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Renal Impairment and Risk of Acute Stroke: The INTERSTROKE Study.

Neuroepidemiology 2021 May 5:1-10. Epub 2021 May 5.

Estudios Clinicos Latinoamerica, Rosario, Argentina.

Background: Previous studies reported an association of renal impairment with stroke, but there are uncertainties underpinning this association.

Aims: We explored if the association is explained by shared risk factors or is independent and whether there are regional or stroke subtype variations.

Methods: INTERSTROKE is a case-control study and the largest international study of risk factors for first acute stroke, completed in 27 countries. Read More

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Intramuscular fatty infiltration and physical function in controlled acromegaly.

Eur J Endocrinol 2021 May 1. Epub 2021 May 1.

E Valassi, Endocrinology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Introduction: Patients with acromegaly show musculoskeletal symptoms which may persist despite disease control. Increased intramuscular fat fraction is a known cause of muscle dysfunction in several disorders.

Objective: To assess the degree of fat fraction in thigh muscles of controlled acromegaly patients, and its relationship with muscle dysfunction. Read More

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Impaired bone microarchitecture and strength in patients with tumor-induced osteomalacia.

J Bone Miner Res 2021 May 5. Epub 2021 May 5.

IDIM, Universidad del Salvador, Buenos Aires, Argentina.

Some studies based on bone biopsy have demonstrated that in patients with tumor-induced osteomalacia (TIO) the mineralization process of the bone matrix is profoundly disturbed. However, the interrelationship between clinical and biochemical features and bone microarchitecture in this disease needs further analysis. With this purpose in mind, we set out three objectives: i) to determine bone microarchitecture and estimated bone strength in a group of patients with tumor-induced osteomalacia using high-resolution peripheral quantitative computed tomography (HR-pQCT) and finite element analysis (FEA), ii) to investigate correlations between duration of disease, biochemical features, bone density, HR-pQCT and FEA parameters, and iii) to compare HR-pQCT and FEA parameters with a healthy control group. Read More

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The Impact of Socioeconomic Status on Stage at Presentation, Receipt of Diagnostic Imaging, Receipt of Treatment, and Overall Survival in Colorectal Cancer Patients.

Int J Cancer 2021 May 5. Epub 2021 May 5.

Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Socioeconomic factors influence patterns of care in colorectal cancer. This study investigates the impact of socioeconomic status (SES) on stage at presentation, receipt of diagnostic imaging, receipt of treatment, and overall survival (OS) in a universal healthcare system. The Ontario Cancer Registry (OCR) was accessed to identify a cohort of patients diagnosed with colorectal adenocarcinoma from 2007-2016 in Ontario, Canada. Read More

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Conditional disease-free survival rates and their associated determinants in patients with epithelial ovarian cancer: A 15-year retrospective cohort study.

Cancer Rep (Hoboken) 2021 May 5:e1416. Epub 2021 May 5.

Oral and Dental Disease Research Center, Department of Operative Dentistry, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: The most common type of ovarian cancer (OC) is epithelial ovarian cancer (EOC) which is the most lethal gynecologic malignancy in adult women.

Aim: This study aimed to determine the conditional disease-free survival (CDFS) rates and their associated determinants in patients with EOC.

Methods And Results: The clinical and demographic data of 335 patients with confirmed EOC at Motahari Clinic (Shiraz, Iran) were retrospectively reviewed and analyzed. Read More

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Serum exosomal lncRNA XIST is a potential non-invasive biomarker to diagnose recurrence of triple-negative breast cancer.

J Cell Mol Med 2021 May 5. Epub 2021 May 5.

Shenzhen Woke Biomedical Technology Co., Ltd., Shenzhen, China.

Exosomal lncRNAs secreted by cancer cells can serve as potential biomarkers in the diagnosis and prognosis of various tumours. Here, we are committed to explore the diagnostic and prognostic value of serum exosomal XIST secreted by tumour cells to predict recurrence in patients with triple-negative breast cancer (TNBC). Significant increments in XIST and exo-XIST from tumour tissues and blood serum were found in reoccurring TNBC patients by comparison with non-recurrences. Read More

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Down-regulation of microRNA-125b-2-3p is a risk factor for a poor prognosis in hepatocellular carcinoma.

Bioengineered 2021 Dec;12(1):1627-1641

Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, P. R. China.

Hepatocellular carcinoma (HCC) is a leading cause of mortality in cancer patients, but the association between miR-125b-2-3p and the onset and prognosis of HCC has not been reported in previous studies; thus, the clinicopathological implications of miR-125b-2-3p in HCC require elaboration. To examine the expression of miR-125b-2-3p in HCC, both in-house RT-qPCR and public datasets were used to calculate the standard mean difference (SMD) and the summary receiver operating characteristic (sROC). MiR-125b-2-3p was markedly lower in HCC than in non-tumor tissue as assessed by the in-house RT-qPCR which was confirmed by the integrative analysis showing the SMD being -0. Read More

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December 2021

Comparisons of Serologic Responses of Early Syphilis to Treatment with a Single-Dose Benzathine Penicillin G Between HIV-Positive and HIV-Negative Patients.

Infect Dis Ther 2021 May 4. Epub 2021 May 4.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung-Shan South Road, Taipei, Taiwan.

Introduction: Poorer serologic responses of early syphilis to treatment have been inconsistently reported in HIV-positive patients compared with HIV-negative patients, but the interpretation of previous studies is limited by discrepant study designs. The present study aimed to evaluate the effect of HIV infection on the treatment response to a single dose of benzathine penicillin G (BPG) for early syphilis.

Methods: From January 2015 to March 2020, adult patients with early syphilis who received a single dose of BPG were enrolled and rapid plasma reagin (RPR) titers were periodically determined. Read More

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Outcomes of infratentorial cranial surgery for tumor resection in older patients: An analysis of the National Surgical Quality Improvement Program.

Surg Neurol Int 2021 8;12:144. Epub 2021 Apr 8.

Department of Neurosurgery, Rhode Island Hospital, Rhode Island, United States.

Background: Poorer outcomes for infratentorial tumor resection have been reported. There is a lack of large multicenter analyses describing infratentorial surgery outcomes in older patients. We characterized outcomes in patients aged ≥65 years undergoing infratentorial cranial surgery. Read More

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Treatment of type IV Pipkin fracture in patients with a high BMI via hip arthroscopy-assisted surgery: a case report.

J Hip Preserv Surg 2020 Aug 21;7(3):518-523. Epub 2020 Dec 21.

Department of Orthopaedic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123, Ta Pei Road, Niao Sung Dist., Kaohsiung, Taiwan.

Pipkin type IV femoral head (FH) fracture-dislocations are usually treated via open surgery. There are many surgical approaches for the treatment of this difficult fracture depending on the fracture pattern. Obesity presents another challenging problem in surgical treatment and sometimes leads to a poorer outcome. Read More

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Understanding global brain network alterations in glioma patients.

Brain Connect 2021 May 5. Epub 2021 May 5.

Amsterdam UMC Locatie VUmc, 1209, Anatomy & Neurosciences and Brain Tumor Center Amsterdam , Amsterdam, Noord-Holland, Netherlands.

Introduction: Glioma patients show increased global brain network clustering relating to poorer cognition and epilepsy. However, it is unclear whether this increase is spatially widespread, localized in the (peri)tumor region only, or decreases with distance from the tumor.

Materials And Methods: Weighted global and local brain network clustering was determined in 71 glioma patients and 53 controls using magnetoencephalography. Read More

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Sex-stratified outcomes of primary percutaneous coronary intervention: A tertiary care experience.

Asian Cardiovasc Thorac Ann 2021 May 4:2184923211014001. Epub 2021 May 4.

Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan.

Background: ST elevation myocardial infarction (STEMI) is an acute cardiac manifestation that requires immediate revascularization preferably through primary percutaneous coronary intervention (PCI). This study aims to describe gender stratified outcomes and epidemiological profile of STEMI patients undergoing treatment at a tertiary care hospital in Karachi, Pakistan.

Methods: A 5-year, retrospective analysis of hospital records was undertaken on confirmed STEMI patients admitted between 2010 and 2014, undergoing primary PCI. Read More

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Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer.

Curr Oncol 2021 Apr 29;28(3):1663-1672. Epub 2021 Apr 29.

Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.

(1) This study investigated the prognostic impact of tumor size in patients with metastatic cervical cancer. (2) Methods: Seventy-three cervical cancer patients in our institute were stratified into two groups based on distant metastasis: para-aortic lymph node metastasis alone (IIIC2) or spread to distant visceral organs with or without para-aortic lymph node metastasis (IVB) to identify primary tumor size and concurrent chemoradiotherapy. (3) Results: The overall survival (OS) for patients with a tumor >6. Read More

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Predictors of Cognitive Performance Among Infants Treated for Brain Tumors: Findings From a Multisite, Prospective, Longitudinal Trial.

J Clin Oncol 2021 May 4:JCO2001687. Epub 2021 May 4.

Department of Psychology, St Jude Children's Research Hospital, Memphis, TN.

Purpose: Infants treated for CNS malignancies experience a significantly poorer response to treatment and are particularly at risk for neuropsychological deficits. The literature is limited and inconsistent regarding cognitive outcomes among this group. We investigated predictors of cognitive outcomes in children treated for brain tumors during infancy as part of a large, prospective, multisite, longitudinal trial. Read More

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Health outcomes among detoxification patients: The role of chronic pain.

Appl Psychol Health Well Being 2021 May 4. Epub 2021 May 4.

Center for Innovation to Implementation, Veterans Affairs (VA) Health Care System, Menlo Park, CA, USA.

Understanding associations between chronic pain and health outcomes among detoxification patients may help improve treatment outcomes and abstinence rates. Exercise is a modifiable lifestyle factor that may reduce the effect of pain on outcomes in this population. The current study examined whether baseline pain, exercise, and their interaction were associated with psychiatric and medical severity, and abstinence self-efficacy, over six months following detoxification. Read More

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Adhesion GPR123 is an indicator for recurrence and prognosis in bladder cancer.

Genes Genomics 2021 May 4. Epub 2021 May 4.

Department of Health Care, Jinan Municipal Hospital of Traditional Chinese Medicine, 76 Gongqingtuan road, Jinan, Shandong, China.

Background: Bladder cancer is a common urinary cancer, and most patients suffer tumor recurrence after surgery. Identifying more prognostic biomarkers is an essential task for precious treatment.

Objective: To evaluate the expression and clinical significance of GPR123, Angiotensin-I a type of adhesion G protein-coupled receptors (aGPCRs), in bladder cancer. Read More

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Pals1 prevents Rac1-dependent colorectal cancer cell metastasis by inhibiting Arf6.

Mol Cancer 2021 May 4;20(1):74. Epub 2021 May 4.

Department of Medical Cell Biology, Medical Clinic D, University Hospital of Münster, Albert-Schweitzer-Campus 1-A14, 48149, Münster, Germany.

Loss of apical-basal polarity and downregulation of cell-cell contacts is a critical step during the pathogenesis of cancer. Both processes are regulated by the scaffolding protein Pals1, however, it is unclear whether the expression of Pals1 is affected in cancer cells and whether Pals1 is implicated in the pathogenesis of the disease.Using mRNA expression data and immunostainings of cancer specimen, we show that Pals1 is frequently downregulated in colorectal cancer, correlating with poorer survival of patients. Read More

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Lung carcinoid tumors with Diffuse Idiopathic Pulmonary NeuroEndocrine Cell Hyperplasia (DIPNECH) exhibit pejorative pathological features.

Lung Cancer 2021 Apr 30;156:117-121. Epub 2021 Apr 30.

Department of Thoracic Surgery, Hôpital Cochin, APHP.CUP, Université de Paris, France. Electronic address:

Introduction: Diffuse Idiopathic Pulmonary NeuroEndocrine Cell Hyperplasia (DIPNECH) is a rare disease often associated with carcinoid tumors. We aimed at evaluating the impact of DIPNECH on characteristics and prognosis of patients who underwent radical treatment of pulmonary carcinoid tumors.

Material And Methods: We reviewed all patients operated on for curative-intent resection of carcinoid tumor in our department from 2001 to 2020. Read More

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Simultaneous multi-slice readout-segmentation of long variable echo-trains for accelerated diffusion-weighted imaging of nasopharyngeal carcinoma: A feasibility and optimization study.

Clin Imaging 2021 Apr 29;79:119-124. Epub 2021 Apr 29.

Department of Radiology, Chongqing University Cancer Hospital, Chongqing, China. Electronic address:

Objectives: We aimed to evaluate the feasibility of simultaneous multi-slice readout segmentation of long variable echo-trains (SMS-RESOLVE) for diffusion-weighted imaging (DWI) of nasopharyngeal carcinoma (NPC) and determine the optimal acceleration factor of SMS-RESOLVE DWI compared with conventional RESOLVE DWI.

Materials And Methods: One hundred and five patients with histologically confirmed NPC were enrolled. DWIs including conventional RESOLVE DWI, SMS-RESOLVE DWI with acceleration factors of 2 and 3 (2 × SMS-RESOLVE and 3 × SMS-RESOLVE) were acquired at b-values of 0 and 800 s/mm. Read More

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Refining genotype-phenotype correlations in 304 patients with autosomal recessive polycystic kidney disease and PKHD1 gene variants.

Kidney Int 2021 Apr 30. Epub 2021 Apr 30.

Department of Pediatrics, University Hospital Cologne and University of Cologne, Faculty of Medicine, Cologne, Germany.

Autosomal recessive polycystic kidney disease (ARPKD) is a severe disease of early childhood that is clinically characterized by fibrocystic changes of the kidneys and the liver. The main cause of ARPKD are variants in the PKHD1 gene encoding the large transmembrane protein fibrocystin. The mechanisms underlying the observed clinical heterogeneity in ARPKD remain incompletely understood, partly due to the fact that genotype-phenotype correlations have been limited to the association of biallelic null variants in PKHD1 with the most severe phenotypes. Read More

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Performance of ABCD-10 and SCORTEN Mortality Prediction Models in a Cohort of Patients with Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.

J Am Acad Dermatol 2021 Apr 30. Epub 2021 Apr 30.

Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address:

Background: ABCD-10 has recently been proposed as an alternative to the SCORTEN model for predicting in-hospital mortality in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis. In contrast to SCORTEN, ABCD-10 incorporates prior dialysis and upweights the impact of cancer.

Objective: To determine ABCD-10's performance compared to SCORTEN in mortality prediction at a large, tertiary burn center. Read More

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Functional Disability Among Older Versus Younger Adults With Advanced Non-Small-Cell Lung Cancer.

JCO Oncol Pract 2021 May 3:OP2001004. Epub 2021 May 3.

Department of Psychology, The Ohio State University, Columbus, OH.

Purpose: To determine patient and disease characteristics associated with functional disability among adults with advanced non-small-cell lung cancer (NSCLC).

Methods: In a prospective cohort of participants newly diagnosed with advanced NSCLC and beginning systemic treatment, functional disability in usual activities, mobility, and self-care was measured using the EuroQol-5D-5L at baseline. Demographics, comorbidities, brain metastases, Eastern Cooperative Oncology Group performance status (ECOG PS), and psychologic variables (depression [Patient Health Questionnaire-9] and anxiety [Generalized Anxiety Disorder 7-item scale]) were captured. Read More

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Rectal Cancer Risk and Survival After Total Colectomy for IBD: A Population-Based Study.

Dis Colon Rectum 2021 May;64(5):583-591

1 Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus N, Denmark 2 Department of Surgery, Section of Coloproctology, Aarhus University Hospital, Aarhus N, Denmark 3 Department of Surgery, Randers Regional Hospital, Randers, Denmark.

Background: Patients undergoing total colectomy for IBD may develop cancer in the rectal remnant, but the association is poorly understood.

Objectives: This study aimed to examine the risk and prognosis of rectal cancer after total colectomy for IBD.

Design: This is a nationwide population-based study. Read More

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Effect of surgical complications on outcomes in breast cancer patients treated with mastectomy and immediate reconstruction.

Breast Cancer Res Treat 2021 May 3. Epub 2021 May 3.

Department of Breast Oncology, H. Lee Moffitt Cancer Center, 10920 McKinley Dr, Tampa, FL, 33612, USA.

Background: Operative complications affect recurrence in non-breast malignancies. Rising rates of mastectomy with immediate reconstruction and their increased post-operative complications fuel concerns for poorer outcome in breast cancer (BC). We sought to determine the effect of complications on recurrence in BC patients. Read More

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COVID-19 and the pituitary.

Pituitary 2021 May 3. Epub 2021 May 3.

Institute of Endocrine and Metabolic Sciences, San Raffaele Vita-Salute University and IRCC Hospital, Via Olgettina 60, 20132, Milan, Italy.

Background: Despite COVID-19 being identified as severe respiratory viral infection, progressively many relevant endocrine manifestations have been reported greatly contributing to the severity of the clinical presentation. Systemic involvement in COVID-19 is due to the ubiquitous expression of angiotensin-converting enzyme 2 (ACE2) receptor, responsible for the entry in the cells of SARS-CoV-2, Several reports in humans and animal models showed a significant ACE2 mRNA expression in hypothalamus and pituitary cells. Moreover, higher mortality and poorer outcomes have been widely described in COVID-19 patients with obesity, diabetes and vertebral fractures, which are all highly prevalent in subjects with pituitary dysfunctions. Read More

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[Solid pseudopapillary neoplasms of the pancreas : Diagnostics, surgical treatment and postoperative outcome].

Chirurg 2021 May 3. Epub 2021 May 3.

Klinik für Allgemein- und Viszeralchirurgie, St. Josef-Hospital Bochum, Klinikum der Ruhr-Universität Bochum, Gudrunstr. 56, 44791, Bochum, Deutschland.

Background: Malignant solid pseudopapillary neoplasms (SPN) are rare tumor entities of the pancreas. The prognosis for SPN is generally excellent, although some tumors have malignant potential and tend to metastasize or relapse.

Objective: The aim was to investigate whether there are histopathological or surgical risk factors that enable the biological potential of SPN to be estimated. Read More

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Long-term outcomes after operative treatment for tibial pilon fractures.

OTA Int 2019 Dec 22;2(4):e043. Epub 2019 Nov 22.

Department of Orthopaedic Surgery, Harvard Medical School Orthopedic Trauma Initiative, Massachusetts General Hospital.

Objectives: Aims of the present study were to establish generalizable outcome data on long-term functional outcomes and health-related quality of life (HRQoL) after operative treatment of pilon fractures on a large scale. Second, it was aimed to examine factors associated with these outcomes.

Design: Retrospective cohort study with follow-up by questionnaire. Read More

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December 2019

Acute total hip arthroplasty versus open reduction internal fixation for posterior wall acetabular fractures in middle-aged patients.

OTA Int 2019 Mar 12;2(1):e014. Epub 2019 Mar 12.

Orthopaedic Surgery, Hennepin County Medical Center, Minneapolis, Minnesota.

Introduction: Open reduction internal fixation (ORIF) is the standard of care for displaced acetabular fractures, but the inability to achieve anatomic reduction, involvement of the posterior wall, articular impaction, and femoral head cartilaginous injury are known to lead to poorer outcomes. Acute total hip arthroplasty (THA) is a reasonable treatment option for older patients with an acetabular fracture and risk factors for a poor outcome, but it is only described in case series. The purpose of this study is to compare outcomes of ORIF and acute THA in middle-aged patients with an acetabular fracture from a single center. Read More

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Long-term Outcomes of Lower Rectal Cancer Patients Treated with Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection after Preoperative Radiotherapy or Chemoradiotherapy.

J Anus Rectum Colon 2021 28;5(2):129-136. Epub 2021 Apr 28.

Department of Gastrointestinal Tract Surgery, School of Medicine Fukushima Medical University, Fukushima, Japan.

Objectives: The standard strategy for advanced rectal cancer (RC) is preoperative short-course radiotherapy (SCRT)/chemoradiotherapy (CRT) plus total mesorectal excision (TME) in Western countries; however, the survival benefit of adding chemotherapy to radiotherapy remains unclear. There is accumulating evidence that either SCRT/CRT or lateral pelvic lymph node dissection (LPND) alone may not be sufficient for local control of advanced RC. We herein retrospectively evaluated the clinical outcomes of patients who were treated by SCRT/CRT+TME+LPND, particularly focusing on the prognostic impact of lateral pelvic lymph node metastasis (LPNM). Read More

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Skin cancer in women of color: Epidemiology, pathogenesis and clinical manifestations.

Int J Womens Dermatol 2021 Mar 2;7(2):127-134. Epub 2021 Feb 2.

Callender Dermatology and Cosmetic Center, Glenn Dale, MD, United States.

Malignant melanoma and nonmelanoma skin cancers (NMSC), which include basal cell carcinoma and squamous cell carcinoma, account for 40% of all neoplasms in white patients, making these cancers the most common malignancy in the United States. Given the large number of NMSC cases in white patients, there is a correspondingly large body of literature addressing various aspects of epidemiology, pathogenesis, and treatment. The incidence of both malignant melanoma and NMSC is well established and remains significantly lower in patients with skin of color (SoC) when compared with white patients. Read More

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