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Association of Sleep Duration and Screen Time With Anxiety of Pregnant Women During the COVID-19 Pandemic.

Front Psychol 2021 20;12:646368. Epub 2021 Apr 20.

Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The COVID-19 pandemic has dramatically changed the patterns of lifestyle and posed psychological stress on pregnant women. However, the association of sleep duration and screen time with anxiety among pregnant women under the backdrop of the COVID-19 pandemic scenario has been poorly addressed. We conducted one large-scale, multicenter cross-sectional study which recruited 1794 pregnant women across middle and west China. Read More

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Cardiovascular disease risk prevention services by pharmacists in Saudi Arabia: what do policymakers and opinion leaders think?

J Pharm Policy Pract 2021 May 6;14(1):42. Epub 2021 May 6.

School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Building Number A15, Sydney, NSW, 2006, Australia.

Background: Cardiovascular disease (CVD) is an emerging contributor to national morbidity and mortality in Saudi Arabia. CVD risk prevention services are limited, particularly with an over-utilised public health sector and an under-utilised and under-resourced primary care sector. Globally, there is evidence that community pharmacists can play a key role in CVD prevention within primary care. Read More

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Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity.

Nucleic Acids Res 2021 May 6. Epub 2021 May 6.

West China Hospital Emergency Department (WCHED), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, Sichuan 610041, China.

The emergence of SARS-CoV-2 infection has posed unprecedented threat to global public health. The virus-encoded non-structural protein 14 (nsp14) is a bi-functional enzyme consisting of an exoribonuclease (ExoN) domain and a methyltransferase (MTase) domain and plays a pivotal role in viral replication. Here, we report the structure of SARS-CoV-2 nsp14-ExoN domain bound to its co-factor nsp10 and show that, compared to the SARS-CoV nsp10/nsp14-full-length complex, SARS-CoV-2 nsp14-ExoN retains an integral exoribonuclease fold and preserves an active configuration in the catalytic center. Read More

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Source Characterization of Multiple Reactive Species at an Abandoned Mine Site Using a Groundwater Numerical Simulation Model and Optimization Models.

Int J Environ Res Public Health 2021 Apr 29;18(9). Epub 2021 Apr 29.

College of Science and Engineering, James Cook University, Townsville, QLD 4814, Australia.

The most important first step in the management and remediation of contaminated groundwater aquifers is unknown contaminant source characterization. Often, the hydrogeological field data available for accurate source characterization are very sparse. In addition, hydrogeological and geochemical parameter estimates and field measurements are uncertain. Read More

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Dance as Lifeline: Transforming Means for Engagement and Connection in Times of Social Isolation.

Health Promot Pract 2021 05;22(1_suppl):64S-69S

Dance for PD, Mark Morris Dance Group, Brooklyn, NY, USA.

Over the past 20 years, dance has emerged as a safe, effective, and evidence-based community intervention that helps thousands of people living with Parkinson's disease around the globe maintain well-being and improve quality of life. From its initial emergence to the present, COVID-19 has posed fundamental challenges to people living with Parkinson's, forcing them to balance the need and desire to stay active and socially connected with the requirement to adhere to strict shelter-at-home orders. As cities and towns worldwide began shutting down in early 2020, people living with Parkinson's found themselves unable to access live dance activities that had provided consistent, reliable physical support; joyful cognitive stimulation; emotional connection; and social engagement. Read More

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Preparing student teachers for classrooms through experiences of critical incidents during remote practicum: A meaningful-experiential learning perspective.

Educ Inf Technol (Dordr) 2021 Apr 23:1-23. Epub 2021 Apr 23.

Department of English Language Teaching, Necmettin Erbakan University, Konya, Turkey.

The Covid-19 pandemic has precipitated dramatic changes in education systems around the world and pre-service teacher preparation programs have been notably impacted by the associated difficulties and constraints. Due to lockdown of universities and schools, practicum placements had to shift from in-person to virtual learning environments. However, being a practical classroom activity, practicum posed particular challenges that prompted teacher educators to make adjustments in their pedagogical strategies to meet the course requirements. Read More

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Overlap of immunotherapy-related pneumonitis and COVID-19 pneumonia: diagnostic and vaccine considerations.

J Immunother Cancer 2021 04;9(4)

Divisions of Hematology/Oncology & Infectious Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

The clinically indistinguishable overlap between pneumonitis caused due to immune checkpoint inhibition (ICI) and pneumonia associated with COVID-19 has posed considerable challenges for patients with cancer and oncologists alike. The cancer community continues to face the challenges that lay at the complex immunological intersection of immune-based cancer therapy and immune dysregulation that results from COVID-19. Is there compounded immune dysregulation that could lead to poor outcomes? Could ICIs, in fact, ameliorate SARS-CoV-2-driven T-cell exhaustion?A little more is known about the kinetics of the viral replication in immunocompromised patients now as compared with earlier during the pandemic. Read More

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A survey on active learning and human-in-the-loop deep learning for medical image analysis.

Med Image Anal 2021 Apr 9;71:102062. Epub 2021 Apr 9.

Department of Computing, Imperial College London, UK.

Fully automatic deep learning has become the state-of-the-art technique for many tasks including image acquisition, analysis and interpretation, and for the extraction of clinically useful information for computer-aided detection, diagnosis, treatment planning, intervention and therapy. However, the unique challenges posed by medical image analysis suggest that retaining a human end-user in any deep learning enabled system will be beneficial. In this review we investigate the role that humans might play in the development and deployment of deep learning enabled diagnostic applications and focus on techniques that will retain a significant input from a human end user. Read More

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Exposure via biotransformation: Oxazepam reaches predicted pharmacological effect levels in European perch after exposure to temazepam.

Ecotoxicol Environ Saf 2021 Jul 23;217:112246. Epub 2021 Apr 23.

Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences (SLU), Umeå, Sweden.

It is generally expected that biotransformation and excretion of pharmaceuticals occurs similarly in fish and mammals, despite significant physiological differences. Here, we exposed European perch (Perca fluviatilis) to the benzodiazepine drug temazepam at a nominal concentration of 2 µg L for 10 days. We collected samples of blood plasma, muscle, and brain in a time-dependent manner to assess its bioconcentration, biotransformation, and elimination over another 10 days of depuration in clean water. Read More

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Antibacterial Composite Materials Based on the Combination of Polyhydroxyalkanoates With Selenium and Strontium Co-substituted Hydroxyapatite for Bone Regeneration.

Front Bioeng Biotechnol 2021 7;9:647007. Epub 2021 Apr 7.

School of Life Sciences, College of Liberal Arts and Sciences, University of Westminster, London, United Kingdom.

Due to the threat posed by the rapid growth in the resistance of microbial species to antibiotics, there is an urgent need to develop novel materials for biomedical applications capable of providing antibacterial properties without the use of such drugs. Bone healing represents one of the applications with the highest risk of postoperative infections, with potential serious complications in case of bacterial contaminations. Therefore, tissue engineering approaches aiming at the regeneration of bone tissue should be based on the use of materials possessing antibacterial properties alongside with biological and functional characteristics. Read More

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Perspectives on facilitating dynamic ecology courses online using active learning.

Ecol Evol 2021 Apr 19;11(8):3473-3480. Epub 2020 Nov 19.

College of Social Sciences Minerva Schools at KGI San Francisco CA USA.

As education methodology has grown to incorporate online learning, disciplines with a field component, like ecology, may find themselves sidelined in this transition. In response to challenges posed by moving classes online, previous studies have assessed whether an online environment can be effective for student learning. This work has found that active learning structures, which maximize information processing and require critical thinking, best support student learning. Read More

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Innovation in a Time of Crisis: Adapting Active Learning Approaches for Remote Biology Courses.

J Microbiol Biol Educ 2021 31;22(1). Epub 2021 Mar 31.

Liberal Studies, New York University, 726 Broadway, 6th Floor, New York, NY 10003.

The sudden switch from predominantly in-person to remote learning across all levels of education due to the COVID-19 pandemic posed many challenges, including transitioning in-person active learning efforts to an online format. Although active learning has increased student engagement in science, it can be challenging to effectively integrate into remote courses. Adapting in-person classroom approaches to maintain timely and effective communication, provide equitable access to course materials, and encourage class participation in remote environments proved especially difficult for many instructors engaging in remote learning during the pandemic, often for the first time. Read More

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Human Gut Bacterial β-Glucuronidase Inhibition: An Emerging Approach to Manage Drug Therapy.

Biochem Pharmacol 2021 Apr 15:114566. Epub 2021 Apr 15.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China. Electronic address:

Bacterial β-glucuronidase enzymes (BGUSs) are at the interface of host-microbial metabolic symbiosis, playing an important role in health and disease as well as medication outcomes (efficacy or toxicity) by deconjugating a large number of endogenous and exogenous glucuronides. In recent years, BGUSs inhibition has emerged as a new approach to manage diseases and medication therapy and attracted an increasing research interest. However, a growing body of evidence underlines great genetic diversity, functional promiscuityand varied inhibition propensity of BGUSs, which have posed big challenges to identifying BGUSs involved in a specific pathophysiological or pharmacological process and developing effective inhibition. Read More

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Hierarchical Hybrid Supports and Synthesis Strategies for Hydrodesulfurization of Recalcitrance Organosulfur Compounds.

Saheed A Ganiyu

Chem Asian J 2021 Apr 15. Epub 2021 Apr 15.

Chemistry department, King Fahd University of Petroleum & Minerals, Dhahran, Saudi Arabia.

It is undisputed that there is a paradigm shift in the global trend of crude oil towards being more sour and heavier than usual light sources. Consequently, the hydrotreating activity becomes a bottleneck with high content of S, N, metals and other impurities than expected. On the other hand, the price of petroleum products lately witnessed instability and fell to the lowest average price (Read More

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Characteristics of improvements in balance control using vibro-tactile biofeedback of trunk sway for multiple sclerosis patients.

J Neurol Sci 2021 Apr 1;425:117432. Epub 2021 Apr 1.

Dept of Neurology, University of Basel Hospital, Basel, Switzerland.

Background And Aims: Previously, we determined that training with vibrotactile feedback (VTfb) of trunk sway improves MS patients' balance impairment. Here, we posed 5 questions: 1) How many weeks of VTfb training are required to obtain the best short-term carry over effect (CoE) with VTfb? 2) How long does the CoE last once VTfb training terminates? 3) Is the benefit similar for stance and gait? 4) Is position or velocity based VTfb more effective in reducing trunk sway? 5) Do patients' subjective assessments of balance control improve?

Methods: Balance control of 16 MS patients was measured with gyroscopes at the lower trunk. The gyroscopes drove directionally active VTfb in a head-band. Read More

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Accurate singlet-triplet gaps in biradicals via the spin averaged anti-Hermitian contracted Schrödinger equation.

J Chem Phys 2021 Apr;154(13):134103

The Department of Chemistry, The James Franck Institute, The University of Chicago, Chicago, Illinois 60637, USA.

The accurate description of biradical systems, and in particular the resolution of their singlet-triplet gaps, has long posed a major challenge to the development of electronic structure theories. Biradicaloid singlet ground states are often marked by strong correlation and, hence, may not be accurately treated by mainstream, single-reference methods such as density functional theory or coupled cluster theory. The anti-Hermitian contracted Schrödinger equation (ACSE), whose fundamental quantity is the two-electron reduced density matrix rather than the N-electron wave function, has previously been shown to account for both dynamic and strong correlations when seeded with a strongly correlated guess from a complete active space (CAS) calculation. Read More

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Team-based, problem-solving exercises using studies of diarrhea and oral rehydration encourage students to integrate knowledge of systems physiology.

Adv Physiol Educ 2021 Jun;45(2):250-258

School of Physiology, Pharmacology and Neuroscience, University of Bristol, University Walk, Bristol, United Kingdom.

We describe an inquiry activity that aims to develop students' ability to interpret findings that span whole body systems and so encourage the integration of knowledge. The scenario we choose was the physiological challenge posed by diarrhea and the physiological mechanisms that underpin oral rehydration therapy. Before the staff-facilitated inquiry activity, students engage with an online information resource and complete a formative, but mandatory, prelaboratory quiz. Read More

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Remote Home Monitoring of Patients With Cancer During the COVID Pandemic: A Pilot Study.

JCO Oncol Pract 2021 Apr 1:OP2000995. Epub 2021 Apr 1.

Inova Schar Cancer Institute, Inova Health System, Falls Church, VA.

Purpose: The COVID-19 pandemic has posed significant challenges in the care of patients with cancer, including how to manage outpatients who are COVID-positive but do not require hospitalization. We explored the use of a remote patient monitoring (RPM) program to care for such outpatients.

Methods: Consecutive patients who were tested for COVID-19 because of symptom onset but were clinically stable were offered enrollment into a pilot RPM program. Read More

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Synchronous Melanoma and Pancreas Malignancies Leading to a Discovery of a CDKN2A Mutation in a Patient with No Known Family History.

Case Rep Oncol 2021 Jan-Apr;14(1):333-337. Epub 2021 Mar 3.

St Vincent's University Hospital, Dublin, Ireland.

We report a case of a 60-year-old male with metachronous primary malignancies, pancreatic cancer and malignant melanoma which recurred simultaneously. Both cancers were challenging to diagnose and throughout the case at different times, the presence of two active malignancies obscured the clinical picture. A bleeding gastric lesion found in the stomach 6 months after a distal pancreatectomy for pancreatic adenocarcinoma revealed metastatic melanoma, presumed secondary from a melanoma excised from the patient's back 2 years previously. Read More

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COVID-19 at War: the Joint Forces Operation in Ukraine.

Disaster Med Public Health Prep 2021 Mar 25:1-20. Epub 2021 Mar 25.

Executive Director Maricopa County Medical Society Phoenix, Arizona

The ongoing pandemic disaster of coronavirus erupted with the first confirmed cases in Wuhan, China in December 2019, caused by the SARS-CoV-2 novel coronavirus, the disease referred to as "COVID-19." The World Health Organization (WHO) confirmed the outbreak and determined it a global pandemic. The current pandemic has infected nearly 100 million people and killed over 2 million. Read More

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Efficient photocatalytic degradation of doxycycline by coupling α-BiO/g-CN composite and HO under visible light.

Environ Res 2021 Mar 15;197:110925. Epub 2021 Mar 15.

Faculty of Resources and Environmental Science, Hubei University, Wuhan, 430062, China.

Antibiotic pollutants have posed a huge threat to the ecological environment and human health. In this work, α-BiO/g-CN composite was prepared and coupled with HO for the rapid and efficient degradation of doxycycline (DOX) in water under visible light irradiation. The composite exhibited enhanced photocatalytic activity and 80. Read More

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COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials.

Nat Rev Clin Oncol 2021 05 15;18(5):313-319. Epub 2021 Mar 15.

Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Emerging efficacy data have led to the emergency use authorization or approval of COVID-19 vaccines in several countries worldwide. Most trials of COVID-19 vaccines excluded patients with active malignancies, and thus data on the safety, tolerability and efficacy of the vaccines in patients with cancer are currently limited. Given the risk posed by the COVID-19 pandemic, decisions regarding the use of vaccines against COVID-19 in patients participating in trials of investigational anticancer therapies need to be addressed promptly. Read More

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Monitoring of SARS-CoV-2 infection in mustelids.

EFSA J 2021 Mar 3;19(3):e06459. Epub 2021 Mar 3.

American mink and ferret are highly susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but no information is available for other mustelid species. SARS-CoV-2 spreads very efficiently within mink farms once introduced, by direct and indirect contact, high within-farm animal density increases the chance for transmission. Between-farm spread is likely to occur once SARS-CoV-2 is introduced, short distance between SARS-CoV-2 positive farms is a risk factor. Read More

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Being a woman, being a soldier, being a mother: a qualitative analysis of perceptions of pregnancy on working lives of women in the Spanish Armed Forces.

BMJ Mil Health 2021 Mar 9. Epub 2021 Mar 9.

Surgery, Medical and Social Sciences, Facultad de Medicina y Ciencias de la Salud, Universidad de Alcalá de Henares, Alcala de Henares, Madrid, Spain.

Introduction: Thirty-two years after Spain first allowed women to join the armed forces, 12% of active troops are women, although there are no data on how many of them are mothers. There is a lack of research related to the impact of motherhood on their careers and the challenges they face as well. Previous quantitative research, within North Atlantic Treaty Organization (NATO) forces, has focused on the increased vulnerability and reduced performance of women returning to service after childbirth. Read More

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The effectiveness of positive appearance and functionality reflective writing tasks on state body image and response to idealised media exposure among 35-60 year-old women.

Body Image 2021 Mar 3;37:127-137. Epub 2021 Mar 3.

School of Health and Behavioural Sciences, University of the Sunshine Coast, Maroochydore DC, Queensland, Australia. Electronic address:

Functionality and appearance-based reflective writing tasks can improve body image in young women. There is limited research investigating these tasks in mature women. This study tested (a) the effectiveness of writing tasks on women's state body image and (b) whether these tasks buffered responses to idealised media. Read More

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Reciprocally-Coupled Gating: Strange Loops in Bioenergetics, Genetics, and Catalysis.

Biomolecules 2021 02 11;11(2). Epub 2021 Feb 11.

Department of Physics and Te Ao Marama Centre for Fundamental Inquiry, University of Auckland, PB 92019, Auckland 1142, New Zealand.

Bioenergetics, genetic coding, and catalysis are all difficult to imagine emerging without pre-existing historical context. That context is often posed as a "Chicken and Egg" problem; its resolution is concisely described by de Grasse Tyson: "The egg was laid by a bird that was not a chicken". The concision and generality of that answer furnish no details-only an appropriate framework from which to examine detailed paradigms that might illuminate paradoxes underlying these three life-defining biomolecular processes. Read More

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February 2021

Malaria parasites differentially sense environmental elasticity during transmission.

EMBO Mol Med 2021 Apr 5;13(4):e13933. Epub 2021 Mar 5.

Integrative Parasitology, Center for Infectious Diseases, Heidelberg University Medical School, Heidelberg, Germany.

Transmission of malaria-causing parasites to and by the mosquito relies on active parasite migration and constitutes bottlenecks in the Plasmodium life cycle. Parasite adaption to the biochemically and physically different environments must hence be a key evolutionary driver for transmission efficiency. To probe how subtle but physiologically relevant changes in environmental elasticity impact parasite migration, we introduce 2D and 3D polyacrylamide gels to study ookinetes, the parasite forms emigrating from the mosquito blood meal and sporozoites, the forms transmitted to the vertebrate host. Read More

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DNA methylation and expression of estrogen receptor alpha in fathead minnows exposed to 17α-ethynylestradiol.

Aquat Toxicol 2021 Apr 23;233:105788. Epub 2021 Feb 23.

US Environmental Protection Agency, Office of Research and Development, Cincinnati, OH, 45268, United States. Electronic address:

The gene expression response thought to underlie the negative apical effects resulting from estrogen exposure have been thoroughly described in fish. Although epigenetics are believed to play a critical role translating environmental exposures into the development of adverse apical effects, they remain poorly characterized in fish species. This study investigated alterations of DNA methylation of estrogen receptor alpha (esr1) in brain and liver tissues from 8 to 10 month old male fathead minnows (Pimephales promelas) after a 2d exposure to either 2. Read More

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Solid-State NMR of Membrane Proteins in Lipid Bilayers: To Spin or Not To Spin?

Acc Chem Res 2021 03 3;54(6):1430-1439. Epub 2021 Mar 3.

Membrane proteins mediate a plethora of cellular functions and represent important targets for drug development. Unlike soluble proteins, membrane proteins require native-like environments to fold correctly and be active. Therefore, modern structural biology techniques have aimed to determine the structure and dynamics of these membrane proteins at physiological temperature and in liquid crystalline lipid bilayers. Read More

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Multi-Specialty Care for Second-Degree Pressure Cooker Explosion Burn Injuries.

Spartan Med Res J 2020 Oct 30;5(2):17738. Epub 2020 Oct 30.

Henry Ford Health System.

Context: Although pressure cookers are very common kitchen utensils used in the United States, only a few cases of serious injuries secondary to pressure cooker explosions have been reported in the medical literature. When second-degree (i.e. Read More

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October 2020