51,098 results match your criteria positive investigation


Influenza-Associated Neurologic Complications in Hospitalized Children.

J Pediatr 2021 Jul 19. Epub 2021 Jul 19.

Divisions of Neurology, The Children's Hospital of Philadelphia; Departments of Neurology, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. Electronic address:

Objectives: To define the incidence and characteristics of influenza-associated neurologic complications in a cohort of children hospitalized at a tertiary care pediatric hospital with laboratory-confirmed influenza, and to identify associated clinical, epidemiologic, and virologic factors.

Study Design: Historical cohort study of children 0.5-18. Read More

View Article and Full-Text PDF

Antibody status and cumulative incidence of SARS-CoV-2 infection among adults in three regions of France following the first lockdown and associated risk factors: a multicohort study.

Int J Epidemiol 2021 Jul 19. Epub 2021 Jul 19.

Paris University, Paris, France.

Background: We aimed to estimate the seropositivity to anti-SARS-CoV-2 antibodies in May-June 2020 after the first lockdown period in adults living in three regions in France and to identify the associated risk factors.

Methods: Between 4 May 2020 and 23 June 2020, 16 000 participants in a survey on COVID-19 from an existing consortium of three general adult population cohorts living in the Ile-de-France (IDF) or Grand Est (GE) (two regions with high rate of COVID-19) or in the Nouvelle-Aquitaine (NA) (with a low rate) were randomly selected to take a dried-blood spot for anti-SARS-CoV-2 antibodies assessment with three different serological methods (ClinicalTrial Identifier #NCT04392388). The primary outcome was a positive anti-SARS-CoV-2 ELISA IgG result against the spike protein of the virus (ELISA-S). Read More

View Article and Full-Text PDF

Male microchimerism in females: a quantitative study of twin pedigrees to investigate mechanisms.

Hum Reprod 2021 Jul 19. Epub 2021 Jul 19.

Amsterdam Reproduction and Development (AR&D) Research Institute, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands.

Study Question: Does having a male co-twin, older brothers, or sons lead to an increased probability of persistent male microchimerism in female members of twin pedigrees?

Summary Answer: The presence of a male co-twin did not increase risk of male microchimerism and the prevalence of male microchimerism was not explained by having male offspring or by having an older brother.

What Is Known Already: Microchimerism describes the presence of cells within an organism that originate from another zygote and is commonly described as resulting from pregnancy in placental mammals. It is associated with diseases with a female predilection including autoimmune diseases and pregnancy-related complications. Read More

View Article and Full-Text PDF

Lower Extremity Biomechanics Predicts Major League Baseball Player Performance.

Orthop J Sports Med 2021 Jul 8;9(7):23259671211015237. Epub 2021 Jul 8.

Department of Orthopaedic Surgery, Wake Forest Baptist Health, Winston-Salem, North Carolina, USA.

Background: Although lower extremity biomechanics has been correlated with traditional metrics among baseball players, its association with advanced statistical metrics has not been evaluated.

Purpose: To establish normative biomechanical parameters during the countermovement jump (CMJ) among Major League Baseball (MLB) players and evaluate the relationship between CMJ-developed algorithms and advanced statistical metrics.

Study Design: Cohort study; Level of evidence, 3. Read More

View Article and Full-Text PDF

The Validation of Clinical Examination and MRI as a Diagnostic Tool for Cruciate Ligaments and Meniscus Injuries of the Knee Against Diagnostic Arthroscopy.

Cureus 2021 Jun 17;13(6):e15727. Epub 2021 Jun 17.

Department of Orthopedic Surgery, King George's Medical University, Lucknow, IND.

Background: This study was conducted to compare the accuracy of MRI findings and clinical examination of ligamentous and meniscal injuries of the knee, taking arthroscopy as a standard diagnostic tool in knee injuries.  Methods: All patients with knee injuries attending the outpatient department or emergency of our hospital underwent clinical examination. Out of them, 60 patients with knee injuries were subjected to clinical examination, MRI, and then arthroscopy. Read More

View Article and Full-Text PDF

Environmental assessment of pediatric Lead exposure in Tehran; a prospective cross-sectional study.

BMC Public Health 2021 Jul 21;21(1):1437. Epub 2021 Jul 21.

Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Ingestion and inhalation are common routes of exposure for lead in humans. Developing countries still have unacceptably high rates of lead toxicity, especially in children. Studies on probable risk factors of lead poisoning in Iranian children are insufficient. Read More

View Article and Full-Text PDF

Efficacy of a Novel Medical Adhesive for Sealing Lung Parenchyma: An in vitro Study in Rabbit Lungs.

Eur Surg Res 2021 Jul 21:1-7. Epub 2021 Jul 21.

Department of Thoracic and Cardiovascular Surgery, University Hospital RWTH Aachen, Aachen, Germany.

Introduction: During thoracic resection procedures, complete hemostasis and aerostasis are priorities. A persistent alveolar air leak is associated with increased morbidity and mortality rates. This study aimed to evaluate whether the novel medical adhesive VIVO (Adhesys Medical GmbH Aachen, Germany) is a reliable alternative sealing technique to routine surgical procedures. Read More

View Article and Full-Text PDF

SFPQ intron retention, reduced expression and aggregate formation are pathological features of amyotrophic lateral sclerosis.

Neuropathol Appl Neurobiol 2021 Jul 20. Epub 2021 Jul 20.

Centre for Motor Neuron Disease Research, Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, New South Wales, Australia.

Aim: Splicing factor proline and glutamine rich (SFPQ) is an RNA-DNA binding protein that is dysregulated in Alzheimer's disease and frontotemporal dementia. Dysregulation of SFPQ, specifically increased intron retention and nuclear depletion, has been linked to several genetic subtypes of ALS, suggesting that SFPQ pathology may be a common feature of this heterogeneous disease. Our study aimed to investigate this hypothesis by providing the first comprehensive assessment of SFPQ pathology in large ALS case-control cohorts. Read More

View Article and Full-Text PDF

Real-time cognitive performance and positive symptom expression in schizophrenia.

Eur Arch Psychiatry Clin Neurosci 2021 Jul 21. Epub 2021 Jul 21.

Institut de Neurosciences Cognitives et Intégratives d'Aquitaine (INCIA), University of Bordeaux/CNRS-UMR 5287, Bordeaux, France.

Deficits in cognitive functions are frequent in schizophrenia and are often conceptualized as stable characteristics of this disorder. However, cognitive capacities may fluctuate over the course of a day and it is unknown if such variation may be linked to the dynamic expression of psychotic symptoms. This investigation used Ecological Momentary Assessment (EMA) to provide mobile tests of cognitive functions and positive symptoms in real time. Read More

View Article and Full-Text PDF

[Avoidability of fetal deaths: reflections on the Brazilian List of Avoidable Causes of Deaths through interventions by the Brazilian Unified National Health System].

Cad Saude Publica 2021 19;37(7):e00265920. Epub 2021 Jul 19.

Departamento de Patologia, Universidade Federal Fluminense, Niterói, Brasil.

Although the Brazilian List of Avoidable Causes of Deaths (LBE in Portuguese), in its version for children under 5 years of age (LBE < 5), does not include stillbirths, some studies have used the list with or without adaptations. We present a proposal for adaptation of the LBE for stillbirths (LBE-OF in Portuguese) and the results of its application to stillbirths in the State of Rio de Janeiro, Brazil, in 2018, compared to the results with LBE < 5. We reviewed the categories from the 10th revision of the International Classification of Diseases (ICD-10) in the LBE < 5 and reassigned them in the avoidability groups, according to time of death in relation to delivery and the causes consistent with stillbirths. Read More

View Article and Full-Text PDF

Sudden Sensorineural Hearing Loss in Mild COVID-19: Case Series and Analysis of the Literature.

Audiol Res 2021 Jul 1;11(3):313-326. Epub 2021 Jul 1.

Unit of Audiology, Department of Experimental and Clinical Medicine, Magna Graecia University, 88100 Catanzaro, Italy.

Background: There is growing evidence of otoneurological involvement of SARS-CoV-2, such as tinnitus and balance disorders and smell and taste disorders, but HL in COVID-19 patients has still been marginally studied. Investigating the role of SARS-CoV-2 as an aetiological factor of Sudden Sensorineural Hearing Loss (SSNHL) may offer the opportunity to address treatment strategies to maximize clinical recovery and avoid side effects.

Methods And Results: For this purpose, we will present case studies of five patients who experienced SSNHL during COVID-19. Read More

View Article and Full-Text PDF

Coinfections with Other Respiratory Pathogens among Patients with COVID-19.

Microbiol Spectr 2021 Jul 21:e0016321. Epub 2021 Jul 21.

Department of Microbiology, All India Institute of Medical Sciencesgrid.413618.9, New Delhi, India.

Emerging evidence indicates that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected individuals are at an increased risk for coinfections; therefore, physicians need to be cognizant about excluding other treatable respiratory pathogens. Here, we report coinfection with SARS-CoV-2 and other respiratory pathogens in patients admitted to the coronavirus disease (COVID) care facilities of an Indian tertiary care hospital. From June 2020 through January 2021, we tested 191 patients with SARS-CoV-2 for 33 other respiratory pathogens using an fast track diagnostics respiratory pathogen 33 (FTD-33) assay. Read More

View Article and Full-Text PDF

Seroprevalence and Molecular Detection of Foot and Mouth Disease Virus in Dairy Cattle Around Addis Ababa, Central Ethiopia.

Vet Med (Auckl) 2021 12;12:187-197. Epub 2021 Jul 12.

National Animal Health Diagnostic and Investigation Center, Sebeta, Ethiopia.

Background: Foot and mouth disease is a debilitating and highly contagious transboundary disease of cattle that can cause a huge economical loss globally. It is a notifiable disease in Ethiopia, and it is thought to be causing a decrease in cattle productivity and production.

Methods: A cross-sectional study and outbreak investigation were performed to estimate seroprevalence, identify associated factors and serotypes of FMDV in dairy cattle around Addis Ababa. Read More

View Article and Full-Text PDF

Plasma lyso-sphingomyelin levels are positively associated with clinical severity in acid sphingomyelinase deficiency.

Mol Genet Metab Rep 2021 Sep 7;28:100780. Epub 2021 Jul 7.

Albert Einstein College of Medicine and the Children's Hospital at Montefiore, Bronx, New York, USA.

Introduction: A reliable biomarker is urgently needed in the diagnosis and management of acid sphingomyelinase deficiency (ASMD, also known as Niemann Pick A, A/B, and B). Lyso-sphingomyelin (LSM) has previously been proposed as a biomarker for this disease. However, existing studies have not investigated the relationship between LSM levels and clinical subtype or severity. Read More

View Article and Full-Text PDF
September 2021

First Record of an Established Population of Triatoma sanguisuga (Hemiptera: Reduviidae) in Richardson County, Nebraska.

J Med Entomol 2021 Jul 20. Epub 2021 Jul 20.

Entomological Sciences Division, Public Health Command-Central, Ft. Sam Houston, TX 78234, USA.

In 2017, a single adult Triatoma sanguisuga (LeConte) (Hemiptera: Reduviidae) was identified from Indian Cave State Park in Nemaha County, NE. The following summer, a single adult specimen was found in a 4-H insect collection at the Nebraska State Fair from Richardson County. A subsequent investigation found that these were collected from a residence in Richardson County and three more adults were collected in 2019. Read More

View Article and Full-Text PDF

Remediation of Mucorales-contaminated Healthcare Linens at a Laundry Facility Following an Investigation of a Case Cluster of Hospital-acquired Mucormycosis.

Clin Infect Dis 2021 Jul 20. Epub 2021 Jul 20.

University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Background: In an investigation of hospital-acquired mucormycosis cases among transplant recipients, healthcare linens (HCLs) delivered to our center were found to be contaminated with Mucorales. We describe an investigation and remediation of Mucorales contamination at the laundry supplying our center.

Methods: We performed monthly RODAC cultures of HCLs upon hospital arrival, and conducted site inspections and surveillance cultures at the laundry facility. Read More

View Article and Full-Text PDF

Informal caregivers of people with a diagnosis of schizophrenia: determinants and predictors of resilience.

J Ment Health 2021 Jul 20:1-8. Epub 2021 Jul 20.

Psychology and Clinical Psychologist, Thanjavur Medical College Hospital, Thanjavur, India.

Background: The extant literature portrays informal caregiving by family members who care for a person with a diagnosis of schizophrenia, as one that involves a tremendous amount of stress and burden.

Aim: This investigation sought to assess informal caregiving experience with regard to variables such as perceived positive aspects, preparedness, resilience, and life satisfaction.

Method: Data was collected from two groups of respondents accessing services at the Thanjavur Medical College Hospital, Tamil Nadu, India. Read More

View Article and Full-Text PDF

Measuring global multi-scale place connectivity using geotagged social media data.

Sci Rep 2021 07 19;11(1):14694. Epub 2021 Jul 19.

Department of Health Promotion, Education, and Behavior, University of South Carolina, Columbia, SC, USA.

Shaped by human movement, place connectivity is quantified by the strength of spatial interactions among locations. For decades, spatial scientists have researched place connectivity, applications, and metrics. The growing popularity of social media provides a new data stream where spatial social interaction measures are largely devoid of privacy issues, easily assessable, and harmonized. Read More

View Article and Full-Text PDF

Comparative and phylogenetic analyses of the chloroplast genomes of species of Paeoniaceae.

Sci Rep 2021 Jul 19;11(1):14643. Epub 2021 Jul 19.

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100193, China.

Plants belonging to family Paeoniaceae are not only economically important ornamental plants but also medicinal plants used as an important source of traditional Chinese medicine. Owing to the complex network evolution and polyploidy evolution of this family, its systematics and taxonomy are controversial and require a detailed investigation. In this study, three complete chloroplast genomes of sect. Read More

View Article and Full-Text PDF

Flexible Bronchoscopy Diagnosis of Uncommon Congenital H-type Tracheoesophageal Fistula, Dual Fistulae, Bronchoesophageal Fistula, and Recurrence of Fistula in Children: A 20-year Experience.

J Bronchology Interv Pulmonol 2021 Jul 19. Epub 2021 Jul 19.

Departments of Pediatric Respiratory and Sleep Medicine Medical Imaging and Nuclear Medicine, Queensland Children's Hospital Centre for Children's Health Research, South Brisbane School of Clinical Medicine, University of Queensland Australian Centre for Health Services Innovation, Queensland University of Technology, Brisbane, QLD, Australia.

Background: Interventional pediatric flexible bronchoscopy has many advantages over radiologic investigations in diagnosing uncommon congenital H-type tracheoesophageal fistula (TEF), dual TEF, bronchoesophageal fistula (BEF) and fistula recurrence including higher rates of identification and anatomic localization with guide wire cannulation. We compare the diagnostic utility of flexible bronchoscopy to radiologic techniques for congenital aerodigestive fistula.

Methods: A single center retrospective review was completed of all cases of pediatric TEF and BEF diagnosed with flexible bronchoscopy between January 2000 and November 2020. Read More

View Article and Full-Text PDF

Effects of Cannabidiol on the In Vitro Lymphocyte Pro-Inflammatory Cytokine Production of Senior Horses.

J Equine Vet Sci 2021 Aug 24;103:103668. Epub 2021 May 24.

MARS Equestrian™ Research Fellow, Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, Lexington, KY, USA.

Cannabis sativa L. contains cannabidiol (CBD), a compound that has many anti-inflammatory properties. In this study, 99. Read More

View Article and Full-Text PDF

Molecular detection and identification of Culex flavivirus in mosquito species from Jeju, Republic of Korea.

Virol J 2021 Jul 19;18(1):150. Epub 2021 Jul 19.

Department of Clinical Laboratory Science, Gwangju Health University, Gwangju, Republic of Korea.

Background: Mosquito-borne flaviviruses are prime pathogens and have been a major hazard to humans and animals. They comprise several arthropod-borne viruses, including dengue virus, yellow fever virus, Japanese encephalitis virus, and West Nile virus. Culex flavivirus (CxFV) is a member of the insect-specific flavivirus (ISF) group belonging to the genus Flavivirus, which is widely distributed in a variety of mosquito populations. Read More

View Article and Full-Text PDF

Fear of COVID-19 and COVID-19 Stress and Association with Sociodemographic and Psychological Process Factors in Cases under Surveillance in a Frontline Worker Population in Borneo.

Int J Environ Res Public Health 2021 Jul 5;18(13). Epub 2021 Jul 5.

Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu 88400, Sabah, Malaysia.

COVID-19 stress and fear of COVID-19 is an increasingly researched construct in the general population. However, its prevalence and association with sociodemographic factors and psychological process variables has not been explored in frontline workers under surveillance in a Bornean population. This study was a cross-sectional study using a sociodemographic questionnaire incorporating two specific epidemiological risk variables, namely specific questions about COVID-19 surveillance status (persons under investigation (PUI), persons under surveillance (PUS), and positive cases) and the nature of frontline worker status. Read More

View Article and Full-Text PDF

HY7015 Promotes Hair Growth in a Telogenic Mouse Model.

J Med Food 2021 Jul;24(7):741-748

R&D Center, Korea Yakult Co. Ltd., Yongin, Korea.

In this study, we describe the effects of HY7015 (HY7015) on promoting mouse hair growth. Since our purpose was to increase hair growth through oral administration, medicinal yeast, at a suitable concentration for application in mice, was used as a positive control. First, experiments were conducted to determine the effect of HY7015 on proliferation of hair follicle dermal papilla cells (HFDPC), which are important contributors to hair growth. Read More

View Article and Full-Text PDF

Exploration of synergistic action of cell wall-degrading enzymes against .

Antimicrob Agents Chemother 2021 Jul 19:AAC0065921. Epub 2021 Jul 19.

UGent Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium.

Background The major global health threat tuberculosis is caused by (Mtb). Mtb has a complex cell envelope - a partially covalently linked composite of polysaccharides, peptidoglycan and lipids, including a mycolic acid layer - which conveys pathogenicity but also protects against antibiotics. Given previous successes in treating gram-positive and -negative infections with cell wall degrading enzymes, we investigated such approach for Mtb. Read More

View Article and Full-Text PDF

Association of assisted reproductive technology with autism spectrum disorder in the offspring: an updated systematic review and meta-analysis.

Eur J Pediatr 2021 Jul 19. Epub 2021 Jul 19.

Laboratory of Biomathematics, University of Thessaly School of Medicine, Larissa, Greece.

This study aims to provide an up-to-date meta-analysis of data from studies investigating the risk of bearing a child with autism spectrum disorder (ASD) after being conceived by assisted reproductive technology (ART). The study was conducted according to the PRISMA Statement. PubMed and Scopus databases were searched up to August 2, 2020. Read More

View Article and Full-Text PDF

The association of age with continuous positive airway pressure ventilation acceptance in an outpatient cohort of patients with obstructive sleep apnea.

J Clin Sleep Med 2021 Jul 19. Epub 2021 Jul 19.

Respiratory and Sleep Medicine, Canberra Hospital, Garran, Australian Capital Territory, Australia.

Study Objectives: This study examined the association between age and CPAP acceptance in a consecutive series of patients with obstructive sleep apnea being managed in a physician-led outpatient CPAP acclimatization program in Canberra, Australia.

Methods: We performed a retrospective consecutive case series analysis of registry data collected from patients attending the Canberra Hospital PAP Acclimatization Clinic between 2011-2019. Data on patient demographics, diagnostic polysomnography results, CPAP device download parameters during acclimatization, and overall CPAP acceptance at the end of acclimatization was extracted from the Clinic Registry. Read More

View Article and Full-Text PDF

The frequency of TLR2 (rs3804099, rs3804100, and rs5743708) and TLR4 (rs4986790 and rs4986791) polymorphisms in women with polycystic ovary syndrome - preliminary study.

Gynecol Endocrinol 2021 Jul 19:1-8. Epub 2021 Jul 19.

Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland.

Introduction: Low-grade chronic inflammation may participate in PCOS etiology. Toll-like receptors (TLRs) may play a pivotal role in the initiation and progression of inflammatory process. We examined TLR2 and TLR4 gene polymorphisms in women with PCOS and their associations with metabolic/hormonal parameters. Read More

View Article and Full-Text PDF

Global, Regional, and National Burden of Myocarditis From 1990 to 2017: A Systematic Analysis Based on the Global Burden of Disease Study 2017.

Front Cardiovasc Med 2021 2;8:692990. Epub 2021 Jul 2.

Cardiovascular Division, Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO, United States.

The global trends in myocarditis burden over the past two decades remain poorly understood and might be increasing during the coronavirus disease 2019 (COVID-19) worldwide pandemic. This study aimed to provide comprehensive estimates of the incidence, mortality, and disability-adjusted life years (DALYs) for myocarditis globally from 1990 to 2017. Data regarding the incidence, mortality, DALY, and estimated annual percentage change (EAPC) between 1990 and 2017 for myocarditis worldwide were collected and calculated from the 2017 Global Burden of Disease study. Read More

View Article and Full-Text PDF

Comprehensive Analysis of the Immune-Oncology Targets and Immune Infiltrates of -Methyladenosine-Related Long Noncoding RNA Regulators in Breast Cancer.

Front Cell Dev Biol 2021 2;9:686675. Epub 2021 Jul 2.

Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Breast cancer (BRCA) has become the highest incidence of cancer due to its heterogeneity. To predict the prognosis of BRCA patients, sensitive biomarkers deserve intensive investigation. Herein, we explored the role of -methyladenosine-related long non-coding RNAs (mA-related lncRNAs) as prognostic biomarkers in BRCA patients acquired from The Cancer Genome Atlas (TCGA; = 1,089) dataset and RNA sequencing (RNA-seq) data ( = 196). Read More

View Article and Full-Text PDF