245 results match your criteria position disturbing

[Health policy and healthcare work: the COVID-19 pandemic as an event?]

Cad Saude Publica 2021 7;37(4):e00240120. Epub 2021 Apr 7.

Universidad Nacional de Mar del Plata, Mar del Plata, Argentina.

The COVID-19 pandemic has taken the world by surprise, disturbing the previous situation affecting countries and the situation of their respective States. "Reality" has been redefined by the pandemic's serious effects. Argentina is no exception, and the citizenry and the State itself have thus been challenged to take a unique position based on values and to conduct action to deal with the consequences in both the immediate and medium terms. Read More

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Migrant in my own country: The long march of migrant workers in India during the COVID-19 pandemic 2020-Failure of postcolonial governments to decolonize Bihar and rebuild Indian civilization after 1947.

Raman Kumar

J Family Med Prim Care 2020 Oct 30;9(10):5087-5091. Epub 2020 Oct 30.

President Academy of Family Physicians of India, President, WONCA SAR The World Organization of Family Doctors, South Asia Region.

The world is passing through the unprecedented crisis of COVID 19 pandemic. A large section of the global population has been living under mandatory mass quarantine, the lockdown, as a strategy towards slowing down the expansion of the pandemic. This lockdown is being eased out across world in a phase wise manner. Read More

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October 2020

Upright BPPV Protocol: Feasibility of a New Diagnostic Paradigm for Lateral Semicircular Canal Benign Paroxysmal Positional Vertigo Compared to Standard Diagnostic Maneuvers.

Front Neurol 2020 19;11:578305. Epub 2020 Nov 19.

Vestibology and ENT Unit, Giovanni Paolo II Hospital, Matera, Italy.

The diagnosis of benign paroxysmal positional vertigo (BPPV) involving the lateral semicircular canal (LSC) is traditionally entrusted to the supine head roll test, also known as supine head yaw test (SHYT), which usually allows identification of the pathologic side and BPPV form (geotropic vs. apogeotropic). Nevertheless, SHYT may not always allow easy detection of the affected canal, resulting in similar responses on both sides and intense autonomic symptoms in patients with recent onset of vertigo. Read More

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November 2020

Drainage on augmentation mammoplasty: Does it work?

J Plast Reconstr Aesthet Surg 2020 Nov 7. Epub 2020 Nov 7.

Department of Plastic, Reconstructive and Aesthetic Surgery, Training and Research State University Hospital of Rio de Janeiro - UERJ-RJ, av. Mal.Rondon, 381.São francisco Xavier. Rio de Janeiro. CEP: 20950-003, Brazil. Electronic address:

Background: Breast prostheses could be associated with complications, despite many studies on surgical materials and techniques. The role of surgical drainage in preventing complications on breast prostheses surgery is controversial.

Objectives: This study aimed to evaluate the role and effectiveness of vacuum drainage in the augmentation mammoplasty. Read More

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November 2020

Interest in Working as an Infection Prevention and Control Nurse and Perception of This Position by Nursing Students-Results of a Pilot Study.

Int J Environ Res Public Health 2020 10 29;17(21). Epub 2020 Oct 29.

Department of Infection Control and Mycology, Jagiellonian University Medical College, 31121 Krakow, Poland.

The results of several studies in the area of infection control in Poland are disturbing. The situation may be shaped by many factors. However, the key factor for effective infection prevention and control is dedicated personnel, especially infection prevention and control nurses (IPCN). Read More

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October 2020

Mutational landscape of K-Ras substitutions at 12th position-a systematic molecular dynamics approach.

J Biomol Struct Dyn 2020 Oct 9:1-15. Epub 2020 Oct 9.

Department of Biomedical Sciences, College of Health and Sciences, Qatar University, Doha, Qatar.

K-Ras is a small GTPase and acts as a molecular switch by recruiting GEFs and GAPs, and alternates between the inert GDP-bound and the dynamic GTP-bound forms. The amino acid at position 12 of K-Ras is a hot spot for oncogenic mutations (G12A, G12C, G12D, G12R, G12S, and G12V), disturbing the active fold of the protein, leading to cancer development. This study aimed to investigate the potential conformational changes induced by these oncogenic mutations at the 12 position, impairing GAP-mediated GTP hydrolysis. Read More

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October 2020

Does eight-plate epiphysiodesis of the proximal tibia in treating angular deformity create intra-articular deformity?

Bone Joint J 2020 Oct;102-B(10):1412-1418

Department of Paediatric Orthopaedics, Altonaer Children's Hospital, Hamburg, Germany.

Aims: Eight-plates are used to correct varus-valgus deformity (VVD) or limb-length discrepancy (LLD) in children and adolescents. It was reported that these implants might create a bony deformity within the knee joint by change of the roof angle (RA) after epiphysiodesis of the proximal tibia following a radiological assessment limited to anteroposterior (AP) radiographs. The aim of this study was to analyze the RA, complemented with lateral knee radiographs, with focus on the tibial slope (TS) and the degree of deformity correction. Read More

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October 2020

High sensitivity, levitated microsphere apparatus for short-distance force measurements.

Rev Sci Instrum 2020 Aug;91(8):083201

Department of Physics, Stanford University, Stanford, California 94305, USA.

A high sensitivity force sensor based on dielectric microspheres in vacuum, optically trapped by a single, upward-propagating laser beam, is described. Off-axis parabolic mirrors are used both to focus the 1064 nm trapping beam and to recollimate it to provide information on the horizontal position of the microsphere. The vertical degree of freedom is readout by forming an interferometer between the light retroreflected by the microsphere and a reference beam, hence eliminating the need for auxiliary beams. Read More

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Bony Orbital Decompression in Patients with High Myopia and Pseudoexophthalmos.

Klin Monbl Augenheilkd 2021 Jan 31;238(1):41-47. Epub 2020 Aug 31.

Klinik für Augenheilkunde, Universitätsklinikum Duisburg-Essen, Essen, Deutschland.

Introduction: High myopic eyes grow in length (> 0.35 mm/dpt) more than in height and width leading to a disturbing unilateral exophthalmos in patients with anisomyopia and - more rarely - a bilateral exophthalmos in high myopia affecting both eyes. Secondary consequences are sicca symptoms and painful eye mobility due to a large bulbus in a too small bony orbit. Read More

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January 2021

Real-Time Analysis of the Respiratory Flow Through a Valved Holding Chamber.

J Aerosol Med Pulm Drug Deliv 2020 08 26;33(4):205-213. Epub 2020 Feb 26.

Department of Pediatrics, Virginia Commonwealth University School of Medicine and the Children's Hospital of Richmond, Richmond, Virginia.

The ability of patients to take, correctly and regularly, aerosol treatments is a key for good control of asthma and chronic obstructive pulmonary disease. Devices that help to improve inhalation technique could train the patient to take their medication properly, reducing risk of exacerbations. In this study we evaluate a new device that by recording real-time respiratory flow into the valved holding chamber (VHC) mouthpiece, could be used to improve patient technique. Read More

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The Influence of Dental Occlusion on Dynamic Balance and Muscular Tone.

Front Physiol 2019 31;10:1626. Epub 2020 Jan 31.

Department of Sport Science, University of Innsbruck, Innsbruck, Austria.

Excellent postural control is essential to improve the physical performance of athletes. Stability of the body during motor tasks depends on different physiological systems. The influence of dental occlusion on body balance has been widely investigated in the past few years. Read More

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January 2020

Inhibition Mechanism of Indoleamine 2, 3-Dioxygenase 1 (IDO1) by Amidoxime Derivatives and Its Revelation in Drug Design: Comparative Molecular Dynamics Simulations.

Front Mol Biosci 2019 28;6:164. Epub 2020 Jan 28.

Laboratory of Tumor Targeted and Immune Therapy, Clinical Research Center for Breast, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, China.

For cancer treatment, in addition to the three standard therapies of surgery, chemotherapy, and radiotherapy, immunotherapy has become the fourth internationally-recognized alternative treatment. Indoleamine 2, 3-dioxygenase 1 (IDO1) catalyzes the conversion of tryptophan to kynurenine causing lysine depletion, which is an important target in the research and development of anticancer drugs. Epacadostat (INCB024360) is currently one of the most potent IDO1 inhibitors, nevertheless its inhibition mechanism still remains elusive. Read More

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January 2020

Development of Cell-Penetration PG-Surfactants and Its Application in External Peptide Delivery to Cytosol.

Bioconjug Chem 2020 03 29;31(3):821-833. Epub 2020 Jan 29.

Department of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho Showa-ku, Nagoya, Aichi 466-8555, Japan.

Recently, development of techniques to deliver pharmacologically active biomacromolecules such as peptides and proteins to cytosol has gained much interest. Here, we applied the peptide gemini (PG)-surfactants to a novel platform to design cell penetration lipopeptides (CP-PGs), which can deliver exogenous peptides and proteins to cytosol. Among the number of candidate CP-PGs having different peptide sequences at the X-, Y-, and Z-positions, we focused on those having two C12 alkyl chains appended to the side chain of two Cys residues, the betaine sequence -Asp-Lys-Asp-Lys- between the alkylated Cys residues (i. Read More

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Moral Distress and Intention to Leave the Profession: Lithuanian Nurses in Municipal Hospitals.

J Nurs Scholarsh 2020 03 13;52(2):201-209. Epub 2019 Dec 13.

Professor, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Purpose: The purpose of this study was to describe the level of moral distress experienced by nurses, situations that most often caused moral distress, and the intentions of the nurses to leave the profession.

Methods: A descriptive, cross-sectional, correlational design was applied in this study. Registered nurses were recruited from five large, urban Lithuanian municipal hospitals representing the five administrative regions in Lithuania. Read More

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EBCOG position statement about the use of herbal medication during pregnancy.

Eur J Obstet Gynecol Reprod Biol 2020 Jan 1;244:38-39. Epub 2019 Nov 1.

Victoria Hospital, Kirkcaldy, Scotland.

Pregnant women often resort to herbal medication to ameliorate the disturbing symptoms associated with pregnancy in the mistaken belief that these are safe and carry no potential harmful effects to the developing fetus. Healthcare personnel must be cognizant of the potential adverse side effects of these substances to be able to better advise their patients. Read More

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January 2020

A novel mitochondrial m.4414T>C MT-TM gene variant causing progressive external ophthalmoplegia and myopathy.

Neuromuscul Disord 2019 09 21;29(9):693-697. Epub 2019 Aug 21.

Highly Specialised Mitochondrial Diagnostic Laboratory, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; Wellcome Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

We report a novel mitochondrial m.4414T>C variant in the mt-tRNA (MT-TM) gene in an adult patient with chronic progressive external ophthalmoplegia and myopathy whose muscle biopsy revealed focal cytochrome c oxidase (COX)-deficient and ragged red fibres. The m. Read More

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September 2019

Redesign of Work Space in Order to Reduce Noise Health Effects.

Mater Sociomed 2019 Jun;31(2):135-140

Academy of Medical Sciences of Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina.

Introduction: Noise represent an unwanted sound that endangers human health in multiple manners and in work setting causes reduction of productivity on one side, and increased waste on the other. Noise pollution occurs when the ear is exposed to the volume of sound that is disturbing, stressful or directly damaging hearing, but also acting on the organism as a whole.

Aim: The aim of the article is to examine the vulnerability of workers working on the "press" machine, and to carry out an analysis and examine the press operator workplace, then perform the noise spread measurement in the press operator work area and compare the current measurements with the permissible levels and analyze the time period of worker exposure, as well as presentation of the effects of noise on productivity and workers health. Read More

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Synthesis and Assessment of 3-Substituted Phenazines as Novel Antichlamydial Agents.

Med Chem 2020 ;16(3):413-421

School of Pharmacy, Nantong University, Nantong 226001, China.

Background: In the past century, many phenazines were isolated from the marine microorganism, and some of these phenazines possessed potent antibacterial activities. We found that a few of the synthesized 4-substituted phenazines could block the infectivity of chlamydiae without host cell toxicity.

Objective: The aim of this study was to design and synthesize two series of novel 3-substituted phenazines to find novel antichlamydial agents. Read More

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November 2020

Disturbing the rhythm of thought: Speech pausing patterns in schizophrenia, with and without formal thought disorder.

PLoS One 2019 31;14(5):e0217404. Epub 2019 May 31.

ICREA (Institució Catalana de Recerca i Estudis Avançats), Barcelona, Spain.

Everyday speech is produced with an intricate timing pattern and rhythm. Speech units follow each other with short interleaving pauses, which can be either bridged by fillers (erm, ah) or empty. Through their syntactic positions, pauses connect to the thoughts expressed. Read More

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January 2020

Using Polarons for sub-nK Quantum Nondemolition Thermometry in a Bose-Einstein Condensate.

Phys Rev Lett 2019 Jan;122(3):030403

ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, 08860 Castelldefels (Barcelona), Spain.

We introduce a novel minimally disturbing method for sub-nK thermometry in a Bose-Einstein condensate (BEC). Our technique is based on the Bose polaron model; namely, an impurity embedded in the BEC acts as the thermometer. We propose to detect temperature fluctuations from measurements of the position and momentum of the impurity. Read More

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January 2019

Short in-Frame Insertions/Deletions in the Coding Sequence of the α-Globin Gene. Consequences of the 3D Structure and Resulting Phenotypes: Hb Choisy as an Example.

Hemoglobin 2018 Sep - Nov;42(5-6):287-293. Epub 2019 Jan 30.

a Institut National de la Sante et de la Recherche Médicale (INSERM) U 955 eq 2 , Institut Mondor de Recherche Biomoléculaire (IMRB) , Créteil , France.

A small group of hemoglobin (Hb) variants result from 'in-frame' deletion/insertion (del/ins). We describe a new variant of this group (Hb Choisy), found on the α1 gene, which is the exact counterpart of a previously published deletional variant, Hb J-Biskra [codons 51-58 (or codons 52-59) (-24 bp) (-TCTGCCCAGGTTAAGGGCCACGGC); HBA1: c.157_180del (or HBA2)]. Read More

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Determination of the Location and Magnetic Moment of Ferromagnetic Objects Based on the Analysis of Magnetovision Measurements.

Sensors (Basel) 2019 Jan 16;19(2). Epub 2019 Jan 16.

Warsaw University of Technology, Institute of Metrology and Biomedical Engineering, 02-525 Warsaw, Poland.

This article is concerned with the localization of ferromagnetic objects on the basis of magnetovision measurement analysis. In the presented case, the concept of localization is understood as the indication of the , , and coordinates of the magnetic moment of the sought object. Magnetovision measurement provides a much simpler, two-dimensional localization of magnetic anomalies compared to existing active and passive mobile devices, largely based on operator knowledge and experience. Read More

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January 2019

A possible founder mutation in FZD6 gene in a Turkish family with autosomal recessive nail dysplasia.

BMC Med Genet 2019 01 14;20(1):15. Epub 2019 Jan 14.

Department of Molecular Biology and Genetics, Boğaziçi University, Istanbul, Turkey.

Background: Autosomal recessive nail dysplasia is characterized by thick and hard nails with a very slow growth on the hands and feet. Mutations in FZD6 gene were found to be associated with autosomal recessive nail dysplasia in 2011. Presently, only seven mutations have been reported in FZD6 gene; five mutations are clustered in the C-terminus, one is at the seventh transmembrane domain, and another is at the very beginning of third extracellular loop. Read More

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January 2019

The Role of Sex Therapy in the Management of Patients with Parkinson's Disease.

Mov Disord Clin Pract 2018 Jan-Feb;5(1):6-13. Epub 2017 Nov 16.

Division of Neurology Tel-Aviv Medical Center Tel Aviv Israel.

Background: Patients with Parkinson disease (PD) and their partners report deterioration in their sexual life. Sexual dysfunction (SD), an important and often ignored aspect, is common in PD. Motor and nonmotor symptoms are involved in limiting pleasure and disturbing function. Read More

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November 2017

Visual feedback of hand and target location does not explain the tendency for straight adapted reaches.

PLoS One 2018 24;13(10):e0206116. Epub 2018 Oct 24.

Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL, United States of America.

Subjects in laboratory settings exhibit straight hand paths-typified by the minimum jerk path-even in the presence of a learned but disturbing force field. At the same time it is known that in this setting, visual feedback strongly influences reaches, biasing them to be straight. Here we examine whether or not this bias can account for the straightness of movements made in a force field. Read More

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Targeting head movements in humans: Compensation for disturbance from simultaneous body rotations.

Hum Mov Sci 2018 Oct 3;61:197-218. Epub 2018 Sep 3.

Neurologische Klinik, Universität Freiburg, Germany.

Vestibular information plays an important role in spatially oriented motor control and perception. With regard to reorienting head movements, little is known of (1) how vestibular mechanisms compensate for disturbances from concurrent passive trunk rotations (e.g. Read More

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October 2018

Optical tweezers for trapping in a microfluidic environment.

Appl Opt 2018 Jul;57(20):5733-5742

Optical tweezers use the force from a light beam to implement a precise gripping tool. Based purely on an optical principle, it works without any bodily contact with the object. In this paper we describe an optical tweezers that targets an application within the framework of nuclear magnetic resonance (NMR) spectroscopy of small objects, which are embedded inside a microfluidic channel that will be integrated in a micro-NMR detector. Read More

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Clavicula fractures: considerations when plating.

Sune Larsson

Injury 2018 Jun;49 Suppl 1:S24-S28

Department of Surgical Sciences, Orthopedics, Uppsala University, Uppsala, Sweden. Electronic address:

The preferred treatment of clavicula midshaft fractures in adults has gone from being very conservative into surgery being frequently recommended. However, based on recent meta-analysis favorable outcome with internal fixation is not as consistent as previously reported. Probably due to a combination of indications for surgery becoming too wide and surgery being performed by a wider group of surgeons. Read More

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Our evolved unique pleasure circuit makes humans different from apes: Reconsideration of data derived from animal studies.

J Syst Integr Neurosci 2018 06 28;4(1). Epub 2018 Feb 28.

Department of Psychiatry, Washington University, St. Louis, MO, USA.

The brain regions tied to pleasure can be triggered by engaging in sex, eating tasty food, watching a movie, accomplishments at school and athletics, consuming drugs, and noble efforts to help the community, the country, and the world. It is noteworthy that research suggests that the latter type of satisfaction, supporting the community, may result in the most substantial positive effects on our immune system. However, these pathways for these effects are not understood. Read More

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