J Chin Med Assoc 2021 Apr 12. Epub 2021 Apr 12.
Division of Gastroenterology and Hepatology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Faculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; Healthcare and Services Center, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Division of Gastroenterology, Department of Medicine, Cheng Hsin General Hospital, Taipei, Taiwan, ROC.
Background: Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) coinfection is common because the two pathogens share their transmission route. Studies have suggested that coinfection is associated with accelerated hepatic fibrosis, increased hepatic decompensation, and hepatocellular carcinoma development. Historically, the sustained virological response (SVR) rates for patients undergoing pegylated interferon (IFN)-based therapy are poor owing to advanced liver disease, immune dysfunction, and poor medical adherence. Read More