70 results match your criteria polysubstance involvement


Delay discounting and neurocognitive performance in young adults with differential patterns of substance use: Findings from the Human Connectome Project.

Exp Clin Psychopharmacol 2021 Jun 3. Epub 2021 Jun 3.

Department of Applied Behavioral Science.

A large proportion of individuals who use psychoactive substances regularly use more than one substance. This pattern of behavior, termed polysubstance use, is associated with greater risks than when consuming only a single substance. The present study examined delay discounting, neurocognitive functioning, and demographic indicators among a large, racially and socioeconomically diverse sample of young adults drawn from the Human Connectome Project who reported either non, mono, or dual use of alcohol, tobacco, and/or cannabis. Read More

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The roles of child maltreatment and fathers in the development of substance use in an at-risk sample of youth: A longitudinal study.

Child Abuse Negl 2021 May 27;118:105130. Epub 2021 May 27.

The Ohio State University College of Social Work, 1947 N. College Rd., Columbus, OH 432100, USA. Electronic address:

Background: Despite ample cross-sectional evidence linking child maltreatment and father involvement to adolescent substance use, little is known about the longitudinal impact of child maltreatment and father involvement in the developmental course of substance use from early adolescence to late adolescence.

Objective: The primary aim of the study was to examine the long-term effects of childhood maltreatment (i.e. Read More

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Drugs and Drug Classes Involved in Overdose Deaths Among Females, United States: 1999-2017.

J Womens Health (Larchmt) 2021 May 20. Epub 2021 May 20.

National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Drug overdose deaths among U.S. women have risen steadily from 1999 to 2017, especially among certain ages. Read More

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Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum.

World Psychiatry 2021 Jun;20(2):171-193

Department of Psychiatry, Stony Brook University, Stony Brook, NY, USA.

The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirical effort to address limitations of traditional mental disorder diagnoses. These include arbitrary boundaries between disorder and normality, disorder co-occurrence in the modal case, heterogeneity of presentation within dis-orders, and instability of diagnosis within patients. This paper reviews the evidence on the validity and utility of the disinhibited externalizing and antagonistic externalizing spectra of HiTOP, which together constitute a broad externalizing superspectrum. Read More

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Trends in substances involved in polysubstance overdose fatalities in Maryland, USA 2003-2019.

Drug Alcohol Depend 2021 Jun 12;223:108700. Epub 2021 Apr 12.

Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 624 N. Broadway, Baltimore, MD, 21205, USA.

Background: The substances driving the overdose epidemic in the United States have changed over time. Since 2013, fentanyl-analogues have become the primary opioids driving the epidemic. Recently, polysubstance related deaths have come to the forefront of the epidemic. Read More

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A Digital Health Tool to Understand and Prevent Cannabis-Impaired Driving Among Youth: A Cross-sectional Study of Responses to a Brief Intervention for Cannabis Use.

JMIR Form Res 2021 Mar 2;5(3):e25583. Epub 2021 Mar 2.

Evolution Health Systems, Toronto, ON, Canada.

Background: Cannabis legalization has raised concern about an increased risk of cannabis-impaired driving, particularly among youth. Youth advocates and policy makers require cost-effective tools to target educational resources to promote responsible cannabis use.

Objective: The objective of this paper is threefold. Read More

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Trends in unintentional polysubstance overdose deaths and individual and community correlates of polysubstance overdose, North Carolina, 2009-2018.

Drug Alcohol Depend 2021 02 2;219:108504. Epub 2021 Jan 2.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 2101 McGavran-Greenberg Hall, CB #7435, Chapel Hill, NC, 27599-7435, United States; Injury Prevention Research Center, University of North Carolina at Chapel Hill, 725 Martin Luther King Jr Blvd, Chapel Hill, NC, 27514, United States. Electronic address:

Background: Polysubstance involvement is increasing among fatal drug overdoses. However, little is known about the epidemiology of polysubstance drug overdoses. This paper describes emerging trends in unintentional polysubstance overdose deaths in North Carolina (NC) and examines associations with individual and community factors. Read More

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February 2021

Poly-prescription drug misuse across the life course: Prevalence and correlates across different adult age cohorts in the U.S.

Int J Drug Policy 2021 Feb 20;88:103017. Epub 2020 Nov 20.

Center for the Study of Drugs, Alcohol, Smoking and Health, School of Nursing, University of Michigan, Ann Arbor, MI, United States; Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI, United States; Institute for Research on Women and Gender, University of Michigan, Ann Arbor, MI, United States; Institute for Social Research, University of Michigan, Ann Arbor, MI, United States.

Background: Most research on prescription drug misuse (PDM) focuses on the misuse of specific classes of psychoactive prescription drugs among adolescents or young adults. The current research addressed important gaps in the literature by assessing poly-prescription drug misuse (poly-PDM), the misuse of more than one class of psychoactive prescription drug, across different adult age cohorts.

Methods: We used the 2015-2018 National Survey on Drug Use and Health to examine the prevalence of past-year poly-PDM and specific combinations of PDM. Read More

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February 2021

Prevention of Alcohol-Exposed Pregnancies and Fetal Alcohol Spectrum Disorder Among Pregnant and Postpartum Women: A Systematic Review.

Alcohol Clin Exp Res 2020 12 20;44(12):2431-2448. Epub 2020 Nov 20.

From the, Child Health Research Centre, (MNE, NR), The University of Queensland, South Brisbane, QLD, Australia.

Background: Prenatal alcohol exposure can result in a wide range of adverse health outcomes, including in some cases fetal alcohol spectrum disorder (FASD), a lifelong neurodevelopmental disorder. Thus, there is pressing need for effective interventions to prevent alcohol-exposed pregnancies (AEPs).

Methods: A systematic review was undertaken to provide an up-to-date analysis of the current prevention literature. Read More

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December 2020

Polysubstance Use Patterns among Justice-Involved Individuals Who Use Opioids.

Subst Use Misuse 2020 20;55(13):2165-2174. Epub 2020 Jul 20.

Center on Drug and Alcohol and Research, University of Kentucky, Lexington, Kentucky, USA.

Aim: The current study explores pre-incarceration polysubstance use patterns among a justice-involved population who use opioids. : Data from prison and jail substance use programing in the state of Kentucky from 2015-2017 was examined. : A cohort of 6,569 individuals who reported both pre-incarceration use of opioids and reported the use of more than one substance per day. Read More

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Determinants of substance use among young people attending an urban primary health center in Delhi.

Int J Adolesc Med Health 2020 Jun 1. Epub 2020 Jun 1.

Department of Community Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Introduction Substance abuse remains one of the major challenges in young people, as it is one of the top five causes of disability-adjusted life years (DALY). The present study aims to find the prevalence and determinants of substance use among young people attending an urban primary health center in Delhi. Methodology Systematic random sampling was used to enroll the calculated sample size of 190. Read More

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and endogenous panophthalmitis: clinical and histopathological features.

Am J Ophthalmol Case Rep 2020 Sep 11;19:100738. Epub 2020 May 11.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, USA.

Purpose: To report an unusual case of endogenous panophthalmitis involving and describe its clinical and histopathological features.

Findings: A 30 year-old man with history of human immunodeficiency virus, polysubstance abuse, syphilis, and recently treated pneumonia presented with polymicrobial endogenous panophthalmitis. Two separate ocular specimens confirmed simultaneous and involvement. Read More

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September 2020

Factors Associated with Child-Welfare Involvement among Prenatally Substance-Exposed Infants.

J Pediatr 2020 07 14;222:35-44.e1. Epub 2020 May 14.

Department of Pediatrics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE; Department of Pediatrics, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA.

Objective: To assess factors impacting child-welfare involvement and child abuse and neglect outcomes among prenatally substance-exposed infants.

Study Design: This was a retrospective review of case registry data regarding substance-exposed infants tracked statewide in Delaware from 2014 to 2018. Differences in maternal, infant, and substance exposure factors by level of child-welfare involvement (screened-in vs screened-out case status) and child abuse and neglect outcomes were examined. Read More

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Older-Adult Marijuana Users in Substance Use Treatment: Characteristics Associated with Treatment Completion.

J Psychoactive Drugs 2020 Jul-Aug;52(3):218-227. Epub 2020 Apr 7.

University of Texas at Austin Steve Hicks School of Social Work , Austin, TX, USA.

More older adults are using marijuana and receiving substance use treatment. We used the 2015-2017 Treatment Episode Data Set-Discharges (TEDS-D) to identify characteristics associated with treatment discharge among those aged 50+ whose admission involved marijuana use. Among these discharges ( = 130,287), 7. Read More

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Drug Use Among Adolescents and Young Adults with Unsuppressed HIV Who Use Alcohol: Identifying Patterns of Comorbid Drug Use and Associations with Mental Health.

AIDS Behav 2020 Oct;24(10):2975-2983

Center for Translational Behavioral Research, Florida State University College of Medicine, Tallahassee, FL, USA.

Youth living with HIV (YLWH; aged 16-24) are at elevated risk of alcohol and drug use. Studies in older populations have identified patterns or profiles of multiple substance use differentially associated with mental health and anti-retroviral therapy (ART) adherence. No studies of YLWH have yet examined such patterns. Read More

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October 2020

Substance Use, Mental Health, and Child Welfare Profiles of Juvenile Justice-Involved Commercially Sexually Exploited Youth.

J Child Adolesc Psychopharmacol 2020 07 26;30(6):389-397. Epub 2020 Mar 26.

Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

To describe the substance use profiles of youth impacted by commercial sexual exploitation (CSE) and explore associations between substance use with mental health diagnoses and child welfare involvement. Data were systematically extracted from the court files of 364 youth who participated between 2012 and 2016 in Los Angeles County's Succeeding Through Achievement and Resilience (STAR) Court, a juvenile delinquency specialty court for youth impacted by CSE. Descriptive statistics and multivariate regression analyses were conducted to quantify associations between youths' substance use with mental health diagnoses and child welfare involvement. Read More

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Patterns of Polysubstance Use among Adults with Tranquilizer Misuse.

Subst Use Misuse 2020 3;55(6):861-870. Epub 2020 Jan 3.

Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA.

The misuse of benzodiazepine tranquilizers is prevalent and is associated with increased risk of overdose when combined with other substances. Yet, little is known about other substance use among those who misuse tranquilizers. This study characterized subgroups of individuals with tranquilizer misuse, based on patterns of polysubstance use. Read More

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January 2020

Individual, Family, and School Correlates across Patterns of High School Poly-substance Use.

Subst Use Misuse 2020 12;55(5):743-751. Epub 2019 Dec 12.

School of Social Work, University of Illinois at Urbana-Champaign, Champaign, Illinois, USA.

Recent popularity in e-cigarette use among high school students and the legalization of marijuana across many states resulted in new patterns of poly-substance use (PSU). The purpose of this study is to understand contemporary patterns of PSU and their associations with individual social-emotional characteristics (sensation seeking, perceived harm, life satisfaction) and social-contextual factors (parental involvement, school norms, academics, and behaviors). Latent class analysis (LCA) was used to identify patterns of PSU among 12th-grade students ( = 8417) from the 2016 Monitoring the Future project. Read More

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Trace amine-associated receptor gene polymorphism increases drug craving in individuals with methamphetamine dependence.

PLoS One 2019 10;14(10):e0220270. Epub 2019 Oct 10.

Research & Development Service, VA Portland Health Care System, Portland, OR, United States of America.

Background: Methamphetamine (MA) is a potent agonist at the trace amine-associated receptor 1 (TAAR1). This study evaluated a common variant (CV) in the human TAAR1 gene, synonymous single nucleotide polymorphism (SNP) V288V, to determine the involvement of TAAR1 in MA dependence.

Methods: Participants (n = 106) with active MA dependence (MA-ACT), in remission from MA dependence (MA-REM), with active polysubstance dependence, in remission from polysubstance dependence, and with no history of substance dependence completed neuropsychiatric symptom questionnaires and provided blood samples. Read More

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Gender Differences in Smoking Among an Urban Emergency Department Sample.

Tob Use Insights 2019 26;12:1179173X19879136. Epub 2019 Sep 26.

The Andrew Levitt Center for Social Emergency Medicine, Highland Hospital, Alameda Health System, Oakland, CA, USA.

Background: Urban emergency department (ED) patients have elevated smoking and substance use compared with the general population. We analyzed gender differences in smoking among an urban ED sample and assessed the contribution of substance use, demographic, and couple factors.

Methods: We conducted a secondary analysis of data obtained from a cross-sectional, observational survey (N = 1037 participants) on drinking, drug use, and intimate partner violence (IPV). Read More

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September 2019

Changes in Opioid-Involved Overdose Deaths by Opioid Type and Presence of Benzodiazepines, Cocaine, and Methamphetamine - 25 States, July-December 2017 to January-June 2018.

MMWR Morb Mortal Wkly Rep 2019 Aug 30;68(34):737-744. Epub 2019 Aug 30.

Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, CDC.

From 2013 to 2017, the number of opioid-involved overdose deaths (opioid deaths) in the United States increased 90%, from 25,052 to 47,600.* This increase was primarily driven by substantial increases in deaths involving illicitly manufactured fentanyl (IMF) or fentanyl analogs mixed with heroin, sold as heroin, or pressed into counterfeit prescription pills (1-3). Methamphetamine-involved and cocaine-involved deaths that co-involved opioids also substantially increased from 2016 to 2017 (4). Read More

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Long-Term Outcome of a Brief Intervention to Address Adolescent Drug Abuse in a School Setting.

J Child Adolesc Subst Abuse 2019 14;28(2):132-141. Epub 2019 Jun 14.

University of Minnesota, Minneapolis, MN, USA.

The present study used data from a randomized controlled trial on brief interventions with adolescents to identify distinct longitudinal patterns of substance use and identify predictors, as well as outcomes associated with those use patterns. Data were originally collected for the purpose of evaluating two brief intervention conditions with adolescents who had been identified in a school setting as abusing alcohol or other drugs (total sample, = 315). Adolescents were randomly assigned to a two-session adolescent only brief intervention (BI-A), a two-session adolescent- plus an additional parent session (BI-AP), or an assessment only control session (CON). Read More

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Association of Cyberbullying Involvement With Subsequent Substance Use Among Adolescents.

J Adolesc Health 2019 11 17;65(5):613-620. Epub 2019 Jul 17.

Department of Psychology, University of Southern California, Los Angeles, California; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California. Electronic address:

Purpose: Adolescent involvement in cyberbullying is common and involves several roles (witness, perpetrator, or victim). Whether different cyberbullying roles are differentially associated with substance use is unknown. The present study examined the associations of adolescent cyberbullying involvement with use and polyuse of various substances. Read More

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November 2019

Polysubstance Use Disorder After Sleeve Gastrectomy.

Cureus 2019 Apr 5;11(4):e4388. Epub 2019 Apr 5.

Internal Medicine, Tufts Medical Center, Boston, USA.

We describe a case of polysubstance use disorder that occurred after sleeve gastrectomy. Alcohol, cannabis, and stimulant use disorder was diagnosed a few years after the bariatric surgery when the patient developed a substance-induced psychotic disorder. Treatments included psychotropic medications to treat his psychosis and involvement in a drug rehabilitation and relapse prevention program. Read More

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Drug Overdose Deaths Involving Cocaine and Psychostimulants with Abuse Potential - United States, 2003-2017.

MMWR Morb Mortal Wkly Rep 2019 May 3;68(17):388-395. Epub 2019 May 3.

Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, CDC.

In 2016, a total of 63,632 persons died from drug overdoses in the United States (1). Drug overdose deaths involving cocaine, psychostimulants with abuse potential (psychostimulants), or both substances combined increased 42.4% from 12,122 in 2015 to 17,258 in 2016. Read More

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Health, Polysubstance Use, and Criminal Justice Involvement Among Adults With Varying Levels of Opioid Use.

JAMA Netw Open 2018 07 6;1(3):e180558. Epub 2018 Jul 6.

Division of General Internal Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora.

Importance: Health profiles and patterns of involvement in the criminal justice system among people with various levels of opioid use are poorly defined. Data are needed to inform a public health approach to the opioid epidemic.

Objective: To examine the association between various levels of opioid use in the past year and physical and mental health, co-occurring substance use, and involvement in the criminal justice system. Read More

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Harm reduction strategies related to dosing and their relation to harms among festival attendees who use multiple drugs.

Drug Alcohol Rev 2019 01 9;38(1):57-67. Epub 2018 Oct 9.

Department of Population Health, New York University Langone Medical Center, New York, USA.

Introduction And Aims: Polysubstance users are a high-risk population for negative health-related consequences. Although some studies have described harm reduction strategies adopted by polysubstance users, studies have not examined their effectiveness in minimising health-related consequences. We aimed to identify dosing-related harm reduction strategies in a sample of polysubstance-using dance festival attendees, and explore the relationship between harm reduction strategies and self-reported adverse health consequences. Read More

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January 2019

Men in Community Correction Programs and Their Female Primary Sex Partners: Latent Class Analysis to Identify the Relationship of Clusters of Drug Use and Sexual Behaviors and HIV Risks.

J Urban Health 2019 06;96(3):411-428

Social Intervention Group, School of Social Work, Columbia University, New York, NY, USA.

Existing research indicates that justice-involved individuals use a variety of different drugs and polysubstance use is common. Research shows that different typologies of drug users, such as polydrug users versus users of a single drug, have differing types of individual-, structural-, and neighborhood-level risk characteristics. However, little research has been conducted on how different typologies of drug use are associated with HIV risks among individuals in community corrections and their intimate sex partners. Read More

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