1,078 results match your criteria positive mesothelial


Clinical and pathophysiological characteristics of valproate-induced pleural effusion.

Clin Toxicol (Phila) 2021 Jul 14:1-8. Epub 2021 Jul 14.

Experimental Research Center ELPEN, ELPEN Pharmaceuticals, Pikermi, Greece.

Introduction: Valproic acid is a carboxylic acid derivative commonly prescribed for several types of seizure disorders or for acute manic episodes in patients with bipolar disorder. Several cases of valproate-induced pleural effusion have been reported, although the precise pathophysiological mechanism remains unknown.

Objective: To describe the presentation of pleural effusion associated with valproate use and to categorize published case reports according to clinical, immunological, and pleural effusion cell type. Read More

View Article and Full-Text PDF

Squamous differentiation in surgically resected malignant pleural mesothelioma with neoadjuvant chemotherapy.

Pathol Int 2021 Jul 13. Epub 2021 Jul 13.

Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan.

We describe a rare case of malignant pleural mesothelioma (MPM) that developed squamous differentiation. MPM can present various patterns of histology, but squamous differentiation has not been reported in any surgically resected cases to date. The patient was a 50-year-old female without smoking habit who had right MPM and underwent pleurectomy/decortication after chemotherapy. Read More

View Article and Full-Text PDF

The clinicopathologic significance of Tks5 expression of peritoneal mesothelial cells in gastric cancer patients.

PLoS One 2021 13;16(7):e0253702. Epub 2021 Jul 13.

Department of Gastroenterological Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background: Gastric cancer (GC) patients frequently develop peritoneal metastasis. Recently, it has been reported that peritoneal mesothelial cells (PMCs) activated by GC cells acquire a migratory capacity and promote GC cell invasion. The invasiveness of PMCs reportedly depends on the activity of Tks5, an adaptor protein required for invadopodia formation. Read More

View Article and Full-Text PDF

Adenomatoid Tumor of the Adrenal Gland: Report of Two Cases and Review of the Literature.

Front Endocrinol (Lausanne) 2021 23;12:692553. Epub 2021 Jun 23.

Department of Pathology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Adenomatoid tumor (AT) is an uncommon benign neoplasm of mesothelial origin, usually occurring in the female and male genital tracts. Extragenital localization such as the adrenal gland is extremely rare. Until now, only 39 cases of adrenal AT have been reported in the English literature. Read More

View Article and Full-Text PDF

HDAC Inhibitor Abrogates LTA-Induced PAI-1 Expression in Pleural Mesothelial Cells and Attenuates Experimental Pleural Fibrosis.

Pharmaceuticals (Basel) 2021 Jun 18;14(6). Epub 2021 Jun 18.

Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei 110, Taiwan.

Lipoteichoic acid (LTA) stimulates pleural mesothelial cell (PMC) to overproduce plasminogen activator inhibitor-1 (PAI-1), and thus may promote pleural fibrosis in Gram-positive bacteria (GPB) parapneumonic effusion (PPE). Histone deacetylase inhibitor (HDACi) was found to possess anti-fibrotic properties. However, the effects of HDACi on pleural fibrosis remain unclear. Read More

View Article and Full-Text PDF

STAT3/HIF-1α signaling activation mediates peritoneal fibrosis induced by high glucose.

J Transl Med 2021 Jun 30;19(1):283. Epub 2021 Jun 30.

Department of Nephrology, Zhongshan Hospital, Fudan University, No. 180, Fenglin Road, Xuhui District, Shanghai, 200032, People's Republic of China.

Background: Epithelial-mesenchymal transition (EMT) of mesothelial cells is a key step in the peritoneal fibrosis (PF). Recent evidence indicates that signal transducer and activator of transcription 3 (STAT3) might mediate the process of renal fibrosis, which could induce the expression of hypoxia-inducible factor-1α (HIF-1α). Here, we investigated the effect of STAT3 activation on HIF-1α expression and the EMT of mesothelial cells, furthermore the role of pharmacological blockade of STAT3 in the process of PF during peritoneal dialysis (PD) treatment. Read More

View Article and Full-Text PDF

CLDN15 is a novel diagnostic marker for malignant pleural mesothelioma.

Sci Rep 2021 Jun 15;11(1):12554. Epub 2021 Jun 15.

Department of Basic Pathology, Graduate School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan.

Malignant mesothelioma is a cancer with a poor survival rate. It is difficult to diagnose mesotheliomas because they show a variety of histological patterns similar to those of various other cancers. However, since currently used positive markers for mesotheliomas may show false positives or false negatives, a novel mesothelial positive marker is required. Read More

View Article and Full-Text PDF

Enhanced mPGES-1 Contributes to PD-Related Peritoneal Fibrosis via Activation of the NLRP3 Inflammasome.

Front Med (Lausanne) 2021 18;8:675363. Epub 2021 May 18.

Department of Nephrology, Shunde Hospital, Southern Medical University (The First People's Hospital of Shunde), Foshan, China.

Microsomal prostaglandin E synthase-1 (mPGES-1)-derived prostaglandin E (PGE2) is a chief mediator of inflammation. However, the role and mechanism of mPGES-1 in peritoneal dialysis (PD)-associated peritoneal fibrosis have not been investigated. In PD patients, mPGES-1 expression in peritoneum tissues and the levels of PGE2, IL-1β, and IL-18 in the dialysate were examined. Read More

View Article and Full-Text PDF

A Preliminary Study of Deep-Learning Algorithm for Analyzing Multiplex Immunofluorescence Biomarkers in Body Fluid Cytology Specimens.

Acta Cytol 2021 Jun 2:1-6. Epub 2021 Jun 2.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles (UCLA), Los Angeles, California, USA.

Introduction: Multiplex biomarker analysis of cytological body fluid specimens is often used to assist cytologists in distiguishing metastatic cancer cells from reactive mesothelial cells. However, evaluating biomarker expression visually may be challenging, especially when the cells of interest are scant. Deep-learning algorithms (DLAs) may be able to assist cytologists in analyzing multiple biomarker expression at the single cell level in the multiplex fluorescence imaging (MFI) setting. Read More

View Article and Full-Text PDF

CA-125 and CCL2 may indicate inflammation in peritoneal dialysis patients.

J Bras Nefrol 2021 May 24. Epub 2021 May 24.

Universidade Federal de São João Del Rei, Campus Centro Oeste, São João Del Rei, MG, Brasil.

Introduction: Progressive structural changes in the peritoneal membrane occur over the course of treatment in peritoneal dialysis (PD), resulting in an increase in cytokines such as CCL2 and structural changes in peritoneal membrane triggering an increase in CA-125 in dialysate, which reflects a probable local inflammatory process, with possible loss of mesothelial cells. Thus, the current study aimed to evaluate the association between plasma and CCL2 and CA-125 dialysate levels in patients undergoing PD.

Methods: Cross-sectional study was conducted with 41 patients undergoing PD. Read More

View Article and Full-Text PDF

Hiding in plain sight: Diagnosing pleural tuberculosis using lung ultrasound.

Ultrasound 2021 May 27;29(2):123-127. Epub 2020 Sep 27.

School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.

Introduction: Diagnosing pleural tuberculosis can be difficult in patients with ambiguous presentation, especially in resource-limited health centres. Thus, lung ultrasound had been studied as a novel method in helping clinicians to diagnose this condition.

Case Presentation: A 48-year-old woman presented with worsening dyspnoea and orthopnoea for one week. Read More

View Article and Full-Text PDF

Metastatic Malignant Peritoneal Mesothelioma Mimicking an Autoinflammatory Syndrome in a 12-Year-Old Boy.

Pediatr Dev Pathol 2021 Apr 19:10935266211008438. Epub 2021 Apr 19.

Department of Oncology, Hospital Universitario La Paz, Madrid, Spain.

A case of a malignant peritoneal mesothelioma mimicking an autoinflammatory syndrome in a 12-year-old boy is reported. The patient initially presented with lymphadenopathy and weight loss but without abdominal pain. Three things confounded the initial diagnosis: a positive test result for a gene related to cryopyrin-associated periodic syndrome, a positive response to the autoinflammatory syndrome treatment, and a lymph node biopsy which showed "hyperplastic mesothelial cells in the lymph sinuses. Read More

View Article and Full-Text PDF

A rare case of primary effusion lymphoma in HIV negative patient: Diagnostic challenges and literature review.

Diagn Cytopathol 2021 Jun 15;49(6):785-789. Epub 2021 Apr 15.

Department of Pathology, Montefiore Hospital and Medical Center/Albert Einstein College of Medicine, New York, New York, USA.

We present a rare case of primary effusion lymphoma (PEL) in a 75 year old, HIV-negative male patient with multiple comorbidities. Imaging studies revealed a massive right pleural effusion and a significant lung collapse with multiple plural soft tissue nodules. Immediate thoracentesis was performed. Read More

View Article and Full-Text PDF

Histological and immunohistochemical characteristics and status studied by FISH in six incidentally detected cases of well-differentiated papillary mesothelioma of the peritoneum.

Indian J Pathol Microbiol 2021 Apr-Jun;64(2):277-281

Division of Pathology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.

Well-differentiated papillary mesothelioma (WDPM) is an uncommon mesothelial neoplasm, which is generally regarded as benign or indolent in terms of its clinical behavior. However, details about WDPM have remained relatively unknown. Therefore, in this study, we examined six incidentally detected cases of WDPM of the peritoneum. Read More

View Article and Full-Text PDF

The significance of detecting glucose transporter 1 and calretinin in serous effusions to differentiate between carcinoma cells and reactive mesothelial cells.

Diagn Cytopathol 2021 Jul 5;49(7):811-816. Epub 2021 Apr 5.

Department of Pathology, Jilin Cancer Hospital, Changchun, China.

Background: The cytologic evaluation of serous effusions to distinguish malignant cells from reactive mesothelial cells (RMCs)was an enormous challenge. The purpose of this study was to investigate the diagnostic value of glucose transporter 1 (GLUT1) and calretinin (CR) in serous effusions of patients with malignant and in order to significantly ameliorate the diagnostic accuracy.

Methods: The expressions of GLUT1 and CR were measured by streptavidin-peroxidase (S-P) immunocytochemical technique in serous effusions of 183 patients with malignant and in 95 patients with benign diseases. Read More

View Article and Full-Text PDF

Brenner tumor associated with rete ovarii: a histologic and immunohistochemical analysis of six cases exploring the relationship between these entities.

Hum Pathol 2021 Jul 1;113:84-91. Epub 2021 Apr 1.

Baylor College of Medicine, Department of Pathology & Immunology, Houston, TX, 77030, USA. Electronic address:

The association of Brenner tumor (BT) with rete ovarii (RO) has been rarely alluded to in the literature. Both entities have debatable histogenesis. In this study of six cases of BT associated with RO, we describe the morphologic features and performed immunohistochemical staining for markers of Mullerian, Wolffian, mesothelial, and sex cord stromal derivation to explore the relationship between these entities. Read More

View Article and Full-Text PDF

Utility of SOX6 and DAB2 for the Diagnosis of Malignant Mesothelioma.

Am J Surg Pathol 2021 Mar 29. Epub 2021 Mar 29.

Department of Pathology, Vancouver General Hospital Department of Pathology, University of British Columbia Department of Pathology, British Columbia Cancer Agency, Vancouver, BC, Canada.

The separation of malignant mesothelioma from non-small cell lung carcinomas can be a difficult problem. Sex-determining region Y box 6 (SOX6) and disabled homolog 2 (DAB2) have recently been proposed as sensitive/specific markers of mesothelial lineage, but have not yet been independently tested for utility in mesothelioma diagnosis. Using tissue microarrays containing mesotheliomas (epithelioid: n=40, sarcomatoid: n=23) and non-small cell lung carcinomas (adenocarcinoma: n=52, squamous cell carcinoma: n=57, large cell carcinoma: n=12) we evaluated the performance of SOX6 and DAB2 by themselves, in conjunction with other established mesothelioma markers (calretinin, WT1, D2-40, CK5/6, HEG1) and combined with 3 broad-spectrum established carcinoma markers: claudin-4, MOC31, and BerEP4. Read More

View Article and Full-Text PDF

Histological sequence of the development of rat mesothelioma by MWCNT, with the involvement of apolipoproteins.

Cancer Sci 2021 Jun 2;112(6):2185-2198. Epub 2021 May 2.

Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture, Tokyo, Japan.

A rat model of mesothelioma development by peritoneal injection of multiwalled carbon nanotube (MWCNT) has been established and found to be useful to understand the mechanisms underlying fibrous particles-associated carcinogenesis. Its detailed histological sequence, however, remains largely obscure. We therefore aimed to assess the time-course of mesothelioma development by MWCNT and evaluate a set of lipoprotein-related molecules as potential mechanism-based biomarkers for the phenomenon. Read More

View Article and Full-Text PDF

Osteopontin mRNA expression by rat mesothelial cells exposed to multi-walled carbon nanotubes as a potential biomarker of chronic neoplastic transformation in vitro.

Toxicol In Vitro 2021 Jun 27;73:105126. Epub 2021 Feb 27.

Toxicology Program, Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695, USA. Electronic address:

Mesothelioma is a cancer of the lung pleura primarily associated with inhalation of asbestos fibers. Multi-walled carbon nanotubes (MWCNTs) are engineered nanomaterials that pose a potential risk for mesothelioma due to properties that are similar to asbestos. Inhaled MWCNTs migrate to the pleura in rodents and some types cause mesothelioma. Read More

View Article and Full-Text PDF

Pseudocarcinomatous Mesothelioma: A Hitherto Unreported Presentation closely simulating primary lung cancer.

Int J Surg Pathol 2021 Feb 24:1066896921997559. Epub 2021 Feb 24.

390233Azienda Unità Sanitaria Locale della Romagna, Santa Maria delle Croci Hospital, Ravenna, Italy.

Malignant mesothelioma (MM) has a wide range of clinical, radiologic, and pathologic presentations, mimicking lung cancer or interstitial lung diseases when predominantly involving the lung parenchyma. The case herein refers to a 79-year-old man, active smoker without asbestos exposure, incidentally discovered to have a pulmonary nodule in the right upper lobe (1.5 cm). Read More

View Article and Full-Text PDF
February 2021

Meningoencephalitis, Vasculitis, and Abortions Caused by in a Herd of Cattle.

Vet Pathol 2021 May 16;58(3):549-557. Epub 2021 Feb 16.

3541Midwestern University, Glendale, AZ, USA.

A cow dairy ( = 2000) in close proximity to a sheep flock had third-trimester abortions and fatalities in cows and calves over a 14-month period. Eighteen of 33 aborted fetuses (55%) had multifocal random suppurative or mononuclear meningoencephalitis with vasculitis. Seventeen of these affected fetuses had intracytoplasmic bacteria in endothelial cells, and 1 fetus with pericarditis had similar bacteria within mesothelial cells or macrophages. Read More

View Article and Full-Text PDF

A Distinctive Adnexal (Usually Paratubal) Neoplasm Often Associated With Peutz-Jeghers Syndrome and Characterized by STK11 Alterations (STK11 Adnexal Tumor): A Report of 22 Cases.

Am J Surg Pathol 2021 Aug;45(8):1061-1074

Massachusetts General Hospital, Harvard Medical School, Boston, MA.

We describe 22 examples of a novel, usually paratubal, adnexal tumor associated with Peutz-Jeghers syndrome in nearly 50% of cases that harbored STK11 alterations in all tested (n=21). The patients ranged from 17 to 66 years (median=39 y) and the tumors from 4.5 to 25. Read More

View Article and Full-Text PDF

Diagnostic mesothelioma biomarkers in effusion cytology.

Cancer Cytopathol 2021 Jul 19;129(7):506-516. Epub 2021 Jan 19.

Department of Pathology, University of Michigan, Ann Arbor, Michigan.

Malignant mesothelioma is a rare malignancy with a poor prognosis whose development is related to asbestos fiber exposure. An increasing role of genetic predisposition has been recognized recently. Pleural biopsy is the gold standard for diagnosis, in which the identification of pleural invasion by atypical mesothelial cell is a major criterion. Read More

View Article and Full-Text PDF

Expression of Calretinin, Marker of Mesothelial Differentiation, in Pancreatic Ductal Adenocarcinoma: A Potential Diagnostic Pitfall.

Turk Patoloji Derg 2021 ;37(2):115-120

Department of Pathology, Rize University Training and Research Hospital, Rize, Turkey.

Objective: Pancreatic ductal adenocarcinoma is one of the most common causes of "peritoneal carcinomatosis" and has an insidious growth pattern. Thus, it falls into the differential diagnosis of other peritoneal malignancies including malignant mesothelioma. Recently, we have encountered an undifferentiated pancreatic carcinoma presenting with peritoneal disease and exhibiting immunoreactivity to calretinin, mimicking mesothelioma. Read More

View Article and Full-Text PDF
January 2021

Microphthalmia-Associated Transcription Factor-Dependent Melanoma Cell Adhesion Molecule Activation Promotes Peritoneal Metastasis of Ovarian Cancer.

Int J Mol Sci 2020 Dec 21;21(24). Epub 2020 Dec 21.

Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8550, Japan.

Ovarian cancer (OvCa) is one of the leading causes of death due to its high metastasis rate to the peritoneum. Recurrent peritoneal tumors also develop despite the use of conventional platinum-based chemotherapies. Therefore, it is still important to explore the factors associated with peritoneal metastasis, as these predict the prognosis of patients with OvCa. Read More

View Article and Full-Text PDF
December 2020

Malignant pleural neoplasm with both differentiation of epithelioid mesothelioma and squamous-cell carcinoma, a rare phenomena.

Diagn Cytopathol 2021 Jun 21;49(6):E234-E237. Epub 2020 Dec 21.

Department of Pathology and Laboratory Medicine, Cooper University Hospital, Camden, New Jersey, USA.

Malignant mesothelioma, a neoplasm arising within the serosal surfaces, has been linked closely to asbestos exposure. We present a case of 72-year-old male with a 27 year work-related history of asbestos exposure who presented with dyspnea. Chest computed tomography scan showed a large, right pleural effusion with compressive right lung atelectasis. Read More

View Article and Full-Text PDF

Helper T cells in malignant pleural effusion.

Cancer Lett 2021 03 10;500:21-28. Epub 2020 Dec 10.

Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. Electronic address:

Malignant pleural effusion (MPE) is a frequent complication of malignancies and poses a clinical problem. CD4 T lymphocytes are the most frequent cell population in MPE. Traditionally, CD4 T cells are classified into two subsets based on cytokine production profiles, type 1 (Th1) and type 2 (Th2) helper T cells, which exhibit distinct functions. Read More

View Article and Full-Text PDF

Significance of mesothelin expression in preoperative endoscopic biopsy specimens for colorectal cancer prognosis.

Oncotarget 2020 Oct 27;11(43):3807-3817. Epub 2020 Oct 27.

Department of Surgery, National Defense Medical College, Tokorozawa, Saitama 359-0042, Japan.

Mesothelin (MSLN) is a cell surface glycoprotein that is normally expressed in the mesothelial cells but highly expressed in several malignant tumors, where the high expression is generally associated with poor prognosis. In this work, 512 patients with stage III colorectal cancer (CRC) were examined to ascertain the prognostic value of MSLN expression in preoperative endoscopic biopsy specimens. MSLN expression was evaluated by immunohistochemical staining. Read More

View Article and Full-Text PDF
October 2020

Can BAP1 expression loss in mesothelial cells be an indicator of malignancy?

J Pathol Transl Med 2020 Nov 9;54(6):497-503. Epub 2020 Nov 9.

University of Health Sciences Kartal Dr Lutfi Kırdar Training and Research Hospital, Istanbul, Turkey.

Background: Malignant mesothelioma is a highly aggressive tumor that can be confused with a benign mesothelial lesion, especially cytomorphologic lesions. BRCA1-associated protein 1 (BAP1) acts as a tumor suppressor. In this study, we aim to investigate the value of BAP1 staining of malignant mesothelioma cases with expression loss and diagnosis in cell block and biopsy tissue. Read More

View Article and Full-Text PDF
November 2020

Notch and Bmp signaling pathways act coordinately during the formation of the proepicardium.

Dev Dyn 2020 12 3;249(12):1455-1469. Epub 2020 Sep 3.

Development of the Epicardium and its Role During Regeneration Laboratory, National Center of Cardiovascular Research Carlos III, Madrid, Spain.

Background: The epicardium is the outer mesothelial layer of the heart. It encloses the myocardium and plays key roles in heart development and regeneration. It derives from the proepicardium (PE), cell clusters that appear in the dorsal pericardium (DP) close to the atrioventricular canal and the venous pole of the heart, and are released into the pericardial cavity. Read More

View Article and Full-Text PDF
December 2020