106,286 results match your criteria pool


JMML tumor cells disrupt normal hematopoietic stem cells by imposing inflammatory stress through overproduction of IL-1β.

Blood Adv 2021 Sep 23. Epub 2021 Sep 23.

Emory University School of Medicine, Atlanta, Georgia, United States.

Development of normal blood cells is often suppressed in juvenile myelomonocytic leukemia (JMML), a myeloproliferative neoplasm (MPN) of childhood, causing complications and impacting therapeutic outcomes. However, the mechanism underlying this phenomenon remains uncharacterized. To address this question, we induced the most common mutation identified in JMML (Ptpn11E76K) specifically in the myeloid lineage with hematopoietic stem cells (HSCs) spared. Read More

View Article and Full-Text PDF
September 2021

Do Various Treatment Modalities of Vesicoureteral Reflux Have Any Adverse Effects in Pediatric Patients? A Meta-Analysis.

Urol Int 2021 Sep 23:1-9. Epub 2021 Sep 23.

Department of Pediatrics, Peking University First Hospital, Beijing, China.

Purpose: Vesicoureteral reflux (VUR) is a risk factor for various renal problems like recurrent urinary tract infections (UTIs), pyelonephritis, renal scarring, hypertension, and other renal parenchymal defects. The interventions followed by pediatricians include low-dose antibiotic treatment, surgical correction, and endoscopy. This meta-analysis aimed to assess the advantages and drawbacks of various primary VUR treatment options. Read More

View Article and Full-Text PDF
September 2021

Evidence of autochthonous transmission of urinary schistosomiasis in Almeria (southeast Spain): An outbreak analysis.

Travel Med Infect Dis 2021 Sep 20:102165. Epub 2021 Sep 20.

Department of Urology, Hospital del Poniente, Ctra. de Almerimar 31, 04700, El Ejido, Almería, Spain.

Background: Schistosomiasis is endemic in 78 countries belonging to tropical and subtropical areas. However, autochthonous transmission of urogenital schistosomiasis was reported in Corsica (France) in 2013. We present evidence of autochthonous transmission of urogenital schistosomiasis in Almería (Spain) in 2003. Read More

View Article and Full-Text PDF
September 2021

Quantitative Pulmonary Neutrophil Dynamics using Computer-Vision Stabilized Intravital Imaging.

Am J Respir Cell Mol Biol 2021 Sep 23. Epub 2021 Sep 23.

University of Illinois At Chicago, Chicago, Illinois, United States;

In vivo intravital imaging in animals models in the lung remains challenging due to respiratory motion artifacts. Here we describe a novel intravital imaging approach based on the computer vision stabilization algorithm, Computer-Vision STabilized intravital imaging (CoVSTii). This method corrects lung movements and deformations at sub-micron precision in respiring mouse lungs. Read More

View Article and Full-Text PDF
September 2021

Non-invasive positive airway pressure therapy for improving erectile dysfunction in men with obstructive sleep apnoea.

Cochrane Database Syst Rev 2021 Sep 23;9:CD013169. Epub 2021 Sep 23.

Cochrane Afilliate Rio de Janeiro, Cochrane, Petrópolis, Brazil.

Background: Obstructive sleep apnoea syndrome (OSAS) is associated with several chronic diseases, including erectile dysfunction (ED). The association of OSAS and ED is far more common than might be found by chance; the treatment of OSAS with non-invasive positive airway pressure therapy is associated with improvement of respiratory symptoms, and may contribute to the improvement of associated conditions, such as ED.

Objectives: To assess the effectiveness and acceptability of non-invasive positive airway pressure therapy for improving erectile dysfunction in OSAS. Read More

View Article and Full-Text PDF
September 2021

1,5-Hydrogen Atom Transfer/Surzur-Tanner Rearrangement: A Radical Cascade Approach for the Synthesis of 1,6-Dioxaspiro[4.5]decane and 6,8-Dioxabicyclo[3.2.1]octane Scaffolds in Carbohydrate Systems.

J Org Chem 2021 Sep 23. Epub 2021 Sep 23.

Síntesis de Productos Naturales, Instituto de Productos Naturales y Agrobiología del CSIC, Avda. Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.

The 1,5-HAT-1,2-(ester)alkyl radical migration (Surzur-Tanner rearrangement) radical/polar sequence triggered by alkoxyl radicals has been studied on a series of -glycosyl substrates with 3--(α,β-d,l-glycopyranosyl)1-propanol and -(α-d,l-glycopyranosyl)methanol structures prepared from chiral pool d- and l-sugar. The use of acetoxy and diphenoxyphosphatoxy as leaving groups provides an efficient construction of 10-deoxy-1,6-dioxaspiro[4.5]decane and 4-deoxy-6,8-dioxabicyclo[3. Read More

View Article and Full-Text PDF
September 2021

Entrustable professional activities framework for assessment of patient handoffs in dentistry.

J Dent Educ 2021 Sep 23. Epub 2021 Sep 23.

Director of Engaged Learning and Assessment, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.

Purpose/objectives: The aim of this study is to report data on the lack of a proper patient handoff system in dentistry and dental education and to present a possible solution to integrate this into curriculum using the "entrustable professional activities" (EPAs) framework.

Methods: Delphi participants from seven US dental schools provided feedback on a preliminary definition of handoff, a mnemonic and an assessment rubric. 2019 American Dental Education Association Commission on Change and Innovation in Dental Education (ADEA CCI) participants further evaluated the handoff EPA using the EQual rubric for EPA quality and structure. Read More

View Article and Full-Text PDF
September 2021

SKAP interacts with Aurora B to guide end-on capture of spindle microtubules via phase separation.

J Mol Cell Biol 2021 Sep 23. Epub 2021 Sep 23.

MOE Key Laboratory for Cellular Dynamics and Hefei National Laboratory for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei 230027, China.

Chromosome segregation in mitosis is orchestrated by the dynamic interactions between the kinetochore and spindle microtubules. Our recent studies show that mitotic motor CENP-E cooperates with SKAP and forms a link between kinetochore core MIS13 complex and spindle microtubule plus-ends to achieve accurate chromosome alignment in mitosis. However, it remains elusive how SKAP regulates kinetochore attachment from lateral association to end-on attachment during metaphase alignment. Read More

View Article and Full-Text PDF
September 2021

Measuring a Broad Spectrum of eHealth Skills in the Web 3.0 Context Using an eHealth Literacy Scale: Development and Validation Study.

J Med Internet Res 2021 Sep 23;23(9):e31627. Epub 2021 Sep 23.

Department of Sport, Physical Education and Health, Hong Kong Baptist University, Hong Kong, China (Hong Kong).

Background: eHealth literacy (EHL) refers to a variety of capabilities that enable individuals to obtain health information from electronic resources and apply it to solve health problems. With the digitization of health care and the wide availability of health apps, a more diverse range of eHealth skills is required to properly use such health facilities. Existing EHL measurements focus mainly on the skill of obtaining health information (Web 1. Read More

View Article and Full-Text PDF
September 2021

Orbiviruses in biting midges and mosquitoes from the Zambezi region, Namibia.

J Gen Virol 2021 Sep;102(9)

Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Free University Berlin, Humboldt-University Berlin, and Berlin Institute of Health, Germany.

The genus includes a variety of pathogenic viruses that are transmitted by biting midges, mosquitoes and ticks. Some of the economically most relevant orbiviruses are endemic to Namibia, like the livestock-pathogenic Bluetongue and African horse sickness viruses. Here, we assessed the diversity of orbiviruses circulating in the Zambezi region of north-eastern Namibia. Read More

View Article and Full-Text PDF
September 2021

Enantiomeric Isopulegol as the Chiral Pool in the Total Synthesis of Bioactive Agents.

Chem Rec 2021 Sep 23. Epub 2021 Sep 23.

Institute of Pharmaceutical Chemistry, University of Szeged, Interdisciplinary Excellent Center, Eötvös utca 6, H-6720, Szeged, Hungary.

Isopulegol, a pool of abundant chiral terpene, has long served as the starting material for the total synthesis of isopulegol-based drugs. As an inexpensive and versatile starting material, this compound continues to serve modern synthetic chemistry. This review highlights the total syntheses of terpenoids in the period from 1980 to 2020 in which with isopulegol applied as a building block. Read More

View Article and Full-Text PDF
September 2021

Interacting elevational and latitudinal gradients determine bat diversity and distribution across the Neotropics.

J Anim Ecol 2021 Sep 23. Epub 2021 Sep 23.

School of Environmental Sciences, University of East Anglia, NR4 7TJ, Norwich, United Kingdom.

New World bats are heavily affected by the biophysical setting shaped by elevation and latitude. This study seeks to understand the patterns of bat species diversity across elevational, latitudinal and vegetation height gradients throughout the Neotropics. Systematically gathered putative and empirical data on bat species distribution across the entire Neotropics were examined using descriptive statistics, spatial interpolation of bat taxonomic, functional and phylogenetic diversity, generalized linear models, generalized linear mixed models, and phylogenetic generalized least squares. Read More

View Article and Full-Text PDF
September 2021

Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling.

ACS Chem Biol 2021 Sep 23. Epub 2021 Sep 23.

Department of Biochemistry, University of Alberta, Edmonton T6G 2H7, Alberta, Canada.

Caspases are a family of enzymes that regulate biological processes such as inflammation and programmed cell death, through proteolysis. For example, in the intrinsic pathway of apoptosis, cell death signaling involves cytochrome release from the mitochondria, which leads to the activation of caspase-9 and eventually the executioners caspase-3 and -7. One key step in our understanding of these proteases is to identify their respective protein substrates. Read More

View Article and Full-Text PDF
September 2021

Gender Comparison of Psychological Reaction Between Breast Cancer Survivors and Their Spouses.

Front Psychol 2021 6;12:722877. Epub 2021 Sep 6.

Xiang Ya Nursing School, Central South University, Changsha, China.

Scant evidence exists among the different psychological issues between patients with breast cancer and their spouses. The objective of our study was to develop the measuring instrument testing psychological reaction and compare the difference in psychological reaction between patients with breast cancer and their spouses during the period of diagnosis and treatment. The semi-structured interview guideline was guided by the psychological stress model. Read More

View Article and Full-Text PDF
September 2021

Triple Oxygen Isotope Measurements (Δ'O) of Body Water Reflect Water Intake, Metabolism, and δO of Ingested Water in Passerines.

Front Physiol 2021 6;12:710026. Epub 2021 Sep 6.

Department of Biological Sciences, Old Dominion University, Norfolk, VA, United States.

Understanding physiological traits and ecological conditions that influence a species reliance on metabolic water is critical to creating accurate physiological models that can assess their ability to adapt to environmental perturbations (e.g., drought) that impact water availability. Read More

View Article and Full-Text PDF
September 2021

Deep mutational scanning of the plasminogen activator inhibitor-1 functional landscape.

Sci Rep 2021 Sep 22;11(1):18827. Epub 2021 Sep 22.

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

The serine protease inhibitor (SERPIN) plasminogen activator inhibitor-1 (PAI-1) is a key regulator of the fibrinolytic system, inhibiting the serine proteases tissue- and urokinase-type plasminogen activator (tPA and uPA, respectively). Missense variants render PAI-1 non-functional through misfolding, leading to its turnover as a protease substrate, or to a more rapid transition to the latent/inactive state. Deep mutational scanning was performed to evaluate the impact of amino acid sequence variation on PAI-1 inhibition of uPA using an M13 filamentous phage display system. Read More

View Article and Full-Text PDF
September 2021

A novel lncRNA Discn fine-tunes replication protein A (RPA) availability to promote genomic stability.

Nat Commun 2021 Sep 22;12(1):5572. Epub 2021 Sep 22.

State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China.

RPA is a master regulator of DNA metabolism and RPA availability acts as a rate-limiting factor. While numerous studies focused on the post-translational regulations of RPA for its functions, little is known regarding how RPA availability is controlled. Here we identify a novel lncRNA Discn as the guardian of RPA availability in stem cells. Read More

View Article and Full-Text PDF
September 2021

3D-Printed Pacifier-Shaped Mouthpiece for fMRI-Compatible Gustometers.

eNeuro 2021 Sep 22. Epub 2021 Sep 22.

Swiss Center for Affective Science, University of Geneva, Switzerland.

Gustometers have made it possible to deliver liquids in functional magnetic resonance imaging (fMRI) settings for decades, and mouthpieces are a critical part of these taste delivery systems. Here, we propose an innovative 3D-printed fMRI mouthpiece inspired by children's pacifiers, allowing human participants to swallow while lying down in an MRI scanner. We used a large sample to validate the effectiveness of our method. Read More

View Article and Full-Text PDF
September 2021

Hypomethylating agents and FLT3 inhibitors as maintenance treatment for acute myeloid leukemia and myelodysplastic syndrome following allogeneic hematopoietic stem cell transplant - a systematic review and meta-analysis.

Transplant Cell Ther 2021 Sep 19. Epub 2021 Sep 19.

Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medical Oncology, Adult Leukemia Program, Dana-Farber Cancer Institute, Boston, MA.

Background: Disease relapse remains the major cause of death among patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) who receive an allogeneic hematopoietic cell transplant (allo-HCT). Maintenance treatment with FLT3 inhibitors and hypomethylating agents (HMA) has been studied in various clinical trials with mixed results.

Objective: To synthesize the current evidence on the efficacy and safety of FLT3 inhibitors and HMA for maintenance therapy following allo-HCT in AML and MDS. Read More

View Article and Full-Text PDF
September 2021

SMAR1 Suppresses the Cancer Stem Cell Population via hTERT Repression in Colorectal Cancer Cells.

Int J Biochem Cell Biol 2021 Sep 19:106085. Epub 2021 Sep 19.

National Centre for Cell Science, Pune, India; Birla Institute of Technology and Science, Goa, India. Electronic address:

One of the hallmarks of a cancer cell is the ability for indefinite proliferation leading to the immortalization of the cell. Activation of several signaling pathways leads to the immortalization of cancer cells via the reactivation of enzyme telomerase (hTERT). hTERT is active in germ cells, stem cells and also cancer cells. Read More

View Article and Full-Text PDF
September 2021

Platelet lysate functionalized GelMA microspheres for improving angiogenesis in endodontic regeneration.

Acta Biomater 2021 Sep 19. Epub 2021 Sep 19.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Engineering Research Center of Oral Translational Medicine, Ministry of Education & National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; Chengdu Shiliankangjian Biotechnology Co., Ltd.. Electronic address:

Rapid angiogenesis is one of the challenges in endodontic regeneration. Recently, tailored polymeric microsphere system that loaded pro-angiogenic growth factors (GFs) is promising in facilitating vascularization in dental pulp regeneration. In addition, the synergistic effect of multiple GFs is considered more beneficial, but combination usage of them is rather complex and costly. Read More

View Article and Full-Text PDF
September 2021

Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling.

Cell Rep 2021 Sep;36(12):109726

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, and Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing, P.R. China. Electronic address:

Gut microbiota-mediated secondary bile acids (BAs) play an important role in energy balance and host metabolism via G protein-coupled receptors and/or nuclear receptors. Emerging evidence suggests that BAs are important for maintaining innate immune responses via these receptors. However, the effect of BAs on autoimmune uveitis is still unknown. Read More

View Article and Full-Text PDF
September 2021

Meta-Analysis of Proportions.

Methods Mol Biol 2022 ;2345:159-172

Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.

The meta-analysis of single proportions has become a popular application over the last two decades. Especially, systematic reviews of prevalence studies are conducted in various fields of science, including medicine, ecology, psychology, or social sciences. In this chapter, we illustrate meta-analysis methods to pool single proportions and to compare proportions from two groups. Read More

View Article and Full-Text PDF
January 2022

Endolysosome iron restricts Tat-mediated HIV-1 LTR transactivation by increasing HIV-1 Tat oligomerization and β-catenin expression.

J Neurovirol 2021 Sep 22. Epub 2021 Sep 22.

Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203, USA.

HIV-1 transactivator of transcription (Tat) protein is required for HIV-1 replication, and it has been implicated in the pathogenesis of HIV-1-associated neurocognitive disorder (HAND). HIV-1 Tat can enter cells via receptor-mediated endocytosis where it can reside in endolysosomes; upon its escape from these acidic organelles, HIV-1 Tat can enter the cytosol and nucleus where it activates the HIV-1 LTR promoter. Although it is known that HIV-1 replication is affected by the iron status of people living with HIV-1 (PLWH), very little is known about how iron affects HIV-1 Tat activation of the HIV-1 LTR promoter. Read More

View Article and Full-Text PDF
September 2021

Interactions between islets and regulatory immune cells in health and type 1 diabetes.

Diabetologia 2021 Sep 22. Epub 2021 Sep 22.

Department of Surgery, University of British Columbia, Vancouver, BC, Canada.

Type 1 diabetes results from defects in immune self-tolerance that lead to inflammatory infiltrate in pancreatic islets, beta cell dysfunction and T cell-mediated killing of beta cells. Although therapies that broadly inhibit immunity show promise to mitigate autoinflammatory damage caused by effector T cells, these are unlikely to permanently reset tolerance or promote regeneration of the already diminished pool of beta cells. An emerging concept is that certain populations of immune cells may have the capacity to both promote tolerance and support the restoration of beta cells by supporting proliferation, differentiation and/or regeneration. Read More

View Article and Full-Text PDF
September 2021

Pragmatic Precision Psychiatry-A New Direction for Optimizing Treatment Selection.

JAMA Psychiatry 2021 Sep 22. Epub 2021 Sep 22.

Department of Statistics, University of Washington, Seattle, Washington.

Importance: Clinical trials have identified numerous prescriptive predictors of mental disorder treatment response, ie, predictors of which treatments are best for which patients. However, none of these prescriptive predictors is strong enough alone to guide precision treatment planning. This has prompted growing interest in developing precision treatment rules (PTRs) that combine information across multiple prescriptive predictors, but this work has been much less successful in psychiatry than some other areas of medicine. Read More

View Article and Full-Text PDF
September 2021

Characterization of wheat-Thinopyrum bessarabicum genetic stock for stripe rust and Karnal bunt resistance.

Braz J Biol 2021 20;83:e246440. Epub 2021 Sep 20.

Hazara University Mansehra, Department of Genetics, Mansehra, Pakistan.

Utilization of modern breeding techniques for developing high yielding and uniform plant types ultimately narrowing the genetic makeup of most crops. Narrowed genetic makeup of these crops has made them vulnerable towards disease and insect epidemics. For sustainable crop production, genetic variability of these crops must be broadened against various biotic and abiotic stresses. Read More

View Article and Full-Text PDF
September 2021

Sustained Replication of Synthetic Canine Distemper Virus Defective Genomes and .

mSphere 2021 Sep 22:e0053721. Epub 2021 Sep 22.

Center for Vaccine Research, University of Pittsburghgrid.21925.3d School of Medicine, Pittsburgh, Pennsylvania, USA.

Defective interfering (DI) genomes restrict viral replication and induce type I interferon. Since DI genomes have been proposed as vaccine adjuvants or therapeutic antiviral agents, it is important to understand their generation, delineate their mechanism of action, develop robust production capacities, assess their safety and longevity, and determine their long-term effects. To address this, we generated a recombinant canine distemper virus (rCDV) from an entirely synthetic molecular clone designed using the genomic sequence from a clinical isolate obtained from a free-ranging raccoon with distemper. Read More

View Article and Full-Text PDF
September 2021

Voices of the community: Exploring the experiences of resettled refugee interpreters at a refugee clinic in a large multicultural city in Texas, United States of America.

Health Soc Care Community 2021 Sep 21. Epub 2021 Sep 21.

School of Nursing, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.

Worldwide refugees numbered nearly 25.9 million in 2018 and, according to the United Nations High Commissioner for Refugees, the crisis grows each year. Research reports that refugees have a high prevalence of mental health conditions and are at increased risk for emotional and mental distress during resettlement. Read More

View Article and Full-Text PDF
September 2021

Pretransplant Hepatitis C Virus Treatment Decreases Access to High-quality Livers.

Transplant Direct 2021 Apr 22;7(4):e684. Epub 2021 Mar 22.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

Background: Despite the revolutionary role of direct-acting antivirals for hepatitis C virus (HCV), the treatment timing for liver transplant candidates remains controversial. We hypothesize that deferring treatment until after liver transplantation improves access to a larger and higher-quality donor pool without a detrimental impact on post-liver transplantation outcomes.

Methods: This single-center study includes recipients that underwent deceased-donor liver transplant with HCV as the primary indication January 1, 2014, to December 31, 2018. Read More

View Article and Full-Text PDF