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Comments on "Acute Colonic Volvulus in a Mexican Population: A Case Series".

Ann Coloproctol 2021 Apr 21. Epub 2021 Apr 21.

Department of General Surgery, Faculty of Medicine, Ataturk University, Erzurum, Turkey.

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The Future of Quality Improvement for Cirrhosis.

Liver Transpl 2021 Apr 22. Epub 2021 Apr 22.

Division of Gastroenterology and Hepatology, University of Michigan.

Cirrhosis has a significant and growing impact on public health and patient reported outcomes. The increasing burden of cirrhosis has led to an emphasis on quality of care with the goal of improving overall outcomes in this high risk population. Existing evidence has shown the significant gaps in quality across process measures (e. Read More

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Medical and nutritional implications in chronic heart failure: strengths and limitations.

Arch Cardiol Mex 2021 ;91(2):221-228

Departamento de Nutriología Clínica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México.

Heart failure (HF) is one of the most important global public health problems, as there is an increase in its prevalence and an estimated 23 million of the world's population live with this problem. HF is defined by the presence of structural and functional abnormalities of the cardiac muscle leading to an impairment of ventricular filling and ejection. Multiple comorbidities have been associated with an increased risk of developing cardiovascular diseases. Read More

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January 2021

Carbon Monoxide Poisoning and Chronic Kidney Disease Risk: A Nationwide, Population-Based Study.

Am J Nephrol 2021 Apr 22:1-12. Epub 2021 Apr 22.

Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Introduction: Patients with carbon monoxide poisoning (COP) commonly have long-term morbidities. However, it is not known whether patients with COP exhibit an increased risk of developing chronic kidney disease (CKD) and whether hyperbaric oxygen therapy (HBOT) alters this risk.

Methods: This study identified 8,618 patients who survived COP and 34,464 propensity score-matched non-COP patients from 2000 to 2013 in a nationwide administrative registry. Read More

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The Burden of Reoperations and Timeline of Problems in 1,530 Cases of Mesh-Related Complications.

Urol Int 2021 Apr 22:1-8. Epub 2021 Apr 22.

Division of Pelvic Medicine and Reconstructive Surgery, University of California Los Angeles-UCLA, São Paulo, Brazil.

Background: Mesh-related complications resulting from pelvic organ prolapse (POP) reconstruction operations may be a devastating experience leading to multiple and complex interventions.

Objectives: The aim of the study was to describe the experience and time frame of management of mesh-related complications in women treated for POP or stress urinary incontinence in a tertiary center.

Methods: 1,530 cases of mesh-related complications were accessed regarding their clinical presentation, number of surgeries, and timeline of surgical treatments to treat multiple clinical complaints until the ultimate operation where all the meshes were removed in a single tertiary center. Read More

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Does Physical Activity Improve Cognition and Academic Performance in Children? A Systematic Review of Randomized Controlled Trials.

Neuropsychobiology 2021 Apr 22:1-29. Epub 2021 Apr 22.

Laboratory of Biosciences of Human Kinetics - LABIMH, Department of Medicine, Tiradentes University (Unit), Aracaju, Brazil.

Introduction: In the last decades, different studies have investigated the effects of exercise or physical activity (PA) on cognitive functions and academic performance in children and adolescents. But given the inconsistencies regarding methodologies and the fact that many studies do not have controlled or randomized designs, a more recent review is needed in order to summarize the different outcomes and methodologies employed and correlate them from an applied perspective.

Objectives: The purpose of the present review is to systematically review and analyze the effects of acute and chronic PA interventions exclusively from randomized controlled trials (RCTs) on cognitive functions and academic performance of children and adolescents. Read More

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Factors Influencing Discussion of Cancer Genetic Testing with Health-Care Providers in a Population-Based Survey.

Public Health Genomics 2021 Apr 22:1-11. Epub 2021 Apr 22.

Department of Biostatistics, UT MD Anderson Cancer Center, Houston, Texas, USA.

Introduction: Discussion of cancer genetic testing with health-care providers (HCPs) is necessary to undergo testing to inform cancer risk assessment and prevention. Given the rapid evolution in genetic testing practice in oncology, we describe the current landscape of population-level cancer genetic testing behaviors.

Methods: A questionnaire including items regarding discussion of cancer genetic testing with HCPs was administered to a nonprobability sample (N = 2,029) of the Texas population. Read More

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Management of Home Parenteral Nutrition: Complications and Survival.

Ann Nutr Metab 2021 Apr 22:1-10. Epub 2021 Apr 22.

Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland.

Background And Aims: Parenteral nutrition (PN) has become an efficient, safe, and convenient treatment over years for patients suffering from intestinal failure. Home PN (HPN) enables the patients to have a high quality of life in their own environment. The therapy management however implies many restrictions and potentially severe lethal complications. Read More

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Outcomes of Interleukin-2 Receptor Antagonist Induction Therapy in Standard-Risk Renal Transplant Recipients Maintained on Tacrolimus: A Systematic Review and Meta-Analysis.

Am J Nephrol 2021 Apr 22:1-13. Epub 2021 Apr 22.

Institute of Medical Sciences, Faculty of Medicine, University of Liverpool, Liverpool, United Kingdom.

Introduction: The additive benefit of interleukin-2 receptor antagonist (IL2-RA) induction in standard-risk kidney transplant recipients, while maintained on tacrolimus-based immunosuppressive therapy, is uncertain.

Methods: We divided the studies included in this meta-analysis into 2 groups: group A (included studies that used same dose of tacrolimus in both arms of each study) and group B (included studies that compared patients who received induction therapy and low-dose tacrolimus vs. those who received no-induction therapy and high dose of tacrolimus). Read More

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Fertility Preservation for Prepubertal Patients at Risk of Infertility: Present Status and Future Perspectives.

Horm Res Paediatr 2021 Apr 22:1-10. Epub 2021 Apr 22.

Childhood Cancer Research Unit, Department of Women's and Children's Health, NORDFERTIL Research Laboratory Stockholm, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden.

The increasing cure rate of cancer has led to a vast population of survivors having to face the late adverse effects of oncological treatments, with fertility impairment being one of the most sensitive issues for patients. Different options to preserve the fertility of adult patients are routinely used in clinical practice. However, fertility preservation strategies for prepubertal patients at risk of infertility are limited to the cryopreservation of immature gonadal tissue. Read More

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Physical Frailty and Cognitive Impairment in Older Adults in United States Nursing Homes.

Dement Geriatr Cogn Disord 2021 Apr 22:1-8. Epub 2021 Apr 22.

Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Introduction: In older US nursing home (NH) residents, there is limited research on the prevalence of physical frailty, its potential dynamic changes, and its association with cognitive impairment in older adults' first 6 months of NH stay.

Methods: Minimum Data Set (MDS) 3.0 is the national database on residents in US Medicare-/Medicaid-certified NHs. Read More

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Prospective experimental treatment of colorectal cancer patients based on organoid drug responses.

ESMO Open 2021 Apr 19;6(3):100103. Epub 2021 Apr 19.

Department of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; Oncode Institute, Utrecht, The Netherlands; Department of Gastrointestinal Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Electronic address:

Background: Organoid technology has recently emerged as a powerful tool to assess drug sensitivity of individual patient tumors in vitro. Organoids may therefore represent a new avenue for precision medicine, as this circumvents many of the complexities associated with DNA- or transcriptional-profiling.

Materials And Methods: The SENSOR trial was a single-arm, single-center, prospective intervention trial to evaluate the feasibility of patient-derived organoids to allocate patients for treatment with off-label or investigational agents. Read More

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Selection of individuals for lung cancer screening based on risk prediction model performance and economic factors - The Ontario experience.

Lung Cancer 2021 Apr 19;156:31-40. Epub 2021 Apr 19.

Prevention and Cancer Control, Ontario Health (Cancer Care Ontario), Toronto, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Introduction: Randomized controlled trials have shown that screening with computed tomography reduces lung cancer mortality but is most effective when applied to high-risk individuals. Accurate lung cancer risk prediction models effectively select individuals for screening. Few pilots or programs have implemented risk models for enrolling individuals for screening in real-world, population-based settings. Read More

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Harms to children from the financial effects of others' drinking.

Int J Drug Policy 2021 Apr 19;94:103254. Epub 2021 Apr 19.

Centre for Alcohol Policy Research, La Trobe University, Australia; Melbourne School of Population and Global Health, University of Melbourne, Australia.

Background: Many children live with parents who drink and experience little impact, but risky or heavy drinking by caregivers can result in a range of harms to children. Alcohol-related financial harms which directly impact children's needs in general populations have been seldom studied.

Objective: The study aims to identify the prevalence and correlates of financial harms from others' drinking affecting children's needs in nine lower- and middle-income (LMICs) and high-income countries (HICs). Read More

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Participatory syndromic surveillance as a tool for tracking COVID-19 in Bangladesh.

Epidemics 2021 Apr 19;35:100462. Epub 2021 Apr 19.

Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, USA.

Limitations in laboratory diagnostic capacity and reporting delays have hampered efforts to mitigate and control the ongoing coronavirus disease 2019 (COVID-19) pandemic globally. To augment traditional lab and hospital-based surveillance, Bangladesh established a participatory surveillance system for the public to self-report symptoms consistent with COVID-19 through multiple channels. Here, we report on the use of this system, which received over 3 million responses within two months, for tracking the COVID-19 outbreak in Bangladesh. Read More

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Bovine cysticercosis in the State of São Paulo, Brazil: Prevalence, risk factors and financial losses for farmers.

Prev Vet Med 2021 Apr 18;191:105361. Epub 2021 Apr 18.

Centro Universitário Central Paulista (UNICEP), Rua Miguel Petroni, 5111, 13563-470, São Carlos, Brazil. Electronic address:

Taenia saginata is the causative agent of bovine cysticercosis (BCC) and human taeniasis, two diseases that have economical and public health importance, respectively. This research focused on determining BCC prevalence in the state of São Paulo state, Brazil, in the period of 2017-2019, as well as associating risk factors related to disease occurrence and estimate the economic impact to beef producers. Data from 6,277,758 bovine carcasses originating from 571 municipalities and 15 different mesoregions in the state of São Paulo was gathered and analyzed. Read More

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Violence risk assessment for young adults receiving treatment for early psychosis.

Int J Law Psychiatry 2021 Apr 19;76:101701. Epub 2021 Apr 19.

Department of Psychiatry, Columbia University Irving Medical Center and New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA.

Aim: Although the absolute risk of violence is small for individuals with mental illnesses, a specific subgroup of individuals who appear to be at increased risk for violence includes young people experiencing emerging or early psychosis. Prior research has identified risk factors for violence in this population, though no prior studies using a formal risk assessment tool have been identified. This study used the Historical Clinical Risk Management-20, version 3 (HCR-20) to identify risk of future violence among a sample of young adults with early psychosis and relevant predictors of risk unique to this population. Read More

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[Proposal for territorial analysis to face the SARS-CoV-2 pandemic based on the Profile of pneumonia and Influenza in Ecuador 2016-2018].

Aten Primaria 2021 Feb 23;53(5):102021. Epub 2021 Feb 23.

Universidad Central del Ecuador, Facultad de Ciencias Médicas, Quito, Ecuador.

Objective: The present study seeks to analyse sociodemographic determinants related to severe acute respiratory infections (SARI) and calculate the priorization index in the cantons of Ecuador to identify areas probably most vulnerable to COVID-19 transmission.

Design: This descriptive ecological observational study.

Setting: 224 cantons (geographical area) of Ecuador with secondary data sources of hospital information. Read More

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February 2021

Sex out of marriage and condom use among homeless youth in Iran.

Public Health 2021 Apr 19;194:116-120. Epub 2021 Apr 19.

HIV/STI Surveillance Research Center, And WHO Collaborating Center for HIV Surveillance Institute for Futures Studies in Health Kerman University of Medical Sciences, Kerman, Iran.

Objectives: Sexual behaviors of homeless youth in Iran have not been well studied. This study aimed to measure the frequency and associated factors of sex out of marriage and condom use among homeless youth in Kerman, Iran.

Study Design: In this cross-sectional study, we recruited 202 homeless youth (age: 15-29 years who experienced 30 or more days of homelessness in the last 12 months) from 11 street locations between September to December 2017. Read More

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CD45RACD25CD127CD4 activated regulatory T cells are correlated with de novo donor-specific anti-HLA antibody formation after kidney transplantation in standard immunosuppression.

Int Immunopharmacol 2021 Apr 19;97:107661. Epub 2021 Apr 19.

Department of Transplant Surgery, Tokai University School of Medicine, Kanagawa, Japan.

Although de novo donor-specific anti-HLA antibodies (dnDSA) remain a barrier for human kidney transplantation (KTx), the role of regulatory T (Treg) cells in dnDSA formation remains unknown. To address this question, we evaluated Treg cell subsets in peripheral blood mononuclear cells in 15 healthy volunteers and 59 KTx recipients using flow cytometric analysis. The post-transplant CD25CD127CD4 Treg cells in KTx recipients were down-regulated compared with those of healthy volunteers (P < . Read More

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Paeoniflorin protects against dextran sulfate sodium (DSS)-induced colitis in mice through inhibition of inflammation and eosinophil infiltration.

Int Immunopharmacol 2021 Apr 19;97:107667. Epub 2021 Apr 19.

Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, China; State Key Laboratory of Pharmaceutical Biotechnology, Medical School, Nanjing University, China; Shenzhen Research Institute of Nanjing University, Shenzhen, China. Electronic address:

Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) that causes inflammation and ulcers in the digestive tract. The treatment commonly includes anti-inflammatory agents like 5-aminosalicylic acid or corticosteroids or biologics for people with UC who are no longer responding to corticosteroids. The radices of Paeonia lactiflora Pall. Read More

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Fine particulate matter and body weight status among older adults in China: Impacts and pathways.

Health Place 2021 Apr 19;69:102571. Epub 2021 Apr 19.

School of Economics and Finance, Xi'an Jiaotong University, 710061 Xi'an, China.

Background: Population ageing and air pollution have become two major public health concerns in China. Longitudinal evidence on the body weight impacts of air pollution among older adults is rare. This study aims to investigate the impacts of ambient particulate matter with aerodynamic diameters ≤2. Read More

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Diagnostic approach to sleep disordered-breathing among patients with grade III obesity.

Sleep Med 2021 Mar 29;82:18-22. Epub 2021 Mar 29.

AP-HP, Groupe Hospitalier Universitaire APHP-Sorbonne Université, site Pitié-Salpêtrière, Service de Pathologies Du Sommeil (Département R3S), F-75013 Paris, France; Sorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.

Sleep apnea test (SAT) is a cost-effective approach to evaluate subjects without associated comorbidities suspected for obstructive sleep apnea (OSA), a disorder particularly common in obese subjects. The association of obesity with awake hypercapnia (carbon dioxide arterial pressure, PaCO ≥45 mmHg) defines the obesity-hypoventilation syndrome (OHS), which in turn results in increased morbidity and mortality compared to simple OSA. Isolated hypoventilation during sleep in obese patients (obesity-related sleep hypoventilation, ORSH) is now considered as an early stage of OHS. Read More

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IDH1 single nucleotide polymorphism improves progression free survival in patients with IDH mutated grade II and III gliomas.

Pathol Res Pract 2021 Apr 19;221:153445. Epub 2021 Apr 19.

Department of Oncology, AUSL Bologna, Bologna, Italy.

Background: A synonymous single nucleotide polymorphism (SNP) is a substitution of a single base that does not modify the primary amino acid sequence but could influence protein function. In patients with brain tumors, the incidence of the silent SNP IDH 1 105GGT (rs11554137) is three times higher than the normal population.

Methods: Our aim was to investigate the prognostic role of the IDH 1 105GGT SNP. Read More

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Development, item analysis, and initial reliability and validity of three forms of a multiple-choice mental health literacy assessment for college students (MHLA-c).

Psychiatry Res 2021 Mar 24;300:113897. Epub 2021 Mar 24.

New York State Psychiatric Institute, New York, NY, USA.

Despite increasing rates of mental health disorders among college students, there are a limited number of validated mental health literacy measures that can be quickly administered and scored in this population. We developed a 54-item multiple-choice measure, consisting of three forms with 18 items on each form. Our items focus on knowledge of more than 20 mental health disorders including their etiology, risk factors, diagnoses, symptoms, treatment, course, and outcome, as well as the application of this knowledge to real world situations. Read More

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