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Conducting a Virtual Research Symposium: Path to Success.

J Nurs Adm 2021 May;51(5):240-241

Author Affiliations: CPM Site Coordinator (Ms Merritt), Director of Education Development and Community Education (Ms Kramer), Research Consultant (Dr Monroe), Research Consultant (Dr Davies), Baptist Health Lexington, Kentucky.

Strategies used to change an annual statewide research symposium from a face-to-face experience to a virtual event at a 434-bed Magnet® redesignated community hospital are described. The program met with success and increased access for attendees. For the 1st time, credited to the virtual format, representatives from all 9 hospitals in the system were able to attend. Read More

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Effects of noise and time delay on E2F's expression level in a bistable Rb-E2F gene's regulatory network.

IET Syst Biol 2021 Apr 21. Epub 2021 Apr 21.

Department of Physics and Institute of Biophysics, Central China Normal University, Wuhan, China.

The bistable Rb-E2F gene regulatory network plays a central role in regulating cellular proliferation-quiescence transition. Based on Gillespie's chemical Langevin method, the stochastic bistable Rb-E2F gene's regulatory network with time delays is proposed. It is found that under the moderate intensity of internal noise, delay in the Cyclin E synthesis rate can greatly increase the average concentration value of E2F. Read More

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Corollary discharge promotes a sustained motor state in a neural circuit for navigation.

Elife 2021 Apr 21;10. Epub 2021 Apr 21.

Physics, Harvard University, Cambridge, United States.

Animals exhibit behavioral and neural responses that persist on longer time scales than transient or fluctuating stimulus inputs. Here, we report that uses feedback from the motor circuit to a sensory processing interneuron to sustain its motor state during thermotactic navigation. By imaging circuit activity in behaving animals, we show that a principal postsynaptic partner of the AFD thermosensory neuron, the AIY interneuron, encodes both temperature and motor state information. Read More

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Increasing nursing student interest in rural healthcare: lessons from a rural rotation program in Democratic Republic of the Congo.

Hum Resour Health 2021 Apr 20;19(1):53. Epub 2021 Apr 20.

ICAP At Columbia University, Kinshasa, Democratic Republic of the Congo.

Background: Many challenges exist in providing equitable access to rural healthcare in the Democratic Republic of the Congo (DRC). WHO recommends student exposure to rural clinical rotations to promote interest in rural healthcare. Challenges to rural engagement include lack of adequate infrastructure and staff to lead rural education. Read More

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From foraging trails to transport networks: how the quality-distance trade-off shapes network structure.

Proc Biol Sci 2021 Apr 21;288(1949):20210430. Epub 2021 Apr 21.

Department of Biology, University of York, UK.

Biological systems are typically dependent on transportation networks for the efficient distribution of resources and information. Revealing the decentralized mechanisms underlying the generative process of these networks is key in our global understanding of their functions and is of interest to design, manage and improve human transport systems. Ants are a particularly interesting taxon to address these issues because some species build multi-sink multi-source transport networks analogous to human ones. Read More

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Music for Wellness in rehabilitation patients: programme description and evaluation results.

Public Health 2021 Apr 16;194:109-115. Epub 2021 Apr 16.

St John of God Health Care, Perth, Western Australia, Australia. Electronic address:

Objective: The evaluation of real-world, hospital-based, arts programmes is important for quality assurance, to increase knowledge of successful practice and awareness of effective arts-health collaborations. The objective of this study was to describe the Music for Wellness programme and evaluation at St John of God Frankston Rehabilitation Hospital, Australia.

Study Design: An impact evaluation and quasi-experimental pre-post study was conducted. Read More

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Learning With and Without Feedback in Children With Developmental Language Disorder.

J Speech Lang Hear Res 2021 Apr 20:1-16. Epub 2021 Apr 20.

Department of Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, MA.

Purpose Intervention provided to school-age children with developmental language disorder often relies on the provision of performance feedback, yet it is unclear whether children with this disorder benefit from feedback-based learning. The study evaluates the effect of performance feedback on learning in children with developmental language disorder. Method Thirteen 8- to 12-year-old children with developmental language disorder and 14 age- and gender-matched children with typical language development completed two learning tasks whose objective was to pair nonword novel names with novel objects. Read More

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Robust Lexically Mediated Compensation for Coarticulation: Christmash Time Is Here Again.

Cogn Sci 2021 Apr;45(4):e12962

Psychological Sciences, University of Connecticut.

A long-standing question in cognitive science is how high-level knowledge is integrated with sensory input. For example, listeners can leverage lexical knowledge to interpret an ambiguous speech sound, but do such effects reflect direct top-down influences on perception or merely postperceptual biases? A critical test case in the domain of spoken word recognition is lexically mediated compensation for coarticulation (LCfC). Previous LCfC studies have shown that a lexically restored context phoneme (e. Read More

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A Scoping Review of Communicating Neuropsychological Test Results to Patients and Family Members.

Neuropsychol Rev 2021 Apr 20. Epub 2021 Apr 20.

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands.

Feedback of neuropsychological test results to patients and family members include psychoeducation and implications for daily life. This scoping review aimed to provide an overview of the literature on neuropsychological feedback and to offer clinical recommendations. In accordance with formal scoping review methodology, PubMed, PsycInfo, Web of Science, CINAHL, and Embase databases were searched. Read More

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Mirtronic miR-4646-5p promotes gastric cancer metastasis by regulating ABHD16A and metabolite lysophosphatidylserines.

Cell Death Differ 2021 Apr 19. Epub 2021 Apr 19.

Key Laboratory of Laboratory Medical Diagnostics designated by Chinese Ministry of Education, Chongqing Medical University, Chongqing, 400016, China.

The aberrant classical miRNAs are considered to play significant roles in tumor progression. However, it remains unclear for nonclassical miRNAs, a set of Drosha-independent miRNAs in the process of various biology. Here, we reveal that a nonclassical miR-4646-5p plays a pivotal role in gastric cancer (GC) metastasis. Read More

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The effectiveness of interruptive prescribing alerts in ambulatory CPOE to change prescriber behaviour & improve safety.

BMJ Qual Saf 2021 Apr 19. Epub 2021 Apr 19.

Department of Internal Medicine, The University of Oklahoma School of Community Medicine, Tulsa, Oklahoma, USA

Background: Prescribing alerts of an electronic health record are meant to be protective, but often are disruptive to providers. Our goal was to assess the effectiveness of interruptive medication-prescriber alerts in changing prescriber behaviour and improving patient outcomes in ambulatory care settings via computerised provider order entry (CPOE) systems.

Methods: A standardised search strategy was developed and applied to the following key bibliographical databases: PubMed, Embase, CINAHL and The Cochrane Library. Read More

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Bacterial community in saline farmland soil on the Tibetan plateau: responding to salinization while resisting extreme environments.

BMC Microbiol 2021 Apr 20;21(1):119. Epub 2021 Apr 20.

School of Ocean Sciences, China University of Geosciences (Beijing), Beijing, 100083, China.

Background: Salinization damages the health of soil systems and reduces crop yields. Responses of microbial communities to salinized soils and their functional maintenance under high salt stress are valuable scientific problems. Meanwhile, the microbial community of the salinized soil in the plateau environment is less understood. Read More

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Soil community feedback and the coexistence of competitors: conceptual frameworks and empirical tests.

James D Bever

New Phytol 2003 Mar;157(3):465-473

Indiana University, Bloomington, IN 47401, USA.

A growing body of empirical work suggests that soil organisms can exert a strong role in plant community dynamics and may contribute to the coexistence of plant species. Some of this evidence comes from examining the feedback on plant growth through changes in the composition of the soil community. Host specific changes in soil community composition can generate feedback on plant growth and this feedback can be positive or negative. Read More

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Contrasting ecosystem responses to climatic events and human activity revealed by a sedimentary record from Lake Yilong, southwestern China.

Sci Total Environ 2021 Apr 16;783:146922. Epub 2021 Apr 16.

College of Earth and Environmental Sciences, MOE Key Laboratory of Western China's Environmental Systems, Lanzhou University, Lanzhou 730000, China.

Global climate change and human activities have significantly impacted lake ecosystems at an accelerating rate in recent decades, but the differences between the responses of lake ecosystems to these two stressors remain unclear. Thus an improved understanding of the long-term influences of climatic and anthropogenic disturbances is necessary for the management of lake ecosystems. In order to address these issues, a sedimentary record was obtained from Lake Yilong in Yunnan Province in southwestern China, where the climate and natural environment are dominated by the Indian Summer Monsoon and there is a long history of human occupation and intensive human activity. Read More

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Reciprocal regulation between the negative regulator PP2CG1 phosphatase and the positive regulator OST1 kinase confers cold response in Arabidopsis.

J Integr Plant Biol 2021 Apr 19. Epub 2021 Apr 19.

State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, 100193, China.

Protein phosphorylation and dephosphorylation have been reported to play important roles in plant cold responses. In addition, phospho-regulatory feedback is a conserved mechanism for biological processes and stress responses in animals and plants. However, it is less well known that a regulatory feedback loop formed by the protein kinase and the protein phosphatase in plant responses to cold stress. Read More

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CDK14/β-catenin/TCF4/miR-26b positive feedback regulation modulating pancreatic cancer cell phenotypes in vitro and tumor growth in mice model in vivo.

J Gene Med 2021 Apr 19:e3343. Epub 2021 Apr 19.

Department of Post-anesthetic ICU, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Introduction: Chemotherapy and radiotherapy have been reported to be basically ineffective for pancreatic ductal adenocarcinoma (PDAC) patients; thus, gene therapy might provide a novel approach for them. CDK14, a new oncogenic member of CDK family involving in pancreatic cancer cell response to Gemcitabine (GEM) treatment, has been reported to be regulated by miRNAs. In this study, we aimed to investigate whether miR-26b regulated CDK14 expression to affect the phenotype of pancreatic cancer cells. Read More

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Daily Motivational Text Messages to Promote Physical Activity in University Students: Results From a Microrandomized Trial.

Ann Behav Med 2021 Apr 19. Epub 2021 Apr 19.

School of Social Welfare, University of California, Berkeley, CA, USA.

Background: Low physical activity is an important risk factor for common physical and mental disorders. Physical activity interventions delivered via smartphones can help users maintain and increase physical activity, but outcomes have been mixed.

Purpose: Here we assessed the effects of sending daily motivational and feedback text messages in a microrandomized clinical trial on changes in physical activity from one day to the next in a student population. Read More

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Crisis Leadership Education for Critical Care Fellows. A Longitudinal Curriculum Using Simulation.

ATS Sch 2020 Feb 21;1(1):11-19. Epub 2020 Feb 21.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine and.

: Leadership and teamwork are critical to the performance of a multidisciplinary team responding to emergencies in the intensive care unit; yet, these skills are variably taught to pulmonary and critical care trainees. Currently, there is no standardized leadership curriculum in critical care training. : We developed a longitudinal crisis leadership curriculum for first-year pulmonary and critical care fellows using high-fidelity simulation as a medium to practice and solidify skills. Read More

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February 2020

Ligand Binding Prolongs Androgen Receptor Protein Half-Life by Reducing its Degradation.

J Endocr Soc 2021 May 5;5(5):bvab035. Epub 2021 Mar 5.

Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA.

Androgens are important in female reproduction, but the molecular actions of androgens in female reproductive tissues are not fully understood. We investigated the androgen-responsive transcriptome in human and mouse granulosa cells (GCs) and surprisingly found that the gene-regulation activity of androgen receptor (AR) in these cells is negligible. We then investigated extranuclear actions of AR and found that in human and mouse GCs, as well as in prostate cancer cells, dihydrotestosterone (DHT) dramatically increases the half-life of its own receptor protein. Read More

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International Migration and Development: A Dyadic Analysis of the Americas, 1970-2010.

Front Sociol 2020 4;5:15. Epub 2020 Mar 4.

Department of Sociology, Wayne State University, Detroit, MI, United States.

This paper assesses the migration-development nexus from a new, relational perspective, providing a closer test of existing theories of cross-national dynamics, including migration and development. Using bilateral data, we assess the relationship between migration (im)balances and wage differentials between pairs of countries in the Americas, from 1970 to 2010. The analysis reveals a positive feedback between international migration and cross-national inequalities. Read More

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Implementing online patient feedback in a 'special measures' acute hospital: A case study using Normalisation Process Theory.

Digit Health 2021 Jan-Dec;7:20552076211005962. Epub 2021 Apr 1.

Centre for Health Technology, University of Plymouth, Plymouth, UK.

Objective: Online patient feedback is becoming increasingly prevalent on an international scale. However, limited research has explored how healthcare organisations implement such feedback. This research sought to explore how an acute hospital, recently placed into 'special measures' by a regulatory body implemented online feedback to support its improvement journey. Read More

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StopWatch: Pilot study for an Apple Watch application for youth with ADHD.

Digit Health 2021 Jan-Dec;7:20552076211001215. Epub 2021 Apr 1.

Stanford University, Stanford, CA, USA.

Introduction: To address the need for non-pharmacologic, scalable approaches for managing attention-deficit and hyperactivity disorder (ADHD) in young people, we report the results of a study of an application developed for a wearable device (Apple Watch) that was designed to track movement and provide visual and haptic feedback for ADHD.

Methods: Six-week, open label pilot study with structured rating scales ADHD and semi-structured qualitative interview. Apple Watch software application given to users that uses actigraphy and graphic interface as well as haptic feedback to provide feedback to users about level of movement during periods of intentional focus. Read More

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Telerounding Has Clinical Value and Enables the Busy Surgeon: A Colorectal Surgeon's Ten-Year Experience.

Am Surg 2021 Apr 18:31348211011131. Epub 2021 Apr 18.

Department of Surgery, 6595University of Pittsburgh, Pittsburgh, PA, USA.

Background: Study of telemedicine and telerounding in surgical specialties is limited. The push for telemedicine during the COVID-19 pandemic has challenged the face-to-face rounding paradigm and creates an opportunity for reflection on the benefits of telemedicine, especially for balancing competing corporate and clinical demands.

Methods: The 117-month video-based inpatient telerounding experience of a colorectal surgeon in an academic medical system was recorded, including patient characteristics, diagnoses, technology, content of telerounding encounters, and logistical considerations. Read More

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Improving the design of an oxidative stress sensing biosensor in yeast.

FEMS Yeast Res 2021 Apr 17. Epub 2021 Apr 17.

Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, M5S 1A1, Canada.

Transcription factor (TF)-based biosensors have proven useful for increasing biomanufacturing yields, large-scale functional screening, and in environmental monitoring. Most yeast TF-based biosensors are built from natural promoters, resulting in large DNA parts retaining considerable homology to the host genome, which can complicate biological engineering efforts. There is a need to explore smaller, synthetic biosensors to expand the options for regulating gene expression in yeast. Read More

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DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells.

Nat Commun 2021 04 16;12(1):2285. Epub 2021 Apr 16.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel.

During Drosophila embryonic development, cell death eliminates 30% of the primordial germ cells (PGCs). Inhibiting apoptosis does not prevent PGC death, suggesting a divergence from the conventional apoptotic program. Here, we demonstrate that PGCs normally activate an intrinsic alternative cell death (ACD) pathway mediated by DNase II release from lysosomes, leading to nuclear translocation and subsequent DNA double-strand breaks (DSBs). Read More

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Pain management in inflammatory bowel disease: feasibility of an online therapist-supported CBT-based self-management intervention.

Pilot Feasibility Stud 2021 Apr 16;7(1):95. Epub 2021 Apr 16.

Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King's College London, London, UK.

Background: Chronic pain is a poorly managed symptom of inflammatory bowel disease (IBD). Cognitive behavioural therapy (CBT) has an evidence base in functional gastrointestinal conditions and chronic pain. This study aimed to test the feasibility and acceptability of a 9-week online facilitator-supported CBT intervention, tailored for people with chronic IBD-related pain. Read More

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Parametric transition from deflagration to detonation in stellar medium.

Phys Rev E 2021 Mar;103(3-1):033106

School of Mathematical Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

The nature of thermonuclear explosions of white-dwarf stars is a fundamental astrophysical issue, the first principle interpretation of which is still commonly regarded as an unresolved problem. There is a general consensus that stellar explosions are a manifestation of the deflagration-to-detonation transition of an outward propagating self-accelerating thermonuclear flame subjected to instability-induced corrugations. A similar problem arises in unconfined terrestrial flames where a positive feedback mechanism leading to the pressure runaway has been identified. Read More

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Unidimensional analysis of the nursing diagnoses of situational low self-esteem and chronic low self-esteem.

Perspect Psychiatr Care 2021 Apr 16. Epub 2021 Apr 16.

Doctor José Frota Hospital, Institute-IJF, Fortaleza, Brazil.

Purpose: To analyze the unidimensionality of the nursing diagnoses low situational self-esteem and low chronic self-esteem proposed by NANDA-I.

Desing And Methods: Diagnostic accuracy study carried out with 180 patients with depressed mood in a psychiatric hospital in northeastern Brazil.

Findings: The analysis of the latent class considered the hypothesis of low self-esteem as a unique construct and included the indicators: Excessive seeking of reassurance, repeatedly unsuccessfulness in life events, rejection of positive feedback, insomnia, solitude, and nonassertive behavior. Read More

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User experience (re)design and evaluation of a self-guided, mobile health app for adolescents with mild Traumatic Brain Injury.

J Form Des Learn 2020 Dec 6;4(2):51-64. Epub 2020 Jan 6.

Cincinnati Children's Hospital Medical Center.

Mild Traumatic Brain Injury (mTBI) is a significant cause of morbidity for adolescents. Currently, there is a lack of evidence-based interventions to address common sequelae of mTBI. To address this gap, we designed a program to promote recovery for adolescents following mTBI. Read More

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December 2020