202 results match your criteria por covid-19


A single dose of SARS-CoV-2 FINLAY-FR-1A vaccine enhances neutralization response in COVID-19 convalescents, with a very good safety profile: An open-label phase 1 clinical trial.

Lancet Reg Health Am 2021 Dec 15;4:100079. Epub 2021 Sep 15.

Finlay Vaccine Institute, 21st Ave. N° 19810 between 198 and 200 Streets, Atabey, Playa, Havana, Cuba.

Background: As a first step towards a vaccine protecting COVID-19 convalescents from reinfection, we evaluated FINLAY-FR-1A vaccine in a clinical trial.

Methods: Thirty COVID-19 convalescents aged 22-57 years were studied: convalescents of mild COVID-19, asymptomatic convalescents, both with PCR-positive at the moment of diagnosis; and individuals with subclinical infection detected by viral-specific IgG. They received a single intramuscular injection of the FINLAY-FR-1A vaccine (50 µg of the recombinant dimeric receptor binding domain). Read More

View Article and Full-Text PDF
December 2021

Characteristics of patients with immune-mediated inflammatory diseases hospitalized for SARS-CoV-2 infection.

Reumatol Clin (Engl Ed) 2021 Sep 16. Epub 2021 Sep 16.

Unidad de Alergología, Servicio de Medicina Interna, Hospital Universitario de la Plana, Villarreal, Castellón, Spain.

Background: Immune-mediated inflammatory diseases (IMID) predispose to a higher infection risk by modifying the host's immune response, which acts as a key factor in SARS-CoV-2 infection resolution. Recent publications show that IMID patients and its treatments do not worsen the outcome of SARS-CoV-2 infection.

Objectives: To describe the clinical characteristics and outcomes of patients with IMID who required hospital admission due to SARS-CoV-2 infection. Read More

View Article and Full-Text PDF
September 2021

[Decline in life expectancy in Madrid's districts in 2020: its correlation with social determinants].

Gac Sanit 2021 Sep 14. Epub 2021 Sep 14.

Madrid Salud, Departamento de Evaluación y Calidad, Ayuntamiento de Madrid, Madrid, España.

Objective: Estimating the decrease in life expectancy (LE) of the population of Madrid and its districts and its relationship with socioeconomic variables in the first year of the COVID-19 pandemic.

Method: Death records were obtained from the Municipal Register of inhabitants (Municipal Statistics Service). Based on Chiang II method, life expectancy at birth and at 65 years of age (LEB and LE65) were calculated, as well as their 95% confidence intervals both for men and women and their gross, net and minimum falls for each district in 2020 over 2019, their correlation with some socioeconomic variables distribution and the existence of multiple linear regression explicative models. Read More

View Article and Full-Text PDF
September 2021

The ongoing evolution of variants of concern and interest of SARS-CoV-2 in Brazil revealed by convergent indels in the amino (N)-terminal domain of the spike protein.

Virus Evol 2021 14;7(2):veab069. Epub 2021 Aug 14.

Instituto Adolfo Lutz, Av. Dr. Arnaldo, 351, São Paulo 01246-000, Brazil.

Mutations at both the receptor-binding domain (RBD) and the amino (N)-terminal domain (NTD) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike (S) glycoprotein can alter its antigenicity and promote immune escape. We identified that SARS-CoV-2 lineages circulating in Brazil with mutations of concern in the RBD independently acquired convergent deletions and insertions in the NTD of the S protein, which altered the NTD antigenic-supersite and other predicted epitopes at this region. Importantly, we detected the community transmission of different P. Read More

View Article and Full-Text PDF

Mental health care of health workers during Covid-19: Recommendations based on evidence and expert consensus.

Rev Colomb Psiquiatr (Engl Ed) 2021 Jul-Sep;50(3):225-231. Epub 2021 Sep 12.

Instituto Global de Excelencia Clínica Keralty, Bogotá D.C., Colombia; Grupo de investigación en Medicina Traslacional, Fundación Universitaria Sanitas, Colombia.

Introduction: The crisis situation generated by COVID-19 and the measures adopted have generated social changes in the normal dynamics of the general population and especially for health workers, who find themselves caring for patients with suspected or confirmed infection. Recent studies have detected in them depression and anxiety symptoms and burnout syndrome, with personal and social conditions impacting their response capacity during the health emergency. Our aim was to generate recommendations for the promotion and protection of the mental health of health workers and teams in the first line of care in the health emergency due to COVID-19. Read More

View Article and Full-Text PDF
September 2021

Neurological symptoms and neuroimaging alterations related with COVID-19 vaccine: Cause or coincidence?

Clin Imaging 2021 Sep 7;80:348-352. Epub 2021 Sep 7.

Department of Radiology, Clínica de Diagnóstico por Imagem (CDPI), Avenida das Américas, 4666, 302A, 303, 307, 325, 326, Barra da Tijuca, Rio de Janeiro, RJ Zip Code: 2640-102, Brazil.

Although vaccination against Coronavirus disease-2019 (COVID-19) is still occurring, several adverse effects temporally related to these vaccines are already being reported, even if through isolated case reports. In the present study, we describe the lesions seen on magnetic resonance imaging (MRI) of three patients who developed neurological symptoms after receiving the ChAdOX1 nCoV-19 vaccine (Oxford/AstraZeneca). The first patient presented with an ischemic stroke in the posterior limb of the left internal capsule, two days after vaccination. Read More

View Article and Full-Text PDF
September 2021

SARS-CoV-2 infection of the central nervous system in a 14-month-old child: A case report of a complete autopsy.

Lancet Reg Health Am 2021 Aug 28:100046. Epub 2021 Aug 28.

Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.

Background: Neurological and other systemic complications occur in adults with severe COVID-19. Here we describe SARS-CoV-2 infection complicated by neuroinvasion in the tissues of a child.

Methods: We performed a complete autopsy of a 14-month-old child who died of COVID-19 pneumonitis. Read More

View Article and Full-Text PDF

[Medico-legal aspects and professional liability of telemedicine in urology.]

Arch Esp Urol 2021 Sep;74(7):637-638

Colegio Oficial de Médicos de Barcelona. Barcelona. España.

Recientemente, Carrión et al. (1) publicaban un acertado análisis sobre el uso de la telemedicina (TM) en urología en el contexto de la pandemia por COVID-19. El escenario de emergencia durante la pandemia debida al SARS-CoV-2 ha propiciado un uso exponencial de la TM que ha permitido mantener el acceso y la continuidad de la atención a los pacientes y apoyar a los profesionales de primera línea, optimizando los servicios presenciales y minimizando las infecciones por transmisión del COVID-19 (2). Read More

View Article and Full-Text PDF
September 2021

A Cross-Sectional Study to Assess Knowledge of COVID-19 among Undergraduate Students in North-Central Ecuador.

Int J Environ Res Public Health 2021 08 18;18(16). Epub 2021 Aug 18.

School of Biological Science and Engineering, Yachay-Tech University, Hacienda San José, Urcuquí 100650, Ecuador.

Adherence to preventive measures is influenced by people's knowledge, attitudes and practices towards a disease; therefore, assessing knowledge of COVID-19 is critical in the overall effort to contain the outbreak. This cross-sectional study was conducted among undergraduates ( = 3621) of different programs and different levels of education associated with universities in north-central Ecuador. The form consisted of 32 questions covering demographics, symptoms, detection, treatment, transmission, prevention and knowledge of the virus. Read More

View Article and Full-Text PDF

Clinical Outcome Prediction in COVID-19 Patients by Lymphocyte Subsets Analysis and Monocytes' iTNF-α Expression.

Biology (Basel) 2021 Aug 1;10(8). Epub 2021 Aug 1.

UOC Biochimica Clinica, AORN Ospedali dei Colli-Monaldi-Cotugno-CTO, 80131 Napoli, Italy.

In December 2019, a novel coronavirus, "SARS-CoV-2", was recognized as the cause of coronavirus disease 2019 (COVID-19). Several studies have explored the changes and the role of inflammatory cells and cytokines in the immunopathogenesis of the disease, but until today, the results have been controversial. Based on these premises, we conducted a retrospective assessment of monocyte intracellular TNF-α expression (iTNF-α) and on the frequencies of lymphocyte sub-populations in twenty-five patients with moderate/severe COVID-19. Read More

View Article and Full-Text PDF

Pathological Features in 100 Deceased Patients With COVID-19 in Correlation With Clinical and Laboratory Data.

Pathol Oncol Res 2021 6;27:1609900. Epub 2021 Aug 6.

Research Institute of Human Morphology, Moscow, Russia.

Autopsies on COVID-19 deceased patients have many limitations due to necessary epidemiologic and preventative measures. The ongoing pandemic has caused a significant strain on healthcare systems and is being extensively studied around the world. Clinical data does not always corelate with post-mortem findings. Read More

View Article and Full-Text PDF

Mortality-related risk factors of COVID-19: a systematic review and meta-analysis of 42 studies and 423,117 patients.

BMC Infect Dis 2021 Aug 21;21(1):855. Epub 2021 Aug 21.

School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, Durban, South Africa.

Background: Mortality rates of coronavirus disease-2019 (COVID-19) continue to rise across the world. The impact of several risk factors on coronavirus mortality has been previously reported in several meta-analyses limited by small sample sizes. In this systematic review, we aimed to summarize available findings on the association between comorbidities, complications, smoking status, obesity, gender, age and D-dimer, and risk of mortality from COVID-19 using a large dataset from a number of studies. Read More

View Article and Full-Text PDF

Acute and Transient Psychotic Disorder induced by fear of coronavirus infection.

Eur J Psychotraumatol 2021;12(1):1954777. Epub 2021 Aug 10.

Department of Psychotic Disorders, Regionspsykiatrien Midt, Viborg, Denmark.

Background: Acute and Transient Psychotic Disorder (ATPD) (ICD-10) is characterized by the sudden onset of psychotic symptoms and can be triggered by psychological stress. In the ICD-10 definition of ATPD, episodes are short-term, lasting from days to three months, followed by complete remission.

Objective: This paper reports the case of a 37-year-old woman with stress-induced new-onset psychosis instigated by fear of coronavirus infection. Read More

View Article and Full-Text PDF

SARS-CoV-2 natural infection in animals: a systematic review of studies and case reports and series.

Vet Q 2021 Dec;41(1):250-267

Faculty of Health Sciences, Universidad Científica del Sur, Lima, Perú.

COVID-19 pandemic is essentially a zoonotic disease. In this context, early in 2020, transmission from humans to certain animals began reporting; the number of studies has grown since. To estimate the pooled prevalence of SARS-CoV-2 natural infection in animals and to determine differences in prevalence between countries, years, animal types and diagnostic methods (RT-PCR or serological tests). Read More

View Article and Full-Text PDF
December 2021

Hemorrhagic stroke associated to COVID-19 infection in Mexico General Hospital.

Cir Cir 2021 ;89(4):435-442

Stereotactic and Radiosurgery Department, Functional Neurosurgery, Mexico General Hospital, Mexico City, Mexico.

IntroducciÓn: en la actual pandemia de COVID-19, existe evidencia creciente que ha identificado el neurotropismo del virus SARS-CoV-2 y sus complicaciones neurológicas, incluida la enfermedad cerebrovascular isquémica y escasamente hemorragia cerebral (HC).

Objetivo: describir las características clínicas, radiológicas, de laboratorio y pronósticas de los pacientes con HC asociada al SARS-CoV-2.

MÉtodos: se incluyeron pacientes consecutivos con prueba de PCR confirmatoria para infección por SARS-CoV-2 y HC. Read More

View Article and Full-Text PDF

Risk factors associated with SARS-CoV-2 pneumonia in the pediatric population.

Bol Med Hosp Infant Mex 2021 ;78(4):251-258

Hospital de Especialidades Pediátricas, Centro Regional de Alta Especialidad Chiapas, Secretaría de Salud, Tuxtla Gutiérrez, Chiapas. Mexico.

IntroducciÓn: Hasta ahora existen pocos estudios sobre las características clínicas de la población pediátrica con neumonía por COVID-19. El objetivo de este estudio fue analizar los datos que se asocian con el desarrollo de neumonía en niños y adolescentes con infección por SARS-CoV-2 en México.

MÉtodos: Se llevó a cabo un análisis secundario de la base de datos de la Dirección General de Epidemiología del Gobierno Mexicano. Read More

View Article and Full-Text PDF

Critically ill infant with multisystem inflammatory syndrome related to COVID-19.

Bol Med Hosp Infant Mex 2021 ;78(4):335-340

Unidad de Terapia Intensiva Pediátrica, Hospital General Regional No. 220 General José Vicente Villada, Instituto Mexicano del Seguro Social, Toluca, State of Mexico. Mexico.

IntroducciÓn: La COVID-19 se ha convertido en una amenaza para la salud pública mundial. Sin embargo, las formas graves en niños son poco frecuentes. Se presenta el caso de un lactante con síndrome inflamatorio multisistémico relacionado con COVID-19. Read More

View Article and Full-Text PDF

COVID-19 and its impact on the control of Aedes (Stegomyia) aegypti mosquito and epidemiological surveillance of arbovirus infections.

Gac Med Mex 2021 ;157(2):187-193

Coordination of Vector-borne Diseases and Zoonosis, Servicios de Salud de Morelos, Cuernavaca, Morelos.

In American countries, simultaneously with the coronavirus disease 2019 (COVID-19) pandemic, epidemics caused by different arboviruses (dengue, chikungunya and Zika viruses) are occurring. In Mexico, several of the strategies to control the Aedes aegypti mosquito, which transmits arboviruses, involve the interaction of health personnel with the community. Due to the COVID-19 pandemic, social distancing and home confinement measures have been implemented. Read More

View Article and Full-Text PDF

Blood system ABO antigens as risk factor for severity of SARS-CoV-2 infection.

Gac Med Mex 2021 ;157(2):174-180

Donation and Transplantation Hospital Coordination.

Introduction: Whether there is an influence of the ABO blood system on SARS-CoV-2 infection is unknown.

Objective: To analyze if there is an association between the ABO system antigens and susceptibility to and severity of SARS-CoV-2 infection.

Material And Methods: The frequency of ABO system antigens was compared in 73 confirmed cases of SARS-CoV-2 infection and 52 clinically healthy donors. Read More

View Article and Full-Text PDF

Different Trends in Excess Mortality in a Central European Country Compared to Main European Regions in the Year of the COVID-19 Pandemic (2020): a Hungarian Analysis.

Pathol Oncol Res 2021 13;27:1609774. Epub 2021 Apr 13.

1st Department of Pulmonology, National Korányi Institute of Pulmonology, Semmelweis University, Budapest, Hungary.

This study examined cumulative excess mortality in European countries in the year of the Covid-19 pandemic and characterized the dynamics of the pandemic in different countries, focusing on Hungary and the Central and Eastern European region. Age-standardized cumulative excess mortality was calculated based on weekly mortality data from the EUROSTAT database, and was compared between 2020 and the 2016-2019 reference period in European countries. Cumulate weekly excess mortality in Hungary was in the negative range until week 44. Read More

View Article and Full-Text PDF

Colorectal Cancer that Highly Express Both and , Suggesting Severe Symptoms to SARS-CoV-2 Infection.

Pathol Oncol Res 2021 15;27:612969. Epub 2021 Apr 15.

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Dali University, Dali, China.

The epidemic of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in the world pose a global health emergency. Cancer has been identified as a risk factor for the novel Coronavirus disease 2019 (COVID-19). The and have been implicated in SARS-CoV-2 infection for mediating viral entry into the host cell. Read More

View Article and Full-Text PDF

C-Reactive protein and SOFA scale: A simple score as early predictor of critical care requirement in patients with COVID-19 pneumonia in Spain.

Rev Esp Anestesiol Reanim 2021 Jan 16. Epub 2021 Jan 16.

Departamento de Anestesiología y Reanimación, Hospital Universitario de Salamanca-IBSAL, Departamento de Medicina, Universidad de Salamanca, Salamanca, España.

Objective: To identify potential markers at admission predicting the need for critical care in patients with COVID-19 pneumonia.

Material And Methods: An approved, observational, retrospective study was conducted between March 15 to April 15, 2020. 150 adult patients aged less than 75 with Charlson comorbidity index ≤6 diagnosed with COVID-19 pneumonia were included. Read More

View Article and Full-Text PDF
January 2021

Extrathoracic manifestations of COVID-19 in adults and presentation of the disease in children.

Radiologia (Engl Ed) 2021 Jul-Aug;63(4):370-383. Epub 2021 May 19.

Servicio de Radiodiagnóstico, Hospital General Universitario de Alicante, Alicante, Spain; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain.

In March 2020, the World Health Organization declared a global pandemic of COVID-19, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); epidemic conditions continue in nearly all countries today. Although the symptoms and imaging manifestations of COVID-19 predominantly involve the respiratory system, it is fundamental to know the manifestations of the disease and its possible complications in other organs to help in diagnosis and orient the prognosis. To improve the diagnostic process without increasing the risk of contagion unnecessarily, it is crucial to know when extrathoracic imaging tests are indicated and which tests are best in each situation. Read More

View Article and Full-Text PDF

Clinical features and prognosis of COVID-19 patients with metabolic syndrome: A multicenter, retrospective study.

Med Clin (Barc) 2021 Jun 17. Epub 2021 Jun 17.

Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China. Electronic address:

Background: Few studies have investigated the impacts of metabolic syndrome (MS) on coronavirus disease 2019 (COVID-19). We described the clinical features and prognosis of confirmed COVID-19 patients with MS during hospitalization and after discharge.

Methods: Two hundred and thirty-three COVID-19 patients from the hospitals in 8 cities of Jiangsu, China were retrospectively included. Read More

View Article and Full-Text PDF

Analysis of Perceptions and Emotional Repercussions in Twitter Users in Colombia During the COVID-19 Pandemic.

Rev Colomb Psiquiatr 2021 Jun 17. Epub 2021 Jun 17.

Departamento de Epidemiología Clínica y Bioestadística, Pontificia Universidad Javeriana, Bogotá, Colombia; Departamento de Psiquiatría y Salud Mental, Pontificia Universidad Javeriana, Bogotá, Colombia; Hospital Universitario San Ignacio, Bogotá, Colombia.

Introduction: The COVID-19 pandemic has negatively impacted mental health. Up to a quarter of the population has reported mental health disorders. This has been studied mainly from a nosological perspective, according to diagnostic criteria. Read More

View Article and Full-Text PDF

Repercussions of COVID-19 on psychiatric inpatient care in Latin America and the Caribbean.

Rev Colomb Psiquiatr 2021 Jun 17. Epub 2021 Jun 17.

Facultad de Psicología, Universidad Nacional de Rosario, Argentina.

Objetive: To characterise the impact of the COVID-19 pandemic on psychiatric hospitalisations in the Latin American and Caribbean (LAC) region.

Methods: Descriptive study. 85 semi-structured interviews were conducted with health workers involved with psychiatric hospitalisations in general hospitals (GHs) and specialised psychiatric hospitals (SHs) from 18 LAC countries. Read More

View Article and Full-Text PDF

Management of patients with Intestinal Bowel Disease and COVID-19: A review of current evidence and future perspectives.

Gastroenterol Hepatol 2021 Jun 23. Epub 2021 Jun 23.

Digestive Disease Department, University of Valencia, Clinic University Hospital of Valencia, Valencia 46010, Spain.

The COVID-19 pandemic has been a challenge for countries and health professionals worldwide. Viral entry by ACE-2 receptor and an excessive activation of the immune system are key to understand both incidence and severity of disease. Inflammatory Bowel Disease (IBD) represents a special condition associated with an inordinate response of the immune system to external agents. Read More

View Article and Full-Text PDF

[Simulation during COVID-19 pandemic in the spanish pediatric intensive care units. New challenges in medical education].

An Pediatr (Barc) 2021 Jun 16. Epub 2021 Jun 16.

Servicio de Cuidados Intensivos Pediátricos, Hospital General Universitario Gregorio Marañón de Madrid, Instituto de Investigación sanitaria del Hospital Gregorio Marañón, Madrid, España.

View Article and Full-Text PDF