11,383 results match your criteria poly-l-lactic acid


Investigating the material modelling of a polymeric bioresorbable scaffold via in-silico and in-vitro testing.

J Mech Behav Biomed Mater 2021 Apr 23;120:104557. Epub 2021 Apr 23.

Computational Engineering and Design Research Group, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton, UK. Electronic address:

The accurate material modelling of poly-l-lactic acid (PLLA) is vital in conducting finite element analysis of polymeric bioresorbable scaffolds (BRS) to investigate their mechanical performance and seek improved scaffold designs. To date, a large variety of material models have been utilised, ranging from simple elasto-plastic models to high fidelity parallel network models. However, no clear consensus has been reached on the appropriateness of these different models and whether simple, less computationally expensive models can serve as acceptable approximations. Read More

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Polymorphic Phase Formation of Liquid Crystals Distributed in Semicrystalline Polymers: An Indicator of Interlamellar and Interspherulitic Segregation.

J Phys Chem Lett 2021 May 3:4378-4384. Epub 2021 May 3.

State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, 38 Zheda Road, Hangzhou 310027, China.

Amorphous and melted components can segregate into the interlamellar or interspherulitic regions of polymer crystals in their blends/mixtures; this phase behavior strongly influences the physical properties and functions of materials. However, it is experimentally difficult to evaluate the spatial distributions of the other components in polymer crystals. Herein, we use a small-molecule liquid crystal (LC) as a probe and find that it forms different solid phases when mixed with the semicrystalline polymer poly(l-lactic acid) (PLLA). Read More

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Randomized, Double-Blind, Placebo-Controlled Study of Poly-L-Lactic acid for Treatment of Cellulite in the Lower Extremities.

J Drugs Dermatol 2021 May;20(5):529-533

Background: Poly-l-lactic acid (PLLA) is an injectable volumizer with biostimulatory properties used for volumetric structural rejuvenation in patients with facial fat volume loss but has increasingly been utilized for off-face applications.

Objective: The objectives of this randomized, double-blind, placebo-controlled single center study was to assess the safety and effectiveness of PLLA for the treatment of lower extremity cellulite in adult women.

Methods: 31 healthy women were enrolled in the study. Read More

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Poly (L-lactic acid) nanofibrous scaffolds support the proliferation and neural differentiation of mouse neural stem and progenitor cells.

Int J Dev Neurosci 2021 May 2. Epub 2021 May 2.

Research Laboratory for Embryology and Stem Cells, Department of Anatomical Sciences, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Background: The distribution and growth of cells on nanofibrous scaffolds seem to be an indispensable precondition in cell tissue engineering. The potential use of biomaterial scaffolds in neural stem cell therapy is increasingly attracting attention.

Aim: In this study, we produced porous nanofibrous scaffolds fabricated from random poly-L-lactic acid (PLLA) to support neurogenic differentiation of neural stem and progenitor cells (NSPCs), isolated from the subventricular zone (SVZ) of the adult mouse brain. Read More

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Moxifloxacin-loaded in situ Synthesized Bioceramic/Poly(L-lactide-co-ε-caprolactone) Composite Scaffolds for Treatment of Osteomyelitis and Orthopedic regeneration.

Int J Pharm 2021 Apr 29:120662. Epub 2021 Apr 29.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

High local intraosseous levels of antimicrobial agents are required for adequate long-term treatment of chronic osteomyelitis (OM). In this study, biodegradable composite scaffolds of poly-lactide-co-ε-caprolactone/calcium phosphate (CaP) were in-situ synthesized using two different polymer grades and synthesis pathways and compared to composites prepared by pre-formed (commercially available) CaP for delivery of the antibiotic moxifloxacin hydrochloride (MOX). Phase identification and characterization by Fourier transform infra-red (FTIR) spectroscopy, X-ray powder diffraction (XRPD) and scanning electron microscope (SEM) confirmed the successful formation of different CaP phases within the biodegradable polymer matrix. Read More

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Effect of Molar Mass on Critical Specific Work of Flow for Shear-Induced Crystal Nucleation in Poly (l-Lactic Acid).

Polymers (Basel) 2021 Apr 13;13(8). Epub 2021 Apr 13.

Interdisciplinary Center for Transfer-oriented Research in Natural Sciences, Martin Luther University Halle-Wittenberg, 06099 Halle/Saale, Germany.

The concept of specific work of flow has been applied for the analysis of critical shearing conditions for the formation of crystal nuclei in poly (l-lactic acid) (PLLA). Systematic variation in both time and rate of shearing the melt in a parallel-plate rheometer revealed that these parameters are interconvertible regarding the shear-induced formation of crystal nuclei; that is, low shear rate can be compensated for by increasing the shear time and vice versa. This result supports the view that critical shearing conditions can be expressed by a single quantity, providing additional options for tailoring polymer processing routes when enhanced nuclei formation is desired/unwanted. Read More

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Development of Epirubicin-Loaded Biocompatible Polymer PLA-PEG-PLA Nanoparticles: Synthesis, Characterization, Stability, and In Vitro Anticancerous Assessment.

Polymers (Basel) 2021 Apr 9;13(8). Epub 2021 Apr 9.

Developmental Medicine Department, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard- Health Affairs (MNG-HA), Riyadh 11481, Saudi Arabia.

Epirubicin (EPI) is an anti-cancerous chemotherapeutic drug that is an effective epimer of doxorubicin with less cardiotoxicity. Although EPI has fewer side effects than its analog, doxorubicin, this study aims to develop EPI nanoparticles as an improved formula of the conventional treatment of EPI in its free form.

Methods: In this study, EPI-loaded polymeric nanoparticles (EPI-NPs) were prepared by the double emulsion method using a biocompatible poly (lactide) poly (ethylene glycol) poly(lactide) (PLA-PEG-PLA) polymer. Read More

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Analysis of semi-solvent effects for PLGA polymers.

Int J Pharm 2021 Apr 26:120627. Epub 2021 Apr 26.

Food and Drug Administration, Center for Drug Evaluation and Research, Office of Generic Drugs, Silver Spring, MD 20993, USA.

Poly(lactide-co-glycolide) polymers (PLGAs) have been used in many clinical formulations of injectable, long-acting formulations. Frequently, PLGAs having different lactide:glycolide (L:G) ratios, molecular weights (MWs), end-groups, and molecular structures have been used individually or in mixtures. To understand the properties of existing formulations made of PLGAs and to develop new formulations, understanding PLGA properties is essential. Read More

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Late Onset Foreign Body Reaction due to Poly-L-Lactic Acid Facial Injections for Cosmetic Purpose.

Ann Dermatol 2020 Dec 11;32(6):519-522. Epub 2020 Nov 11.

Department of Dermatology, Eulji University Hospital, Eulji University School of Medicine, Daejeon, Korea.

The safety and efficacy of Poly-L-lactic acid (PLLA) as an injectable facial volumizer for the treatment of lipoatrophy and facial rejuvenation has been widely proven. We experienced a remarkable case of deep-seated nodules on both the cheeks of 57-year-old female 18-months after administration of PLLA filler injection for cosmetic purpose and performed a skin biopsy. With hematoxylin and eosin stain, the nodule showed non-caseating granulomas consisting of histiocytes with central foreign bodies in the dermis. Read More

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December 2020

In Situ Ambient Preparation of Perovskite-Poly(l-lactic acid) Phosphors for Highly Stable and Efficient Hybrid Light-Emitting Diodes.

ACS Appl Mater Interfaces 2021 Apr 28. Epub 2021 Apr 28.

Chair of Biogenic Functional Materials, Technical University of Munich, Schulgasse 22, Straubing D-94315, Germany.

Metal halide perovskite (MHP)-based phosphor-converted light-emitting diodes (pc-LEDs) are limited by the low MHP stability under storage/operation conditions. A few works have recently established the in situ synthesis of MHPs into polymer matrices as an effective strategy to enhance the stability of MHP with a low-cost fabrication. However, this is limited to petrochemical-based polymers. Read More

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Patient-Specific 3-Dimensional Model of Smooth Muscle Cell and Extracellular Matrix Dysfunction for the Study of Aortic Aneurysms.

J Endovasc Ther 2021 Apr 26:15266028211009272. Epub 2021 Apr 26.

Amsterdam Cardiovascular Sciences, Department of Vascular Surgery, Amsterdam University Medical Centers, Location VUmc, Amsterdam, The Netherlands.

Introduction: Abdominal aortic aneurysms (AAAs) are associated with overall high mortality in case of rupture. Since the pathophysiology is unclear, no adequate pharmacological therapy exists. Smooth muscle cells (SMCs) dysfunction and extracellular matrix (ECM) degradation have been proposed as underlying causes. Read More

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Construction of novel amphiphilic chitosan-polylactide graft copolymer nanodroplets for contrast enhanced ultrasound tumor imaging.

J Biomater Appl 2021 Apr 25:8853282211011766. Epub 2021 Apr 25.

School of Pharmacy, Hubei University of Science and Technology, Xianning, China.

In this experiment, a new amphiphilic chitosan-poly(lactide) graft copolymer was synthesized and characterized by IR, H-NMR, XRD, TGA. The obtained chitosan-poly (lactide) graft copolymer was used as the matrix material to prepare nanodroplets (NDs) encapsulating with liquid PFP by double-emulsion and solvent evaporation method. The resulting NDs were characterized by photon correlation spectroscopy and transmission electron microscopy (TEM). Read More

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Investigation on large elastoplastic deformation in expansion and springback for a composited bioresorbable stent.

J Mech Behav Biomed Mater 2021 Apr 20;119:104500. Epub 2021 Apr 20.

Department of Applied Mechanics, University of Science and Technology Beijing, Beijing, 100083, China; National Center for Materials Service Safety, University of Science and Technology Beijing, Beijing, 100083, China. Electronic address:

Mechanical performances for a composited bioresorbable stent were investigated by using the finite element method, which concerns the elastoplastic large deformation of expansion and springback during stent implantation. The introduced stent is composited by the outer layer of poly-L-lactic acid (PLLA) and the core of magnesium alloy (Mg alloy). As comparisons, meanwhile two single-material stents of PLLA and Mg alloy with the same geometric structures as the composited stent were considered. Read More

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Biological compatibility, thermal and in vitro simulated degradation for poly(p-dioxanone)/poly(lactide-co-glycolide)/poly(ethylene succinate-co-glycolide).

J Biomed Mater Res B Appl Biomater 2021 Apr 24. Epub 2021 Apr 24.

College of Chemistry and Materials Science, Fujian Key Laboratory of Polymer Science, Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, Fujian Normal University, Fuzhou, China.

Bio-absorbable polymers are widely desired to be applied and used as biomaterials for surgery hemostatic and medical tissue engineering devices. Ring-opening copolymerization reaction was applied to synthesize poly(ethylene succinate-co-glycolide) (PES-b-PGA). Stannous octoate was used as a catalyst whereas poly(ethylene succinate) was used as a macro-initiator to react with glycolide. Read More

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Long-term viability and extensibility of an in situ regenerated canine aortic wall using hybrid warp-knitted fabric.

Interact Cardiovasc Thorac Surg 2021 Apr 21. Epub 2021 Apr 21.

Healthcare Business Development-Medical Device, Teijin Limited, Tokyo, Japan.

Objectives: Many surgical materials promoting tissue regeneration have been explored for use in paediatric cardiac surgery. The aim of this study is to evaluate the long-term viability and extensibility of the canine aortic wall regenerated using a novel synthetic hybrid fabric.

Methods: The sheet is a warp-knitted fabric of biodegradable (poly-l-lactic acid) and non-biodegradable (polyethylene terephthalate) yarns coated with cross-linked gelatine. Read More

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Comparative Evaluation of Safety and Efficacy of a Novel Hyaluronic Acid-polynucleotide/Poly-L-lactic Acid Composite Dermal Filler.

Aesthetic Plast Surg 2021 Apr 19. Epub 2021 Apr 19.

R&D Research team, Inventage Lab Inc. Jungwon-gu, Seongnam, 13438, Gyeonggi, Korea.

Background: Poly-L-lactic acid (PLLA) is widely used in tissue engineering. The natural polymer hyaluronic acid (HA) shows excellent biocompatibility and affects cell signaling, proliferation, and differentiation. In addition, a polynucleotide (PN) induces cell growth of human skin fibroblasts and osteoblasts. Read More

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Core-Shell Poly(l-lactic acid)-Hyaluronic Acid Nanofibers for Cell Culture and Pelvic Ligament Tissue Engineering.

J Biomed Nanotechnol 2021 Mar;17(3):399-406

Pelvic organ prolapse (POP) has become one of the most common serious diseases affecting parous women. Weakening of pelvic ligaments plays an essential role in the pathophysiology of POP. Currently, synthetic materials are widely applied for pelvic reconstructive surgery. Read More

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Polymeric nano- and microparticulate drug delivery systems for treatment of biofilms.

Adv Drug Deliv Rev 2021 Apr 26;174:30-52. Epub 2021 Apr 26.

The Danish National Research Foundation and Villum Foundation's Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics (IDUN), Department of Health Technology, Technical University of Denmark, Ørsteds Plads 345C, 2800 Kongens Lyngby, Denmark. Electronic address:

Now-a-days healthcare systems face great challenges with antibiotic resistance and low efficacy of antibiotics when combating pathogenic bacteria and bacterial biofilms. Administration of an antibiotic in its free form is often ineffective due to lack of selectivity to the infectious site and breakdown of the antibiotic before it exerts its effect. Therefore, polymeric delivery systems, where the antibiotic is encapsulated into a formulation, have shown great promise, facilitating a high local drug concentration at the site of infection, a controlled drug release and less drug degradation. Read More

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Formulation of Next Generation Multi-Compartment Microcapsules by Reversible Electrostatic Attraction.

Chemistry 2021 Apr 12. Epub 2021 Apr 12.

Fraunhofer IAP: Fraunhofer-Institut fur Angewandte Polymerforschung IAP, Microencapsulation/Polysaccharides, GERMANY.

Combination of several active substances in one carrier is often limited due to the solubility, stability and phase separation issues. These issues are addressed by an innovative capsule design, in which nanocapsules are assembled on the microcapsule surface by electrostatic forces forming a pH responsive hierarchical capsule@capsule system. Here, melamine-formaldehyde (MF) microcapsules with a negative surface charge were synthesized and coated with novel MF-polyethyleneimine (PEI) copolymer to achieve a positive charge of ζ = + 28 mV. Read More

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Intracisternal administration of tanshinone IIA-loaded nanoparticles leads to reduced tissue injury and functional deficits in a porcine model of ischemic stroke.

IBRO Neurosci Rep 2021 Jun 5;10:18-30. Epub 2021 Jan 5.

Regenerative Bioscience Center, University of Georgia, Athens, GA 30602, United States.

Background: The absolute number of new stroke patients is annually increasing and there still remains only a few Food and Drug Administration (FDA) approved treatments with significant limitations available to patients. Tanshinone IIA (Tan IIA) is a promising potential therapeutic for ischemic stroke that has shown success in pre-clinical rodent studies but lead to inconsistent efficacy results in human patients. The physical properties of Tan-IIA, including short half-life and low solubility, suggests that Poly (lactic-co-glycolic acid) (PLGA) nanoparticle-assisted delivery may lead to improve bioavailability and therapeutic efficacy. Read More

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Clinical experience of poly-L-lactic acid injections for body contouring treatment.

J Cosmet Dermatol 2021 Apr 8. Epub 2021 Apr 8.

Galderma Aesthetics, Global Medical Affairs, Uppsala, Sweden.

Introduction: Clinical data on body contouring with injectable poly-L-lactic acid are sparsely reported in published literature. This study describes the lead author's clinical experience using injectable poly-L-lactic acid for body contouring in various anatomic locations.

Methods: Twenty consecutive patients undergoing body contouring treatments with poly-L-lactic acid were prospectively followed. Read More

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Design and characterization of 3D printed, neomycin-eluting poly-L-lactide mats for wound-healing applications.

J Mater Sci Mater Med 2021 Apr 8;32(4):44. Epub 2021 Apr 8.

Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, USciences 600 S 43rd St, Philadelphia, PA, 19143, USA.

This study evaluates the suitability of 3D printed biodegradable mats to load and deliver the topical antibiotic, neomycin, for up to 3 weeks in vitro. A 3D printer equipped with a hot melt extruder was used to print bandage-like wound coverings with porous sizes appropriate for cellular attachment and viability. The semicrystalline polyester, poly-l-lactic acid (PLLA) was used as the base polymer, coated (post-printing) with polyethylene glycols (PEGs) of MWs 400 Da, 6 kDa, or 20 kDa to enable manipulation of physicochemical and biological properties to suit intended applications. Read More

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Visualization of Inter- and Intramolecular Interactions in Poly(3-hydroxybutyrate)/Poly(L-lactic acid) (PHB/PLLA) Blends During Isothermal Melt Crystallization Using Attenuated Total Reflection Fourier Transform infrared (ATR FT-IR) Spectroscopic Imaging.

Appl Spectrosc 2021 Apr 22:37028211010216. Epub 2021 Apr 22.

Department of Chemical Engineering, 4615Imperial College London, South Kensington Campus, London, UK.

Inter- and intramolecular interactions in multicomponent polymer systems influence their physical and chemical properties significantly and thus have implications on their synthesis and processing. In the present study, chemical images were obtained by plotting the peak position of a spectral band from the data sets generated using in situ attenuated total reflection Fourier transform infrared (ATR FT-IR) spectroscopic imaging. This approach was successfully used to visualize changes in intra- and intermolecular interactions in poly(3-hydroxybutyrate)/poly(L-lactic acid) (PHB/PLLA) blends during the isothermal melt crystallization. Read More

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Tuning morphology of Pickering emulsions stabilised by biodegradable PLGA nanoparticles: How PLGA characteristics influence emulsion properties.

J Colloid Interface Sci 2021 Aug 17;595:202-211. Epub 2021 Mar 17.

Université Paris-Saclay, CNRS, Institut Galien Paris-Saclay, 92296 Châtenay-Malabry, France. Electronic address:

In this study, we proved that the stabilisation of Pickering emulsions by polymer nanoparticles (NPs) heavily depends on polymer characteristics. We prepared NPs with four poly(lactide-co-glycolide) polymers (PLGA), of different molar masses (14,000 and 32,000 g/mol) and end groups (acid or alkylester). NPs were either bare (without stabilising polymer) or covered by polyvinyl alcohol (PVA). Read More

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Ursolic acid-loaded lipid-core nanocapsules reduce damage caused by estrogen deficiency in wound healing.

Colloids Surf B Biointerfaces 2021 Mar 24;203:111720. Epub 2021 Mar 24.

Department of Pharmaceutical Sciences, State University of Ponta Grossa, Paraná, Brazil.

The skin aging process in women is accelerated due to decreases in serum estrogen levels triggered by the menopause process. Hence, poly(L-lactic acid) lipid-core nanocapsules containing ursolic acid (NPLA-UA) were developed using the interfacial deposition of the preformed polymer methodology as a strategy to reduce damages to the healing process caused by hormonal deficiency in ovariectomized rats. The colloidal suspensions of nanocapsules presented adequate size and morphology (254 and 375 nm), negative zeta potential (-31 and -37 mV), high encapsulation efficiency (99. Read More

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Incorporating redox-sensitive nanogels into bioabsorbable nanofibrous membrane to acquire ROS-balance capacity for skin regeneration.

Bioact Mater 2021 Oct 21;6(10):3461-3472. Epub 2021 Mar 21.

The Key Laboratory for Ultrafine Materials of Ministry of Education, State Key Laboratory of Bioreactor Engineering, Engineering Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.

Facing the high incidence of skin diseases, it is urgent to develop functional materials with high bioactivity for wound healing, where reactive oxygen species (ROS) play an important role in the wound healing process mainly adjustment of immune response and neovasculation. In this study, we developed a kind of bioabsorbable materials with ROS-mediation capacity for skin disease therapy. Firstly, redox-sensitive poly(N-isopropylacrylamide-acrylic acid) (PNA) nanogels were synthesized by radical emulsion polymerization method using a disulfide molecule as crosslinker. Read More

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October 2021

Nucleation of Poly(lactide) Partially Wet Droplets in Ternary Blends with Poly(butylene succinate) and Poly(ε-caprolactone).

Macromolecules 2020 Mar 25;53(5):1726-1735. Epub 2020 Feb 25.

Department of Chemistry and Industrial Chemistry, University of Genova, via Dodecaneso, 31, 16146 Genova, Italy.

This work presents the first investigation on the crystallization behavior of partially wet droplets in immiscible ternary blends. Poly(lactide), poly(ε-caprolactone), and poly(butylene succinate) (PLA, PCL, and PBS, respectively) were melt blended in a 10/45/45 weight ratio to produce a "partial wetting" morphology with droplets of the PLA minor phase located at the interface between the other two major components. The crystallization process of the higher melting PLA droplets was studied by polarized light optical microscopy, while the other components remain in the molten state. Read More

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Modelling Stretch Blow Moulding of Poly (l-lactic acid) for the Manufacture of Bioresorbable Vascular Scaffold.

Polymers (Basel) 2021 Mar 22;13(6). Epub 2021 Mar 22.

School of Mechanical and Aerospace Engineering, Queen's University Belfast, Belfast BT9 5AH, UK.

Stretch blow moulding (SBM) has been employed to manufacture bioresorbable vascular scaffold (BVS) from poly (l-lactic acid) (PLLA), whilst an experience-based method is used to develop the suitable processing conditions by trial-and-error. FEA modelling can be used to predict the forming process by the scientific understanding on the mechanical behaviour of PLLA materials above the glass transition temperature (). The applicability of a constitutive model, the 'glass-rubber' (GR) model with material parameters from biaxial stretch was examined on PLLA sheets replicating the biaxial strain history of PLLA tubes during stretch blow moulding. Read More

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Biocomposites of Epoxidized Natural Rubber/Poly(lactic acid) Modified with Natural Fillers (Part I).

Int J Mol Sci 2021 Mar 19;22(6). Epub 2021 Mar 19.

Faculty of Biotechnology and Food Sciences, Institute of Fermentation Technology and Microbiology, Lodz University of Technology, Wolczanska 171/173, 90-924 Lodz, Poland.

The study aimed to prepare sustainable and degradable elastic blends of epoxidized natural rubber (ENR) with poly(lactic acid) (PLA) that were reinforced with flax fiber (FF) and montmorillonite (MMT), simultaneously filling the gap in the literature regarding the PLA-containing polymer blends filled with natural additives. The performed study reveals that FF incorporation into ENR/PLA blend may cause a significant improvement in tensile strength from (10 ± 1) MPa for the reference material to (19 ± 2) MPa for the fibers-filled blend. Additionally, it was found that MMT employment in the role of the filler might contribute to ENR/PLA plasticization and considerably promote the blend elongation up to 600%. Read More

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Tailoring Nano-Porous Surface of Aligned Electrospun Poly (L-Lactic Acid) Fibers for Nerve Tissue Engineering.

Int J Mol Sci 2021 Mar 29;22(7). Epub 2021 Mar 29.

School of Life Sciences, Nantong University, Nantong 226019, China.

Despite the existence of many attempts at nerve tissue engineering, there is no ideal strategy to date for effectively treating defective peripheral nerve tissue. In the present study, well-aligned poly (L-lactic acid) (PLLA) nanofibers with varied nano-porous surface structures were designed within different ambient humidity levels using the stable jet electrospinning (SJES) technique. Nanofibers have the capacity to inhibit bacterial adhesion, especially with respect to (). Read More

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