20,433 results match your criteria polychlorinated biphenyl

Toxic effects of 2,4,4'- trichlorobiphenyl (PCB-28) on growth, photosynthesis characteristics and antioxidant defense system of Lemna minor L.

Plant Physiol Biochem 2021 Jun 20;166:505-511. Epub 2021 Jun 20.

Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, China; Advanced Analysis and Testing Center, Nanjing Forestry University, Nanjing, China.

Polychlorinated biphenyls (PCBs) are a common category of persistent man-made organic pollutants that are widespread in the ambient environment. Although Lemna minor L. is an extensively applied plant for aquatic remediation in ecotoxicology research worldwide, little is known regarding its responses to the potentially toxic effects of PCBs. Read More

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Ambient air monitoring around the dioxin remediation site in Da Nang, Vietnam, using passive air samplers.

Environ Monit Assess 2021 Jun 21;193(7):434. Epub 2021 Jun 21.

Institute of Bio-Medicine, Vietnam-Russia Tropical Centre, 63 Nguyen Van Huyen, Hanoi, Vietnam.

The concentrations and temporal variations of polychlorodibenzo-p-dioxins and polychlorodibenzofurans (PCDDs/PCDFs) in ambient air between March 2013 and February 2017 were investigated by passive air samplers containing polyurethane foam (PUF) disks in the dioxin remediation area using in-pile thermal desorption (IPTD) technology at Da Nang airport, Vietnam. The PCDD/PCDF concentrations in ambient air at each site depended on the location of the emission sources and the wind direction, the dioxin contamination level of excavated materials, the periods of excavation and transport, and the operation of the IPTD treatment system. The PCDD/PCDF concentrations were the highest in the former Agent Orange mixing and loading area (AOMLA), which was the closest to the IPTD system, with total toxic equivalent (TEQ) values ranging from 0. Read More

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Dechlorination of short-chain chlorinated paraffins by the metal sodium dispersion method.

Chemosphere 2021 Jun 14;283:131201. Epub 2021 Jun 14.

Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Katsura, Nisikyo-ku, Kyoto, 615-8540, Japan.

Short-chain chlorinated paraffins (SCCPs) are listed in Annex A (elimination) of the Stockholm Convention on persistent organic pollutants, and products containing SCCPs require detoxification. In the present study, the metal sodium (Na) dispersion method was applied to a wax sample containing SCCPs (58%, C-C and Cl-Cl) to assess the dechlorination effect. Effective dechlorination of SCCPs was confirmed using 2-L and 20-L reaction systems. Read More

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Response of soil enzyme activity and soil bacterial community to PCB dissipation across different soils.

Chemosphere 2021 Jun 16;283:131229. Epub 2021 Jun 16.

Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin, 300071, China. Electronic address:

Soils are a repository for polychlorinated biphenyls (PCBs). A pot incubation experiment was performed with four soils (black soil, paddy soil, oasis soil, and fluvo-aquic soil) treated with Aroclor 1242 to achieve PCB concentrations of 5 mg kg. The soil enzyme activities of protease, phosphatase, catalase, dehydrogenase, and laccase were determined by spectrophotometry. Read More

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The impacts of weathering on concentration and bioaccessibility of organic pollutants associated with plastic pellets (nurdles) in coastal environments.

Mar Pollut Bull 2021 Jun 17;170:112592. Epub 2021 Jun 17.

University of Texas Marine Science Institute, 750 Channel View Drive, Port Aransas, TX 78373, United States of America. Electronic address:

Nurdles, the pre-production plastic pellets, are a major source of plastic pollution in marine environments due to unregulated spills during production and transportation. We analyzed the types of plastics and associated organic pollutants on nurdles collected along the shoreline of Gulf of Mexico in Texas. Our results showed that the nurdles were made from polyethylene (81. Read More

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Contamination knows no borders: Toxic organic compounds pollute plastics in the biodiversity hotspot of Revillagigedo Archipelago National Park, Mexico.

Mar Pollut Bull 2021 Jun 17;170:112623. Epub 2021 Jun 17.

Instituto Politécnico Nacional, Centro Interdisciplinario de Ciencias Marinas (CICIMAR-IPN), Av. IPN s/n, Colonia Playa Palo de Santa Rita, C.P. 23096 La Paz, Baja California Sur, Mexico.

Plastic pollution is ubiquitous and not even remote protected islands are safe from it. Floating debris can adsorb toxic compounds that concentrate on their surface, being available to the animals that ingest them. For this reason, a baseline study of plastic pollution was conducted in the remote Revillagigedo Archipelago, in the Mexican Pacific Ocean. Read More

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The early-life exposome and epigenetic age acceleration in children.

Environ Int 2021 Jun 15;155:106683. Epub 2021 Jun 15.

ISGlobal, Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain. Electronic address:

The early-life exposome influences future health and accelerated biological aging has been proposed as one of the underlying biological mechanisms. We investigated the association between more than 100 exposures assessed during pregnancy and in childhood (including indoor and outdoor air pollutants, built environment, green environments, tobacco smoking, lifestyle exposures, and biomarkers of chemical pollutants), and epigenetic age acceleration in 1,173 children aged 7 years old from the Human Early-Life Exposome project. Age acceleration was calculated based on Horvath's Skin and Blood clock using child blood DNA methylation measured by Infinium HumanMethylation450 BeadChips. Read More

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Legacy and emerging contaminants in common guillemot Uria aalge eggs in Ireland and Wales.

Chemosphere 2021 Jun 12;283:131161. Epub 2021 Jun 12.

Marine and Freshwater Research Centre, Galway-Mayo Institute of Technology, Galway, Ireland.

Guillemot eggs from multiple Irish colonies and one Welsh colony were analysed for legacy pollutants such as polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and other organochlorine compounds (OCs), as well as metals. Stable isotope ratios of carbon (δC) and nitrogen (δN) were measured in eggs to understand the influence of diet on contaminant levels detected. Wide-scope target and suspect screening techniques were used on a single guillemot egg, providing novel information on contaminants of emerging concern. Read More

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[The human body burden of polychlorinated biphenyls in serum of residents in an area from Hubei Province].

Zhonghua Yu Fang Yi Xue Za Zhi 2021 Jun;55(6):792-796

Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China.

Concentrations of dioxin-like polychlorinated biphenyls (dl-PCBs) and non-dioxin-like PCBs (ndl-PCBs) in 26 serum samples of the residents from Hubei Province were analyzed via high-resolution gas chromatograph tandem high-resolution mass spectrometer (HRGC-HRMS) method. Total concentrations of twelve dl-PCBs (Σdl-PCBs) were in range of 366.30-4 945. Read More

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'Cry-for-help' in contaminated soil: a dialogue among plants and soil microbiome to survive in hostile conditions.

Environ Microbiol 2021 Jun 17. Epub 2021 Jun 17.

Department of Food, Environmental and Nutritional Sciences, DeFENS, University of Milan, Via Celoria 2, Milan, 20133, Italy.

An open question in environmental ecology regards the mechanisms triggered by root chemistry to drive the assembly and functionality of a beneficial microbiome to rapidly adapt to stress conditions. This phenomenon, originally described in plant defence against pathogens and predators, is encompassed in the 'cry-for-help' hypothesis. Evidence suggests that this mechanism may be part of the adaptation strategy to ensure the holobiont fitness in polluted environments. Read More

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Historical record of polychlorinated biphenyls in a sediment core from Lake Biwa, Japan: Significance of unintentional emission and weathering signals revealed by full congener-specific analysis.

Sci Total Environ 2021 Sep 21;788:147913. Epub 2021 May 21.

Center of Advanced Technology for the Environment (CATE), Graduate School of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama 790-8566, Japan. Electronic address:

The occurrence of 209 PCB congeners was determined in a sediment core dated between 1930 and 2019 from Lake Biwa, a typical temperate monomictic lake in Japan. Concentrations of total PCBs ranged from 5.3 to 48 ng/g dry weight (dw), showing a highest peak at the 1960s to 1970s. Read More

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September 2021

Effects of gestational exposures to chemical mixtures on birth weight using Bayesian factor analysis in the Health Outcome and Measures of Environment (HOME) Study.

Environ Epidemiol 2021 Jun 8;5(3):e159. Epub 2021 Jun 8.

Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia.

Studying the effects of gestational exposures to chemical mixtures on infant birth weight is inconclusive due to several challenges. One of the challenges is which statistical methods to rely on. Bayesian factor analysis (BFA), which has not been utilized for chemical mixtures, has advantages in variance reduction and model interpretation. Read More

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Characterization of Compound-Specific Chlorine Isotopologue Distributions of Polychlorinated Organic Compounds by GC-HRMS for Source Identification.

Anal Chem 2021 Jun 15. Epub 2021 Jun 15.

State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China.

Distributions of chlorine isotopologues are potentially a fingerprint feature of organochlorines. However, the exact distributions remain little known. This study measured compound-specific chlorine isotopologue distributions of six polychlorinated organic compounds (POCs) for source identification. Read More

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PCB plasma level in different occupational groups in Iran.

Toxicol Ind Health 2021 Jun 15:7482337211024818. Epub 2021 Jun 15.

Community and Preventive Medicine Department, 48439Tehran University of Medical Sciences, Tehran, Iran.

Despite the ban of polychlorinated biphenyls (PCBs) some decades ago, concerns regarding their adverse health effects are continuing, because the workers employed for installation and repair of electrical equipment may be still exposed to PCBs. This study aimed to assess serum PCBs levels in workers in different industries. To do this, we determined the serum concentrations of 9 non-dioxin-like PCBs and 12 dioxin-like PCBs in 147 workers from seven occupational groups and 35 housewives. Read More

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Effects of curcumin on the bioavailability of dioxin-like pollutants in rats.

Sci Rep 2021 Jun 14;11(1):12461. Epub 2021 Jun 14.

Zhejiang Provincial Center for Disease Control and Prevention, Binsheng Road 3399, Hangzhou, 310051, China.

The effects of curcumin on the bioavailability of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were investigated in Sprague-Dawley rats. Tetra- and penta-chlorinated PCDFs had the lowest bioavailability and hexa-chlorinated PCDD/Fs had the highest, while there was no obvious change in that of DL-PCBs. Curcumin markedly reduced the toxic equivalent (TEQ) of PCDD/Fs in rats, illustrating the potential to competitively inhibit absorption of PCDD/Fs by the epithelial cells of the small intestine due to the similar chemical structure (diphenyl) between curcumin and PCDD/Fs. Read More

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Analysis of elimination half-lives in MamTKDB 1.0 related to bioaccumulation: Requirement of repeated administration and blood plasma values underrepresent tissues.

Environ Int 2021 Jun 10;155:106592. Epub 2021 Jun 10.

European Chemicals Agency, P.O. Box 400, FI-00121 Helsinki, Finland.

When building the novel public mammalian toxicokinetic database (MamTKDB) we collected and included 3927 elimination half-lives (t) for 1407 xenobiotics in various species (rat, human, mouse, dog, monkey, rabbit, cattle, pig, sheep, guinea pig, hamster, horse and goat) with specification of compartment (whole body, organ/tissue, cell type, medium) studied. Here we describe and analyse the collected data in MamTKDB 1.0. Read More

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Population-level effects of polychlorinated biphenyl (PCB) exposure on highly vulnerable Indo-Pacific humpback dolphins from their largest habitat.

Environ Pollut 2021 Jun 7;286:117544. Epub 2021 Jun 7.

School of Marine Sciences, Zhuhai Key Laboratory of Marine Bioresources and Environment, Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, Pearl River Estuary Marine Ecosystem Research Station, Ministry of Education, Sun Yat-Sen University, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai, 519082, China. Electronic address:

While polychlorinated biphenyl (PCB)-related risks have been reported at the cellular, organ, and individual levels in some marine mammals, studies quantifying the PCB-associated population-level effects are limited. Here, we combined chemical analysis and individual-based model simulation to investigate the impact of PCBs on the Indo-Pacific humpback dolphin (sub)population from the Pearl River Estuary (PRE). An annual PCB accumulation rate of 0. Read More

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First nationwide exposure profile of major persistent organic pollutants among Korean adults and their determinants: Korean National Environmental Health Survey Cycle 3 (2015-2017).

Int J Hyg Environ Health 2021 Jun 10;236:113779. Epub 2021 Jun 10.

Environmental Health Research Division, National Institute of Environmental Research, Ministry of Environment, Incheon, Republic of Korea. Electronic address:

Since 2009, Korea has measured the exposure levels of major environmental chemicals and heavy metals among representative adult populations through the Korean National Environmental Health Survey (KoNEHS). However, exposure to persistent organic pollutants (POPs) has never been assessed. This study reports the serum concentrations of twenty-four POPs and their influencing factors for Korean adults (n = 1295) who participated in the KoNEHS Cycle 3 (2015-2017). Read More

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Are chlorine isotopologues of polychlorinated organic pollutants binomially distributed? Theoretical evaluation, numerical simulation, experimental evidences and implications for chlorine isotope analysis and source identification.

Chemosphere 2021 Jun 7;282:131099. Epub 2021 Jun 7.

State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China. Electronic address:

Relative abundances of chlorine isotopologues of polychlorinated organic compounds (POCs) are commonly recognized to comply with binomial distribution. This study investigated whether chlorine isotopologue distributions of polychlorinated organic pollutants are binomial and evaluated implications of the distributions to relevant analytical and environmental research by theoretical derivation, numerical simulation and experiment. Chlorine kinetic isotope effects and equilibrium isotope effects vary in stepwise chlorination reactions, leading to inconsistent chlorine isotope ratios on different reaction positions of products, which results in non-binomial chlorine isotopologue distributions of the products. Read More

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Novel clades of soil biphenyl degraders revealed by integrating isotope probing, multi-omics, and single-cell analyses.

ISME J 2021 Jun 11. Epub 2021 Jun 11.

Department of Isotope Biogeochemistry, Helmholtz Centre for Environmental Research-UFZ, 04318, Leipzig, Germany.

Most microorganisms in the biosphere remain uncultured and poorly characterized. Although the surge in genome sequences has enabled insights into the genetic and metabolic properties of uncultured microorganisms, their physiology and ecological roles cannot be determined without direct probing of their activities in natural habitats. Here we employed an experimental framework coupling genome reconstruction and activity assays to characterize the largely uncultured microorganisms responsible for aerobic biodegradation of biphenyl as a proxy for a large class of environmental pollutants, polychlorinated biphenyls. Read More

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Unraveling metabolic flexibility of rhodococci in PCB transformation.

Chemosphere 2021 May 25;282:130975. Epub 2021 May 25.

Ruđer Bošković Institute, Division for Marine and Environmental Research, Zagreb, Croatia.

Even though the genetic attributes suggest presence of multiple degradation pathways, most of rhodococci are known to transform PCBs only via regular biphenyl (bph) pathway. Using GC-MS analysis, we monitored products formed during transformation of 2,4,4'-trichlorobiphenyl (PCB-28), 2,2',5,5'-tetrachlorobiphenyl (PCB-52) and 2,4,3'-trichlorobiphenyl (PCB-25) by previously characterized PCB-degrading rhodococci Z6, T6, R2, and Z57, with the aim to explore their metabolic pleiotropy in PCB transformations. A striking number of different transformation products (TPs) carrying a phenyl ring as a substituent, both those generated as a part of the bph pathway and an array of unexpected TPs, implied a curious transformation ability. Read More

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Effects of Polychlorinated Biphenyls on Animal Reproductive Systems and Epigenetic Modifications.

Bull Environ Contam Toxicol 2021 Jun 10. Epub 2021 Jun 10.

Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, 250014, China.

Polychlorinated biphenyls (PCBs) are a group of highly toxic endocrine-disrupting chemicals comprising 209 homologs. PCBs are extensively found in the environment and can induce typical estrogenic and profound, long-lasting effects on animals. In this article, the introduction of PCB residues into the environment and the pathways of PCB enrichment in animals are described. Read More

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Cytochrome P450: Implications for human breast cancer.

Oncol Lett 2021 Jul 24;22(1):548. Epub 2021 May 24.

Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

The treatment options for breast cancer include endocrine therapy, targeted therapy and chemotherapy. However, some patients with triple-negative breast cancer cannot benefit from these methods. Therefore, novel therapeutic targets should be developed. Read More

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Using tree swallows to assess reductions in PCB exposure as a result of dredging at Great Lakes Restoration Initiative (GLRI) sites in the Upper Midwest, USA.

Ecotoxicology 2021 Jun 4. Epub 2021 Jun 4.

U.S. Geological Survey, Upper Midwest Environmental Sciences Center, La Crosse, WI, USA.

Tree swallows (Tachycineta bicolor) were used to assess the effectiveness of reducing polychlorinated biphenyl (PCB) exposure to wildlife as a result of contaminated sediment removal at locations across the Great Lakes under two dredging scenarios, full or spot dredging. For comparative purposes, other locations where no dredging occurred were also assessed. Calculating accumulation rate, from the mass of a contaminant in tree swallow eggs and nestling carcasses, is a useful tool to assess the effectiveness of sediment removal. Read More

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The inhibitory mechanism of natural soil colloids on the biodegradation of polychlorinated biphenyls by a degrading bacterium.

J Hazard Mater 2021 08 20;415:125687. Epub 2021 Mar 20.

Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China; University of the Chinese Academy of Sciences, Beijing 100049, China.

In spite of extensive studies of soil model components, the role of natural soil colloids in the biodegradation of organic pollutants remain poorly understood. Accordingly, the present study selected Mollisol colloids (MCs) and Ultisol colloids (UCs) to investigate their effects on the biodegradation of 3, 3', 4, 4'-tetrachlorobiphenyl (PCB77) by Bradyrhizobium diazoefficiens USDA 110. Results demonstrated that both natural soil colloids significantly decreased the biodegradation of PCB77, which partly resulted from the significant decrease in the bioaccessibility of PCB77. Read More

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Modelling past human internal exposure to lower chlorinated indicator PCBs using proxies - A calculation based on multiple longitudinal PCB analyses.

Sci Total Environ 2021 Aug 21;784:147250. Epub 2021 Apr 21.

Institute for Occupational, Social and Environmental Medicine, Medical Faculty, RWTH Aachen University, Pauwelsstraße 30, D-52074 Aachen, Germany. Electronic address:

Polychlorinated biphenyls (PCBs) are persistent organic pollutants with former applications in electric transformers, capacitors, hydraulic fluids or joint sealants. While current internal exposure to PCBs can be readily assessed by human biomonitoring, the evaluation of longgone past exposures, in particular the estimation of past exposure to lower chlorinated non-dioxin-like PCB 28, 52 or 101 is limited due to the relatively short biological half-life of these PCB-congeners. This study was aimed to find a proxy that would allow an estimation of the former plasma level for these congeners even several years after exposure cessation. Read More

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Seasonal variation and positive matrix factorization result reveal the sources of giant pandas' exposure to POPs.

Ecotoxicol Environ Saf 2021 Aug 1;219:112363. Epub 2021 Jun 1.

Shaanxi Wild Animal Research Center, Zhouzhi, Xi'an 710402, China.

Persistent organic pollutant (POPs) contamination was analyzed in samples collected from wild and captive giant pandas to characterize seasonal variation in concentrations of POPs and possible sources. POP concentrations in bamboo and fecal samples collected from captive pandas showed significant fluctuations compared with those collected from wild pandas in each season. The highest polychlorinated biphenyl (PCB) and organochlorine pesticide (OCP) concentrations were 1380 pg g dw and 3140 pg g dw, respectively, which were observed in captive bamboo samples in the summer. Read More

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Exploring associations between prenatal exposure to multiple endocrine disruptors and birth weight with exposure continuum mapping.

Environ Res 2021 Jun 2;200:111386. Epub 2021 Jun 2.

Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, USA.

Background: Improved understanding of how prenatal exposure to environmental mixtures influences birth weight or other adverse outcomes is essential in protecting child health.

Objective: We illustrate a novel exposure continuum mapping (ECM) framework that combines the self-organizing map (SOM) algorithm with generalized additive modeling (GAM) in order to integrate spatially-correlated learning into the study mixtures of environmental chemicals. We demonstrate our method using biomarker data on chemical mixtures collected from a diverse mother-child cohort. Read More

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The Role of Biotransformation in the Activity of Endocrine Disruptors.

Curr Drug Metab 2021 Jun 3. Epub 2021 Jun 3.

Department of Toxicology, Faculty of Pharmacy, Ege University, Izmir, Turkey.

An "endocrine disruptor" has been broadly defined as an exogenous chemical that interferes with the production, release, transport, metabolism, binding, action, or elimination of endogenous hormones which are responsible for homeostasis, reproduction, development or behaviour. Diverse groups of chemicals such as pharmaceuticals, phytoestrogens, natural hormones, and synthetic chemicals such as pesticides, plasticizers, phthalates, parabens, polychlorinated/polybrominated biphenyls, bisphenols are shown to interfere with the endocrine system and defined as EDs in the last three decades. As for all chemicals, the biotransformation of EDs has a decisive role in their potential toxic effects. Read More

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Background exposure to polychlorinated biphenyls and all-cause, cancer-specific, and cardiovascular-specific mortality: A systematic review and meta-analysis.

Environ Int 2021 Sep 31;154:106663. Epub 2021 May 31.

Paris-Saclay University, UVSQ, Inserm, Gustave Roussy, "Exposome and Heredity" Team, CESP UMR1018, F-94805 Villejuif, France. Electronic address:

Background: Polychlorinated biphenyls (PCBs) are a large family of man-made organic, ubiquitous, and persistent contaminants with endocrine-disrupting properties. PCBs have been associated with numerous adverse health effects and were classified as carcinogenic to humans, but their long-term impact on mortality risk in the general population is unknown.

Objective: To conduct a systematic review and meta-analysis in order to assess whether background exposure levels of PCBs increase all-cause and cancer- and cardiovascular-specific mortality risk in the general population. Read More

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September 2021