100,662 results match your criteria poor vision


Transgenerational plasticity in the eye size of .

Biol Lett 2021 Jun 16;17(6):20210143. Epub 2021 Jun 16.

Department of Biology, University of Texas at Arlington, Arlington, TX 76019, USA.

It is well established that environmental signals can induce phenotypic responses that persist for multiple generations. The induction of such 'transgenerational plasticity' (TGP) depends upon the ability of organisms to accurately receive and process information from environmental signals. Thus, sensory systems are likely intertwined with TGP. Read More

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Multi-Resolution Aitchison Geometry Image Denoising for Low-Light Photography.

IEEE Trans Image Process 2021 Jun 15;PP. Epub 2021 Jun 15.

In the low-photon imaging regime, noise in the image sensors is dominated by shot noise, best modeled statistically as Poisson distribution. In this work, we show that the Poisson likelihood function is very well matched with the Bayesian estimation of the "difference of log of contrast of pixel intensities." More specifically, our work is rooted in statistical compositional data analysis, whereby we reinterpret the Aitchison geometry as a multi-resolution analysis in the log-pixel domain. Read More

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Subliminal perception is continuous with conscious vision and can be predicted from prestimulus EEG activity.

Eur J Neurosci 2021 Jun 15. Epub 2021 Jun 15.

Department of Psychology, Åbo Akademi University, Turku, Finland.

Individuals are able to discriminate visual stimuli they report not consciously seeing. This phenomenon is known as "subliminal perception." Such capacity is often assumed to be relatively automatic in nature, and rely on stimulus-driven activity in low-level cortical areas. Read More

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Parkinson's-disease-related changes in the behavioural synergy between eye movements and postural movements.

Eur J Neurosci 2021 Jun 14. Epub 2021 Jun 14.

Univ. Lille, Unité INSERM 1172, CHU Lille, Lille, France.

Patients with Parkinson's disease (PD patients) have been shown to exhibit abnormally low levels of synergy in their posture control. The goal of this study is to determine how synergic interactions between vision and posture are affected in PD patients. These synergic interactions were expected to be impaired because PD affects the basal ganglia, which are involved in the modulation of both types of movement. Read More

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Studying the ophthalmic toxicity potential of developed Ketoconazole loaded nanoemulsion formulation for ophthalmic administration.

Toxicol Mech Methods 2021 Jun 14:1-27. Epub 2021 Jun 14.

Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.

Ocular fungal infections are one of the essential reasons of vision loss especially in developing countries for tropical regions. Ketoconazole (KZ), a broad-spectrum anti-fungal drug, is a lipophilic compound and practically insoluble in water. Since topical ophthalmic drug delivery confronts low bioavailability, an in situ gel formulation designed to improve the residence time and consequently the bioavailability. Read More

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Paracentral Acute Middle Maculopathy Revealing a Giant Aortic Aneurysm.

Ocul Immunol Inflamm 2021 Jun 14:1-5. Epub 2021 Jun 14.

Department of Neurology, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.

: This report describes a case with paracentral acute middle maculopathy revealing a giant aortic aneurysm.: A 41-year-old man presented with unilaterally unexplained sudden vision loss in the left eye. Fundoscopy revealed a slightly pale r -26etinal reflex in the superior retinal hemifield. Read More

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Monocular Diplopia in Idiopathic Intracranial Hypertension: A Case Report and Literature Review.

Eur J Case Rep Intern Med 2021 4;8(5):002509. Epub 2021 May 4.

Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy.

Background: Diplopia is the double vision of a single object, and can be binocular or monocular. Binocular diplopia is caused by the misalignment of the visual axes, with images falling on the fovea of the fixating eye and on the extra-foveal retina of the non-fixating eye, as a consequence of both neurological (i.e. Read More

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Vision with spatial light modulator simulating multifocal contact lenses in an adaptive optics system.

Biomed Opt Express 2021 May 21;12(5):2859-2872. Epub 2021 Apr 21.

Instituto de Optica "Daza de Valdes", Consejo Superior de Investigaciones Cientificas, IO-CSIC, Serrano, 121, Madrid 28006, Spain.

Visual simulators are useful tools to provide patients experience of multifocal vision prior to treatment. In this study, commercially available center-near aspheric multifocal contact lenses (MCLs) of low, medium, and high additions were mapped on a spatial light modulator (SLM) and validated on a bench. Through focus visual acuity (TFVA) was measured in subjects through the SLM and real MCLs on the eye. Read More

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Hydrophobin HGFI assisted immunobiologic sensor based on a cascaded taper integrated ultra-long-period fiber grating.

Biomed Opt Express 2021 May 19;12(5):2790-2799. Epub 2021 Apr 19.

Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China.

A new type of cascaded taper integrated ultra-long-period fiber grating (ULPFG) based immunobiologic sensor has been developed that benefits from the self-assembled monolayer of class I hydrophobin HGFI. Due to the cascaded arc, discharge tapers constitute an ultra-long-period and circular symmetrical refractive index modulation along fiber axial direction, and by local integration in one period, the mode coupling would generate to the higher harmonic of LP, LP and LP modes in the wavelength range from 1300 nm to 1620 nm. The hydrophobic characteristic of the ULPFG surface is modified employing the HGFI, and the antibody molecule probes could be absorbed strongly on the HGFI nano-film, furthermore, the performances of immunobiologic sensing are investigated employing multiple control groups of matched and mismatched antigen molecule targets. Read More

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A low-cost, high-performance video-based binocular eye tracker for psychophysical research.

J Eye Mov Res 2021 May 5;14(3). Epub 2021 May 5.

Carl Zeiss Vision International GmbH, Aalen, Germany.

We describe a high-performance, pupil-based binocular eye tracker that approaches the performance of a well-established commercial system, but at a fraction of the cost. The eye tracker is built from standard hardware components, and its software (written in Visual C++) can be easily implemented. Because of its fast and simple linear calibration scheme, the eye tracker performs best in the central 10 degrees of the visual field. Read More

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Usability Evaluation of a Tablet-Based Intervention to Prevent Intradialytic Hypotension in Dialysis Patients During In-Clinic Dialysis: Mixed Methods Study.

JMIR Hum Factors 2021 Jun 14;8(2):e26012. Epub 2021 Jun 14.

School of Information, University of Michigan, Ann Arbor, MI, United States.

Background: Patients on hemodialysis receive dialysis thrice weekly for about 4 hours per session. Intradialytic hypotension (IDH)-low blood pressure during hemodialysis-is a serious but common complication of hemodialysis. Although patients on dialysis already participate in their care, activating patients toward IDH prevention may reduce their risk of IDH. Read More

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G-Protein-Coupled Receptors and Ischemic Stroke: a Focus on Molecular Function and Therapeutic Potential.

Mol Neurobiol 2021 Jun 12. Epub 2021 Jun 12.

Anatomical Sciences Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.

In ischemic stroke, there is only one approved drug, tissue plasminogen activator, to be used in clinical conditions for thrombolysis. New neuroprotective therapies for ischemic stroke are desperately needed. Several targets and pathways have been shown to confer neuroprotective effects in ischemic stroke. Read More

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Non-infectious uveitis affecting the posterior segment treated with fluocinolone acetonide intravitreal implant: 3-year fellow eye analysis.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, St. Franziskus Hospital Muenster, Muenster, Germany.

Background: Prevention of non-infectious uveitis of the posterior segment (NIU-PS) recurrence using 0.2 μg/day fluocinolone acetonide implant (FAi) was assessed over 3 years (NCT01694186). Outcomes for FAi-treated and fellow eyes with NIU-PS were compared, to evaluate FAi versus conventional treatment strategies. Read More

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Interventions to improve district-level routine health data in low-income and middle-income countries: a systematic review.

BMJ Glob Health 2021 Jun;6(6)

Department of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK

Background: Routine health information system(s) (RHIS) facilitate the collection of health data at all levels of the health system allowing estimates of disease prevalence, treatment and preventive intervention coverage, and risk factors to guide disease control strategies. This core health system pillar remains underdeveloped in many low-income and middle-income countries. Efforts to improve RHIS data coverage, quality and timeliness were launched over 10 years ago. Read More

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Effectiveness of a Teleophthalmology Vision Center in Treating Corneal Disorders and Its Associated Economic Benefits.

Cornea 2021 Jun 9. Epub 2021 Jun 9.

Department of Cornea and Refractive Surgery, Aravind Eye Care System, Madurai, India; Department of Cataract, S.V. Aravind Eye Hospital, Aravind Eye Care System, Tirupati, India.

Purpose: The aim of this study was to study the clinical and economic impact of a teleophthalmology-based vision center (VC) in the management of corneal diseases in rural south India.

Methods: Data of patients with corneal disorders who visited the VC in the year 2019 were analyzed for the total number of outpatient visits, the proportion of corneal cases that were treated at the VC, those referred to the base hospital (BH), and the costs of treatment.

Results: In 2019, 1131 (10%) of 10,850 patients who visited the VC were diagnosed with corneal disorders. Read More

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Convolutional fusion network for monaural speech enhancement.

Neural Netw 2021 May 25;143:97-107. Epub 2021 May 25.

Intelligent Sensing and Communications Research Group, School of Engineering, Newcastle University, Newcastle upon, Tyne NE1 7RU, UK. Electronic address:

Convolutional neural network (CNN) based methods, such as the convolutional encoder-decoder network, offer state-of-the-art results in monaural speech enhancement. In the conventional encoder-decoder network, large kernel size is often used to enhance the model capacity, which, however, results in low parameter efficiency. This could be addressed by using group convolution, as in AlexNet, where group convolutions are performed in parallel in each layer, before their outputs are concatenated. Read More

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Early recovery of frontal EEG slow wave activity during propofol sedation predicts outcome after cardiac arrest.

Resuscitation 2021 Jun 7. Epub 2021 Jun 7.

Department of Anaesthesiology, Intensive Care and Pain Medicine, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Aim Of The Study: EEG slow wave activity (SWA) has shown prognostic potential in post-resuscitation care. In this prospective study, we investigated the accuracy of continuously measured early SWA for prediction of the outcome in comatose cardiac arrest (CA) survivors.

Methods: We recorded EEG with a disposable self-adhesive frontal electrode and wireless device continuously starting from ICU admission until 48 h from return of spontaneous circulation (ROSC) in comatose CA survivors sedated with propofol. Read More

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Investigation of the accuracy of a low-cost, portable, autorefractor to provide well-tolerated eyeglass prescriptions: a randomized crossover trial.

Ophthalmology 2021 Jun 7. Epub 2021 Jun 7.

Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

Purpose: To compare patient preferences for eye glasses prescribed using a low-cost portable wavefront autorefractor versus standard subjective refraction.

Design: Randomized, cross-over clinical trial PARTICIPANTS: Patients aged 18-40 years presenting with refractive errors to a tertiary eye hospital in Southern India.

Methods: Participants underwent subjective refraction (SR) followed by autorefraction (AR) using the monocular version of the QuickSee device. Read More

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Predictive visuo-motor communication through neural oscillations.

Curr Biol 2021 Jun 3. Epub 2021 Jun 3.

Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy; Laboratory of Medical Physics and Magnetic Resonance, IRCCS Stella Maris, Pisa, Italy. Electronic address:

The mechanisms coordinating action and perception over time are poorly understood. The sensory cortex needs to prepare for upcoming changes contingent on action, and this requires temporally precise communication that takes into account the variable delays between sensory and motor processing. Several theorists have proposed synchronization of the endogenous oscillatory activity observed in most regions of the brain as the basis for an efficient and flexible communication protocol between distal brain areas, a concept known as "communication through coherence. Read More

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Calibration of the Activity Inventory Item Bank: A Patient-Reported Outcome Measurement Instrument for Low Vision Rehabilitation.

Transl Vis Sci Technol 2021 May;10(6):12

Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Purpose: To provide calibrated item measures and rating category thresholds for the Activity Inventory (AI), an adaptive visual function questionnaire, from difficulty ratings obtained from a large sample of new low vision patients at pre-rehabilitation baseline.

Methods: Baseline AI (510 items) rating scale data from five previous low vision rehabilitation outcome studies (n = 3623) were combined, and the method of successive dichotomizations was used to estimate calibrated item measures and rating category thresholds. Infit statistics were analyzed to evaluate the fit of the data to the model. Read More

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Advanced Retinal Imaging and Ocular Parameters of the Rhesus Macaque Eye.

Transl Vis Sci Technol 2021 May;10(6)

Department of Ophthalmology & Vision Science, School of Medicine, University of California-Davis, Sacramento, CA, USA.

Purpose: To determine the range of normal ocular biometry and perform advanced retinal imaging and functional assessment of the rhesus macaque eye.

Methods: We performed ocular phenotyping on rhesus macaques at the California National Primate Research Center. This process consisted of anterior and posterior segment eye examination by ophthalmologists, advanced retinal imaging, and functional retinal electrophysiology. Read More

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Microperimetry Hill of Vision and Volumetric Measures of Retinal Sensitivity.

Transl Vis Sci Technol 2021 Jun;10(7):12

Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford Biomedical Research Centre, Oxford, UK.

Purpose: Mean retinal sensitivity is the main output measure used in microperimetry. It is, however, of limited use in patients with poor vision because averaging is weighted toward zero in those with significant scotomas creating an artificial floor effect. In contrast, volumetric measures avoid these issues and are displayed graphically as a hill of vision. Read More

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Truncating a densely connected convolutional neural network with partial layer freezing and feature fusion for diagnosing COVID-19 from chest X-rays.

MethodsX 2021 5;8:101408. Epub 2021 Jun 5.

Batangas State University.

Deep learning and computer vision revolutionized a new method to automate medical image diagnosis. However, to achieve reliable and state-of-the-art performance, vision-based models require high computing costs and robust datasets. Moreover, even with the conventional training methods, large vision-based models still involve lengthy epochs and costly disk consumptions that can entail difficulty during deployment due to the absence of high-end infrastructures. Read More

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Invaginating Structures in Synapses - Perspective.

Front Synaptic Neurosci 2021 24;13:685052. Epub 2021 May 24.

Advanced Imaging Core, National Institute on Deafness and Other Communication Disorders/National Institutes of Health, Bethesda, MD, United States.

Invaginating structures are common in the synapses of most animals. However, the details of these invaginating structures remain understudied in part because they are not well resolved in light microscopy and were often misidentified in early electron microscope (EM) studies. Utilizing experimental techniques along with the latest advances in microscopy, such as focused ion beam-scanning EM (FIB-SEM), evidence is gradually building to suggest that the synaptic invaginating structures contribute to synapse development, maintenance, and plasticity. Read More

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Neuro-Ophthalmological Findings as First Manifestation of Occipital Tuberculoma.

Neuroophthalmology 2021 17;45(2):120-125. Epub 2020 Jul 17.

Ophthalmology Residents.

We present a 54-year-old male garbage collector, who came to the ophthalmology department due to one-month history of bilateral blurred vision, palinopsia, headache and visual geometrical hallucinations. The examination showed a normal anterior segment, a homonymous left upper central scotoma and tilted segmental hypoplasia of the optic nerve of the left eye. Contrast-enhanced brain magnetic resonance imaging showed a mass lesion in the right occipital cortex. Read More

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Abnormal interhemispheric functional connectivity in patients with strabismic amblyopia: a resting-state fMRI study using voxel-mirrored homotopic connectivity.

BMC Ophthalmol 2021 Jun 9;21(1):255. Epub 2021 Jun 9.

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

Background: Previous studies have demonstrated that strabismus amblyopia can result in markedly brain function alterations. However, the differences in spontaneous brain activities of strabismus amblyopia (SA) patients still remain unclear. Therefore, the current study intended to employthe voxel-mirrored homotopic connectivity (VMHC) method to investigate the intrinsic brain activity changes in SA patients. Read More

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A woman in her forties with unilateral blurred vision and pain upon eye movement.

Tidsskr Nor Laegeforen 2021 06 3;141(9). Epub 2021 Jun 3.

Background: Toxoplasmosis is a relatively common cause of infectious papillitis and neuroretinitis, which may affect both immunocompetent and immunodeficient patients.

Case Presentation: A previously healthy woman in her mid-forties presented with subacute onset of unilateral blurred vision and retrobulbar pain exacerbated by eye movements. Ophthalmological assessment revealed decimal best-corrected visual acuity of 0. Read More

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Oral antibiotics for chronic blepharitis.

Cochrane Database Syst Rev 2021 Jun 9;6:CD013697. Epub 2021 Jun 9.

Byers Eye Institute, Stanford University, Palo Alto, California, USA.

Background: Posterior blepharitis is common and causes ocular surface and lid damage as well as discomfort. It affects 37% to 47% of all ophthalmology patients; its incidence increasing with age. It is a multifactorial disease associated with multiple other pathologies, such as rosacea, meibomianitis, and infections. Read More

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An Audiovisual 3D-Immersive Stimulation Program in Hemianopia Using a Connected Device.

Am J Case Rep 2021 Jun 9;22:e931079. Epub 2021 Jun 9.

Donald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.

BACKGROUND Homonymous hemianopia is a loss of conscious vision in one hemifield, strongly affecting everyday life. Audiovisual stimulation programs improve visual perception in the blind hemifield; however, they use large equipment operated in clinical settings. Such treatments require frequent visits at the clinic, hampering the patient's adherence and compliance. Read More

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Survey and enlightenment on the wearing of protective equipment of nurses working on the front line against COVID-19.

Medicine (Baltimore) 2021 May;100(19):e25924

Deparment of Vascular Surgery, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, People's Republic of China.

Abstract: At present, coronavirus disease 2019 (COVID-19) remains a significant challenge for health workers around the world. This survey aims to highlight the status of the implementation of occupational protection measures for nurses working on the front line against COVID-19, and to analyze the problems in the process of wearing protective equipment.This cross-sectional study was conducted among 165 nurses who worked in COVID-19-stricken areas in China in March 2020. Read More

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