145,220 results match your criteria positive association

Liver fibrosis and fatty liver are independently associated with cardiovascular disease risk.

J Gastroenterol Hepatol 2021 Jun 21. Epub 2021 Jun 21.

Department of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan.

Objective: The association between liver fibrosis, fatty liver, and cardiovascular disease (CVD) risk is unknown. Hence, this study aimed to investigate the association of liver fibrosis and fatty liver with CVD risk independent of already known CVD risk comorbidities.

Methods: This is a prospective study registered with the University Hospital Medical Information Network clinical trial registry (UMIN000036175). Read More

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Maternal essential metals, thyroid hormones, and fetal growth: Association and mediation analyses in Chinese pregnant women.

J Trace Elem Med Biol 2021 Jun 12;68:126809. Epub 2021 Jun 12.

Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, 511443, China. Electronic address:

Background: Essential metals play critical roles in fetal growth and development, but results from human studies are inconsistent. Additionally, whether maternal thyroid hormone (TH) levels mediate the associations between essential metals and fetal growth remains unknown.

Methods: Data for analysis were extracted from the Information System of Guangdong Women and Children Hospital between January 2017 and December 2019. Read More

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Assessment of exposure-response relationship for bevacizumab in patients with metastatic colorectal cancer.

Biomed Pharmacother 2021 Jun 18;141:111827. Epub 2021 Jun 18.

Medical Oncology Unit, Severo Ochoa University Hospital, Madrid, Spain.

Limited literature is available for bevacizumab exposure-response relationship and there is not a concentration threshold associated with an optimal disease control. This prospective observational study in patients with metastatic colorectal cancer (mCRC) aims to evaluate, in a real-life setting, the relationship between bevacizumab through concentrations at steady state (C) and disease control. C were drawn, coinciding with the radiological evaluation of the response (progression or clinical benefit). Read More

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Spatio-temporal distribution and agroecological factors associated with canine leptospirosis in Great Britain.

Prev Vet Med 2021 Jun 6;193:105407. Epub 2021 Jun 6.

Royal Veterinary College, Hawkshead Lane, Hatfield, Hertfordshire, United Kingdom.

Leptospirosis is an important global zoonotic disease that affects a wide range of mammalian species. Canine leptospirosis outbreaks have been reported after metereological events such as flooding (eg. in Brazil and the United States of America) suggesting an environmental association, but there has been no such study in Great Britain (GB). Read More

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Associations of affective and cognitive empathy with depressive symptoms among a sample of Chinese college freshmen.

J Affect Disord 2021 Jun 4;292:652-659. Epub 2021 Jun 4.

Research Center for Psychology and Behavioral Sciences, Soochow University, Suzhou, China; School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China. Electronic address:

Background: College freshmen are at high risk for mental and socioemotional problems after entering a new environment. However, few investigators have evaluated the associations between empathy and depressive symptoms among college freshmen. The present study examined the presence and associations of affective and cognitive empathy with depressive symptoms among college freshmen in China. Read More

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Serum zinc concentration and risk of adverse outcomes to in vitro fertilization and embryo transfer: A prospective cohort study in northern China.

Sci Total Environ 2021 Jun 10;792:148405. Epub 2021 Jun 10.

Center of Reproductive Medicine, Peking University People's Hospital, Beijing 100044, PR China. Electronic address:

Zinc (Zn) plays an important role in female reproductive health. Few studies have currently assessed the effects of female Zn level on the outcome of in vitro fertilization-embryo transfer (IVF-ET). This study investigated the association between serum Zn concentration and IVF-ET outcomes, and the potential effects of some lifestyles on this association. Read More

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African midwifery students' self-assessed confidence in postnatal and newborn care: A multi-country survey.

Midwifery 2021 May 29;101:103051. Epub 2021 May 29.

Department of Women's and Children's Health, Uppsala University, Sweden.

Background: Majority of maternal and new-born deaths occur within 28 hours and one week after birth. These can be prevented by well-educated midwives. Confidence in postnatal and newborn care skills depend on the quality of midwifery education. Read More

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A Retrospective, Observational Analysis of Tumor Infiltrating Lymphocytes and Tumor Regression in Melanoma.

J Surg Res 2021 Jun 18;267:203-208. Epub 2021 Jun 18.

Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA.

Background: Tumor infiltrating lymphocytes (TILs) and regression are thought to be distinct markers of the immune response to melanoma.

Objective: This study sought to analyze the relationship of TIL grade and presence of regression to each other and to other prognostic histopathologic and clinical values in melanoma.

Materials And Methods: A retrospective analysis was conducted using patients diagnosed with melanoma between 2013 and 2019 whose complete histopathologic reports were available. Read More

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Agreement between ACR TI-RADS and EU TI-RADS scoring systems in the diagnosis of 473 thyroid nodules from a single-center in Brazil.

Endocr Pract 2021 Jun 18. Epub 2021 Jun 18.

Division of Surgery, Pathology and Endocrinology, Agamenon Magalhães Hospital, State Secretary of Health, Recife, Brazil; University of Pernambuco Medical School, Recife, Brazil.

Objectives: This study compares two ultrasound-based risk-stratification systems in malignancy risk assessment of thyroid nodules and the clinical applicability of these guidelines in Brazil.

Methods: We retrospectively reviewed the ultrasound findings of 314 patients (473 thyroid nodules) who underwent fine needle aspiration (FNA) biopsy and/or surgery between February 2018 and March 2019. All nodules were classified using two systems: The Thyroid Imaging, Reporting, and Data System of the American College of Radiology (ACR-TIRADS) and the TIRADS of the European Thyroid Association (EU-TIRADS). Read More

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Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial.


Lancet Respir Med 2021 Jun 18. Epub 2021 Jun 18.

Background: Respiratory complications are an important cause of postoperative morbidity. We aimed to investigate whether continuous positive airway pressure (CPAP) administered immediately after major abdominal surgery could prevent postoperative morbidity.

Methods: PRISM was an open-label, randomised, phase 3 trial done at 70 hospitals across six countries. Read More

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Heat health risk assessment analysing heatstroke patients in Fukuoka City, Japan.

PLoS One 2021 21;16(6):e0253011. Epub 2021 Jun 21.

Kyushu Environmental Evaluation Association, Fukuoka, Japan.

Background: Climate change, as a defining issue of the current time, is causing severe heat-related illness in the context of extremely hot weather conditions. In Japan, the remarkable temperature increase in summer caused by an urban heat island and climate change has become a threat to public health in recent years.

Methods: This study aimed to determine the potential risk factors for heatstroke by analysing data extracted from the records of emergency transport to the hospital due to heatstroke in Fukuoka City, Japan. Read More

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Stunting in pre-school and school-age children in the Peruvian highlands and its association with Fasciola infection and demographic factors.

PLoS Negl Trop Dis 2021 Jun 21;15(6):e0009519. Epub 2021 Jun 21.

Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, United States of America.

Fascioliasis is a zoonotic trematode infection that is endemic in the highlands of Peru. Chronic fascioliasis can be asymptomatic and remain undiagnosed for years. Chronic malnutrition in children, as manifested by stunting, leads to delayed cognitive development and lost productivity. Read More

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Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study.

PLoS One 2021 21;16(6):e0252859. Epub 2021 Jun 21.

Faculty of Dentistry, Department of Restorative Dentistry, Unit of Periodontology, Universiti Kebangsaaan Malaysia, Kuala Lumpur, Malaysia.

Patients with rheumatoid arthritis (RA) experience a higher prevalence of periodontitis. This study aimed to examine the variation of periodontitis experienced with different serotypes suffered by RA patients and to examine the relationship between the different medications taken for RA that may influence this relationship. Two hundred and sixty RA and control participants underwent standardized periodontal examinations. Read More

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Association of Blood Trihalomethane Concentrations with Risk of All-Cause and Cause-Specific Mortality in U.S. Adults: A Prospective Cohort Study.

Environ Sci Technol 2021 Jun 21. Epub 2021 Jun 21.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, United States.

Water chlorination can lead to the formation of disinfection byproducts, including trihalomethanes (THMs). However, few epidemiologic studies have explored associations between THM exposure and mortality. This study included 6720 adults aged ≥40 years from the National Health and Nutrition Examination Survey 1999-2012 who had blood THM concentrations quantified. Read More

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Association Between Race and COVID-19 Outcomes Among 2.6 Million Children in England.

JAMA Pediatr 2021 Jun 21. Epub 2021 Jun 21.

Primary Care Epidemiology, Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Importance: Although children mainly experience mild COVID-19 disease, hospitalization rates are increasing, with limited understanding of underlying factors. There is an established association between race and severe COVID-19 outcomes in adults in England; however, whether a similar association exists in children is unclear.

Objective: To investigate the association between race and childhood COVID-19 testing and hospital outcomes. Read More

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Lactic acid bacteria strains relieve hyperuricaemia by suppressing xanthine oxidase activity a short-chain fatty acid-dependent mechanism.

Food Funct 2021 Jun 21. Epub 2021 Jun 21.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. and School of Food Science and Technology, Jiangnan University, Wuxi 214122, China and National Engineering Research Center for Functional Food, Jiangnan University, Wuxi 214122, China.

Globally, the incidence of hyperuricaemia is steadily increasing. The evidence increasingly suggests an association between hyperuricaemia and the gut microbiota, which may enable the development of a novel therapeutic approach. We studied the effects of treatment with lactic acid bacteria (LAB) on hyperuricaemia and their potential underlying mechanisms. Read More

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Identification and Evolution of Cas9 tracrRNAs.

CRISPR J 2021 Jun;4(3):438-447

Department of Molecular Engineering, Corteva AgriscienceJohnston, TM, Johnston, Iowa, USA.

Clustered regularly interspaced palindromic repeats (CRISPR)-associated (Cas)9 transactivating CRISPR RNAs (tracrRNAs) form distinct structures essential for target recognition and cleavage and dictate exchangeability between orthologous proteins. As noncoding RNAs that are often apart from the CRISPR array, their identification can be arduous. In this article, a new bioinformatic method for the detection of Cas9 tracrRNAs is presented. Read More

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Comparison of Next-Generation Sequencing-Based Human Leukocyte Antigen Typing with Clinical Flow Cytometry and Allele-Specific PCR Melting Assays for HLA-B27 Genotyping.

J Appl Lab Med 2021 Jun 21. Epub 2021 Jun 21.

Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT.

Background: Due to the strong association between ankylosing spondylitis and Human Leukocyte Antigen (HLA)-B27, accurate identification of HLA-B27 is important in the diagnosis of patients with suspected spondyloarthritides. For this study, we compared a high-resolution HLA-B typing method to the clinical flow cytometry and allele-specific PCR melting assays to determine clinical benefits of high-resolution testing.

Methods: Residual clinical samples submitted for HLA-B27 testing by flow cytometry were tested by single-locus HLA-B genotyping using next-generation sequencing (NGS), and PCR with melting curve analysis, currently used as a reflex test for indeterminate flow cytometry results. Read More

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Incidence of Clostridioides difficile infection (CDI) related to antibiotic prescribing by GP surgeries in Wales.

J Antimicrob Chemother 2021 Jun 21. Epub 2021 Jun 21.

Department of Mathematics and Statistics, University of Strathclyde, Glasgow G1 1XH, Scotland.

Background: Clostridioides difficile infection (CDI) is a healthcare-acquired infection (HAI) causing significant morbidity and mortality. Welsh CDI rates are high in comparison with those in England and Scotland.

Objectives: This retrospective ecological study used aggregated disease surveillance data to understand the impact of total and high-risk Welsh GP antibiotic prescribing on total and stratified inpatient/non-inpatient CDI incidence. Read More

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Detection of SARS-CoV-2 antibodies in pediatric patients: An Iranian referral hospital-based study.

Hum Antibodies 2021 Jun 12. Epub 2021 Jun 12.

Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: As the extent of the pandemic and its seroprevalence pattern has been less clarified in pediatrics to date, we aimed to conduct this study to investigate the clinical and laboratory characteristics of COVID-19 in Iranian children, with a focus on evaluating the antibody prevalence and its relation with the laboratory tests.

Methods: All children with highly suspected COVID-19 were included. Anti-nucleoprotein SARS-CoV-2 were measured using SARS-CoV-2 immunoglobulin M (IgM) and SARS-CoV-2 IgG ELISA kits. Read More

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Porcine teschovirus, sapelovirus, and enterovirus in Swiss pigs: multiplex RT-PCR investigation of viral frequencies and disease association.

J Vet Diagn Invest 2021 Jun 21:10406387211025827. Epub 2021 Jun 21.

Institute of Virology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland.

Porcine teschovirus (PTV), sapelovirus (PSV-A), and enterovirus (EV-G) are enteric viruses that can infect pigs and wild boars worldwide. The viruses have been associated with several diseases, primarily gastrointestinal, neurologic, reproductive, and respiratory disorders, but also with subclinical infections. However, for most serotypes, proof of a causal relationship between viral infection and clinical signs is still lacking. Read More

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Major dietary patterns and metabolic syndrome associated with severity of coronary artery disease: A structural equation modeling.

Nutr Health 2021 Jun 21:2601060211020655. Epub 2021 Jun 21.

48439Tehran University of Medical Sciences, Department of Epidemiology and Biostatistics, School of Public Health, Iran.

Background: The association of dietary patterns and metabolic syndrome with the severity of coronary artery disease (CAD) is little known.

Aim: This study aimed to explore the relationship between major dietary patterns and the severity of CAD among newly discovered patients by using structural equation modeling (SEM).

Methods: In this cross-sectional study, we included 423 newly diagnosed patients with CAD, aged 35-65 years, who underwent coronary angiography. Read More

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Integrating Genomic Professional Skills Into Nursing Practice: Results From a Large Cohort of Israeli Nurses.

J Nurs Scholarsh 2021 Jun 20. Epub 2021 Jun 20.

Delta Lambda at-Large Associate professor, Department of Nursing, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: To explore the association of genomic knowledge, self-epistemic authority (SEA; i.e., subjective perception of knowledge expertise), perceived importance of genomics in nursing, and the integration of genomic skills into nursing practice. Read More

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Association of advanced glycation end-products levels with vascular events in postmenopausal women.

Geriatr Gerontol Int 2021 Jun 20. Epub 2021 Jun 20.

Department of Orthopedic Surgery, Jikei University School of Medicine, Tokyo, Japan.

Aim: Advanced glycation end-products (AGEs) are a known factor that accelerates vascular complications. AGEs (e.g. Read More

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Future orientation among at-risk youth in Israel.

Health Soc Care Community 2021 Jun 21. Epub 2021 Jun 21.

School of Education, Tel Aviv University, Tel Aviv, Israel.

Although future orientation (FO) has been empirically linked with resilience, literature concerning the factors and the mechanisms that play a role in promoting positive FO among at-risk youth is scarce. This study investigated the contribution of mentoring to the FO of at-risk youth and the mediating role of their perceived life skills in this relationship. The participants included 198 adolescents (16-19 years old) from 11 schools for at-risk youth in Israel. Read More

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Microbial exposures in moisture-damaged schools and associations with respiratory symptoms in students: A multi-country environmental exposure study.

Indoor Air 2021 Jun 21. Epub 2021 Jun 21.

Environmental Health Unit, Finnish Institute for Health and Welfare, Kuopio, Finland.

Moisture-damaged buildings are associated with respiratory symptoms and underlying diseases among building occupants, but the causative agent(s) remain a mystery. We first identified specific fungal and bacterial taxa in classrooms with moisture damage in Finnish and Dutch primary schools. We then investigated associations of the identified moisture damage indicators with respiratory symptoms in more than 2700 students. Read More

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Elevated F-EDN correlates with mucosal eosinophil degranulation in patients with IBS-A possible association with microbiota?

J Leukoc Biol 2021 Jun 21. Epub 2021 Jun 21.

Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Eosinophils have been linked to functional dyspepsia; however, less is known about their role in irritable bowel syndrome (IBS). This study tested the hypothesis of alterations in levels of fecal eosinophil-derived neurotoxin (F-EDN) and eosinophil density and degranulation within the colonic mucosa of IBS patients compared with healthy controls (HC). Colonic biopsies were collected from 37 IBS patients and 20 HC and analyzed for eosinophil numbers and local degranulation of eosinophil cationic protein (ECP) by histologic procedures. Read More

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Children Exposed to IPV: Impact of Multiple Father Figures.

Matern Child Health J 2021 Jun 21. Epub 2021 Jun 21.

Johns Hopkins University School of Nursing, Baltimore, MD, USA.

Purpose: Exposure to intimate partner violence (IPV) has been associated with adverse infant developmental outcomes; however, the influence of the number of father-figures (abusive vs non-abusive) has on young infants' risk for neurodevelopmental delays has not been examined.

Procedures: A secondary data analysis was conducted from the Domestic Violence Enhanced Perinatal Home Visits (DOVE) study of abused pregnant women (N = 239) and their infants' neurodevelopment from baseline through 12-months postpartum.

Results: Although all women reported decreased violence from baseline to 12 months postpartum, there was a significant main effect between baseline IPV scores and infant risk for developmental delay at 12 months (β = . Read More

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Hypoglossal nerve stimulation for obstructive sleep apnea: updated position paper of the German Society of Oto-Rhino-Laryngology, Head and Neck Surgery.

Eur Arch Otorhinolaryngol 2021 Jun 21. Epub 2021 Jun 21.

Work Group Apnea of the German Society for Sleep Research and Medicine (DGSM) (DGSM), Schwalmstadt-Treysa, Germany.

Since the first statement of the German Society of Oto-Rhino-Laryngology, hypoglossal nerve stimulation (HNS) is meanwhile an established treatment option for obstructive sleep apnea (OSA). There are three HNS systems available in Germany which differ in their technical details of the underlying comparable basic principle. For the unilateral HNS with respiratory sensing, several comparative studies, high-volume register analysis and long-term reports exist. Read More

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Psychosocial Health Effects Of Covid-19 Infection On Persons In Treatment Centers In Lagos, Nigeria.

Brain Behav Immun Health 2021 Jun 15:100284. Epub 2021 Jun 15.

Department of Community Health and Primary Care, College of Medicine University of Lagos, Lagos, Nigeria.

Introduction: Prior research has highlighted the psychosocial impact of infectious diseases on individuals and the community at large. However, little is known about the psychosocial implications of COVID-19. This study set out to determine the rate as well as correlates of anxiety and depressive symptoms among persons managed as in-patients for COVID-19 in Lagos, Nigeria. Read More

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