33,200 results match your criteria poor understanding


Stability of ligand-induced protein conformation influences affinity in maltose-binding protein.

J Mol Biol 2021 May 3:167036. Epub 2021 May 3.

Department of Biochemistry, Groningen Biomolecular Science and Biotechnology Institute University of Groningen, Nijenborgh 4, Groningen 9747 AG, The Netherlands. Electronic address:

Our understanding of what determines ligand affinity of proteins is poor, even with high-resolution structures available. Both the non-covalent ligand-protein interactions and the relative free energies of available conformations contribute to the affinity of a protein for a ligand. Distant, non-binding site residues can influence the ligand affinity by altering the free energy difference between a ligand-free and ligand-bound conformation. Read More

View Article and Full-Text PDF

COVID-19 incidence and mortality in the Metropolitan Region, Chile: Time, space, and structural factors.

PLoS One 2021 6;16(5):e0250707. Epub 2021 May 6.

Programa Centro Salud Pública, Facultad de Ciencias Médicas, Universidad de Santiago, Estación Central, Santiago, Chile.

Demographic, health, and socioeconomic factors significantly inform COVID-19 outcomes. This article analyzes the association of these factors and outcomes in Chile during the first five months of the pandemic. Using the municipalities Metropolitan Region's municipalities as the unit of analysis, the study looks at the role of time dynamics, space, and place in cases and deaths over a 100-day period between March and July 2020. Read More

View Article and Full-Text PDF

Metastasectomy of Sequential Asynchronous Metastatic Renal Cell Carcinoma to the Pancreas, Thyroid, Skin, Contralateral Kidney, and Lung with Cumulative Survival Beyond 10 Years: A Case Report and Clinicopathologic Review.

Am J Case Rep 2021 May 6;22:e931696. Epub 2021 May 6.

Department of Urology, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

BACKGROUND One-third of renal cell carcinoma cases present with an initial metastasis to various organs, emphasizing the tumor's unpredictable behavior. Prognosis is poor once metastasis is discovered. Multiple-organ involvement with metastatic lesions has a particularly dismal survival rate. Read More

View Article and Full-Text PDF

Addressing Obstetric Health Disparities among Refugee Populations: Training the Next Generation of Culturally Humble OB/GYN Medical Providers.

Teach Learn Med 2020 Oct 8:1-8. Epub 2020 Oct 8.

Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa, USA.

The burden of increasing obstetric morbidity and mortality in the United States disproportionately affects marginalized and vulnerable populations, including refugees. Many factors have been attributed to this disparity in birth outcomes, such as linguistic, cultural, and health system limitations. However, refugee health disparities have received little attention in the U. Read More

View Article and Full-Text PDF
October 2020

Terms of engagement for working with patients in a person-centred partnership: A secondary analysis of qualitative data.

Health Soc Care Community 2021 May 6. Epub 2021 May 6.

National Institute for Health Research, Applied Research Collaboration South West Peninsula (PenARC), Faculty of Health, Medicine, Dentistry and Human Sciences, University of Plymouth, Plymouth, UK.

Evidence is emerging of the potential of person-centred approaches to create partnerships between professionals and patients while also containing healthcare costs. This is important for enhancing outcomes in individuals with complex needs, who consistently report poor experiences with care. The shift towards person-centred care (PCC) is, however, a radical departure from the norm, with increased expectations of both professional and patient. Read More

View Article and Full-Text PDF

Theory of Mind in Offending: A Systematic Review.

Trauma Violence Abuse 2021 May 6:15248380211013143. Epub 2021 May 6.

School of Psychology, 2240University of Kent, Canterbury, United Kingdom.

Theory of mind (ToM) impairment is associated with poor social functioning in some psychological disorders (e.g., autism and schizophrenia). Read More

View Article and Full-Text PDF

Therapeutic cancer vaccine therapy for acute myeloid leukemia.

Immunotherapy 2021 May 6. Epub 2021 May 6.

Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.

Antitumor function of the immune system has been harnessed to eradicate tumor cells as cancer therapy. Therapeutic cancer vaccines aim to help immune cells recognize tumor cells, which are difficult to target owing to immune escape. Many attempts at vaccine designs have been conducted throughout the last decades. Read More

View Article and Full-Text PDF

Incidence, risk factors, and long-term outcomes associated with antibody-mediated rejection - the Long-Term Deterioration of Kidney Allograft Function (DeKAF) prospective cohort study.

Clin Transplant 2021 May 5:e14337. Epub 2021 May 5.

Department of Medicine, Hennepin County Medical Center, Hennepin Healthcare, Minneapolis Minnesota, USA.

Major gaps remain in our understanding of antibody-mediated rejection (AMR) after kidney transplant. We examined incidence, risk factors, response to treatment, and effects on outcomes of AMR at 7 transplant programs in the Long-Term Deterioration of Kidney Allograft Function prospective study cohort. Among 3131 kidney recipients, there were 194 observed AMR cases (6. Read More

View Article and Full-Text PDF

Navigational strategies underlying temporal phototaxis in Drosophila larvae.

J Exp Biol 2021 May 6. Epub 2021 May 6.

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.

Navigating across light gradients is essential for survival for many animals. However, we still have a poor understanding of the algorithms that underlie such behaviors. Here we develop a novel closed-loop phototaxis assay for Drosophila larvae in which light intensity is always spatially uniform but updates depending on the location of the animal in the arena. Read More

View Article and Full-Text PDF

Exploring Health Literacy, Transition Readiness, and Healthcare Utilization in Medicaid Chronically Ill Youth.

J Adolesc Health 2021 May 2. Epub 2021 May 2.

Center for Innovation in Pediatric Practice, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio; College of Medicine, Department of Pediatrics, The Ohio State University, Columbus, Ohio.

Purpose: Youths with special healthcare needs face challenges transitioning from pediatric to adult health care. Understanding possible mechanisms contributing to poor healthcare transition could improve care. This study explores associations between health literacy (HL), transition readiness, and healthcare utilization. Read More

View Article and Full-Text PDF

Public views on plastic pollution: Knowledge, perceived impacts, and pro-environmental behaviours.

J Hazard Mater 2021 Jun 28;412:125227. Epub 2021 Jan 28.

Centre for Environmental and Marine Studies (CESAM), Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal.

Nowadays, plastic pollution is considered an issue of global concern. This environmental problem results from human industrial and domestic activities, associated with poor management, from manufacturing processes to products' end life. In this perspective, human consumption and management of daily used plastic materials can play a determinant role to control this environmental issue. Read More

View Article and Full-Text PDF

"The sky is the limit; I am going there": experiences of hope among young women receiving a conditional cash transfer in rural South Africa.

Cult Health Sex 2021 May 5:1-17. Epub 2021 May 5.

MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Young women in South Africa face elevated risk of HIV infection compared to male peers. Cash transfers may mitigate their risk for HIV; however, there is limited understanding of mechanisms of impact. We explored hope as one potential mechanism. Read More

View Article and Full-Text PDF

How to manage endings in unsuccessful therapy: A qualitative comparison of youth and clinician perspectives.

Psychother Res 2021 May 5:1-14. Epub 2021 May 5.

Research Department for Clinical, Educational and Health Psychology, University College London, London, UK.

Approximately half of those who access child and adolescent mental health services do not show measurable improvement in symptoms. This study aimed to provide practice recommendations for managing treatment endings, particularly when outcomes have not improved. Semi-structured interviews were carried out with 26 young people with a history of anxiety and/or depression along with 7 roundtable sessions with 52 mental health clinicians. Read More

View Article and Full-Text PDF

Technology in the management of type 2 diabetes - present status and future prospects.

Diabetes Obes Metab 2021 May 5. Epub 2021 May 5.

Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.

The growing incidence of type 2 diabetes (T2D) is a significant health concern, representing 90% of diabetes cases worldwide. As the disease progresses, resultant insulin deficiency and hyperglycaemia necessitates insulin therapy in many cases. It has been recognised that a significant number of people who have a clinical requirement for insulin therapy, alongside their healthcare professionals, are reluctant to intensify treatment with insulin due to fear of hypoglycaemia, poor understanding of treatment regimens or lack of engagement and are therefore at higher risk of developing complications from poor glycaemic control. Read More

View Article and Full-Text PDF

Current status of gastrointestinal tract cancer brain metastasis and the use of blood-based cancer biomarker biopsy.

Clin Exp Metastasis 2021 May 5. Epub 2021 May 5.

Division of Molecular Oncology, Department of Translational Molecular Medicine, Saint John's Cancer Institute at Providence Saint John's Health Center, 2200 Santa Monica Blvd, Santa Monica, CA, 90404, USA.

Brain metastasis (BM) frequently occurs in patients with cutaneous melanoma, lung, and breast cancer; although, BM rarely arises from cancers of the gastrointestinal tract (GIT). The reported incidence of GIT cancer BM is less than 4%. In the last few years, effective systemic therapy has prolonged the survival of GIT patients and consequently, the incidence of developing BM is rising. Read More

View Article and Full-Text PDF

Oral Health in Rheumatoid Arthritis: Listening to Patients.

JDR Clin Trans Res 2021 May 5:23800844211012678. Epub 2021 May 5.

Department of Internal Medicine, Max Rady School of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Canada.

Introduction: Rates of periodontal disease and tooth loss are increased in individuals with rheumatoid arthritis (RA). Understanding factors that contribute to the increased burden of periodontal disease in RA is critical to improving oral health and arthritis outcomes.

Objectives: To determine the perceptions held by people with RA relating to their oral health, to identify patient-centered priorities for oral health research, and to inform optimal strategies for delivering oral health knowledge. Read More

View Article and Full-Text PDF

Leveraging clinical epigenetics in heart failure with preserved ejection fraction: a call for individualized therapies.

Eur Heart J 2021 May 5. Epub 2021 May 5.

Center for Molecular Cardiology, University of Zürich, Wagistrasse 12, Schlieren CH-8952, Switzerland.

Described as the 'single largest unmet need in cardiovascular medicine', heart failure with preserved ejection fraction (HFpEF) remains an untreatable disease currently representing 65% of new heart failure diagnoses. HFpEF is more frequent among women and associates with a poor prognosis and unsustainable healthcare costs. Moreover, the variability in HFpEF phenotypes amplifies complexity and difficulties in the approach. Read More

View Article and Full-Text PDF

Cilostazol eliminates radiation-resistant glioblastoma by re-evoking big conductance calcium-activated potassium channel activity.

Am J Cancer Res 2021 15;11(4):1148-1169. Epub 2021 Apr 15.

Institute of Basic Medical Sciences, National Cheng Kung University Hospital Taiwan.

In spite of radio- and chemotherapy, glioblastoma (GBM) develops therapeutic resistance leading to recurrence and poor prognosis. Therefore, understanding the underlying mechanisms of resistance is important to improve the treatment of GBM. To this end, we developed a radiation-resistant cell model by exposure to consecutive periods of irradiation. Read More

View Article and Full-Text PDF

Evaluation of clinical performance and survival rate of Straumann dental implants in Saudi Population based on cross-sectional study.

Sci Rep 2021 May 4;11(1):9526. Epub 2021 May 4.

Department of Restorative Dentistry, State University of New York at Buffalo School of Dental Medicine, Buffalo, New York, USA.

Risk indicators of peri-implantitis is still contradictory and somehow unclear in present literature therefore efforts should be done for better understanding of the exact etiology of peri-implant disease progression. The present study aimed to assess risk indicators associated with peri-implantitis by observing the changes in several periodontal parameters after implant placement. This cross-sectional study included 213 female and 271 male patients aged 26-87 years, who received 484 titanium implants (Straumann, Switzerland) at King Saud University's Dental College, Saudi Arabia. Read More

View Article and Full-Text PDF

An exploratory pilot study of the effect of modified hygiene kits on handwashing with soap among internally displaced persons in Ethiopia.

Confl Health 2021 May 4;15(1):35. Epub 2021 May 4.

Department of Disease Control, London School of Hygiene and Tropical Medicine, London, UK.

Background: Internally displaced persons fleeing their homes due to conflict and drought are particularly at risk of morbidity and mortality from diarrhoeal diseases. Regular handwashing with soap (HWWS) could substantially reduce the risk of these infections, but the behaviour is challenging to practice while living in resource-poor, informal settlements. To mitigate these challenges, humanitarian aid organisations distribute hygiene kits, including soap and handwashing infrastructure. Read More

View Article and Full-Text PDF

Understanding the characteristics of US cancer survivors with informal caregivers.

Cancer 2021 May 4. Epub 2021 May 4.

Agency for Healthcare Research and Quality, Rockville, Maryland.

Background: Although informal caregivers such as family and friends provide people with cancer needed physical care and emotional support, little is known about which individuals have access to such caregivers. The purpose of this article is to provide a nationally representative description of the sociodemographic characteristics of cancer survivors who have or had an informal caregiver in the United States.

Methods: Cross-sectional data were taken from the Experiences With Cancer Survivorship Supplement of the Medical Expenditure Panel Survey in 2011, 2016, and 2017. Read More

View Article and Full-Text PDF

Project20: Does continuity of care and community-based antenatal care improve maternal and neonatal birth outcomes for women with social risk factors? A prospective, observational study.

PLoS One 2021 4;16(5):e0250947. Epub 2021 May 4.

Department of Women and Children's Health, Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.

Background: Social factors associated with poor childbirth outcomes and experiences of maternity care include minority ethnicity, poverty, young motherhood, homelessness, difficulty speaking or understanding English, migrant or refugee status, domestic violence, mental illness and substance abuse. It is not known what specific aspects of maternity care work to improve the maternal and neonatal outcomes for these under-served, complex populations.

Methods: This study aimed to compare maternal and neonatal clinical birth outcomes for women with social risk factors accessing different models of maternity care. Read More

View Article and Full-Text PDF

Patients with Chronic Urticaria Remain Largely Undertreated: Results from the DERMLINE Online Survey.

Dermatol Ther (Heidelb) 2021 May 4. Epub 2021 May 4.

Department of Dermatology and Allergy, School of Medicine, Technical University of Munich, Munich, Germany.

Introduction: Chronic urticaria (CU) is an unpredictable disease, with high disease burden and a significant negative impact on quality of life, especially in patients of working age. Many patients are undertreated, and there is poor awareness of strategies to manage patients with CU in the real-world setting. The current study aimed to gain a better understanding of CU from the patients' perspective, including the body areas most affected by wheals and angioedema, the disease burden and current use of the healthcare system. Read More

View Article and Full-Text PDF

Sexual Dimorphism in Alternative Metabolic Pathways of L-Arginine in Circulating Leukocytes in Young People with Type 1 Diabetes Mellitus.

Endocr Res 2021 May 4:1-11. Epub 2021 May 4.

Department of Pathological Biochemistry, Institute of Biochemistryafter H. Buniatyan, NAS RA, Yerevan, Armenia.

: Sexual dimorphism in specific biochemical pathways and immune response, underlies the heterogeneity of type 1 diabetes mellitus (T1DM) and affects the outcome of immunotherapy. Arginase and nitric oxide (NO) synthase (NOS) metabolize L-arginine and play opposite roles in the immune response and autoimmune processes. We hypothesized that the above mentioned enzymes can be involved in sex and age differences in T1DM and its treatment. Read More

View Article and Full-Text PDF

Perceived knowledge, coping and diagnostic-therapeutic pathways of infertile couples trying to conceive: an Italian survey.

Minerva Obstet Gynecol 2021 May 4. Epub 2021 May 4.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Background: The last decades' increasing infertility risk factors have brought to a growing number of infertile couples. Knowledge regarding infertility and possible treatments ishowever-poor, leading to difficulty in coping and understanding. Knowing infertile couples' perceptions and needs may help clinicians develop services that better address these needs. Read More

View Article and Full-Text PDF

Oncogenic SNORD12B activates the AKT-mTOR-4EBP1 signaling in esophageal squamous cell carcinoma via nucleus partitioning of PP-1α.

Oncogene 2021 May 4. Epub 2021 May 4.

Shandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong Province, China.

Esophageal cancer is a complex malignancy and the sixth leading cause of cancer death worldwide. In Eastern Asia including China, about 90% of all incident cases have esophageal squamous cell carcinoma (ESCC). Mounting evidence elucidates that aberrant expression of various non-coding RNAs (ncRNAs) contributes to ESCC progression, but it remains unclear how small nucleolar RNAs (snoRNAs) are involved in ESCC development. Read More

View Article and Full-Text PDF

Impact of Air Pollution on Allergic Rhinitis and Asthma: Consensus Statement by Indian Academy of Pediatrics.

Indian Pediatr 2021 May 3. Epub 2021 May 3.

President 2020, Indian Academy of Pediatrics.

Justification: Rising air pollution is an ever-growing threat to many human diseases. Poor air quality has been directly correlated with respiratory allergies with a disproportionate affection among the pediatric age group. A clear understanding of common air pollutants and their potential contribution in allergic rhinitis and asthma is lacking. Read More

View Article and Full-Text PDF

Explaining the reasons for not maintaining the health guidelines to prevent COVID-19 in high-risk jobs: a qualitative study in Iran.

BMC Public Health 2021 05 3;21(1):848. Epub 2021 May 3.

Health Promotion Research Center, Iran University of Medical Sciences, Tehran, Iran.

Background: Although the workers in many occupations are at the greatest risk of catching and spreading COVID-19 due to assembling and contacting people, the owners of these occupations do not follow COVID-19 health instructions. The purpose of this study is to explain the reasons for not maintaining health guidelines to prevent COVID-19 in high-risk jobs in Iran.

Methods: The present study was conducted with a qualitative approach among people with high-risk jobs in Tehran during March and April of 2020. Read More

View Article and Full-Text PDF

Predictors of iron consumption for at least 90 days during pregnancy: Findings from National Demographic Health Survey, Pakistan (2017-2018).

BMC Pregnancy Childbirth 2021 May 3;21(1):352. Epub 2021 May 3.

Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.

Background: Iron supplementation is considered an imperative strategy for anemia prevention and control during pregnancy in Pakistan. Although there is some evidence on the predictors of iron deficiency anemia among Pakistani women, there is a very limited understanding of factors associated with iron consumption among Pakistani pregnant women. Thus, this study aimed to investigate the predictors of iron consumption for at least ≥90 days during pregnancy in Pakistan. Read More

View Article and Full-Text PDF