Circ Res 2017 Oct 23;121(10):1182-1191. Epub 2017 Aug 23.
From the Department of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center (Y.C., N.B., M.K., T.L., R.T.) and Department of Biochemistry (R.D.P.), University of Washington, Seattle; Department of Cell Biology and Molecular Medicine, Rutgers New Jersey Medical School, Newark (P.Z., N.N., J.S.); and Howard Hughes Medical Institute, Seattle, WA (R.D.P.).
Rationale: AMPK (AMP-activated protein kinase) is a heterotrimeric protein that plays an important role in energy homeostasis and cardioprotection. Two isoforms of each subunit are expressed in the heart, but the isoform-specific function of AMPK remains unclear.
Objective: We sought to determine the role of γ2-AMPK in cardiac stress response using bioengineered cell lines and mouse models containing either isoform of the γ-subunit in the heart. Read More