24,838 results match your criteria positive dynamics


COVID-19 transmission: a positive perspective.

Horm Mol Biol Clin Investig 2021 Jul 30. Epub 2021 Jul 30.

Department of Community Medicine, AIIMS Nagpur, Nagpur, Maharashtra, India.

Objectives: To understand the dynamics of infectivity of COVID-19 and allay the fear and anxiety associated with it in healthcare workers and the society.

Case Presentation: Three individuals accompanied their pediatric patients in the COVID ward but did not develop infection. Information about their knowledge and perspective about the disease and the protective measures undertaken by them during their stay in the hospital was gathered by administering a questionnaire 14 days after discharge. Read More

View Article and Full-Text PDF

Dynamic Intracranial Pressure Waveform Morphology Predicts Ventriculitis.

Neurocrit Care 2021 Jul 30. Epub 2021 Jul 30.

Department of Neurology, Columbia University Vagelos College of Physicians and Surgeons, 177 Fort Washington Ave, 8 Milstein - 300 Center, New York, NY, USA.

Background: Intracranial pressure waveform morphology reflects compliance, which can be decreased by ventriculitis. We investigated whether morphologic analysis of intracranial pressure dynamics predicts the onset of ventriculitis.

Methods: Ventriculitis was defined as culture or Gram stain positive cerebrospinal fluid, warranting treatment. Read More

View Article and Full-Text PDF

Protecting patients and staff in residential treatment centers during exposure to COVID-19: commentary.

Addict Sci Clin Pract 2021 Jul 30;16(1):49. Epub 2021 Jul 30.

Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Background: The COVID-19 pandemic has created a crisis in access to addiction treatment. Programs with residential components have been particularly impacted as they try to keep infection from spreading in facilities and contributing to further community spread of the virus. This crisis highlights the ongoing daily trade-offs that organizations must weigh as they balance the risks and benefits of individual patients with those of the group of patients, staff and the community they serve. Read More

View Article and Full-Text PDF

Dynamics of urban landscape nexus spatial dependence of ecosystem services in rapid agglomerate cities of Ethiopia.

Sci Total Environ 2021 Jul 23;798:149192. Epub 2021 Jul 23.

Addis Ababa University, Center for Environmental Science, Ethiopia.

Understanding the dependence of ecosystem services (ESs) on the dynamics of human-semi nature-coupled ecosystems is crucial for urban ecosystem resilience. In the present study, the responses of ESs to land use land cover transitions were explored and compared, selecting Addis Ababa, Adama, Hawassa, and Bahir Dar cities in Ethiopia. The geospatial data and benefit transfer approach was used to estimate the nexus over a three-decade period (1990-2020). Read More

View Article and Full-Text PDF

Respiratory cryptosporidiosis in Malawian children with diarrheal disease.

PLoS Negl Trop Dis 2021 Jul 30;15(7):e0009643. Epub 2021 Jul 30.

Paediatrics and Child Health Research Group, Malawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.

Background: Respiratory cryptosporidiosis has been documented in children with diarrhea. We sought to describe the dynamics of respiratory involvement in children hospitalized with gastrointestinal (GI) diarrheal disease.

Methods: We conducted a prospective, observational longitudinal study of Malawian children 2-24 months hospitalized with diarrhea. Read More

View Article and Full-Text PDF

Relative Humidity Predicts Day-to-Day Variations in COVID-19 Cases in the City of Buenos Aires.

Environ Sci Technol 2021 Jul 30. Epub 2021 Jul 30.

Leloir Institute-IIBBA/CONICET, Av. Patricias Argentinas 435, CBA, Buenos Aires C1405BWE, Argentina.

Possible links between the transmission of COVID-19 and meteorology have been investigated by comparing positive cases across geographical regions or seasons. Little is known, however, about the degree to which environmental conditions modulate the daily dynamics of COVID-19 spread at a given location. One reason for this is that individual waves of the disease typically rise and decay too sharply, making it hard to isolate the contribution of meteorological cycles. Read More

View Article and Full-Text PDF

Genomic epidemiology and transmission dynamics of SARS-CoV-2 in congregate healthcare facilities in Santa Clara County, California.

Clin Infect Dis 2021 Jul 30. Epub 2021 Jul 30.

County of Santa Clara, Public Health Department, San Jose, California, USA.

Background: Outbreaks of SARS-CoV-2 in long term care facilities (LTCFs) cause significant morbidity and mortality. Mapping viral transmission within and between by combining genomic sequencing with epidemiologic investigations enables targeting infection control interventions.

Methods: We conducted weekly surveillance of residents and staff in LTCFs in Santa Clara County, CA with at least one confirmed COVID-19 case between March and July 2020. Read More

View Article and Full-Text PDF

Habitat isolation and the cues of three remote predators differentially modulate prey colonization dynamics in pond landscapes.

Oecologia 2021 Jul 29. Epub 2021 Jul 29.

Community Ecology Lab, Department of Biology, Vrije Universiteit Brussel, Pleinlaan 2, B-1050, Brussels, Belgium.

Recent evidence suggests predators may change colonization rates of prey in nearby predator-free patches as an example of context-dependent habitat selection. Such remote predator effects can be positive when colonizers are redirected to nearby patches (habitat compression), or negative when nearby patches are avoided (risk contagion). However, it is unknown to what extent such responses are predator- and prey-specific and change with increasing distance from predator patches. Read More

View Article and Full-Text PDF

Detection of Molecular Residual Disease Using Personalized Circulating Tumor DNA Assay in Patients With Colorectal Cancer Undergoing Resection of Metastases.

JCO Precis Oncol 2021 Jul 21;5. Epub 2021 Jul 21.

Unit of Surgical Pathology, Department of Medicine (DIMED), University of Padua, Padua, Italy.

Purpose: More than 50% of patients with stage IV colorectal cancer (metastatic colorectal cancer [mCRC]) relapse postresection. The efficacy of postoperative systemic treatment is limited in this setting. Thus, these patients would greatly benefit from the use of a reliable prognostic biomarker, such as circulating tumor DNA (ctDNA) to identify minimal or molecular residual disease (MRD). Read More

View Article and Full-Text PDF

Spatiotemporal Dynamics of Affective and Semantic Valence Among Women.

Front Hum Neurosci 2021 13;15:602192. Epub 2021 Jul 13.

Key Laboratory of Modern Teaching Technology, Ministry of Education, Shaanxi Normal University, Xi'an, China.

As an important dimension of emotional assessment, valence can refer to affective valence reflecting an emotional response, or semantic valence reflecting knowledge about the nature of a stimulus. A previous study has used repeated exposure to separate these two similar cognitive processes. Here, for the first time, we compared the spatiotemporal dynamics of the affective and semantic modes of valence by combining event-related potentials with repeated exposure. Read More

View Article and Full-Text PDF

In vitro monitoring of HTR2A-positive neurons derived from human-induced pluripotent stem cells.

Sci Rep 2021 Jul 29;11(1):15437. Epub 2021 Jul 29.

Department of Prosthodontics, School of Dentistry, Showa University, 2-1-1 Kitasenzoku, Ohta-ku, Tokyo, 145-8515, Japan.

The serotonin 5-HT receptor (5-HTR) has been receiving increasing attention because its genetic variants have been associated with a variety of neurological diseases. To elucidate the pathogenesis of the neurological diseases associated with 5-HTR gene (HTR2A) variants, we have previously established a protocol to induce HTR2A-expressing neurons from human-induced pluripotent stem cells (hiPSCs). Here, we investigated the maturation stages and electrophysiological properties of HTR2A-positive neurons induced from hiPSCs and constructed an HTR2A promoter-specific reporter lentivirus to label the neurons. Read More

View Article and Full-Text PDF

SKAP2 as a new regulator of oligodendroglial migration and myelin sheath formation.

Glia 2021 Jul 29. Epub 2021 Jul 29.

Institute of Neuropathology, University Hospital Muenster, Muenster, Germany.

Oligodendroglial progenitor cells (OPCs) are highly proliferative and migratory cells, which differentiate into complex myelin forming and axon ensheathing mature oligodendrocytes during myelination. Recent studies indicate that the oligodendroglial cell population is heterogeneous on transcriptional and functional level depending on the location in the central nervous system. Here, we compared intrinsic properties of OPC from spinal cord and brain on functional and transcriptional level. Read More

View Article and Full-Text PDF

Frost tolerance in apricot (Prunus armeniaca L.) receptacle and pistil organs: how is the relationship among amino acids, minerals, and cell death points?

Int J Biometeorol 2021 Jul 29. Epub 2021 Jul 29.

Department of Genetics and Bioengineering, Faculty of Engineering, Yeditepe University, 34755, Istanbul, Turkey.

To the better management of spring frost problem in the apricot cultivars, evaluation of biochemical changes in flower and/or flower organs during bud break could be one of the key factors. In this study, the relationship between the biochemical metabolites such as amino acids and minerals in the receptacle and pistil organs of two different apricot cultivars (frost-sensitive and frost-tolerant) and their relative effects on the frost tolerance of the cultivars and their organs were investigated during full blooming stage. In both apricot cultivars, it was found that the cell death points (CDP) of flower receptacle (- 6. Read More

View Article and Full-Text PDF

Characterizing the Relationship Between Western Corn Rootworm (Coleoptera: Chrysomelidae) Larval Survival on Cry3Bb1-Expressing Corn and Larval Development Metrics.

J Econ Entomol 2021 Jul 29. Epub 2021 Jul 29.

Department of Entomology, University of Nebraska, Lincoln, NE 68583, USA.

The western corn rootworm, Diabrotica virgifera virgifera LeConte (Coleoptera: Chrysomelidae), is a significant pest of field corn, Zea mays L. (Poales: Poaceae), across the United States Corn Belt. Widespread adoption and continuous use of corn hybrids expressing the Cry3Bb1 protein to manage the western corn rootworm has resulted in greater than expected injury to Cry3Bb1-expressing hybrids in multiple areas of Nebraska. Read More

View Article and Full-Text PDF

Satellite-detected ammonia changes in the United States: Natural or anthropogenic impacts.

Sci Total Environ 2021 May 25;789:147899. Epub 2021 May 25.

Department of Computer Science and Software Engineering, Samuel Ginn College of Engineering, Auburn University, Auburn, AL, USA.

Ammonia (NH) is the most abundant alkaline component and can react with atmospheric acidic species to form aerosols that can lead to numerous environmental and health issues. Increasing atmospheric NH over agricultural regions in the US has been documented. However, spatiotemporal changes of NH concentrations over the entire US are still not thoroughly understood, and the factors that drive these changes remain unknown. Read More

View Article and Full-Text PDF

Lean and obese microbiota: differences in fermentation of food-by-products.

Benef Microbes 2021 Jul 29:1-16. Epub 2021 Jul 29.

Maastricht University - campus Venlo, Centre for Healthy Eating & Food Innovation, Villafloraweg 1, 5928 SZ Venlo, the Netherlands.

The aim of the study was to investigate the potential prebiotic effects of food-by-products (cassava bagasse (n=3), orange bagasse (n=2) and passion fruit peel (n=3)) using an model simulating the proximal colon, and to assess possible differences in fermentation when using faecal microbiota from lean or obese people. Fermentation of the by-products was compared to a control medium and the prebiotic inulin. The effects of the by-products on the dynamics of the gut microbiota differed according to the type of microbiota, as well as the type of by-product used. Read More

View Article and Full-Text PDF

When intuition falters: repeated testing accuracy during an epidemic.

Eur J Epidemiol 2021 Jul 28. Epub 2021 Jul 28.

Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Widespread, repeated testing using rapid antigen tests to proactively detect asymptomatic SARS-CoV-2 infections has been a promising yet controversial topic during the COVID-19 pandemic. Concerns have been raised over whether currently authorized lateral flow tests are sufficiently sensitive and specific to detect enough infections to impact transmission whilst minimizing unnecessary isolation of false positives. These concerns have often been illustrated using simple, textbook calculations of positivity rates and positive predictive value assuming fixed values for sensitivity, specificity and prevalence. Read More

View Article and Full-Text PDF

Anthropogenic forcing and response yield observed positive trend in Earth's energy imbalance.

Nat Commun 2021 Jul 28;12(1):4577. Epub 2021 Jul 28.

Program in Atmospheric and Oceanic Sciences, Princeton University, Princeton, NJ, USA.

The observed trend in Earth's energy imbalance (TEEI), a measure of the acceleration of heat uptake by the planet, is a fundamental indicator of perturbations to climate. Satellite observations (2001-2020) reveal a significant positive globally-averaged TEEI of 0.38 ± 0. Read More

View Article and Full-Text PDF

FREQUENT LEPTOSPIRA SPP. DETECTION BUT ABSENCE OF TULA ORTHOHANTAVIRUS IN MICROTUS SPP. VOLES, NORTHWESTERN SPAIN.

J Wildl Dis 2021 Jul 28. Epub 2021 Jul 28.

Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Südufer 10, 17493 Greifswald-Insel Riems, Germany.

The common vole (Microtus arvalis) is a major agricultural pest in Europe and is a reservoir for several zoonotic agents, such as Leptospira spp. and Tula orthohantavirus (TULV). However, little is known about the occurrence of those pathogens in voles from Spain, where the species has largely expanded its distribution range in the past decades, causing agricultural pests and zoonotic diseases. Read More

View Article and Full-Text PDF

Resident cardiac macrophages mediate adaptive myocardial remodeling.

Immunity 2021 Jul 21. Epub 2021 Jul 21.

Departmental of Medicine, Washington University School of Medicine; Department of Pathology and Immunology, Washington University School of Medicine; Department of Developmental Biology, Washington University School of Medicine. Electronic address:

Cardiac macrophages represent a heterogeneous cell population with distinct origins, dynamics, and functions. Recent studies have revealed that C-C Chemokine Receptor 2 positive (CCR2) macrophages derived from infiltrating monocytes regulate myocardial inflammation and heart failure pathogenesis. Comparatively little is known about the functions of tissue resident (CCR2) macrophages. Read More

View Article and Full-Text PDF

Mechanical energy and propulsion mechanics in roller-skiing double-poling at increasing speeds.

PLoS One 2021 28;16(7):e0255202. Epub 2021 Jul 28.

Centre for Elite Sports Research, Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.

Objectives: The aim of this study was to examine the effect of speed on mechanical energy fluctuations and propulsion mechanics in the double-poling (DP) technique of cross-country skiing.

Methods: Kinematics and dynamics were acquired while fourteen male skiers performed roller-skiing DP on a treadmill at increasing speeds (15, 21 and 27 km∙h-1). Kinetic (Ekin), potential (Epot), and total (Ebody) body mechanical energy and pole power (Ppole) were calculated. Read More

View Article and Full-Text PDF

Bundled Payment Episodes Initiated by Physician Group Practices: Medicare Beneficiary Perceptions of Care Quality.

J Gen Intern Med 2021 Jul 28. Epub 2021 Jul 28.

Abt Associates, Cambridge, MA, USA.

Background: The Bundled Payments for Care Improvement (BPCI) initiative incentivizes participating providers to reduce total Medicare payments for an episode of care. However, there are concerns that reducing payments could reduce quality of care.

Objective: To assess the association of BPCI with patient-reported functional status and care experiences. Read More

View Article and Full-Text PDF

Marinomonas vulgaris sp. nov., a marine bacterium isolated from seawater in a coastal intertidal zone of Zhoushan island.

Arch Microbiol 2021 Jul 28. Epub 2021 Jul 28.

College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, 310018, People's Republic of China.

A Marinomonas-like, Gram-stain-negative, strictly aerobic and rod to ovoid-shaped bacterium, designated as strain A79, was isolated from the seawater mixtures of oyster shells and brown algae in a coastal intertidal zone of Zhoushan, China. The strain was positive for oxidase and catalase. Colonies grown on marine agar for 48 h were round, milky white, smooth and moist with the diameter of 2-3 mm. Read More

View Article and Full-Text PDF

Protonation states at different pH, conformational changes and impact of glycosylation in synapsin Ia.

Phys Chem Chem Phys 2021 Jul 28. Epub 2021 Jul 28.

H.E.J., Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. and Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.

Synapsin I (SynI) is the most abundant brain phosphoprotein present at presynaptic terminals that regulates neurotransmitter release, clustering of synaptic vesicles (SVs) at active zones, and stimulates synaptogenesis and neurite outgrowth. Earlier studies have established that SynI displays pH-dependent tethering of SVs to actin filaments and exhibits a maximum binding around neutral pH, however, the effect of pH shift from acidic to basic on the conformational stability of SynI has not been explored yet. Another important aspect of SynIa is its O-GlcNAcylation (O-GlcNac) at the Thr87 position, which is responsible for the positive regulation of synaptic plasticity linked to learning and memory in mice. Read More

View Article and Full-Text PDF

SARS-CoV-2 (COVID-19), viral load and clinical outcomes; lessons learned one year into the pandemic: A systematic review.

Authors:
Santosh Shenoy

World J Crit Care Med 2021 Jul 9;10(4):132-150. Epub 2021 Jul 9.

Department of General and Colorectal Surgery, KCVA and University of Missouri at Kansas City, Missouri, MO 64128, United States.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is diagnosed real time reverse transcriptase polymerase chain reaction (RT-PCR) and reported as a binary assessment of the test being positive or negative. High SARS-CoV-2 viral load is an independent predictor of disease severity and mortality. Quantitative RT-PCR may be useful in predicting the clinical course and prognosis of patients diagnosed with coronavirus disease 2019 (COVID-19). Read More

View Article and Full-Text PDF

Population consequences of climate change through effects on functional traits of lentic brown trout in the sub-Arctic.

Sci Rep 2021 Jul 27;11(1):15246. Epub 2021 Jul 27.

Department of Ecology and Natural Resource Management, Norwegian University of Life Sciences, P. O. Box 5003, NO-1432, Aas, Norway.

Climate-induced plasticity in functional traits has received recent attention due to the immense importance phenotypic variation plays in population level responses. Here, we explore the effect of different climate-change scenarios on lentic populations of a freshwater ectotherm, the brown trout (Salmo trutta L.), through climate effects on functional traits. Read More

View Article and Full-Text PDF

Plant mixture balances terrestrial ecosystem C:N:P stoichiometry.

Nat Commun 2021 07 27;12(1):4562. Epub 2021 Jul 27.

Faculty of Natural Resources Management, Lakehead University, Thunder Bay, ON, Canada.

Plant and soil C:N:P ratios are of critical importance to productivity, food-web dynamics, and nutrient cycling in terrestrial ecosystems worldwide. Plant diversity continues to decline globally; however, its influence on terrestrial C:N:P ratios remains uncertain. By conducting a global meta-analysis of 2049 paired observations in plant species mixtures and monocultures from 169 sites, we show that, on average across all observations, the C:N:P ratios of plants, soils, soil microbial biomass and enzymes did not respond to species mixture nor to the species richness in mixtures. Read More

View Article and Full-Text PDF

Dynamics of a stage-structured predator-prey model: cost and benefit of fear-induced group defense.

J Theor Biol 2021 Jul 24:110846. Epub 2021 Jul 24.

Agricultural and Ecological Research Unit, Indian Statistical Institute, 203, B. T. Road, Kolkata 700108, India.

In the predator-prey system, predators can affect the prey population (1) by direct killing and (2) by inducing predation fear, which ultimately force preys to adopt some anti-predator strategies. However, the anti-predator strategy is not the same for all individual preys of different life stages. Also, anti-predator behavior has both cost and benefit, but most of the mathematical models observed the dynamics by incorporating its cost only. Read More

View Article and Full-Text PDF

Amphipathic Barbiturates as Mimics of Antimicrobial Peptides and the Marine Natural Products Eusynstyelamides with Activity against Multi-resistant Clinical Isolates.

J Med Chem 2021 Jul 27. Epub 2021 Jul 27.

Department of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of Norway, NO-9037 Tromsø, Norway.

We report a series of synthetic cationic amphipathic barbiturates inspired by the pharmacophore model of small antimicrobial peptides (AMPs) and the marine antimicrobials eusynstyelamides. These ,'-dialkylated-5,5-disubstituted barbiturates consist of an achiral barbiturate scaffold with two cationic groups and two lipophilic side chains. Minimum inhibitory concentrations of 2-8 μg/mL were achieved against 30 multi-resistant clinical isolates of Gram-positive and Gram-negative bacteria, including isolates with extended spectrum β-lactamase-carbapenemase production. Read More

View Article and Full-Text PDF

Comparative diagnosis interest of NfL and pNfH in CSF and plasma in a context of FTD-ALS spectrum.

J Neurol 2021 Jul 27. Epub 2021 Jul 27.

Department of Aging Psychiatry, Hospital Le Vinatier, Bron, France.

Objective: The 'Frontotemporal dementia-Amyotrophic lateral sclerosis Spectrum' (FAS) encompasses different phenotypes, including cognitive disorders (frontotemporal dementia, FTD) and/or motor impairments (amyotrophic lateral sclerosis, ALS). The aim of this study was to apprehend the specific uses of neurofilaments light chain (NfL) and phosphorylated neurofilaments heavy chain (pNfH) in a context of FAS.

Methods: First, NfL and pNfH were measured in 39 paired cerebrospinal fluid (CSF) and plasma samples of FAS and primary psychiatric disorders (PPD) patients, considered as controls. Read More

View Article and Full-Text PDF