9,763 results match your criteria portal thrombosis


iScience 2021 Sep 10:103115. Epub 2021 Sep 10.

Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.

Numerous studies have provided single-cell transcriptome profiles of host responses to SARS-CoV-2 infection. Critically lacking however is a datamine that allows users to compare and explore cell profiles to gain insights and develop new hypotheses. To accomplish this, we harmonized datasets from COVID-19 and other control condition blood, bronchoalveolar lavage, and tissue samples, and derived a compendium of gene signature modules per cell type, subtype, clinical condition, and compartment. Read More

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September 2021

Portal Vein Tumor Thrombosis and Hepatocellular Carcinoma - The Changing Tides.

J Hepatocell Carcinoma 2021 7;8:1089-1115. Epub 2021 Sep 7.

Department of Hepatobiliary and Pancreatic Surgery, The Center for Integrated Oncology and Precision Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, People's Republic of China.

Portal vein involvement is considered one of the most fearful complications of hepatocellular carcinoma (HCC). Portal vein tumor thrombosis (PVTT) is associated with aggressive tumor biology (high grade), high tumor burden (number and size of lesions), high levels of serum markers (AFP), poor liver function (deranged LFT), and poor performance status of patients. The Barcelona Clinic Liver Cancer staging system places HCC patients with PVTT in advanced stage (BCLC Stage-C). Read More

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September 2021

Brachytherapy with Iodine-125 seeds for treatment of portal vein-branch tumor thrombus in patients with hepatocellular carcinoma.

BMC Cancer 2021 Sep 14;21(1):1020. Epub 2021 Sep 14.

Department of Interventional Radiology, The First Hospital of China Medical University, No.155 Nanjing Road, Heping District, Shenyang, 110000, Liaoning, China.

Background: There is currently no widely-accepted consensus for the management of hepatocellular carcinoma with portal vein tumor thrombus. We evaluate the safety and efficacy of ultrasound-guided percutaneous brachytherapy with iodine-125 seeds for the treatment of hepatocellular carcinoma with portal vein-branch tumor thrombus (PVBTT).

Methods: Sixty-nine hepatocellular carcinoma patients with PVBTT were enrolled; 34 received transarterial chemoembolization (TACE) combined with iodine-125 seeds implanted in the PVBTT; 35 were treated with TACE alone. Read More

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September 2021

Pregnancy outcomes in women with Budd-Chiari syndrome or portal vein thrombosis A multicentre retrospective cohort study.

BJOG 2021 Sep 14. Epub 2021 Sep 14.

Department of Obstetrics and Gynaecology, Amsterdam UMC, University of Amsterdam, Amsterdam Reproduction & Development research institute, Amsterdam, The Netherlands.

Objective: To evaluate current practice and outcomes of pregnancy in women previously diagnosed with Budd-Chiari syndrome and/or portal vein thrombosis, with and without concomitant portal hypertension.

Design And Setting: Multicentre retrospective cohort study between 2008-2021.

Population: Women who conceived in the predefined period after the diagnosis of Budd-Chiari syndrome and/or portal vein thrombosis. Read More

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September 2021

[Arthroscopic meniscus transplantation without bone blocks].

Oper Orthop Traumatol 2021 Sep 14. Epub 2021 Sep 14.

Klinik für Orthopädie und Unfallchirurgie, Martin Luther Krankenhaus Berlin, Caspar-Theyß-Straße 27-31, 14193, Berlin, Deutschland.

Objective: Replacement of the lateral or medial meniscus with an allogeneic graft.

Indications: Complete loss of inner or outer meniscus.

Contraindications: Grade 3 to 4 cartilage damage in the corresponding compartment, uncorrected varus or valgus deformities > 5°, symptomatic instabilities. Read More

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September 2021

Predictors of portal vein thrombosis after laparoscopic splenectomy and azygoportal disconnection in hepatitis B cirrhosis: a prospective study.

Surg Endosc 2021 Sep 13. Epub 2021 Sep 13.

Department of Hepatobiliary Surgery, Clinical Medical College, Yangzhou University, 98 West Nantong Rd, Yangzhou, 225000, Jiangsu, China.

Background: The thrombosis of the main and intrahepatic branches of the portal vein (TMIP) is potentially lethal and deemed a common complication following laparoscopic splenectomy and azygoportal disconnection (LSD) in patients with cirrhosis and portal hypertension (PH). The predictors of TMIP after LSD remain unclear. The aim of this prospective study was to explore the predictive and risk factors for TMIP after LSD in cirrhotic patients with PH caused only by hepatitis B virus. Read More

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September 2021

Delayed-Onset Portal Venous Thrombosis After Ingestion of 3% Hydrogen Peroxide.

J Emerg Med 2021 Sep 10. Epub 2021 Sep 10.

Division of Medical Toxicology, Department of Emergency Medicine, University of California San Diego Health System, San Diego, California.

Background: Identification of portal venous gas on radiographic imaging is well documented after the ingestion of hydrogen peroxide, as is its resolution after hyperbaric therapy. Although hyperbaric therapy may resolve the gastrointestinal symptoms associated with the presence of portal venous gas, the principle rationale for performing hyperbaric therapy is to prevent subsequent central nervous system oxygen embolization.

Case Report: We describe a patient with portal venous gas identified by computed tomography after the ingestion of 3% hydrogen peroxide, managed without hyperbaric therapy, who subsequently developed portal venous thrombosis. Read More

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September 2021

[Analysis of the short-and medium-term curative effect of TIPS approach combined with AngioJet thrombus aspiration technology treatment in acute portal vein thrombosis].

Zhonghua Gan Zang Bing Za Zhi 2021 Aug;29(8):754-758

Department of Vascular Surgery, Henan Provincial People's Hospital; Department of Vascular Surgery, People's Hospital of Zhengzhou University; Henan Provincial Intervention Treatment Center, Zhengzhou 450003, China.

To evaluate the short- and medium-term clinical efficacy of TIPS approach combined with AngioJet thrombus aspiration technology treatment in acute portal vein thrombosis. 63 cases with acute portal vein thrombosis treated in our center from May 2017 to July 2019 were studied retrospectively, including 49 males and 14 females, aged 35-61 (46 ± 5) years. TIPS approach (with/without) combined with Angiojet thrombus aspiration and gastroesophageal varices embolization was performed simultaneously according to the patient's condition. Read More

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Catastrophic Thromboembolic Syndrome During the COVID-19 Pandemic.

Cureus 2021 Aug 3;13(8):e16854. Epub 2021 Aug 3.

Cardiothoracic Surgery, Jersey Shore University Medical Center, Neptune City, USA.

Since March 2020, the SARS-CoV-2 virus known to cause COVID-19 has presented in many ways and it seems to affect almost all organ systems. One of its detrimental effects is on the coagulation system. Disruption of the coagulation pathway or hypercoagulability has been reported extensively in many articles and studies. Read More

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Portal Vein Thrombosis and Splenic Infarction in a COVID-19 Patient.

Cureus 2021 Aug 2;13(8):e16843. Epub 2021 Aug 2.

Internal Medicine, Jersey Shore University Medical Center/Saint Francis Medical Center Program, Trenton, USA.

COVID-19 is a novel viral infection that primarily affects the lungs and runs the gamut from a mild, self-limiting, febrile illness to respiratory failure and death. It manifested as a global pandemic in 2020 and has since claimed millions of lives. Only a few months into this pandemic, it became evident that the viral infection leads to a hypercoagulable state. Read More

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Treatment for hepatocellular carcinoma with tumor thrombosis in the hepatic vein or inferior vena cava: A comprehensive review.

World J Gastrointest Surg 2021 Aug;13(8):796-805

Research Laboratory and Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 434000, Hubei Province, China.

Hepatocellular carcinoma (HCC) is the most common type of liver cancer with a high mortality rate worldwide. The percentage of HCC patients with vascular invasion is high. However, tumor thrombus in the hepatic vein (HVTT) has a lower incidence than tumor thrombus in the portal vein (PVTT). Read More

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Is SARS-CoV-2 infection an emerging risk factor for splanchnic venous thrombosis?

Clin Hemorheol Microcirc 2021 Sep 5. Epub 2021 Sep 5.

Department of Internal Medicine, Ospedale Maggiore "Carlo Alberto Pizzardi", Bologna, Italy.

Objective: Thrombosis represents one of the most feared complications of the COronaVIrus Disease-2019 (COVID-19). Although pulmonary embolism and deep venous thrombosis are the most described complications, some investigations reported thrombotic localization also in the splanchnic venous district.

Methods: We describe the case of a patient with SARS-CoV-2 infection presenting with abdominal pain and diagnosed with portal vein thrombosis. Read More

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September 2021

Cirrhosis and partial portal thrombosis leading to severe variceal bleeding, an unusual presentation of sarcoidosis.

Acta Clin Belg 2021 Sep 12:1-5. Epub 2021 Sep 12.

Department of Critical Care, Vrije Universiteit Brussel, Brussel, UZ Brussel, Belgium.

Introduction: Sarcoidosis is a systemic granulomatous disease, characterized by the formation of non-necrotizing granulomas. Even though granulomas are frequently found in liver biopsy, related symptoms rarely occur. In the current article, a case report is pictured to increase the knowledge on portal hypertension in hepatic sarcoidosis. Read More

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September 2021

Minor Role of Hemostatic Alternation in Portal Vein Thrombosis Pathogenesis Revealed by Global Measurement.

J Hepatol 2021 Sep 9. Epub 2021 Sep 9.

Hepatology Unit, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China; Hepatology Unit, Zengcheng Branch, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

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September 2021

Key Role of Personalized Dosimetry in Dose Adjustment for Selective Internal Radiotherapy: Retrospective Study of Patients Treated With 90Y Resin Microspheres.

Clin Nucl Med 2021 Sep 8. Epub 2021 Sep 8.

From the Radiopharmacie Service de Médecine Nucléaire Service de Radiologie et d'Imagerie Diagnostique et Interventionnelle Service d'Hépato-Gastro-Entérologie et Oncologie Digestive, CHU de Bordeaux, Bordeaux, France.

Purpose: Selective internal radiotherapy with 90Y microspheres is widely used for the treatment of patients with liver cancer. A dosimetric analysis using the dosimetry software Simplicit90y (Boston Scientific, Natick, MA) was conducted to define doses to the tumor and healthy liver, and to determine a threshold tumor dose that could predict progression-free survival.

Methods: Patients experiencing hepatocellular carcinoma and treated with 90Y-labeled resin microspheres were included in a retrospective study. Read More

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September 2021

Cancer-Associated Fibroblasts Promote Vascular Invasion of Hepatocellular Carcinoma via Downregulating Decorin-integrin β1 Signaling.

Front Cell Dev Biol 2021 24;9:678670. Epub 2021 Aug 24.

Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, China.

Hepatocellular carcinoma (HCC) is a common malignancy worldwide, and the high ratio of recurrence and metastasis remains the main cause of its poor prognosis. Vascular invasion of HCC includes microvascular invasion (MVI) and portal vein tumor thrombosis (PVTT) and is regarded as a common roadmap of intrahepatic metastasis in HCC. However, the molecular mechanism underlying vascular invasion of HCC is largely unknown. Read More

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Peritoneal patch in vascular reconstruction during pancreaticoduodenectomy for pancreatic cancer: a single centre experience.

Acta Chir Belg 2021 Sep 10:1-22. Epub 2021 Sep 10.

Medico-Surgical Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Erasme Hospital, Université Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium.

Background: Concomitant venous resection during pancreaticoduodenectomy (PD) for pancreatic adenocarcinoma with mesenterico-portal vein involvement is increasingly performed to achieve oncological resection. This study aims to report a single centre experience in peritoneal patch (PP) as autologous graft for vascular reconstruction (VR) during PD.

Methods: A retrospective analysis of all patients who underwent PD + VR with PP between December 2019 and September 2020 was performed, using a prospective collected database. Read More

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September 2021

Portomesenteric Vein Thrombosis after Bariatric Surgery: An Online Survey.

J Clin Med 2021 Sep 6;10(17). Epub 2021 Sep 6.

PhD Program in Applied Medical-Surgical Sciences, University of Rome "Tor Vergata", 00133 Rome, Italy.

Portomesenteric vein thrombosis (PMVT) is a rare post-operative complication of bariatric procedures, occurring in between 0.3% and 1% of cases. A structured questionnaire consisting of 27 items was available online to members of the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) to investigate the occurrence of PMVT. Read More

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September 2021

Predictors for thromboembolism in patients with cholangiocarcinoma.

J Cancer Res Clin Oncol 2021 Sep 9. Epub 2021 Sep 9.

Department of Medicine (Oncology, Gastroenterology, Hepatology, Pulmonology, and Infectious Diseases), University Cancer Center Leipzig (UCCL), University of Leipzig Medical Center, Leipzig, Germany.

Background: Patients with cancer are at increased risk of thromboembolic events contributing significantly to cancer-related morbidity and mortality. Because cholangiocarcinoma is a rare type of cancer, the incidence of thromboembolism in this patient population is not well defined.

Methods: Patients with cholangiocarcinoma treated at the University Cancer Center Leipzig between January 2014 and December 2018 were analyzed retrospectively regarding the incidence of arterial and venous thromboembolism. Read More

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September 2021

[Cirrhosis and coagulation : implications for clinical practice].

Rev Med Suisse 2021 Sep;17(749):1495-1498

Clinique de médecine interne générale, HFR Fribourg, 1752 Villars-sur-Glâne.

Coagulation disorders related to abnormalities in hepatic synthesis are well known as prognostic factors in hepatic cirrhosis. The risk of bleeding, mainly linked to portal hypertension, must be weighed against the risk of thrombosis, the most frequent manifestation of which is portal venous thrombosis. Conventional laboratory tests are not a reliable reflection of this delicate balance. Read More

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September 2021

A systematic review and meta-analysis of anticoagulation therapy for portal vein thrombosis in patients with cirrhosis: to treat or not to treat?

Hepatol Int 2021 Sep 6. Epub 2021 Sep 6.

Department of Pharmacy, Peking University Third Hospital, No.49 Huayuan North Road, Beijing, 100191, China.

Purpose: To date, the optimal treatment for portal vein thrombosis (PVT) in cirrhotic patients has not been established in guidelines or consensus. We conducted a systematic review and meta-analysis to evaluate the effect of anticoagulation therapy in patients with cirrhosis and PVT.

Methods: PubMed, Embase, the Cochrane Central Register of Controlled Trials, and ClinicalTrials. Read More

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September 2021

A rare case of congenital aneurysm of the portal system at level of spleno-porto-mesenteric confluence complicated by massive thrombosis.

Radiol Case Rep 2021 Nov 30;16(11):3369-3373. Epub 2021 Aug 30.

IBB CNR Naples, Via De Amicis, 95, 80145 Naples, Italy.

Portal venous aneurysm is a rare and potential dangerous vascular pathology, which can result in thrombosis or rupture. It may be congenital or acquired. Acquired form can be related mainly to portal hypertension, chronic hepatic disease, and trauma. Read More

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November 2021

Management of Acute Portal Vein Thrombosis With Serial Mechanical Thrombectomy and tPA in a Pediatric Liver Transplant Recipient: A Case Report.

Transplant Proc 2021 Sep 2. Epub 2021 Sep 2.

Baylor College of Medicine, Michael E. DeBakey Department of Surgery, Division of Abdominal Transplantation, Houston, Texas.

Background: Acute portal vein thrombosis is a major cause of fulminant allograft failure in pediatric liver transplantation. Timely intervention is critical to save the graft and patient. Serial interventional radiologic management of this condition is scarcely reported in the literature. Read More

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September 2021

Technical note: A fast and accurate analytical dose calculation algorithm for I seed-loaded stent applications.

Med Phys 2021 Sep 4. Epub 2021 Sep 4.

Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA.

Purpose: The safety and clinical efficacy of I seed-loaded stent for the treatment of portal vein tumor thrombosis (PVTT) have been shown. Accurate and fast dose calculation of the I seeds with the presence of the stent is necessary for the plan optimization and evaluation. However, the dosimetric characteristics of the seed-loaded stents remain unclear and there is no fast dose calculation technique available. Read More

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September 2021

Clinical characteristics of cirrhosis patients with umbilical vein recanalization: A retrospective analysis.

Medicine (Baltimore) 2021 Sep;100(35):e26774

The Department of Gastroenterology, the First People Hospital of JiuJiang, JiangXi, China.

Abstract: Umbilical Vein Recanalization (UVR) may occur in patients with long-standing portal hypertension and liver cirrhosis. This study aimed to investigate the clinical significance of UVR.Medical records of a cohort of patients with cirrhosis (n = 247) who were hospitalized at the Digestive Medicine Center of the Second Affiliated Hospital of Nanchang University from January 2012 to October 2015 were accessed. Read More

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September 2021

Machine Perfusion of Donation After Circulatory Death Liver and Lungs Before Combined Liver-lung Transplantation.

Transplant Direct 2021 Jul 18;7(7):e718. Epub 2021 Jun 18.

Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Shortage of deceased donor organs for transplantation has led to the increased use of organs from donation after circulatory death (DCD) donors. There are currently no reports describing outcomes after multiorgan transplantation with DCD livers. The use of DCD organs for multiorgan transplantation can be enhanced if the detrimental effects of prolonged cold ischemia and subsequent ischemia-reperfusion injury are overcome. Read More

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Direct Oral Anticoagulants Versus Warfarin for Treatment of Thrombosis or Atrial Fibrillation in Patients With Cirrhosis: A Retrospective Cohort Study.

Ann Pharmacother 2021 Sep 1:10600280211025050. Epub 2021 Sep 1.

Ochsner Health, New Orleans, LA, USA.

Background: Evidence for direct oral anticoagulants (DOACs) in patients with cirrhosis is limited. Few patients with Child-Turcotte-Pugh (CTP) class B and C cirrhosis have been studied.

Objective: To compare major bleeding rates in patients with cirrhosis receiving a DOAC versus warfarin. Read More

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September 2021

Challenging anticoagulation cases: Acute extensive portal vein thrombosis in a patient without cirrhosis - Evidence-based management of a rare clinical entity.

Thromb Res 2021 Aug 18;206:133-136. Epub 2021 Aug 18.

Department of Medicine, McGill University, Canada; Research Institute, McGill University Health Centre, Canada.

Acute non-cirrhotic and non-malignant portal vein thrombosis (aPVT) is a rare and heterogenous condition. Current guidelines recommend early initiation of therapeutic anticoagulation to prevent extension of thrombosis, and favor recanalization. Although not formally defined, a poor outcome in the acute setting would include thrombosis extension with progression to intestinal infarction. Read More

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Portal inflow reconstruction between distal collateral vessels after renoportal anastomosis in a liver transplant patient with extensive portomesenteric venous thrombosis.

Asian J Surg 2021 Aug 27. Epub 2021 Aug 27.

Department of Surgery, Gachon University Gil Medical Center 21 Namdong-daero, 774 beon-gil,Namdong-Gu, Inchon, Zip-code: 21565, South Korea.

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Recanalization of Chronic Noncirrhotic, Nonmalignant Splanchnic Thromboses is Feasible: A Transsplenic Assisted Patient-Tailored Approach.

J Vasc Interv Radiol 2021 09 20;32(9):1377-1385. Epub 2021 Jul 20.

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland.

The purpose of this study was to evaluate the feasibility of recanalization of chronic noncirrhotic, nonmalignant splanchnic thromboses with a transsplenic assisted patient-tailored approach with or without transjugular intrahepatic portosystemic shunt (TIPS) creation. In this retrospective study, 10 patients (median age, 48.4 years; interquartile range, 5. Read More

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September 2021