277 results match your criteria polyps sizes

Endoscopic Findings in Patients With PTEN Hamartoma Tumor Syndrome Undergoing Surveillance.

J Clin Gastroenterol 2021 Jul 7. Epub 2021 Jul 7.

Departments of Internal Medicine Gastroenterology, Hepatology, and Nutrition Colorectal Surgery Genomic Medicine Institute Center for Personalized Genetic Healthcare Pathology and Laboratory Medicine Institute Sanford R. Weiss, M.D. Center for Hereditary Colorectal Neoplasia, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH.

Goals And Background: Phosphatase and tensin homolog hamartoma tumor syndrome (PHTS) is an inherited disorder that increases the risk for cancer in multiple organ systems, including breast, endometrial, thyroid, and the gastrointestinal tract. Surveillance is recommended however there lacks data to describe the change in polyposis phenotype and cancer incidence over surveillance. Our aim is to describe the polyposis phenotype and cancer incidence in PHTS patients undergoing endoscopic surveillance. Read More

View Article and Full-Text PDF

Usefulness of a Colonoscopy Cap with an External Grid for the Measurement of Small-Sized Colorectal Polyps: A Prospective Randomized Trial.

J Clin Med 2021 May 27;10(11). Epub 2021 May 27.

Department of Internal Medicine, Wonju College of Medicine, Yonsei University, Wonju 24626, Korea.

Accurate measurement of polyp size during colonoscopy is crucial. The usefulness of cap-assisted colonoscopy and external grid application on monitor (gCAP) was evaluated for polyp size measurement in this 3-year, single-center, single-blind, randomized trial. Using the endoscopic forceps width as reference, the discrepancy percent (DP), error rate (ER), and measurement time were compared between gCAP and visual estimation (VE) after randomization. Read More

View Article and Full-Text PDF

Microscopic Colitis and Risk of Colon Adenomas: A Multicenter Retrospective Cohort Study.

Clin Gastroenterol Hepatol 2021 May 29. Epub 2021 May 29.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address:

Microscopic colitis (MC) is a common cause of chronic watery diarrhea, with the highest incidence in women over age 50. Cross-sectional studies have suggested that patients with MC have a lower incidence of adenomatous colon polyps compared with those without MC. The existing literature is limited by cross-sectional design, small sample sizes, lack of longitudinal follow-up, and the use of average-risk patients, rather than those with chronic diarrhea, as controls. Read More

View Article and Full-Text PDF

Correlation of LINE-1 Hypomethylation With Size and Pathologic Extent of Dysplasia in Colorectal Tubular Adenomas.

Clin Transl Gastroenterol 2021 Jun 1;12(6):e00369. Epub 2021 Jun 1.

Division of Digestive Diseases, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA.

Introduction: Conventional adenomas (tubular adenoma [TA] or tubulovillous adenoma) and sessile serrated lesions (SSLs) are neoplastic precancerous lesions frequently detected in patients undergoing average risk screening colonoscopy and polyp surveillance. Metachronous risk stratification of adenomas is currently limited to histologic features and size of polyps. We report long interspersed nucleotide element-1 (LINE-1) methylation levels in SSL in comparison to TA and the impact of TA size and presence of high-grade dysplasia (HGD) on LINE-1 methylation. Read More

View Article and Full-Text PDF

Comparison of Polypoidal Choroidal Vasculopathy Lesion Sizes Measured on Multicolor Imaging and Indocyanine Green Angiography.

Transl Vis Sci Technol 2021 02;10(2):35

National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.

Purpose: To evaluate the areas of lesion components of polypoidal choroidal vasculopathy (PCV) measured using multicolor imaging compared to indocyanine green angiography (ICGA).

Methods: In a prospective study of 50 consecutive treatment-naïve PCV patients, multicolor imaging and ICGA were performed. The images were independently graded by reading center-certified retinal specialists to confirm the diagnosis of PCV and identify lesion components. Read More

View Article and Full-Text PDF
February 2021

Laparoscopic Cholecystectomy for Gallbladder Dysfunction and Polyps: Incidence and Follow up.

JSLS 2021 Apr-Jun;25(2)

University Hospital Hairmyres, Lanarkshire, Scotland, UK.

Aim: This study aims to evaluate the incidence, indications, management, and long term follow up of cholecystectomy in patients with no gallstones, other than acalculous acute cholecystitis.

Methods: Prospectively collected data of 5675 patients undergoing laparoscopic cholecystectomy (LC) over 28 years was extracted and analyzed. Patients with biliary symptoms, no stones on ultrasound scans and abnormal hepatobiliary iminodiacetic acid scans, and those with confirmed gallbladder polyps (GBP) were included. Read More

View Article and Full-Text PDF

Gastric polyp detection in gastroscopic images using deep neural network.

PLoS One 2021 28;16(4):e0250632. Epub 2021 Apr 28.

School of Automation, Southeast University, Nanjing, China.

This paper presents the research results of detecting gastric polyps with deep learning object detection method in gastroscopic images. Gastric polyps have various sizes. The difficulty of polyp detection is that small polyps are difficult to detect from the background. Read More

View Article and Full-Text PDF

Accurate measurement of colorectal polyps using computer-aided analysis.

Eur J Gastroenterol Hepatol 2021 May;33(5):701-708

Department of Gastroenterology, Zhongshan Hospital Xiamen University, Xiamen.

Introduction: As we know, the majority of colorectal cancers are thought to evolve from colorectal adenomas. In this study, we explored the use of Computer-aided diagnosis (CAD) in the detection of colorectal polyps and the estimation of their sizes, which is important for the diagnosis and management of colorectal cancer.

Materials And Methods: As the distance between colonoscopy and lesion increases, magnification tends to decrease. Read More

View Article and Full-Text PDF

Congenital Hairy Polyp Causing Severe Upper Airway Obstruction in a Newborn: A Case Report.

Am J Case Rep 2021 Mar 25;22:e930200. Epub 2021 Mar 25.

Department of Special Surgery, School of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

BACKGROUND Hairy polyps are rare tumors mainly comprising fatty tissues covered by skin and hair follicles, with varied localizations and sizes. Early excision of the polyps by surgery is an effective treatment resulting in a permanent cure. We present a case of successful management of severe obstruction of the oropharynx in a newborn who presented with a large mass of congenital hairy polyp. Read More

View Article and Full-Text PDF

Artificial Intelligence-Based Assessment of Colorectal Polyp Histology by Elastic-Scattering Spectroscopy.

Dig Dis Sci 2021 Mar 24. Epub 2021 Mar 24.

Research Service, VA Boston Healthcare System, 150 South Huntington Ave., Boston, MA, 02130, USA.

Background: Colonoscopic screening and surveillance for colorectal cancer could be made safer and more efficient if endoscopists could predict histology without the need to biopsy and perform histopathology on every polyp. Elastic-scattering spectroscopy (ESS), using fiberoptic probes integrated into standard biopsy tools, can assess, both in vivo and in real time, the scattering and absorption properties of tissue related to its underlying pathology.

Aims: The objective of this study was to evaluate prospectively the potential of ESS to predict polyp pathology accurately. Read More

View Article and Full-Text PDF

Prophylactic clipping to prevent delayed colonic post-polypectomy bleeding: meta-analysis of randomized and observational studies.

Surg Endosc 2021 Mar 9. Epub 2021 Mar 9.

Division of Gastroenterology, Department of Medicine, University of Calgary, TRW 6D19, 3280 Hospital Drive NW, Calgary, AB, T2N 4Z6, Canada.

Background And Aims: Delayed post-polypectomy bleeding (DPPB) is a commonly described adverse event following polypectomy. Prophylactic clipping may prevent DPPB in some patient subgroups. We performed a meta-analysis to assess both the efficacy and real-world effectiveness of prophylactic clipping. Read More

View Article and Full-Text PDF

Responsiveness and convergent validity of the chronic rhinosinusitis patient-reported outcome (CRS-PRO) measure in CRS patients undergoing endoscopic sinus surgery.

Int Forum Allergy Rhinol 2021 Mar 16. Epub 2021 Mar 16.

Department of Otolaryngology-Head and Neck Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.

Background: The chronic rhinosinusitis patient-reported outcome (CRS-PRO) measure is a 12-item measure with previously demonstrated validity in chronic rhinosinusitis (CRS) patients receiving medical therapy. This study establishes the factor structure, responsiveness, and convergent validity of the CRS-PRO following endoscopic sinus surgery (ESS).

Methods: Northwestern CRS Subject Registry patients had pre-ESS, 3-month (n = 111; CRS without nasal polyps [CRSsNP] = 60, CRS with nasal polyps [CRSwNP] = 51), and 6-month (n = 86; CRSsNP = 47, CRSwNP = 39) post-ESS assessments where patients completed the CRS-PRO, 22-item Sino-Nasal Outcome Test (SNOT-22), and four Patient-Reported Outcomes Measurement (PROM) Information System (PROMIS) short forms (general health measures). Read More

View Article and Full-Text PDF

State-of-the-art overview on biological treatment for CRSwNP.

Rhinology 2021 Apr;59(2):151-163

Department of Otorhinolaryngology, Head and Neck Surgery, Academic Medical Centre (AMC), Amsterdam, the Netherlands.

Background: The majority of patients with uncontrolled severe CRSwNP, asthma and atopic dermatitis share a similar T helper 2 type inflammation linked to their underlying phenotype. This discovery has triggered new research around treatments targeting specific cytokines driving inflammation in CRSwNP like IL-4, IL-13, IL-5 and IgE. Biologicals are increasingly tested as additional tre- atment for patients suffering from severe chronic rhinosinusitis with nasal polyps (CRSwNP). Read More

View Article and Full-Text PDF

Giant Villous Adenoma: A Rare Case of Colorectal Adenoma that Mimic Colorectal Cancer.

Mymensingh Med J 2021 Jan;30(1):220-223

Dr Md Ashek Mahmud Ferdaus, Assistant Professor, Department of Colorectal Surgery, Mymensingh Medical College (MMC), Mymensingh, Bangladesh; E-mail:

Colorectal cancer being the 4th most common cause of cancer death in which most arise from a preexisting adenomatous polyp. Among the various adenomas Giant villous adenoma (GVA) is less common. We came across a 65 years female with intermittent per rectal mucus discharge for last 10 years and intermittent fresh, painless, scanty per rectal bleeding along with weakness and fatigue for last 5 years. Read More

View Article and Full-Text PDF
January 2021

Prognostic Factors for Advanced Colorectal Neoplasia in Inflammatory Bowel Disease: Systematic Review and Meta-analysis.

Gastroenterology 2021 Apr 29;160(5):1584-1598. Epub 2020 Dec 29.

Inflammatory Bowel Disease Centre, Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, the Netherlands. Electronic address:

Background And Aims: Patients with inflammatory bowel disease (IBD) have an increased risk of colorectal cancer (CRC). We performed a systematic review and meta-analysis to identify all prognostic factors for advanced colorectal neoplasia (aCRN, high-grade dysplasia, or CRC) in patients with IBD.

Methods: A systematic literature search was conducted according to the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines. Read More

View Article and Full-Text PDF

Endoscopic mucosal ablation - an alternative treatment for colonic polyps: Three case reports.

World J Gastroenterol 2020 Dec;26(45):7258-7262

Department of Endoscopy, University Medical Center of El Paso, El Paso, TX 79905, United States.

Background: Endoscopic resection of non-invasive lesions is now the standard of care for lesions in the GI tract. However, resection techniques require extensive training, are not available in all endoscopy centers and are prone to complications. Endoscopic mucosal ablation (EMA) is a combination of resection and ablation techniques and it may offer an alternative in the management of such lesions. Read More

View Article and Full-Text PDF
December 2020

Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen.

Cochrane Database Syst Rev 2020 12 21;12:CD007245. Epub 2020 Dec 21.

Department of Reproductive Medicine, University of California, San Diego, La Jolla, California, USA.

Background: Adjuvant tamoxifen reduces the risk of breast cancer recurrence in women with oestrogen receptor-positive breast cancer. Tamoxifen also increases the risk of postmenopausal bleeding, endometrial polyps, hyperplasia, and endometrial cancer. The levonorgestrel-releasing intrauterine system (LNG-IUS) causes profound endometrial suppression. Read More

View Article and Full-Text PDF
December 2020

PolypSegNet: A modified encoder-decoder architecture for automated polyp segmentation from colonoscopy images.

Comput Biol Med 2021 01 13;128:104119. Epub 2020 Nov 13.

Department of EEE, BUET, ECE Building, West Palashi, Dhaka, 1205, Bangladesh. Electronic address:

Colorectal cancer has become one of the major causes of death throughout the world. Early detection of Polyp, an early symptom of colorectal cancer, can increase the survival rate to 90%. Segmentation of Polyp regions from colonoscopy images can facilitate the faster diagnosis. Read More

View Article and Full-Text PDF
January 2021

Colon Capsule Endoscopy vs. CT Colonography Following Incomplete Colonoscopy: A Systematic Review with Meta-Analysis.

Cancers (Basel) 2020 Nov 13;12(11). Epub 2020 Nov 13.

Department of Clinical Research, University of Southern Denmark, 5230 Odense M, Denmark.

Following incomplete colonoscopy (IC) patients often undergo computed tomography colonography (CTC), but colon capsule endoscopy (CCE) may be an alternative. We compared the completion rate, sensitivity and diagnostic yield for polyp detection from CCE and CTC following IC. A systematic literature search resulted in twenty-six studies. Read More

View Article and Full-Text PDF
November 2020

Deficiency of Splicing Factor 1 (SF1) Reduces Intestinal Polyp Incidence in Mice.

Biology (Basel) 2020 Nov 13;9(11). Epub 2020 Nov 13.

Department of Pharmaceutical Sciences, Texas Southern University, Houston, TX 77004, USA.

Background: Splicing factor 1 (SF1) is a conserved alternative splicing factor expressed in many different mammalian cell types. The genetically modified (or ) mice express reduced levels of SF1 protein in mouse tissues, including in cells of the intestines. Mutational inactivation of human adenomatous polyposis coli (APC) gene deregulates the signaling pathway and is a frequent genetic event in colon cancers. Read More

View Article and Full-Text PDF
November 2020

Inflammation-driven vascular dysregulation in chronic rhinosinusitis.

Int Forum Allergy Rhinol 2021 Jun 2;11(6):976-983. Epub 2020 Nov 2.

Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT.

Background: Altered neovascularity is typically observed in chronic inflammatory diseases with overlapping pathophysiology to that observed in chronic rhinosinusitis (CRS). However, characterization of these inflammatory-induced vascular-mediated changes in CRS is limited. Understanding the underlying vascular changes in CRS will allow for strategic design and development of new drug-delivery technologies that exploit vascular permeability for increased extravasation into the target sinonasal tissues. Read More

View Article and Full-Text PDF

Real-time artificial intelligence-based histologic classification of colorectal polyps with augmented visualization.

Gastrointest Endosc 2021 03 16;93(3):662-670. Epub 2020 Sep 16.

Research Service, VA Boston Healthcare System, Boston, MA; Department of Biomedical Engineering, Boston University College of Engineering, Boston, MA; Department of Medicine, Section of Gastroenterology, VA Boston Healthcare System, Boston, MA; Department of Medicine, Boston University School of Medicine, Boston, MA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Background And Aims: Artificial intelligence (AI)-based computer-aided diagnostic (CADx) algorithms are a promising approach for real-time histology (RTH) of colonic polyps. Our aim is to present a novel in situ CADx approach that seeks to increase transparency and interpretability of results by generating an intuitive augmented visualization of the model's predicted histology over the polyp surface.

Methods: We developed a deep learning model using semantic segmentation to delineate polyp boundaries and a deep learning model to classify subregions within the segmented polyp. Read More

View Article and Full-Text PDF

Divergent bitter and sweet taste perception intensity in chronic rhinosinusitis patients.

Int Forum Allergy Rhinol 2021 May 26;11(5):857-865. Epub 2020 Aug 26.

Monell Chemical Senses Center, Philadelphia, PA.

Background: Bitter and sweet taste receptors are present in the human upper airway, where they have roles in innate immunity. Previous studies have shown that 1 of the 25 bitter receptors, TAS2R38, responds to specific bacterial signaling molecules and evokes 1 type of a defense response in the upper airway, whereas ligands of sweet receptors suppress other types of defense responses.

Methods: We examined whether other bitter taste receptors might also be involved in innate immunity by using sensory responses to bitter compounds that are not ligands of TAS2R38 (quinine and denatonium benzoate) to assess the sensitivity of other bitter receptors in chronic rhinosinusitis (CRS) patients. Read More

View Article and Full-Text PDF

Differential diagnosis of umbilical polyps and granulomas in children: sonographic and pathologic correlations.

Ultrasonography 2021 Apr 26;40(2):248-255. Epub 2020 May 26.

Department of Pathology, Keimyung University Dongsan Hospital, Daegu, Korea.

Purpose: The sonographic differential diagnosis of umbilical polyps and granulomas in children based on correlations with pathologic findings.

Methods: We retrospectively analyzed the ultrasonographic findings of twenty-two umbilical masses in children that were pathologically confirmed as umbilical polyps or umbilical granulomas by surgery. We analyzed size, depth, echogenicity, internal content, intralesional vascularity, and the presence of unobliterated medial umbilical ligament. Read More

View Article and Full-Text PDF

Long-term imaging of the photosensitive, reef-building coral Acropora muricata using light-sheet illumination.

Sci Rep 2020 06 25;10(1):10369. Epub 2020 Jun 25.

School of Life Sciences, University of Essex, Colchester, CO4 3SQ, UK.

Coral reefs are in alarming decline due to climate emergency, pollution and other man-made disturbances. The numerous ecosystem services derived from coral reefs are underpinned by the growth and physical complexity of reef-forming corals. Our knowledge of their fundamental biology is limited by available technology. Read More

View Article and Full-Text PDF

Effect of PIERCE1 on colorectal cancer.

Exp Anim 2020 Nov 25;69(4):414-422. Epub 2020 Jun 25.

Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Yonsei Ro 50, Seodaemun-gu, Seoul 03722, Republic of Korea.

Colorectal cancer is the second most lethal cancer type across all ages and sexes, the many mechanisms of which are still currently being further elucidated. PIERCE1 has been known to be involved in the cell cycle and proliferation, the expression of which is regulated by stress conditions in a p53-dependent manner. Through a database search, we found that PIERCE1 was significantly augmented in patients with colorectal carcinoma compared to normal samples, suggesting its possible role in tumor regulation. Read More

View Article and Full-Text PDF
November 2020

Nasal nebulization inhalation of budesonide for chronic rhinosinusitis with nasal polyps: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 May;99(22):e20354

Department of Otorhinolaryngology, Second Hospital of Jiamusi Agricultural Reclamation, Jiamusi, China.

Background: Chronic rhinosinusitis and nasal polyps (CRNP) is a common public health concern for general population, and is thought to negatively impact their quality of life. Although previous studies have reported that nasal nebulization inhalation of budesonide (NNIB) can benefit patients with such condition, its conclusions are still inconsistent. Thus, this study will assess the efficacy and safety of NNIB for the treatment of CRNP. Read More

View Article and Full-Text PDF

Rates of Incomplete Resection of 1- to 20-mm Colorectal Polyps: A Systematic Review and Meta-Analysis.

Gastroenterology 2020 09 8;159(3):904-914.e12. Epub 2020 May 8.

Montreal University Hospital Research Center (CRCHUM), Montreal, Canada; Division of Gastroenterology, Montreal University Hospital Center (CHUM), Montreal, Canada. Electronic address:

Background & Aims: Incomplete resection of neoplastic colorectal polyps can result in postcolonoscopy colorectal cancer. We performed a systematic review and meta-analysis to determine the incomplete resection rate (IRR) of colorectal polyps and associated factors.

Methods: We searched MEDLINE, EMBASE, EBM Reviews, and CINAHL to identify full-text articles that reported IRRs of polyps 1 to 20 mm, published until March 2019. Read More

View Article and Full-Text PDF
September 2020

Comparison of underwater and conventional endoscopic mucosal resection for removing sessile colorectal polyps: a propensity-score matched cohort study.

Endosc Int Open 2019 Nov 31;7(11):E1528-E1536. Epub 2019 Oct 31.

Department of Gastroenterology, Chimei Medical Center, Tainan, Taiwan.

 Endoscopic mucosal resection (EMR) is a standard method for removing sessile colorectal polyps ≥ 10 mm. Recently, underwater EMR (UEMR) has been introduced as a potential alternative. However, the effectiveness and safety of UEMR compared with conventional EMR is un clear. Read More

View Article and Full-Text PDF
November 2019

Asphyxia Caused by a Giant Fibrovascular Polyp of the Esophagus.

ACG Case Rep J 2019 Jul 23;6(7):e00126. Epub 2019 Jul 23.

Pontificia Universidad Católica del Ecuador (PUCE), Quito, Ecuador.

Fibrovascular polyps (FVPs) are rare, benign tumors of the esophagus; they usually appear as an intraluminal mass within the esophagus, which can grow and reach enormous sizes if left untreated. They can cause a variety of symptoms, from mild dysphagia to life-threatening asphyxia. Diagnosis is challenging because FVPs can resemble any respiratory condition, which can lead to misdiagnosis and potentially dangerous therapies. Read More

View Article and Full-Text PDF