34,075 results match your criteria poor oral

Survival predictors and outcomes of patients with recurrent and/or metastatic head and neck cancer treated with chemotherapy plus cetuximab as first-line therapy: A real-world retrospective study.

Cancer Treat Res Commun 2021 Apr 14;27:100375. Epub 2021 Apr 14.

Instituto Português de Oncologia de Coimbra Francisco Gentil Av. Prof. Dr. Bissaya Barreto n.º 98, 3000-075 Coimbra Portugal.

Background: In patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) the estimated prognosis is usually poor. Patient-specific factors that affect prognosis should be considered when choosing therapy. We conducted a retrospective, single-center analysis in patients treated with first line platinum and antiEGFR antibody-containing regimen. Read More

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Emerging Drug Delivery Strategies for Idiopathic Pulmonary Fibrosis Treatment.

Eur J Pharm Biopharm 2021 Apr 18. Epub 2021 Apr 18.

Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA. Electronic address:

Idiopathic pulmonary fibrosis (IPF) is a debilitating and fatal condition that causes severe scarring of the lungs. While the pathogenesis of IPF continues to be extensively studied and several factors have been considered, an exact cause has yet to be established. With inadequate treatment options and no cure available, overall disease prognosis is still poor. Read More

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Evaluation of the diagnostic performance of an oral fluid screening test device for substance abuse at traffic controls.

Clin Biochem 2021 Apr 18. Epub 2021 Apr 18.

Department of Medical Biochemistry, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey.

Introduction: The aim of this study was to evaluate the analytical performance of the Kite Biotechnology Oral fluid (OF) screening test device, which is used for roadside screening of cannabis, opiates, amphetamines, methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA), cocaine and benzodiazepines by comparing samples with matched plasma samples, analysed via liquid chromatography-tandem mass spectrometry (LC-MS/MS) for confirmation.

Methods: OF and plasma samples were obtained simultaneously from a total of 100 subjects. OF samples were analysed by OF screening test based on immunochromatography. Read More

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Oral Health Status among Adult Employees in Kuwait.

Oral Health Prev Dent 2021 Jan;19(1):245-253

Purpose: To determine the oral health status among adult employees in Kuwait.

Materials And Methods: This cross-sectional study was performed on a convenience sample (n = 1294) of adult employees. Their ages ranged from 19 to 77 years (mean 36. Read More

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January 2021

Dental pathologies in tumor patients with bone metastases or multiple myeloma scheduled for antiresorptive therapy.

Future Oncol 2021 Apr 21. Epub 2021 Apr 21.

Private Practice for Oral & Maxillofacial Surgery, A-5020, Salzburg, Austria.

Medication-related osteonecrosis of the jaw (MRONJ) is a potentially severe complication of mainly antiresorptive drugs. We evaluated the frequency of dentoalveolar pathologies in patients scheduled for antiresorptive therapy in a 'real-world' setting, also including patients with poor oral health potentially requiring tooth extractions and/or other dentoalveolar surgery. This approach is in contrast to the setting of recent randomized trials with restrictive exclusion criteria. Read More

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Association Between Oral Health Literacy and Number of Remaining Teeth Among the Thai Elderly: A Cross-Sectional Study.

Clin Cosmet Investig Dent 2021 12;13:113-119. Epub 2021 Apr 12.

Master of Science Program in Geriatric Dentistry and Special Patients Care (International Program), Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.

Purpose: Limited oral health literacy is associated with poor oral health status. This study aimed to determine the association between oral health literacy (OHL) and the number of remaining teeth (NRT) among Thailand's older population.

Patients And Methods: This cross-sectional study was conducted between July 1, 2020 and September 30, 2020 at the Subdistrict Health Promoting Hospitals in Panare, Pattani, Thailand. Read More

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The intergenerational interplay of adversity on salivary inflammation in young children and caregivers.

Psychoneuroendocrinology 2021 Apr 17;128:105222. Epub 2021 Apr 17.

Department of Biobehavioral Health, The Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA 16802, USA. Electronic address:

Systemic inflammation links exposure to early childhood adversity to later disease. The associations among adversity and disease risk might in part operate through poor oral hygiene and subsequent periodontal inflammation, which can be measured in saliva. Few studies, however, have examined the association between adversity and salivary inflammation in young children. Read More

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Dual blockade of EGFR and CDK4/6 delays head and neck squamous cell carcinoma progression by inducing metabolic rewiring.

Cancer Lett 2021 Apr 17. Epub 2021 Apr 17.

Department of Biochemistry and Molecular Biology, USA; Fred and Pamela Buffett Cancer Center, USA; Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, 68198, USA. Electronic address:

Despite preclinical success, monotherapies targeting EGFR or cyclin D1-CDK4/6 in Head and Neck squamous cell carcinoma (HNSCC) have shown a limited clinical outcome. Here, we aimed to determine the combined effect of palbociclib (CDK4/6) and afatinib (panEGFR) inhibitors as an effective strategy to target HNSCC. Using the TCGA-HNSCC co-expression analysis, we found that patients with high EGFR and cyclin D1 expression showed enrichment of gene clusters associated with cell-growth, glycolysis, and epithelial to mesenchymal transition processes. Read More

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Sinonasal and gastrointestinal bacterial composition and abundance are stable after 1 week of once-daily oral antibiotic treatment for chronic rhinosinusitis.

Int Forum Allergy Rhinol 2021 Apr 20. Epub 2021 Apr 20.

Department of Surgery, University of Auckland, Auckland, New Zealand.

Background: Despite the widespread prescription of antibiotics for the treatment of chronic rhinosinusitis (CRS), their efficacy remains uncertain. Limited penetration of systemic antibiotics into the sinonasal mucosa has been reported previously by this group. This study aimed to investigate the short-term effects of antibiotics on the sinus and gut microbiota as well as any relationships these had with drug distribution. Read More

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Nurse-led service for children with gastrostomies: a 2-year review.

Br J Nurs 2021 Apr;30(8):462-466

Consultant Paediatric Surgeon, Evelina London Children's Hospital, London.

Background: Percutaneous endoscopic gastrostomy (PEG) feeding can provide long-term nutritional support for patients with a functional gastrointestinal system but insufficient oral intake. Some patients, however, may require jejunal feeding, which can be achieved using a PEG tube with jejunal extension (PEG-J). A previous review at a tertiary paediatric hospital revealed poor documentation and a high incidence of buried bumper syndrome (BBS) in children with gastrostomies. Read More

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Increased miR-21-3p and miR-487b-3p serum levels during anaphylactic reaction in food allergic children.

Pediatr Allergy Immunol 2021 Apr 19. Epub 2021 Apr 19.

Department of Allergy and Immunology, IIS-Fundación Jiménez Díaz, UAM, Madrid, Spain.

Background: Anaphylaxis is the most severe manifestation of allergic disorders. The poor knowledge of its molecular mechanisms often leads to underdiagnosis. MicroRNAs (miRNA) regulate physiological and pathological processes and they have been postulated as promising diagnostic markers. Read More

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Higher Dispositional Optimism Predicts Better Health-Related Quality of Life After Esophageal Cancer Surgery: A Nationwide Population-Based Longitudinal Study.

Ann Surg Oncol 2021 Apr 19. Epub 2021 Apr 19.

Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Purpose: To assess whether higher dispositional optimism could predict better health-related quality of life (HRQL) after esophageal cancer surgery.

Methods: This Swedish nationwide longitudinal study included 192 patients who underwent esophagectomy for cancer. The exposure was dispositional optimism measured by the Life Orientation Test-Revised (LOT-R) at 1 year post-surgery. Read More

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Evaluating the Prevalence of Musculoskeletal Neck Pain in Dental Hygiene Students.

J Dent Hyg 2021 Apr;95(2):58-62

Professor and the Director of the Division of Dental Hygiene and vice-chair of the Department of Dental Medicine; all at the University of New Mexico School of Medicine, Albuquerque, NM, USA.

Poor ergonomics is one of the leading factors in developing musculoskeletal disorders. The purpose of this study was to evaluate the level of forward neck flexion of dental hygiene students during manual scaling procedures while wearing magnification loupes and investigate the prevalence of musculoskeletal neck pain. convenience sample of second year dental hygiene students was recruited for this observational study (n=24). Read More

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Improvement of the Bioavailability and Anti-Hepatic Alveolar Echinococcosis by Albendazole-Isethionate/Hypromellose Acetate Succinate (HPMC-AS) Complex.

Antimicrob Agents Chemother 2021 Apr 19. Epub 2021 Apr 19.

Department of Hepatopancreatobiliary Surgery Affiliated Hospital of Qinghai University, Qinghai, 810001, P. R. China.

Maximizing the pharmacodynamics of albendazole (ABZ), which is used to treat echinococcoses, is essential for the long-term treatment of echinococcosis patients. ABZ is a weak base whose solubility depends on the pH value of the solvent. After it has been orally administered, its solubility drops sharply from when it is in gastric juices (pH 1. Read More

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The Association of Preoperative Opioid Use With Revision Surgery and Complications Following Carpometacarpal Arthroplasty.

J Hand Surg Am 2021 Apr 16. Epub 2021 Apr 16.

Department of Orthopaedic Surgery, Emory University, Atlanta, GA. Electronic address:

Purpose: Preoperative opioid use has been shown to be associated with poor outcomes following different upper-extremity surgeries. We aimed to examine the relationship between preoperative opioid use and outcomes following carpometacarpal (CMC) arthroplasty. We hypothesized that patients prescribed higher daily average numbers of preoperative oral morphine equivalents (OMEs) would show higher rates of complications and revision surgery. Read More

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The Influence of Dissonance Induction and Assessment Reactivity in Improving Adherence to COVID-19 Precautionary Measures: A Cluster Randomised Controlled Trial.

Int Dent J 2021 Mar 20. Epub 2021 Mar 20.

Assistant Professor, Department of Periodontics, SIBAR Institute of Dental Sciences, Guntur, AP, India.

Background: During the coronavirus disease 2019 (COVID-19) pandemic, adherence to suggested precautionary measures has been emphasized as important in preventing and curtailing its spread. However, strict adherence to precautionary measures can be demanding.

Methods: This cluster randomised controlled trial done among 1517 undergraduate dental students tested the effectiveness of 'dissonance induction' (DI) and 'assessment reactivity' (AR) in improving adherence to World Health Organization (WHO) measures as compared to a control group. Read More

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Oral Health Status of Children Who Require In-Home Medical Care.

J Dent Child (Chic) 2021 Jan;88(1):29-34

Dr. Turrioni is an assistant professor, Department of Pediatric Dentistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil;, Email:

To evaluate the oral health status of children who require in-home medical care, their oral hygiene and eating habits, and the association between oral health status and medical conditions.
Legal guardians of children who need in-home medical care were interviewed regarding their socioeconomic level and their children's medical and dental history, as well as their oral hygiene habits. An oral exam assessed the children's plaque level, caries experience, and periodontal disease. Read More

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January 2021

Associations between a history of sexual abuse and dental anxiety, caries experience and oral hygiene status among adolescents in sub-urban South West Nigeria.

BMC Oral Health 2021 Apr 19;21(1):196. Epub 2021 Apr 19.

International Research Center of Excellence, Institute of Human Virology Nigeria, Abuja, Nigeria.

Introduction: Sexual and oral health are important areas of focus for adolescent wellbeing. We assessed for the prevalence of sexual abuse among adolescents, oral health factors associated with this history, and investigated whether sexual abuse was a risk indicator for dental anxiety, caries experience and poor oral hygiene.

Methods: This was a cross-sectional study conducted between December 2018 and January 2019 among adolescents 10-19 years old in Ile-Ife, Nigeria. Read More

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Well tolerability and highly effective treatment response for hepatitis C virus-human immunodeficiency virus coinfected patients treated by all oral direct acting antivirals.

J Chin Med Assoc 2021 Apr 12. Epub 2021 Apr 12.

Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; Healthcare and Services Center, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Division of Gastroenterology, Department of Medicine, Cheng Hsin General Hospital, Taipei, Taiwan, ROC.

Background: Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) coinfection is common because the two pathogens share their transmission route. Studies have suggested that coinfection is associated with accelerated hepatic fibrosis, increased hepatic decompensation, and hepatocellular carcinoma development. Historically, the sustained virological response (SVR) rates for patients undergoing pegylated interferon (IFN)-based therapy are poor owing to advanced liver disease, immune dysfunction, and poor medical adherence. Read More

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Role of Mechanotransduction in Periodontal Homeostasis and Disease.

J Dent Res 2021 Apr 17:220345211007855. Epub 2021 Apr 17.

Division of Oral Biotechnology, Center for Dental Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Novel findings broaden the concept of mechanotransduction (MT) in biophysically stimulated tissues such as the periodontium by considering nuclear MT, convergence of intracellular MT pathways, and mechanoresponsive cotranscription factors such as Yes-associated protein 1 (YAP1). Regarding periodontal disease, recent studies have elucidated the role of bacterial gingipain proteases in disturbing the barrier function of cadherins, thereby promoting periodontal inflammation. This leads to dysregulation of extracellular matrix homeostasis via proteases and changes the cell's biophysical environment, which leads to alterations in MT-induced cell behavior and loss of periodontal integrity. Read More

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Silicon Oxynitrophosphide Nanoscale Coating Enhances Antioxidant Marker-Induced Angiogenesis During in vivo Cranial Bone-Defect Healing.

JBMR Plus 2021 Apr 18;5(4):e10425. Epub 2021 Mar 18.

Bone-Muscle Research Center University of Texas at Arlington Arlington TX USA.

Critical-sized bone defects are challenging to heal because of the sudden and large volume of lost bone. Fixative plates are often used to stabilize defects, yet oxidative stress and delayed angiogenesis are contributing factors to poor biocompatibility and delayed bone healing. This study tests the angiogenic and antioxidant properties of amorphous silicon oxynitrophosphide (SiONPx) nanoscale-coating material on endothelial cells to regenerate vascular tissue in vitro and in bone defects. Read More

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Rivaroxaban triggered multifocal intratumoral hemorrhage of the cabozantinib-treated diffuse brain metastases: A case report and review of literature.

Open Med (Wars) 2021 9;16(1):618-623. Epub 2021 Apr 9.

Department of Neurosurgery, Zhongshan Hospital Xiamen University, Xiamen, 361004, Fujian, People's Republic of China.

Brain metastases (BMs) are the most common intracranial malignancy with poor prognosis. Patients with intracranial tumors are at greater risk for thrombotic complications and intracranial hemorrhage. Rivaroxaban is a potent oral anticoagulant with the high selectivity of direct factor Xa inhibition. Read More

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Identification of a Gene Prognostic Signature for Oral Squamous Cell Carcinoma by RNA Sequencing and Bioinformatics.

Biomed Res Int 2021 1;2021:6657767. Epub 2021 Apr 1.

Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China.

Objectives: Oral squamous cell carcinoma (OSCC) is the most common oral cancer and has a poor prognosis. We aimed to identify new biomarkers or potential therapeutic targets for OSCC.

Materials And Methods: Four pairs of tumor and adjacent normal tissues were collected from OSCC patients, and differentially expressed genes (DEGs) were screened via high-throughput RNA sequencing (RNA-seq). Read More

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Clinical Characteristics According to Age and Duration of Symptoms to Be Considered for Rapid Diagnosis of Pediatric Intussusception.

Front Pediatr 2021 31;9:651297. Epub 2021 Mar 31.

Department of Surgery, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.

The purpose of this study was to evaluate whether clinical findings in children with ileocolic intussusception differ based on age and duration of symptoms and to assess the clinical characteristics of diagnosed and undiagnosed patients to determine which symptoms make diagnosis more difficult. We reviewed 536 medical records of <15-year-old children diagnosed with ileocolic intussusception between 2008 and 2019. We divided the children into three categories according to age (<1 year, 1-2 years, and ≥2 years). Read More

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Excision repair cross-complementing group 2 upregulation is a potential predictive biomarker for oral squamous cell carcinoma recurrence.

Oncol Lett 2021 Jun 7;21(6):450. Epub 2021 Apr 7.

Translational Research Center, Kaohsiung Medical University Hospital, Kaohsiung 807377, Taiwan, R.O.C.

Oral cancer is the fourth most common type of cancer among males in Taiwan, and the prognosis for patients with advanced-stage oral squamous cell carcinoma (OSCC) remains poor. The present study investigated the prognostic value of three DNA repair genes, namely excision repair cross-complementing group 1 (ERCC1), ERCC2 and X-ray repair cross-complementing group 1 (XRCC1) in OSCC. The protein expression levels of XRCC1, ERCC1 and ERCC2 in oral cell lines were analyzed via western blotting and immunohistochemistry using samples from 98 patients with biopsy-proven OSCC, while the χ test was used to analyze the clinicopathological association. Read More

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Cannabis-Induced Hypodopaminergic Anhedonia and Cognitive Decline in Humans: Embracing Putative Induction of Dopamine Homeostasis.

Front Psychiatry 2021 30;12:623403. Epub 2021 Mar 30.

Department of Psychiatry, Washington University School of Medicine, St Louis, MO, United States.

Over years, the regular use of cannabis has substantially increased among young adults, as indicated by the rise in cannabis use disorder (CUD), with an estimated prevalence of 8. 3% in the United States. Research shows that exposure to cannabis is associated with hypodopaminergic anhedonia (depression), cognitive decline, poor memory, inattention, impaired learning performance, reduced dopamine brain response-associated emotionality, and increased addiction severity in young adults. Read More

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A promising nanomatrix system of simvastatin for oral delivery: Evaluation in vitro and in vivo.

Pak J Pharm Sci 2020 Nov;33(6):2489-2495

Department of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, PR China.

Because of the low solubility, the oral bioavailability of simvastatin (SV) was poor, which restricted the application in clinic. In order to increase the dissolution and the oral absorption of simvastatin, we prepared a novel solid nanomatrix of SV with pharmaceutical acceptable nano-sized silica and Eudragit®. The nanomatrix was prepared using solvent evaporate method and the formulation was optimized. Read More

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November 2020

Sucralfate as an Adjunct to Analgesia to Improve Oral Intake in Children With Infectious Oral Ulcers: A Randomized, Double-Blind, Placebo-Controlled Trial.

Ann Emerg Med 2021 Apr 15. Epub 2021 Apr 15.

Department of Pediatric Emergency Medicine, University of Texas Austin Dell Medical School, Austin, TX.

Study Hypothesis: We hypothesized that sucralfate along with oral analgesics (acetaminophen or ibuprofen) administered in the emergency department leads to a clinically significant improvement in oral intake in children with acute infectious oral ulcers.

Methods: This was a randomized, double-blind, placebo-controlled trial of sucralfate versus placebo conducted between 2017 and 2018 in an urban pediatric emergency department. Children aged 6 months to 5 years with acute, infectious oral ulcers and poor oral intake received either acetaminophen at 15 mg/kg or ibuprofen at 10 mg/kg and were then randomized to receive sucralfate at 20 mg/kg per dose up to 1 g or a placebo solution. Read More

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Risk and survival of second primary malignancies following diagnosis of gastric mucosa-associated lymphoid tissue lymphomas: A population-based study.

Curr Probl Cancer 2021 Apr 2:100735. Epub 2021 Apr 2.

Department of Gastroenterology, The First Affiliated Hospital of Soochow University, 899 Pinghai Road, Suzhou, 215006, Jiangsu, China. Electronic address:

Whether gastric mucosa-associated lymphoid tissue lymphoma (GML) is associated with a higher risk of second primary malignancy (SPM) remains controversial. This study aimed to evaluate the detailed risk of SPM and its prognosis in patients with GML based on a large population-based cohort. The Surveillance, Epidemiology, and End Results database was searched to identify patients who were diagnosed with GML during 2000-2014. Read More

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Long-term oral anticoagulation for atrial fibrillation in low and middle income countries.

Indian Heart J 2021 Mar-Apr;73(2):244-248. Epub 2021 Feb 10.

Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

With increasing life-expectancy and changing demographics, non-valvular atrial fibrillation (AF) is currently the most common indication for long-term oral anticoagulation (OAC) in low and middle income countries (LMICs). Due to a decreasing trend in the prevalence of rheumatic heart disease (RHD), valve disease as a primary cause of AF now constitutes a small fraction of all people with AF. Moreover, emerging data also indicate that, patients with significant valve disease and AF may have a risk of stroke similar to, if not lower than, those with non-valvular AF. Read More

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February 2021