20 results match your criteria polyps 5 cm

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Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation.

Cell Death Dis 2020 12 10;11(12):1045. Epub 2020 Dec 10.

Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 291, 00161, Rome, Italy.

Eukaryotic Translation Initiation Factor 5A (EIF5A) is a translation factor regulated by hypusination, a unique posttranslational modification catalyzed by deoxyhypusine synthetase (DHPS) and deoxyhypusine hydroxylase (DOHH) starting from the polyamine spermidine. Emerging data are showing that hypusinated EIF5A regulates key cellular processes such as autophagy, senescence, polyamine homeostasis, energy metabolism, and plays a role in cancer. However, the effects of EIF5A inhibition in preclinical cancer models, the mechanism of action, and specific translational targets are still poorly understood. Read More

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December 2020

Distinctive crypt shape in a sessile serrated adenoma/polyp: Distribution of Ki67-, p16INK4a-, WNT5A-positive cells and intraepithelial lymphocytes.

Oncol Rep 2017 Aug 15;38(2):775-784. Epub 2017 Jun 15.

Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.

Serrated lesions in the colorectum are currently predominantly classified as hyperplastic polyps (HPs), sessile serrated adenomas/polyps (SSA/Ps), and traditional serrated adenomas (TSAs) according to their morphology. However, the histological morphology and the molecular changes in the serrated lesions are still unclear. We performed immunohistochemistry for Ki67, p16INK4a, and WNT5A in human HPs (n=22), SSA/Ps (n=41), and TSAs (n=19). Read More

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Age dictates a steroid-resistant cascade of Wnt5a, transglutaminase 2, and leukotrienes in inflamed airways.

J Allergy Clin Immunol 2017 Apr 20;139(4):1343-1354.e6. Epub 2016 Aug 20.

Center of Allergy and Environment (ZAUM), Member of the German Center for Lung Research (DZL), Technical University of Munich and Helmholtz Center Munich, Munich, Germany. Electronic address:

Background: Airway remodeling is a detrimental and refractory process showing age-dependent clinical manifestations that are mechanistically undefined. The leukotriene (LT) and wingless/integrase (Wnt) pathways have been implicated in remodeling, but age-specific expression profiles and common regulators remained elusive.

Objective: We sought to study the activation of the LT and Wnt pathways during early- or late-onset allergic airway inflammation and to address regulatory mechanisms and clinical relevance in normal human bronchial epithelial cells (NHBEs) and nasal polyp tissues. Read More

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Increased phosphorylation of STAT5b, but not STAT5a, in nasal polyps.

Am J Rhinol Allergy 2015 May-Jun;29(3):182-7

Department of Oto-Rhino-Laryngology and Facial Plastic Surgery, University of Luebeck, Luebeck, Germany.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a recurrent, benign, extensively proliferating disease that is triggered by inflammation. The signaling pathways in sinusitis and the regulation by intracellular signaling peptides and proteins are not fully understood. Signal transducer and activator of transcription (STAT) 5a and STAT5b are two closely related phosphokinases involved in the regulation of diverse cellular functions, including proliferation and apoptosis. Read More

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February 2016

PARP-1 expression is increased in colon adenoma and carcinoma and correlates with OGG1.

PLoS One 2014 19;9(12):e115558. Epub 2014 Dec 19.

Department of Clinical Biochemistry, Collegium Medicum, Nicolaus Copernicus University, Karlowicza 24, PO-85-092 Bydgoszcz, Poland.

The ethiology of colon cancer is largely dependent on inflammation driven oxidative stress. The analysis of 8-oxodeoxyguanosine (8-oxodGuo) level in leukocyte DNA of healthy controls (138 individuals), patients with benign adenomas (AD, 137 individuals) and with malignant carcinomas (CRC, 169 individuals) revealed a significant increase in the level of 8-oxodGuo in leukocyte DNA of AD and CRC patients in comparison to controls. The counteracting mechanism is base excision repair, in which OGG1 and PARP-1 play a key role. Read More

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December 2015

Detection of colon polyps by a novel, polymer pattern-based full blood test.

J Transl Med 2013 Nov 4;11:278. Epub 2013 Nov 4.

INDAGO GmbH, Deutscher Platz 5a, Leipzig D-04103, Germany.

Numerous studies have shown that early screening for the presence of pre-cancerous colon polyps and their subsequent removal decreases the risk of developing colon cancer. Colonoscopy is currently the most effective screening method, but due to the invasive nature of the procedure many patients avoid forgo testing. Futhermore, the procedure itself requires perfect execution by the gastroenterologist. Read More

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November 2013

[Up-regulation of Wnt5A in chronic rhinosinusitis with nasal polyps].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2010 Dec;24(23):1064-7

Department of Otolaryngology Head and Neck Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Objective: Wnt5A contributes to the inflammatory activation of mononuclear cells and tissue remodeling. Hence we compared Wnt5A expression between chronic rhinosinusitis (CRS) patients with and without nasal polyps (NPs), analyzed its possible role in the pathogenesis of CRS.

Method: The expression of Wnt5A and of pLRP6 were compared between controls, CRSwNP and CRSsNP by means of western blotting and immunohistochemistry. Read More

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December 2010

Elevation of WNT5A expression in polyp formation in Lkb1+/- mice and Peutz-Jeghers syndrome.

J Pathol 2011 Apr 21;223(5):584-92. Epub 2011 Feb 21.

Colorectal Cancer Genetics, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, Whitechapel, London, UK.

Peutz-Jeghers syndrome (PJS) is a rare, inherited disease caused by germline mutation of the LKB1 gene. Patients with PJS develop characteristic polyps in the digestive tract and carry an elevated risk of cancers in multiple organs, including the intestinal tract. While LKB1 is capable of phosphorylating AMPK and regulates the mTOR pathway, it is also known to be a multitasking protein that can influence other cellular processes, including cell polarity. Read More

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Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients.

Mutagenesis 2010 Sep 9;25(5):463-71. Epub 2010 Jun 9.

Department of Molecular Biology, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, 02-106 Warsaw, Poland.

Oxidative stress is involved in the pathogenesis of colon cancer. We wanted to elucidate at which stage of the disease this phenomenon occurs. In the examined groups of patients with colorectal cancer (CRC, n = 89), benign adenoma (AD, n = 77) and healthy volunteers (controls, n = 99), we measured: vitamins A, C and E in blood plasma, 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydroguanine (8-oxoGua) in leukocytes and urine, leukocyte 8-oxoGua excision activity, mRNA levels of APE1, OGG1, 8-oxo-7,8-dihydrodeoxyguanosine 5'-triphosphate pyrophosphohydrolase (MTH1) and OGG1 polymorphism. Read More

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September 2010

Human topoisomerase II-alpha is highly expressed in sinonasal-inverted papilloma, but not in inflammatory polyp.

J Cell Mol Med 2008 Sep-Oct;12(5A):1551-8. Epub 2008 Jun 9.

Department of Head and Neck Surgery, Rabin Medical Center, Petah Tikva, Israel.

Sinonasal-inverted papilloma is a benign tumour with a high rate of recurrence, but possible malignant transformation. Therefore, investigation of predisposition to malignant transformation of sinonasal-inverted papilloma gives clinicians the opportunity for adequate treatment. Topoisomerase II-alpha (topoII-alpha) and Ki67 are markers of cell proliferation in both normal and neoplastic tissues and its level o expression could be used as a predictive parameter. Read More

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February 2009

Non-steroidal anti-inflammatory drugs in cancer prevention and therapy.

Anticancer Res 2007 Sep-Oct;27(5A):3147-62

Department of Laboratory Medicine and Advanced Biotechnologies, IRCCS San Raffaele Pisana, Rome, Italy.

Long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) can be regarded as an effective approach for cancer chemoprevention, as demonstrated by a bulk of clinical and experimental evidence. However, the clinical use of these drugs as chemopreventive agents is limited by many open questions about the optimal drug, dose, duration of therapy and knowledge about the mechanism(s) by which these drugs act. In particular, the recent data on cardiovascular toxicity of coxibs has posed some limitations on the use of NSAIDs for cancer chemoprevention in the general population. Read More

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November 2007

Does nonsteroidal anti-inflammatory drug use modify the effect of a low-fat, high-fiber diet on recurrence of colorectal adenomas?

Cancer Epidemiol Biomarkers Prev 2005 Oct;14(10):2359-65

Department of Nutritional Sciences, The Pennsylvania State University, 5A Henderson Building, University Park, PA 16802, USA.

The Polyp Prevention Trial was designed to evaluate the effects of a high-fiber (18 g/1,000 kcal), high-fruit and -vegetable (3.5 servings/1,000 kcal), low-fat (20% energy) diet on recurrence of adenomatous polyps. Participants > or =35 years of age, with histologically confirmed colorectal adenoma(s) removed in the prior 6 months, were randomized to the intervention or control group. Read More

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October 2005

NTP Toxicology and Carcinogenesis Studies of Oxymetholone (CAS NO. 434-07-1) in F344/N Rats and Toxicology Studies of Oxymetholone in B6C3F1 Mice (Gavage Studies).

Authors:

Natl Toxicol Program Tech Rep Ser 1999 Aug;485:1-233

Oxymetholone is a synthetic anabolic steroid used to treat a variety of conditions, including hypogonadism and delayed puberty. It is also used to correct hereditary angioneurotic edema, manage carcinoma of the breast, promote a positive nitrogen balance following injury or surgery, and stimulate erythropoiesis. Considerable amounts of androgens are consumed by athletes in attempts to improve athletic performance. Read More

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Up-regulation of macrophage wnt gene expression in adenoma-carcinoma progression of human colorectal cancer.

Br J Cancer 1999 Oct;81(3):496-502

ICRF Molecular Oncology Laboratory, John Radcliffe Hospital, Oxford, UK.

Defects in the APC-beta-catenin pathway are common in colon cancer. We investigated whether aberrant regulation of upstream ligands stimulating this pathway occur in colon cancer. Using RNAase protection analysis, six out of eight wnt genes were expressed in 14 matched cases of normal, adenomatous and malignant colorectal tissues. Read More

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October 1999

Lectin immunohistochemistry study of nasal inverted papilloma and associated neoplasms.

Anticancer Res 1997 Sep-Oct;17(5A):3691-6

Department of Otolaryngology, Faculty of Medicine, National Cheng Kung University, Tainan, Taiwan.

Background: We aimed to investigate the tumor biology of nasal IP and identify the biological characteristics associated with early diagnosis and malignant transformation.

Materials And Methods: Lectins immunohistochemistry were performed on inverted papilloma (IP), and associated neoplasms. IP synchronized with polyp or squamous cell carcinoma (SCC) and IP metachronized with SCC were analyzed and correlated to clinical information. Read More

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January 1998

Evidence for the involvement of the Wnt 2 gene in human colorectal cancer.

Oncogene 1996 Jan;12(1):153-8

Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Israel.

Colorectal cancer (CRC) is one of the most frequent cancers in humans. It develops via a multistage process involving alterations of both protooncogenes and tumor suppressor genes. In the present report we determined the level of expression of several Wnt genes in CRC by RT-PCR and direct sequencing. Read More

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January 1996

Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis.

Clin Cancer Res 1995 Nov;1(11):1421-8

Departments of Cancer Biology, Urology, and Colorectal Surgery, Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

RNA decay in IFN-treated cells is controlled by 2'5'-linked oligoadenylate (2-5A)-dependent RNase (RNase L), a uniquely regulated endoribonuclease that requires short 5'-phosphorylated, 2-5A for its activity. Because RNase L is also implicated in the regulation of cell proliferation, we monitored its expression in colorectal adenocarcinomas and noncancerous polyps from familial adenomatous polyposis patients. Elevated levels of RNase L mRNA and activity were found in 17 of 20 tumors compared with corresponding normal mucosa. Read More

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November 1995

Evaluation of the ras and myc oncoproteins in benign gastric lesions.

Anticancer Res 1990 Sep-Oct;10(5A):1127-33

Ippokration General Hospital, Athens, Greece.

Ras and c-myc oncoprotein expression was analyzed using specific monoclonal antibodies Y13-259 (for ras p21) and mycl-9E10 (for c-myc p62) in 144 histological sections derived from benign gastric lesions. Increased expression of ras p21 was observed in inflammatory metaplastic, dysplastic, hyperplastic and cystic histological changes, and on the basis of ras p21 staining three distinct histological groups emerged: (i) cystic changes, hyperplastic polyps; (ii) inflammatory gastritis; (iii) metaplastic, dysplastic and adenomatous polyps. Elevated levels of ras p21 expression were found at significantly higher levels than those of c-myc expression in dysplastic lesions. Read More

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December 1990

Phenotypic and genetic alterations in pre-cancerous cells in the colon.

Anticancer Res 1988 Sep-Oct;8(5A):1005-13

State University of New York, Stony Brook 11794.

Cell dysplasia in polyps and in ulcerative colitis are thought to be the pre-cancerous lesion leading to invasive colon cancer. Many polyps and dysplastic lesions in ulcerative colitis have phenotypic changes (blood group antigen, cytokeratins, CEA, TAG-72.3 antigen expression) and genetic changes (c-K-ras mutation, enhanced c-myc expression and pp60c-src activity) which are characteristic of invasive cancers. Read More

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November 1988
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