442 results match your criteria positive ctp

Crystallographic analysis of TarI and TarJ, a cytidylyltransferase and reductase pair for CDP-ribitol synthesis in Staphylococcus aureus wall teichoic acid biogenesis.

J Struct Biol 2021 Apr 2:107733. Epub 2021 Apr 2.

Department of Biochemistry and Molecular Biology and Centre for Blood Research, The University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada. Electronic address:

The cell wall of many pathogenic Gram-positive bacteria contains ribitol-phosphate wall teichoic acid (WTA), a polymer that is linked to virulence and regulation of essential physiological processes including cell division. CDP-ribitol, the activated precursor for ribitol-phosphate polymerization, is synthesized by a cytidylyltransferase and reductase pair known as TarI and TarJ, respectively. In this study, we present crystal structures of Staphylococcus aureus TarI and TarJ in their apo forms and in complex with substrates and products. Read More

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Development of a Computed Tomography Perfusion Protocol to Support Large Animal Resuscitation Research.

J Trauma Acute Care Surg 2021 Mar 23. Epub 2021 Mar 23.

R Adams Cowley Shock Trauma Center, University of Maryland Medical System, Baltimore, Maryland, USA Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.

Background: Adequate cerebral perfusion is crucial for a positive neurological outcome in trauma; however, it is difficult to characterize in the acute setting with non-invasive methods. Intra-arterial computed tomography perfusion (IA-CTP) may offer a solution. The aim of this study is to develop an IA-CTP protocol for resuscitation research. Read More

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Pivotal trial of the Neuroform Atlas stent for treatment of posterior circulation aneurysms: one-year outcomes.

J Neurointerv Surg 2021 Mar 15. Epub 2021 Mar 15.

Department of Neuroscience, St Vincent Mercy Hospital, Toledo, Ohio, USA.

Background: Stent-assisted coiling of wide-necked intracranial aneurysms (IAs) using the Neuroform Atlas Stent System (Atlas) has shown promising results.

Objective: To present the primary efficacy and safety results of the ATLAS Investigational Device Exemption (IDE) trial in a cohort of patients with posterior circulation IAs.

Methods: The ATLAS trial is a prospective, multicenter, single-arm, open-label study of unruptured, wide-necked, IAs treated with the Atlas stent and adjunctive coiling. Read More

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Neutrophil-to-lymphocyte ratio is associated with malnutrition risk estimated by the Royal Free Hospital-Nutritional Prioritizing Tool in hospitalized cirrhosis.

JPEN J Parenter Enteral Nutr 2021 Mar 15. Epub 2021 Mar 15.

Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin, China.

Background: Liver cirrhosis is characterized by immune dysfunction contributing to malnutrition. We previously revealed neutrophil-to-lymphocyte ratio (NLR) as an indicator of disordered immune system. Herein we aimed to i) determine the optimal NLR cut-off that best predicts malnutrition risk; ii) clarify the association between NLR and nutritional status. Read More

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Use of a convolutional neural network to identify infarct core using computed tomography perfusion parameters.

Proc SPIE Int Soc Opt Eng 2021 Feb 15;11596. Epub 2021 Feb 15.

Department of Biomedical Engineering, University at Buffalo, Buffalo NY, 14260.

Purpose: Computed tomography perfusion (CTP) is used to diagnose ischemic strokes through contralateral hemisphere comparisons of various perfusion parameters. Various perfusion parameter thresholds have been utilized to segment infarct tissue due to differences in CTP software and patient baseline hemodynamics. This study utilized a convolutional neural network (CNN) to eliminate the need for non-universal parameter thresholds to segment infarct tissue. Read More

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February 2021

Successful HCV Therapy Reduces Liver Disease Severity and Inflammation Biomarkers in HIV/HCV-Coinfected Patients With Advanced Cirrhosis: A Cohort Study.

Front Med (Lausanne) 2021 1;8:615342. Epub 2021 Feb 1.

Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.

Eradication of hepatitis C virus (HCV) promotes an improvement in liver disease and the deactivation of the immune system. Here, we aimed to evaluate the changes in liver disease scores and plasma biomarkers following HCV clearance with direct-acting antivirals (DAAs) in HIV-infected patients with advanced HCV-related cirrhosis. We performed an observational study of 50 patients with advanced cirrhosis who received DAAs therapy. Read More

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February 2021

Investigation of convolutional neural networks using multiple computed tomography perfusion maps to identify infarct core in acute ischemic stroke patients.

J Med Imaging (Bellingham) 2021 Jan 10;8(1):014505. Epub 2021 Feb 10.

University at Buffalo, Department of Biomedical Engineering, Buffalo, New York, United States.

To assess acute ischemic stroke (AIS) severity, infarct is segmented using computed tomography perfusion (CTP) software, such as RAPID, Sphere, and Vitrea, relying on contralateral hemisphere thresholds. Since this approach is potentially patient dependent, we investigated whether convolutional neural networks (CNNs) could achieve better performances without the need for contralateral hemisphere thresholds. CTP and diffusion-weighted imaging (DWI) data were retrospectively collected for 63 AIS patients. Read More

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January 2021

Hepatitis D virus antibodies and liver function profile among patients with chronic hepatitis B infection in Abuja, Nigeria.

J Infect Dev Ctries 2021 Jan 31;15(1):141-146. Epub 2021 Jan 31.

Department of Microbiology, University of Abuja Teaching Hospital, Abuja, Nigeria.

Introduction: Hepatitis D virus (HDV) is a satellite virus of hepatitis B virus (HBV). An estimated 5% of HBV infected individuals worldwide have HDV infection. There is paucity of studies in Nigeria on the burden of HDV infection. Read More

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January 2021

Gender-related disparities in the frequencies of PD-1 and PD-L1 positive peripheral blood T and B lymphocytes in patients with alcohol-related liver disease: a single center pilot study.

PeerJ 2021 20;9:e10518. Epub 2021 Jan 20.

Department of Gastroenterology with Endoscopy Unit, Medical University of Lublin, Poland, Lublin, Poland.

Background: Exposure to excessive alcohol consumption dysregulates immune signaling. The programed cell death 1 (PD-1) receptor and its ligand PD-L1 play a critical role in the protection against immune-mediated tissue damage. The aim of our study was evaluation of the PD-1/PDL-1 expression on peripheral T and B lymphocytes, its correlation with markers of inflammation and the severity of liver dysfunction in the course of alcohol-related liver disease (ALD). Read More

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January 2021

Impact of SARS-CoV-2 Pandemic on "Stroke Code" Imaging Utilization and Yield.

AJNR Am J Neuroradiol 2021 Feb 4. Epub 2021 Feb 4.

Radiology (A.B.Z., J.M.S., B.K.P., C.G.F., P.C.S.).

Background And Purpose: Indirect consequences of the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) pandemic include those related to failure of patients to seek or receive timely medical attention for seemingly unrelated disease. We report our experience with stroke code imaging during the early pandemic months of 2020.

Materials And Methods: Retrospective review of stroke codes during the 2020 pandemic and both 2020 and matched 2019 prepandemic months was performed. Read More

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February 2021

Effect of Collagen Tripeptide and Adjusting for Climate Change on Skin Hydration in Middle-Aged Women: A Randomized, Double-Blind, Placebo-Controlled Trial.

Front Med (Lausanne) 2020 11;7:608903. Epub 2021 Jan 11.

Integrated Research Institute for Natural Ingredients and Functional Foods, Yangsan, South Korea.

Although collagen is widely used in various forms as a functional ingredient in skin care products, the effect of oral supplementation of collagen tripeptides (CTPs) on human skin is unclear. Moreover, the majority of the positive outcomes of CTP reported so far have not considered the effect of weather conditions. Therefore, we tested the effect of CTP and adjusting for climate change on skin properties in middle-aged women. Read More

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January 2021

Correlation of Alberta Stroke Program Early Computed Tomography Score With Computed Tomography Perfusion Core in Large Vessel Occlusion in Delayed Time Windows.

Stroke 2021 Jan 7;52(2):498-504. Epub 2021 Jan 7.

Department of Radiology (S.V., J.V., B.C., V.K., T.T., A.V.), University of Cincinnati Medical Center, OH.

Background And Purpose: The Alberta Stroke Program Early Computed Tomography (CT) Score (ASPECTS) and CT perfusion (CTP) are commonly used to predict the ischemic core in acute ischemic strokes. CT angiography source images (CTA-SI) can also provide additional information to identify the extent of ischemia. Our objective was to investigate the correlation of noncontrast CT (NCCT) ASPECTS and CTA-SI ASPECTS with CTP core volumes. Read More

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January 2021

Congenital Membranous Stapes Footplate Producing Episodic Pressure-Induced Perilymphatic Fistula Symptoms.

Front Neurol 2020 10;11:585747. Epub 2020 Nov 10.

Department of Otorhinolaryngology, Saitama Medical University, Saitama, Japan.

Recent third window syndrome studies have revealed that the intact bony labyrinth and differences in the stiffness of the oval and round windows are essential for proper cochlear and vestibular function. Herein we report a patient with a congenital dehiscence of the right stapes footplate. This dehiscence caused long-standing episodic pressure-induced vertigo (Hennebert sign). Read More

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November 2020

Development and validation of novel diagnostic nomogram for tuberculous pleurisy based on TB-IGRA results.

Int J Tuberc Lung Dis 2020 11;24(11):1178-1185

Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

To establish the diagnostic nomogram for tuberculous pleurisy (TP) based on TB-interferon-gamma release assays (TB-IGRA), as well as clinical and peripheral blood characteristics. Patients who underwent TB-IGRA tests during hospitalisation and were finally diagnosed, were retrospectively and continuously enrolled. TP was divided into confirmed TP (cTP) and presumptive TP (pTP), and corresponding diagnostic nomograms were established. Read More

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November 2020

A new model to predict response to direct-acting antiviral therapy in decompensated cirrhotics due to hepatitis C virus.

Clin Exp Hepatol 2020 Sep 30;6(3):253-262. Epub 2020 Sep 30.

TNMC & BYL Nair Charitable Hospital, Mumbai, India.

Aim: Decompensated hepatitis C virus (HCV) cirrhosis is a difficult to treat cohort, and there is no gold standard predictor of response to direct-acting antiviral (DAA) therapy. We conducted this study to look for factors responsible for improvement in post-therapy status, i.e. Read More

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September 2020

Therapeutic Nature Activities: A Step Toward the Labor Market for Traumatized Refugees.

Int J Environ Res Public Health 2020 10 16;17(20). Epub 2020 Oct 16.

Competence Centre for Transcultural Psychiatry (CTP), Mental Health Centre Ballerup, 2750 Ballerup, Denmark.

Background: Globally, the number of refugees is growing. For many refugees, entering the labor market in their new country of residence is challenging. Some remain forever dependent on welfare services, and this not only weakens their chances of integration, but also harms their health and well-being. Read More

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October 2020

Legacy phosphorus concentration-discharge relationships in surface runoff and tile drainage from Ohio crop fields.

J Environ Qual 2020 May 27;49(3):675-687. Epub 2020 Apr 27.

USDA-ARS, Soil Drainage Research Unit, 590 Woody Hayes Dr., Columbus, OH, 43210, USA.

Legacy phosphorus (P) in agricultural soils can be transported to surface waters via runoff and tile drainage, where it contributes to the development of harmful and nuisance algal blooms and hypoxia. However, a limited understanding of legacy P loss dynamics impedes the identification of mitigation strategies. Edge-of-field data from 41 agricultural fields in northwestern Ohio, USA, were used to develop regressions between legacy P concentrations (C) and discharge (Q) for two P fractions: total P (TP) and dissolved reactive P (DRP). Read More

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Prognostic Significance of Serum Insulin-Like Growth Factor-1 in Hepatocellular Cancer Patients: A Validation Study.

J Hepatocell Carcinoma 2020 16;7:143-153. Epub 2020 Sep 16.

University of Texas, MD Anderson Cancer Center, Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine, Houston, Texas, USA.

Background: The Child-Turcotte-Pugh score (CTP) is the most commonly used tool to assess hepatic reserve and predict survival in hepatocellular cancer (HCC). The CTP stratification accuracy has been questioned and attempts have been made to improve the objectivity of the system. Serum insulin-like growth factor-1 (IGF-1)-CTP has been proposed to improve CTP prognostic accuracy. Read More

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September 2020

Incidence and Intensity of Catastrophic Health-care Expenditure for Type 2 Diabetes Mellitus Care in Iran: Determinants and Inequality.

Diabetes Metab Syndr Obes 2020 18;13:2865-2876. Epub 2020 Aug 18.

Research Center for Environmental Determinants of Health, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: The present study aimed to assess the prevalence and intensity of catastrophic health-care expenditures (CHE) relating to type 2 diabetes mellitus care and inequality in facing such expenditures in Iran.

Methods: A total of 1065 type 2 diabetes patients were included in this cross-sectional study. A multistage sampling method was used to select the samples. Read More

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Prevalence of RLS among subjects with chronic liver disease and its effect on sleep and mood.

Sleep Med 2020 09 4;73:144-152. Epub 2020 Jun 4.

Department of Psychiatry, All India Institute of Medical Sciences, Rishikesh, 249203, India. Electronic address:

Background: Earlier studies have shown that prevalence of RLS among patients with chronic liver disease (CLD) ranges between 6.6% and 100%. However, most of these studies had used questionnaires to diagnose RLS reported contradictory findings regarding risk factors for RLS. Read More

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September 2020

Value of Vascular and Non-Vascular Pattern on Computed Tomography Perfusion in Patients With Acute Isolated Aphasia.

Stroke 2020 08 20;51(8):2480-2487. Epub 2020 Jul 20.

Comprehensive Stroke Center, Department of Neuroscience, Hospital Clinic, University of Barcelona and August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Spain (S.R., A. Rodríguez, S.A., V.O., A. Renú, L.L., C.L., X.U., A.C.).

Background And Purpose: Acute onset aphasia may be due to stroke but also to other causes, which are commonly referred to as stroke mimics. We hypothesized that, in patients with acute isolated aphasia, distinct brain perfusion patterns are related to the cause and the clinical outcome. Herein, we analyzed the prognostic yield and the diagnostic usefulness of computed tomography perfusion (CTP) in patients with acute isolated aphasia. Read More

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Immunotherapy in Hepatocellular Cancer Patients with Mild to Severe Liver Dysfunction: Adjunctive Role of the ALBI Grade.

Cancers (Basel) 2020 Jul 10;12(7). Epub 2020 Jul 10.

Department of Medicine, Division of Gastroenterology and Hepatology, Taipei Veterans General Hospital and Institute of Clinical Medicine, National Yang-Ming University, Taipei 11217, Taiwan.

Immune checkpoint inhibitors (ICI) have shown positive results in patients with hepatocellular carcinoma (HCC). As liver function contributes to prognosis, its precise assessment is necessary for the safe prescribing and clinical development of ICI in HCC. We tested the accuracy of the albumin-bilirubin (ALBI) grade as an alternative prognostic biomarker to the Child-Turcotte-Pugh (CTP). Read More

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Processing of Positive Visual Stimuli Before and After Symptoms Provocation in Posttraumatic Stress Disorder - A Functional Magnetic Resonance Imaging Study of Trauma-Affected Male Refugees.

Chronic Stress (Thousand Oaks) 2020 Jan-Dec;4:2470547020917623. Epub 2020 May 4.

Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Denmark.

Background: Symptoms of anhedonia are often central to posttraumatic stress disorder (PTSD), but it is unclear how anhedonia is affected by processes induced by reliving past traumatic memories.

Methods: Sixty-nine male refugees (PTSD = 38) were interviewed and scanned with functional magnetic resonance imaging while viewing positive, neutral and Scrambled Pictures after being read personalized scripts evoking an emotionally neutral memory and a traumatic memory. We further measured postprovocation state symptoms, physiological measures and PTSD symptoms. Read More

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Dual-Energy CT Follow-Up After Stroke Thrombolysis Alters Assessment of Hemorrhagic Complications.

Front Neurol 2020 19;11:357. Epub 2020 May 19.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

We aimed to determine whether dual-energy CT (DECT) follow-up can differentiate contrast staining (CS) from intracranial hemorrhage (ICH) in stroke patients treated with intravenous thrombolysis (IVT), who had undergone acute stroke imaging using CT angiography (CTA), and CT perfusion (CTP). : Between November 2012 and January 2018, 168 patients at our comprehensive stroke center underwent DECT follow-up within 36 h after IVT and acute CTA with or without CTP but did not receive intra-arterial imaging or treatment. Two independent readers evaluated plain monochromatic CT (pCT) alone and compared this with a second reading of a combined DECT approach using pCT and water- and iodine-weighted images, establishing and grading the ICH diagnosis, per Heidelberg and Safe Implementation of Treatments in Stroke Monitoring Study (SITS-MOST) classifications. Read More

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Catastrophic health expenditure: A comparative analysis of smoking and non-smoking households in China.

PLoS One 2020 29;15(5):e0233749. Epub 2020 May 29.

School of Management, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.

Introduction: Smoking is hazardous to health and places a heavy economic burden on individuals and their families. Clearly, smoking in China is prevalent since China is the largest consumer of tobacco in the world. Chinese smoking and nonsmoking households were compared in terms of the incidence and intensity of Catastrophic Health Expenditures (CHEs). Read More

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September 2020

Assessment of computed tomography perfusion software in predicting spatial location and volume of infarct in acute ischemic stroke patients: a comparison of Sphere, Vitrea, and RAPID.

J Neurointerv Surg 2021 Feb 26;13(2):130-135. Epub 2020 May 26.

Biomedical Engineering, University at Buffalo-The State University of New York, Buffalo, New York, USA

Background: CT perfusion (CTP) infarct and penumbra estimations determine the eligibility of patients with acute ischemic stroke (AIS) for endovascular intervention. This study aimed to determine volumetric and spatial agreement of predicted RAPID, Vitrea, and Sphere CTP infarct with follow-up fluid attenuation inversion recovery (FLAIR) MRI infarct.

Methods: 108 consecutive patients with AIS and large vessel occlusion were included in the study between April 2019 and January 2020 . Read More

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February 2021

Comparative Study of Ultrasound-guided Percutaneous Omental Biopsy in Cirrhotics and Noncirrhotics.

J Clin Exp Hepatol 2020 May-Jun;10(3):194-200. Epub 2019 Oct 31.

Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India.

Background: To evaluate the safety and efficacy of ultrasound-guided (US-guided) omental biopsy in patients with liver cirrhosis and compare these with the noncirrhotic patients.

Methods: We retrospectively studied the US-guided omental biopsies (73 males, 14 females with mean age 52.71 ± 15. Read More

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October 2019

Diagnostic accuracy of stress myocardial computed tomography perfusion imaging to detect myocardial ischemia: a comparison with coronary flow velocity reserve derived from transthoracic Doppler echocardiography.

J Cardiol 2020 09 27;76(3):251-258. Epub 2020 Apr 27.

Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine, Toon, Japan.

Background: Our aim was to evaluate the ability of adenosine triphosphate (ATP)-stress myocardial computed tomography perfusion (CTP) imaging to detect myocardial ischemia in the left anterior descending artery (LAD) territory, and to compare this method with coronary flow velocity reserve (CFVR) measured by transthoracic Doppler echocardiography (TTDE).

Methods: ATP-stress CTP and CFVR were performed in 50 patients with stable angina pectoris. Myocardial ischemia assessed from CTP imaging was defined as qualitative visual perfusion defects and reduced myocardial blood flow (MBF) based on quantitative assessment. Read More

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September 2020

Assessment of Semi-automated Computed Tomographic Measures of Segmental Perfusion Defects in a Swine Model () of Intermediate Coronary Lesions.

Comp Med 2020 06 30;70(3):258-265. Epub 2020 Apr 30.

Cardiology Service, Brooke Army Medical Center, Fort Sam Houston, Texas;, Email:

Computed tomographic myocardial perfusion (CTP) imaging is a tool that shows promise in emergent settings for defining the hemodynamic significance of coronary artery disease. In this study, we examined the accuracy with which the transmural perfusion ratio (TPR) derived through semiautomated CTP analysis reflected segmental perfusion defects associated with intermediate coronary artery lesions in swine. Lesions (diameter stenosis, 65% ± 11%) of the left anterior descending coronary artery (LAD) were created in 10 anesthetized female swine (weight, 47. Read More

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Evaluation of TP-E Interval and TP-E/QT Ratio in Panic Disorder.

Medicina (Kaunas) 2020 Apr 28;56(5). Epub 2020 Apr 28.

Department of Psychiatry, M.D, Kahta State Hospital, 02450Adıyaman, Turkey.

The autonomic nervous system (ANS) is involved in panic disorders. ANS dysfunction has been shown to be associated with ventricular arrhythmia and increased heterogeneity of ventricular repolarization. However, there remains limited evidence of the relationship between panic disorders and ventricular depolarization markers, including the Tp-e interval and Tp-e/QT ratio. Read More

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