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Eur J Heart Fail 2022 May 22. Epub 2022 May 22.

ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.

The left atrium is a dynamic chamber with peculiar characteristics. Stressors and disease mechanisms may deeply modify its structure and function, leading to left atrial remodeling and disease. Left atrial disease is a predictor of poor outcomes. Read More

J Clin Ultrasound 2022 May 21. Epub 2022 May 21.

Department of Cardiology, Koç University Hospital, Istanbul, Turkey.

Objective: Pulmonary complications are common in patients with liver cirrhosis. Devolopment of pulmonary hypertension (PH) is associated with a poor prognosis in these patients. Pulmonary arterial stiffness (PAS) is considered an early sign of pulmonary vascular remodeling. Read More

Cancer Cell Int 2022 May 21;22(1):197. Epub 2022 May 21.

NHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, No. 12 Changjia Lane, Jingzhong Street, Mianyang, 621000, People's Republic of China.

Background: This study aims to clarify the mechanistic action of long non-coding RNA (lncRNA) SNHG12 in the development of renal cell carcinoma (RCC), which may be associated with promoter methylation modification by KMT2B and the regulation of the E2F1/CEP55 axis.

Methods: TCGA and GEO databases were used to predict the involvement of SNHG12 in RCC. Knockdown of SNHG12/E2F1/CEP55 was performed. Read More

Cell Discov 2022 May 21;8(1):48. Epub 2022 May 21.

Department of Cell Biology and Department of Gastroenterology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

PCIF1 (phosphorylated CTD interacting factor 1) is the first reported RNA N6,2'-O-dimethyladenosine (mAm) methyltransferase. However, the pathological significance of PCIF1 and mAm modification remains unknown. Here we find that both PCIF1 expression and mAm modification are significantly elevated in gastric cancer tissues. Read More

Cell Death Dis 2022 May 21;13(5):488. Epub 2022 May 21.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, PR China.

Cervical cancer (CC) patients with lymph node metastasis (LNM) have a poor prognosis. Clarification of the detailed mechanisms underlying LNM may provide potential clinical therapeutic targets for CC patients with LNM. However, the molecular mechanism of LNM in CC is unclear. Read More

Cell 2022 May 13. Epub 2022 May 13.

CRCM, Inserm, CNRS, Institut Paoli-Calmettes, Aix-Marseille Univ, Epithelial Stem Cells and Cancer Lab, Equipe labellisée LIGUE contre le cancer, Marseille 13273, France. Electronic address:

X inactivation (XCI) is triggered by upregulation of XIST, which coats the chromosome in cis, promoting formation of a heterochromatic domain (Xi). XIST role beyond initiation of XCI is only beginning to be elucidated. Here, we demonstrate that XIST loss impairs differentiation of human mammary stem cells (MaSCs) and promotes emergence of highly tumorigenic and metastatic carcinomas. Read More

Cytokine 2022 May 18;155:155911. Epub 2022 May 18.

Department of Critical Care Medicine, Affiliated Yixing People's Hospital, Jiangsu University, Yixing, China. Electronic address:

Background: Recently, many diagnostic biomarkers were reported, but each had its own limitation. However, there is a need for an effective sensitivity and specificity of biomarker in diagnosis and prognosis of sepsis. In this context, progranulin (PGRN), at elevated levels, has been associated with poor prognosis in infectious diseases. Read More

Clin Neurol Neurosurg 2022 May 17;218:107294. Epub 2022 May 17.

Department of Neurosurgery, Clinical Medical College,Yangzhou University, Yangzhou 225000, China. Electronic address:

Objectives: The study aimed to investigate disorders of consciousness (DOC) mechanisms of patients with severe traumatic brain injury (sTBI) related to default mode network (DMN) and to introduce a machine learning model that predicts the prognosis of these patients for 6 months.

Methods: The sTBI patients suffering from DOC and healthy controls underwent functional magnetic resonance imaging. We defined patients with Extended Glasgow Outcome Score ≥ 5 as good outcome group, otherwise they were poor outcome group. Read More

J Clin Neurosci 2022 May 18;101:137-143. Epub 2022 May 18.

Department of Nephrology, Qilu Hospital of Shandong University, Jinan, China. Electronic address:

The present study aimed to investigate the clinical manifestations, epidemiological characteristics, and outcomes of Chinese patients with voltage-gated potassium channel complex (VGKC) antibody-associated encephalitis. Patients diagnosed with VGKC antibody-associated encephalitis at our institution between January 2016 and December 2020 were included in this study. We retrospectively evaluated their clinical features, auxiliary examination results, treatments details, long-term outcomes, and risk factors for poor outcome. Read More

Lung Cancer 2022 May 5;169:13-21. Epub 2022 May 5.

Centre de Recherche des Cordeliers, Sorbonne Université, INSERM, Université Paris Cité, Team Inflammation, Complement and Cancer, F-75006 Paris, France; Department of Pathology, Hôpitaux Universitaire Paris Centre, Cochin Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.

Introduction: SMARCA4/BRG1 loss of expression occurs in 5-10% of non-small cell lung carcinomas (NSCLC). We investigated the pathological, molecular and immune environment characteristics of this deficiency among NSCLC, its impact on overall survival (OS) of resected patients and the sensitivity to anti-PD1 inhibitors in metastatic patients.

Materials And Methods: BRG1 expression was assessed by immunohistochemistry to identify SMARCA4-deficient NSCLC (SD-NSCLC) from the cancer tissue collection of Cochin Hospital (Paris, France). Read More

Eur J Heart Fail 2022 May 21. Epub 2022 May 21.

University of Bergen, Stavanger University Hospital, Stavanger, Norway.

Background: Pulmonary hypertension (PHT) may complicate heart failure with reduced ejection fraction (HFrEF) and is associated with a substantial symptom burden and poor prognosis. Sildenafil, a phosphodiesterase-5 (PDE-5) inhibitor, might have beneficial effects on pulmonary haemodynamics, cardiac function and exercise capacity in HFrEF and PHT.

Aims: To determine the safety, tolerability, and efficacy of sildenafil in patients with HFrEF and indirect evidence of PHT. Read More

Egypt Heart J 2022 May 21;74(1):42. Epub 2022 May 21.

Department of Cardiology, Farhat Hached University Hospital Center, Sousse, Tunisia.

Background: The incidence of in-stent restenosis (ISR) remains relatively common despite the use of drug-eluting stents. Outcomes and prognostic factors following ISR revascularization are still being investigated. We aimed to describe the outcomes following different ISR treatment strategies in order to identify prognostic factors associated with worse outcomes. Read More

Egypt Heart J 2022 May 21;74(1):40. Epub 2022 May 21.

Clinical Research Development Center, Taleghani and Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Angiosarcoma is a malignant rare tumor that originates from vascular endothelial cells that cover lymphatic or blood vessels. Cardiac angiosarcoma is the most prevalent sarcoma entail the heart. It has low incidence rate and poor prognosis. Read More

Cancer Med 2022 May 21. Epub 2022 May 21.

Department of Gastroenterology, Beijing Friendship Hospital, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Capital Medical University, Beijing, China.

Background: Esophageal neuroendocrine carcinoma (ENEC) is an extremely rare type of malignancy. Clinical data of ENEC are limited to case reports and case series. More information is needed on its clinical feature, management, and prognosis. Read More

J Obstet Gynaecol Res 2022 May 21. Epub 2022 May 21.

Department of Clinical Laboratory, Tianjin Central Hospital of Obstetrics and Gynecology, Affiliated Maternity Hospital of Nankai University, Tianjin, China.

Aim: To explore whether HE4 was associated with clinical risk prognostic factors and survival outcome in primary fallopian tube carcinoma patients.

Methods: Ninety-six primary fallopian tube carcinoma (PFTC) patients from March 2011 to June 2019 were enrolled in this study. Serum CA125 and HE4 concentrations were measured at four time points including primary diagnosis, postsurgery, pre-recurrence, and recurrence. Read More

J Food Biochem 2022 May 21:e14221. Epub 2022 May 21.

Department of Otolaryngology Head and Neck Surgery, Shin-Kong Wu-Ho-Su Memorial Hospital, Taipei, Taiwan.

Human oral squamous cell carcinoma (OSCC) has been one of the most common oral cancers owing to high percentage of betel nuts chewers, smokers, and alcohol consumption. With current treatment strategies in OSCC, more than half patients relapse and develop distant metastases with poor prognosis. To overcome the incident, OSCC poses a challenge in current therapies and treatments. Read More

J Perinat Med 2022 May 23. Epub 2022 May 23.

Department of Obstetrics and Gynecology, Daqing Longnan Hospital, Daqing, Heilongjiang, P. R. China.

Objectives: Preeclampsia with severe features (PECsf) is a common disease in pregnant women. let-7a and IFN-gamma (interferon-gamma) are involved in diagnosis and prognosis of preeclampsia. This study explored effects of let-7a and IFN-gamma on PECsf patients. Read More

Cell Mol Biol Lett 2022 May 20;27(1):41. Epub 2022 May 20.

Department of Medical Genetics, Naval Medical University, Shanghai, 200433, China.

Background: The molecular mechanisms driving hepatocellular carcinoma (HCC) remain largely unclear. As one of the major epitranscriptomic modifications, N-methyladenosine (mA) plays key roles in HCC. The aim of this study was to investigate the expression, roles, and mechanisms of action of the RNA methyltransferase methyltransferase-like protein 16 (METTL16) in HCC. Read More

BMC Cancer 2022 May 20;22(1):564. Epub 2022 May 20.

Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

Background: Ribosomal protein S6 (S6), a downstream effect media of the AKT/mTOR pathway, not only is a part of 40S small subunit of eukaryotic ribosome, but also involves in protein synthesis and cell proliferation during cancer development.

Methods: In present study, we explore the association between phosphorylated S6 (p-S6) protein expression and clinicopathological features as well as prognostic implications in NSCLC. P-S6 was detected in tissue microarrays (TMAs) containing 350 NSCLC, 53 non-cancerous lung tissues (Non-CLT), and 88 cases of matched metastatic lymph node lesions via immunohistochemistry (IHC). Read More

Pediatr Surg Int 2022 May 20. Epub 2022 May 20.

Department of Surgery, Division of Pediatric Surgery, Medical University of South Carolina, Charleston, SC, USA.

Introduction: This study tested the hypothesis that complication accrual during pediatric extracorporeal life support (ECLS) increases mortality irrespective of indication for support.

Methods: Prospectively collected Extracorporeal Life Support Organization (ELSO) registry data for all neonatal and pediatric patients cannulated for ECLS at our institution from 1/1/2015 to 12/31/2020 was stratified based on the presence or absence of complications. We excluded renal replacement therapy from complications, as this is frequently and empirically applied within our practice. Read More

Hypertens Res 2022 May 20. Epub 2022 May 20.

Department of Endocrinology and Hypertension, Tokyo Women's Medical University, Tokyo, Japan.

Patients with adrenal Cushing's syndrome have a poor prognosis due to the autonomous hypersecretion of endogenous cortisol from the adrenal gland. Although several clinical examinations have been developed to manifest the autonomous hypersecretion of endogenous cortisol in this syndrome, it is unknown which parameter of cortisol overproduction is best associated with the adrenal cortisol content and bone and vascular complications of this syndrome. Therefore, the present study was undertaken to evaluate the parameter(s) associated with the adrenal cortisol content in patients with adrenal Cushing's syndrome, as well as to assess the associations between these parameters and the vascular and bone complications of this syndrome. Read More

Int J Colorectal Dis 2022 May 20. Epub 2022 May 20.

Department of Oncology, Dazhou Central Hospital, Dazhou, 635000, Sichuan, China.

Purpose: The study aimed to explore the value of tumor deposits in stage III colorectal cancer (CRC) and verify whether patients with more tumor deposit numbers have higher risk of recurrence.

Methods: The retrospective cohort analysis was performed at two cancer centers of China. Stage III CRC patients who underwent radical resection at the center between April 2008 and February 2019 were identified. Read More

Mol Cell Biochem 2022 May 20. Epub 2022 May 20.

Department of Chemistry, Indian Institute of Technology Bombay, Mumbai, 400076, India.

Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer associated with poor prognosis, higher grade, and a high rate of metastatic occurrence. Limited therapeutic interventions and the compounding issue of drug resistance in triple-negative breast cancer warrants the discovery of novel therapeutic targets and diagnostic modules. To this view, in addition to proteins, lipids also regulate cellular functions via the formation of membranes that modulate membrane protein function, diffusion, and their localization; thus, orchestrating signaling hot spots enriched in specific lipids/proteins on cell membranes. Read More

Clin Exp Nephrol 2022 May 20. Epub 2022 May 20.

Department of Pathology, Keio University School of Medicine, Tokyo, Japan.

Introduction: Acute kidney injury (AKI) is a worldwide concern and it leads to a poor prognosis or end-stage kidney disease. The purpose of this study was to clarify the characteristics of patients with AKI in whom kidney biopsy was performed using data of the Japan Renal Biopsy Registry (J-RBR).

Methods: We screened 38,351 cases that were registered in the J-RBR from 2007 to 2018. Read More

Sci Rep 2022 May 20;12(1):8552. Epub 2022 May 20.

Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Youzheng Street 23, Nangang District, Harbin, 150001, Heilongjiang Province, China.

The utility of noncontrast computed tomography markers in the prognosis of spontaneous intracerebral hemorrhage has been studied. This study aimed to investigate the predictive value of the computed tomography (CT) irregularity shape for poor functional outcomes in patients with spontaneous intracerebral hemorrhage. We retrospectively reviewed all 782 patients with intracranial hemorrhage in our stroke emergency center from January 2018 to September 2019. Read More

Cell Death Dis 2022 May 20;13(5):480. Epub 2022 May 20.

Department of Thoracic Surgery, Tangdu Hospital, The Air Force Medical University, 1 Xinsi Road, Xi'an, 710038, China.

Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide, with high incidence and mortality rates and low survival rates. However, the detailed molecular mechanism of ESCC progression remains unclear. Here, we first showed significantly higher WNT5A and SNAIL expression in ESCC samples than in corresponding paracancerous samples. Read More

Eur J Surg Oncol 2022 May 13. Epub 2022 May 13.

Department of Hepatic Surgery, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address:

Background And Aims: Ruptured hepatocellular carcinoma (rHCC) generally has a very poor prognosis and is currently classified as T4 in the tumor-node-metastasis (TNM) staging system. In this study, we aimed to demonstrate the actual impact of rHCC, as well as the positive effect of hepatectomy in patients with Barcelona Clinic Liver Cancer (BCLC) stage 0/A rHCC.

Methods: We enrolled 86 patients with rHCC after surgery and 526 patients with non-rHCC after surgery or transcatheter arterial chemoembolization (TACE). Read More

Gynecol Oncol 2022 May 17. Epub 2022 May 17.

Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130022, China. Electronic address:

Objective: The role of kallikrein-related peptidase 5 (KLK5) has been studied in several diseases, including skin and ovarian cancers. However, its role in cervical cancer remains unclear, particularly in regulating the radiation resistance and growth of cervical cancer cells. Radiation resistance of cervical cancer is associated with local recurrence, distant metastasis, and reduced survival. Read More

Taiwan J Obstet Gynecol 2022 May;61(3):517-520

Department of Obstetrics and Gynecology, Taipei City Hospital, Women and Children Campus, Taiwan; Department of Biomedical Engineering, National Yang Ming Chiao Tung University - Yang Ming Campus, Taiwan. Electronic address:

Objective: To study the etiology of congenital hydrocephalus in genetic aqueduct stenosis.

Case Report: We report the case of a 31-year-old pregnant female, G2P0A1, with a history of hyperthyroidism under medical control. The patient received regular prenatal care, with no specific findings in the Level II ultrasound at 21 weeks of gestation. Read More