of pooled data from five clinical trials.

Lancet Haematol 2021 Oct;8(10):e711-e722

Division of Oncology and Cancer Immunotherapy Program, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. Electronic address:

Background: CNS relapse of acute lymphocytic leukaemia is difficult to treat. Durable remissions of relapsed or refractory B-cell acute lymphocytic leukaemia have been observed following treatment with CD19-directed chimeric antigen receptor (CAR) T cells; however, most trials have excluded patients with active CNS disease. We aimed to assess the safety and activity of CAR T-cell therapy in patients with a history of CNS relapsed or refractory B-cell acute lymphocytic leukaemia. Read More

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October 2021

Immunohistochemical comparison of three programmed death-ligand 1 (PD-L1) assays in triple-negative breast cancer.

PLoS One 2021 24;16(9):e0257860. Epub 2021 Sep 24.

Department of Surgery, Kansai Medical University, Osaka, Japan.

Background: Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer. A recent study demonstrated the efficacy of anti-PD-L1 (anti-programmed death ligand-1) immunotherapy in patients with TNBC. However, the identification of TNBC patients who may benefit from immunotherapy is a critical issue. Read More

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September 2021

Effects of spray-dried animal plasma on growth performance, survival, feed utilization, immune responses, and resistance to Vibrio parahaemolyticus infection of Pacific white shrimp (Litopenaeus vannamei).

PLoS One 2021 24;16(9):e0257792. Epub 2021 Sep 24.

APC LLC, 2425 SE Oak Tree Court, Ankeny, Iowa, United States of America.

Spray-dried animal plasma (SDP) in feed for several animal species provides health benefits, but research about use of SDP in shrimp feed is very limited. The objectives of the present study were to investigate the effects of dietary SDP on growth performance, feed utilization, immune responses, and prevention of Vibrio parahaemolyticus infection in Pacific white shrimp (Litopenaeus vannamei). In Experiment 1, the post-larvae were divided into five groups (four tank/group and 80 shrimp/tank) and fed four times daily diets with porcine SDP at 0, 1. Read More

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September 2021

Assessed and perceived oral health of older people who visit the dental practice, an exploratory cross-sectional study.

PLoS One 2021 24;16(9):e0257561. Epub 2021 Sep 24.

Flemish-Netherlands Geriatric Oral Research Group (BENECOMO), Dutch Association for Gerodontology, Bunnik, The Netherlands.

Objectives: To assess the oral health of older people who visit the community dental practice from both the dentists' and the patients' perspective.

Materials And Methods: In this exploratory cross-sectional study the oral health of Dutch community dwelling older people was assessed. A representative sample of general dental practitioners was asked to randomly and prospectively select one older patient and describe this patient using a specially-developed registration form; in addition the patient was requested to complete a questionnaire. Read More

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September 2021

Does Post-Traumatic Spectrum Comorbidity Influence Symptom Severity in Bipolar Disorders? A Cross-Sectional Study in a Real-World Setting.

Psychiatr Danub 2021 Sep;33(Suppl 9):41-46

Department of Psychiatry, University of Perugia, Piazzale Lucio Severi, 1, 06132, S. Andrea delle Fratte, Perugia, Italy.

Background: The present cross-sectional study investigates the relationship between post-traumatic spectrum comorbidity and the severity of symptoms in subjects diagnosed with Bipolar Disorders (BD).

Subjects And Methods: In- and outpatients diagnosed with BD according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) were consecutively recruited. Sociodemographic and clinical data were collected. Read More

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September 2021

Preliminary Study of Virtual-reality-guided Meditation for Veterans with Stress and Chronic Pain.

Altern Ther Health Med 2021 Sep 24. Epub 2021 Sep 24.

Context: Studies have found evidence for meditation's positive effects on health and well-being, but the difficulty of learning and engaging in meditation practice has been identified as a major barrier. Virtual reality (VR) technology may facilitate meditation practice by immersing users in a distraction-free and calming virtual environment, although this theory has yet to be rigorously tested.

Objective: This study intended to examine the efficacy of VR-guided meditation in a population of US veterans as a tool to facilitate meditation and relaxation practice for reduction of stress and chronic pain as well as to elicit participants' feedback regarding their perceptions of VR-guided meditation. Read More

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September 2021

Effectiveness of Mindful Self-Compassion Training Supported by Online Peer Groups in China: A Pilot Study.

Altern Ther Health Med 2021 Sep 24. Epub 2021 Sep 24.

Context: Self-compassion training involves the cultivation of feelings of warmth and safety, presence, and interconnectedness. Mindful Self-Compassion (MSC) training in a group setting has been found to increase self-compassion, mindfulness, and emotional well-being.

Objective: The current study intended to examine the outcomes of live, online, videoconference-based MSC training with online peer-support for nonclinical populations in different cities in China. Read More

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September 2021

The effects of group art therapy on adolescents' self-concept and peer relationship: A mixed-method study.

New Dir Child Adolesc Dev 2021 Sep 24. Epub 2021 Sep 24.

Department of Psychology and Counselling, Universiti Tunku Abdul Rahman (UTAR), Perak, Malaysia.

This study examined the effects of group art therapy on self-concept and peer relationships among adolescents using a mixed-method approach. Twelve recruited adolescents from a high school in Northern Taiwan attended weekly 2-h group art therapy sessions for 8 weeks. Through a discovery-oriented approach incorporating focus group interviews and individual interviews, qualitative results revealed that the participants started getting to know themselves better and were able to explore their inner selves while noticing their own emotions. Read More

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September 2021

From Requisite to Right: Assessing and Addressing Paid Maternity Leave in US Psychiatry Residency Programs.

Acad Psychiatry 2021 Sep 24. Epub 2021 Sep 24.

University of Maryland School of Medicine/Sheppard Pratt, Baltimore, MD, USA.

Objective: Data on the physical and mental health benefits of paid maternity leave for mothers and infants is abundant. Data on the make-up of current maternity leave policies in US psychiatry residency programs is not. This survey of program directors was undertaken to assess the components of their program's policies and the perceived impact of maternity leave on the training of childbearing residents, co-residents, and programs. Read More

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September 2021

Cultural Influences on Sibling Relationships, Roles, and Self-Concept in the Context of Autism: Perspectives of Latino/a/x and non-Latino/a/x Siblings.

J Autism Dev Disord 2021 Sep 24. Epub 2021 Sep 24.

Alpert Medical School of Brown University, Providence, RI, USA.

Siblings describe positive and negative aspects of autism and often assume lifelong support roles. Less is known about cultural influences on sibling relationships. This qualitative study characterizes processes linking siblings' autism conceptualizations, sibling relationships, and self-concept using a multicultural framework. Read More

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September 2021

Longitudinal associations between positive attributes and psychopathology and their interactive effects on educational outcomes.

Eur Child Adolesc Psychiatry 2021 Sep 24. Epub 2021 Sep 24.

Universidade Federal Do Rio Grande Do Sul, Ramiro Barcelos, 2350 - room 2202, Porto Alegre, 90035-003, Brazil.

Psychopathology is associated with impaired learning and early termination of schooling, whereas positive attributes are associated with better educational outcomes. However, it is important to understand if and how psychopathology and positive attributes longitudinally impact each other so we could shed light on where to intervene to promote educational outcomes through these constructs. A large prospective school-based community cohort of youths (5-15 years of age, 45% female) were assessed and followed up for 3 years (n = 2010; 80% retention). Read More

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September 2021

PET/CT imaging of head-and-neck and pancreatic cancer in humans by targeting the "Cancer Integrin" αvβ6 with Ga-68-Trivehexin.

Eur J Nucl Med Mol Imaging 2021 Sep 24. Epub 2021 Sep 24.

Institute of Pathology, Technische Universität München, Munich, Germany.

Purpose: To develop a new probe for the αvβ6-integrin and assess its potential for PET imaging of carcinomas.

Methods: Ga-68-Trivehexin was synthesized by trimerization of the optimized αvβ6-integrin selective cyclic nonapeptide Tyr2 (sequence: c[YRGDLAYp(NMe)K]) on the TRAP chelator core, followed by automated labeling with Ga-68. The tracer was characterized by ELISA for activities towards integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1, as well as by cell binding assays on H2009 (αvβ6-positive) and MDA-MB-231 (αvβ6-negative) cells. Read More

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September 2021

Radiomics for detecting prostate cancer bone metastases invisible in CT: a proof-of-concept study.

Eur Radiol 2021 Sep 24. Epub 2021 Sep 24.

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, University of Zurich, Raemistr. 100, CH-8091, Zurich, Switzerland.

Objectives: To investigate, in patients with metastatic prostate cancer, whether radiomics of computed tomography (CT) image data enables the differentiation of bone metastases not visible on CT from unaffected bone using  Ga-PSMA PET imaging as reference standard.

Methods: In this IRB-approved retrospective study, 67 patients (mean age 71 ± 7 years; range: 55-84 years) showing a total of 205  Ga-PSMA-positive prostate cancer bone metastases in the thoraco-lumbar spine and pelvic bone being invisible in CT were included. Metastases and 86  Ga-PSMA-negative bone volumes in the same body region were segmented and further post-processed. Read More

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September 2021

Early dynamics of circulating tumor DNA predict chemotherapy responses for patients with esophageal cancer.

Carcinogenesis 2021 Sep 24. Epub 2021 Sep 24.

Division of Biomedical Research & Development, Iwate Medical University Institute for Biomedical Sciences, Yahaba, Iwate, Japan.

We investigated whether early circulating tumor DNA (ctDNA) changes, measured using digital PCR (dPCR), can predict later chemotherapy responses in esophageal squamous cell cancer (ESCC). We compared the dynamics of ctDNA and tumor volumes during chemotherapy in 42 ESCC. The accuracy of predictions of later chemotherapy responses were evaluated by the ratio of the variant allele frequency (VAF) of ctDNA (post-/pre-ctDNA) and the total tumor volume (post-/pre-volume) before and after an initial chemotherapy cycle using a receiver-operating characteristic curve analysis. Read More

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September 2021

Cognitive decline according to amyloid uptake in patients with poststroke cognitive impairment.

Medicine (Baltimore) 2021 Sep;100(38):e27252

Department of Neurology, The Catholic University of Korea Eunpyeong St. Mary's Hospital, Seoul, Republic of Korea.

Background And Purpose: Poststroke cognitive impairment (PSCI) is common, but the impact of β-amyloid (Aβ) on PSCI is uncertain. The proposed study will investigate amyloid pathology in participants with PSCI and how differently their cognition progress according to the amyloid pathology.

Methods: This multicenter study was designed to be prospective and observational based on a projected cohort size of 196 participants with either newly developed cognitive impairment, or rapidly aggravated CI, within 3 months after acute cerebral infarction. Read More

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September 2021

Atypical asthma in children who present with isolated chest tightness: risk factors and clinical features.

J Asthma 2021 Sep 24:1-9. Epub 2021 Sep 24.

Allergy Department, Capital Institute of Pediatrics, Beijing, China.

Objective: Asthmatic children presenting with chest tightness as the only symptom have not been widely recognized. This study attempted to find risk factors, summarize clinical features and offer some suggestions for the diagnosis of this atypical asthma. We studied 94 children, aged 6 to 14 years, who complained only of chest tightness. Read More

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September 2021