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Quality of life of patients with cancer undergoing chemotherapy in hospitals in Belo Horizonte, Minas Gerais State, Brazil: does individual characteristics matter?

Cad Saude Publica 2021 15;37(8):e00002220. Epub 2021 Sep 15.

Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.

This study aims to evaluate changes in quality of life of cancer patients at the beginning of the first and the second cycle of chemotherapy (CT) in hospitals in Belo Horizonte, Minas Gerais State, Brazil. Longitudinal, prospective, descriptive study with a quantitative approach. We enrolled 230 patients, from a broader cohort, diagnosed with the five most frequent types of cancer (breast, colorectal, cervical, lung, and head and neck), aged 18 years or older, who were initiating CT for the first time. Read More

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September 2021

Dynamical analysis of SEIS model with nonlinear innate immunity and saturated treatment.

Eur Phys J Plus 2021 17;136(9):952. Epub 2021 Sep 17.

Department of Mathematics, University of Delhi, Delhi, 110007 India.

In this paper, we develop an SEIS model with Holling type II function representing the innate immunity as well as the saturated treatment. We obtain the existence and stability criteria for the equilibrium points. We observe that when the reproduction number is less than unity, the disease-free equilibrium always exists and is locally asymptotically stable. Read More

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September 2021

Development and Validation of a Risk-Adapted Scoring Model for Metachronous Upper Tract Urothelial Carcinoma Following Radical Cystectomy.

J Urol 2021 Sep 22:101097JU0000000000002211. Epub 2021 Sep 22.

Department of Urology, Mayo Clinic, Rochester, Minnesota.

Introduction: The incidence and risk factors for metachronous upper tract urothelial carcinoma (UTUC) following radical cystectomy (RC) remain incompletely defined, which has limited the ability to individualize postoperative surveillance.

Methods: A retrospective review of two institutional registries was performed to identify patients undergoing RC for urothelial carcinoma. Multivariable Cox proportional hazard models for metachronous post-RC UTUC were developed in one institutional dataset and validated in the second institutional dataset. Read More

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September 2021

Which is the best alternative to estimate muscle mass for sarcopenia diagnosis when DXA is unavailable?

Arch Gerontol Geriatr 2021 Sep 3;97:104517. Epub 2021 Sep 3.

FCNAUP - Faculdade de Ciências da Nutrição e Alimentação, Universidade do Porto, 4150-180 Porto, Portugal; LAETA-INEGI - Faculdade de Engenharia, Universidade do Porto, Porto, Portugal.

Background: Dual x-ray absorptiometry (DXA) is widely adopted to estimate muscle mass for research, but for daily practice is only available in a limited number of facilities.

Aim: To elucidate if it is anthropometry or bioelectrical impedance analysis (BIA) the method more concordant with DXA in estimating muscle mass for sarcopenia diagnosis among older adults, and to investigate the impact of several cut-off points in sarcopenia frequency.

Methods: 159 older adults (≥65 years) were included in a cross-sectional analysis. Read More

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September 2021

Clinical Factors Related to Loculation of Fluid in Central Serous Chorioretinopathy.

Am J Ophthalmol 2021 Sep 18. Epub 2021 Sep 18.

Department of Ophthalmology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan. Electronic address:

Purpose: To elucidate clinical factors related to the presence of loculation of fluid (LOF) in the posterior choroid in central serous chorioretinopathy (CSC).

Design: Retrospective, cross-sectional study.

Methods: This single-center study included 158 eyes from 158 patients with CSC who were classified into LOF and non-LOF groups. Read More

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September 2021

Supporting resident well-being on and outside the ICU during the COVID-19 pandemic: the use and value of institutional interventions and individual strategies.

Med Educ Online 2021 Dec;26(1):1978129

Professional Performance & Compassionate Care Research Group, Department of Medical Psychology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

During the COVID-19 pandemic, resident well-being has been shown to be at risk, which may interfere with residents' process of professional development during their educational trajectory. Therefore, we developed a well-being program for residents, aimed to help residents maintain their well-being during the COVID-19 pandemic. We explored residents' perceptions of their well-being as well as their perceived support of the well-being program during the COVID-19 pandemic. Read More

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December 2021

LI-RADS ancillary features favoring benignity: is there a role in LR-5 observations?

Eur Radiol 2021 Sep 20. Epub 2021 Sep 20.

Section of Radiology - Department of Biomedicine, Neuroscience and Advanced Diagnostics, BiND, University Hospital "Paolo Giaccone", Via del Vespro 129, 90127, Palermo, Italy.

Objectives: The Liver Imaging Reporting and Data System algorithm allows category downgrade in the presence of ancillary features (AFs) favoring benignity, even in observations categorized as LR-5. This study aims to assess the role of AFs favoring benignity in LR-5 observations and their impact on category downgrade.

Methods: This study included high-risk patients with at least one LR-5 observation imaged with gadoxetate disodium MRI. Read More

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September 2021

How physicians evaluate patients with dementia who present with shortness of breath.

J Am Geriatr Soc 2021 Sep 20. Epub 2021 Sep 20.

Center for the Study of Healthcare Innovation, Implementation, and Policy, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.

Background: Whether the presence of dementia in patients makes it difficult for physicians to assess the risk such patients might have for serious conditions such as pulmonary embolism (PE) is unknown. Our objective was to examine the differential association of four clinical factors (deep venous thrombosis (DVT)/PE, malignancy, recent surgery, and tachycardia) with PE testing for patients with dementia compared to patients without dementia.

Methods: We performed a cross-sectional study of emergency department (ED) visits to 104 Veterans Affairs (VA) hospitals from 2011 to 2018 by patients aged 60 years and over presenting with shortness of breath (SOB). Read More

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September 2021

Combination of osmotic stress and sugar stress response mechanisms is essential for Gluconacetobacter diazotrophicus tolerance to high-sucrose environments.

Appl Microbiol Biotechnol 2021 Sep 20. Epub 2021 Sep 20.

Laboratório de Biotecnologia (Setor de Biologia Integrativa), Universidade Estadual Do Norte Fluminense Darcy Ribeiro (UENF), Campos dos Goytacazes, Rio de Janeiro, Brazil.

Sugar-rich environments represent an important challenge for microorganisms. The osmotic and molecular imbalances resulting from this condition severely limit microbial metabolism and growth. Gluconacetobacter diazotrophicus is one of the most sugar-tolerant prokaryotes, able to grow in the presence of sucrose concentrations up to 30%. Read More

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September 2021

Engineering anaerobic digestion via optimizing microbial community: effects of bactericidal agents, quorum sensing inhibitors, and inorganic materials.

Appl Microbiol Biotechnol 2021 Sep 20. Epub 2021 Sep 20.

Department of Biological Functions Engineering, Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu-ku, Kitakyushu, 808-0196, Japan.

Anaerobic digestion of sewage sludge (SS) is one of the effective ways to reduce the waste generated from human life activities. To date, there are many reports to improve or repress methane production during the anaerobic digestion of SS. In the anaerobic digestion process, many microorganisms work positively or negatively, and as a result of their microbe-to-microbe interaction and regulation, methane production increases or decreases. Read More

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September 2021

Data-driven operation of the resilient electric grid: A case of COVID-19.

J Eng (Stevenage) 2021 Aug 9. Epub 2021 Aug 9.

School of Electrical Engineering and Computer Science Washington State University Pullman Washington USA.

Electrical energy is a vital part of modern life, and expectations for grid resilience to allow a continuous and reliable energy supply has tremendously increased even during adverse events (e.g. Ukraine cyberattack, Hurricane Maria). Read More

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Determinants of Aedes mosquito density as an indicator of arbovirus transmission risk in three sites affected by co-circulation of globally spreading arboviruses in Colombia, Ecuador and Argentina.

Parasit Vectors 2021 Sep 19;14(1):482. Epub 2021 Sep 19.

School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada.

Background: The global impact of Zika virus in Latin America has drawn renewed attention to circulating mosquito-borne viruses in this region, such as dengue and chikungunya. Our objective was to assess socio-ecological factors associated with Aedes mosquito vector density as a measure of arbovirus transmission risk in three cities of potentially recent Zika virus introduction: Ibagué, Colombia; Manta, Ecuador; and Posadas, Argentina, in order to inform disease mitigation strategies.

Methods: We sampled Aedes mosquito populations in a total of 1086 households, using indoor and peridomestic mosquito collection methods, including light traps, resting traps, traps equipped with chemical attractant and aspirators. Read More

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September 2021

Tarlov cysts in back pain patients: prevalence, measurement method and reporting points.

Authors:
Muhammad Shoyab

Br J Radiol 2021 Sep 19:20210505. Epub 2021 Sep 19.

Al Haramain Hospital Private Limited, Sylhet, Bangladesh.

Objective: Determining the prevalence of Tarlov cysts in low back pain patients.

Methods And Materials: The picture archiving & communication system (PACS) & hospital information system (HIS) of a corporate hospital were retrospectively analyzed to determine the percentage of Tarlov cysts among patients undergoing spinal MRI for back pain over 3 years (January 2017 to December 2019).

Results: 384 patients had undergone spinal MRI for back pain over the study period, and 25 of them (6. Read More

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September 2021

[Influence of chemosensional disorders on taste preferences in cancer patients who are receiving oral nutrition supplements].

Vopr Pitan 2021 22;90(4):122-128. Epub 2021 Jul 22.

V.A. Almazov National Medical Research Center of the Ministry of Healthcare of the Russian Federation, 197341, St. Petersburg, Russian Federation.

Chemosensory disorders (CSD) such as disorders of taste and smell are one of the causes of malnutrition in cancer patients. of the research was to evaluate the influence of CSD on taste preferences in cancer patients receiving oral nutritional supplements (ONS). . Read More

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ASSESSMENT OF ENDOTHELIAL DYSFUNCTION IN PREGNANT WOMEN WITH OBESITY AND PREECLAMPSIA.

Wiad Lek 2021 ;74(8):1905-1909

POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE.

Objective: The aim: To assess the values of endothelial vascular growth factor (VEGF) in blood serum and circulating endothelial microparticles CD32+CD40+ in the peripheral blood of pregnant women depending on the severity of obesity and presence of preeclampsia.

Patients And Methods: Materials and methods: the study included 122 pregnant women divided into groups in accordance with their height and weight parameters and presence of preeclampsia. We studied the serum VEGF concentration by enzyme-linked immunosorbent assay, carried out the count of CD32+CD40+ circulating endothelial microparticles in the peripheral blood by using flow cytometry. Read More

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September 2021

Electrophoretic deposition of collagen/chitosan films with copper-doped phosphate glasses for orthopaedic implants.

J Colloid Interface Sci 2021 Sep 1;607(Pt 1):869-880. Epub 2021 Sep 1.

Centre for Energy, Materials and Telecommunications, Institut National de la Recherche Scientifique, 1650 Boulevard Lionel-Boulet Varennes, Québec J3X 1S2, Canada. Electronic address:

Coatings with bioactive properties play a key role in the success of orthopaedic implants. Recent studies focused on composite coatings incorporating biocompatible elements that can increase the nucleation of hydroxyapatite (HA), the mineral component of bone, and have promising bioactive and biodegradable properties. Here we report a method of fabricating composite collagen, chitosan and copper-doped phosphate glass (PG) coatings for biomedical applications using electrophoretic deposition (EPD). Read More

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September 2021

Evoglow-Pp1 and mCherry proteins: a dual fluorescent labeling system for lactic acid bacteria.

Appl Microbiol Biotechnol 2021 Sep 18. Epub 2021 Sep 18.

Departamento de Tecnología de Alimentos, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Carretera de La Coruña Km 7.5, 28040, Madrid, Spain.

Fluorescent proteins are widely used for cell and protein tracking. Most of these proteins show a high signal and need the presence of oxygen to emit fluorescence. Among them, the fluorescent protein mCherry stands up because of its bright signal and fast maturation. Read More

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September 2021

Biopsy bacterial signature can predict patient tissue malignancy.

Sci Rep 2021 Sep 17;11(1):18535. Epub 2021 Sep 17.

Cancer [email protected], University College Cork, Cork, Ireland.

Considerable recent research has indicated the presence of bacteria in a variety of human tumours and matched normal tissue. Rather than focusing on further identification of bacteria within tumour samples, we reversed the hypothesis to query if establishing the bacterial profile of a tissue biopsy could reveal its histology / malignancy status. The aim of the present study was therefore to differentiate between malignant and non-malignant fresh breast biopsy specimens, collected specifically for this purpose, based on bacterial sequence data alone. Read More

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September 2021

Trigger point injection for post-mastectomy pain: a simple intervention with high rate of long-term relief.

NPJ Breast Cancer 2021 Sep 17;7(1):123. Epub 2021 Sep 17.

Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.

Post-mastectomy pain syndrome (PMPS) is a common and often debilitating condition. The syndrome is defined by chest wall pain unresponsive to standard pain medications and the presence of exquisite point tenderness along the inframammary fold at the site of the T4 and T5 cutaneous intercostal nerve branches as they exit from the chest wall. Pressure at the site triggers and reproduces the patient's spontaneous or motion-evoked pain. Read More

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September 2021

Perineural dexamethasone reduces rebound pain after ropivacaine single injection interscalene block for arthroscopic shoulder surgery: a randomized controlled trial.

Reg Anesth Pain Med 2021 Sep 17. Epub 2021 Sep 17.

Department of Anesthesiology and Pain Medicine, College of Medicine, Ewha Womans University, Seoul, South Korea

Background And Objectives: A single injection interscalene block (ISB) is a common regional analgesic technique in patients undergoing arthroscopic shoulder surgery. However, rebound pain after ISB resolution may reduce its overall benefit. Our primary aim was to assess whether perineural dexamethasone reduces the intensity and incidence of rebound pain in patients undergoing arthroscopic shoulder surgery under general anesthesia combined with a preoperative single injection ISB. Read More

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September 2021

Effect of tacrolimus on the expression of Park7 in glomerular podocytes injured by puromycin aminonucleoside.

Zhongguo Dang Dai Er Ke Za Zhi 2021 Sept 15;23(9):951-958

Department of Pediatrics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China (Yu L, Email:

Objectives: To study the effect of puromycin aminonucleoside (PAN) on the apoptosis of mouse podocyte clone 5 (MPC-5) and the expression of recombinant human Parkinson's disease 7 (Park7) and to study the protective mechanism of tacrolimus (FK506) against MPC-5 injury.

Methods: MPC-5 cells were cultured and then divided into three groups: blank control (control), PAN, and FK506. The cells in the PAN group were added with PAN (with a concentration of 50 mg/L) to establish a model of MPC-5 injury, and those in the FK506 group were added with PAN (with a concentration of 50 mg/L) and FK506 (with a concentration of 5 mg/L). Read More

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September 2021

Biophysical matter in a marine estuary identified by the Sentinel-3B OLCI satellite and the presence of terrestrial iron (Fe) nanoparticles.

Mar Pollut Bull 2021 Sep 14;173(Pt A):112925. Epub 2021 Sep 14.

Department of Civil and Environmental, Universidad de la Costa, CUC, Calle 58 # 55-66, Barranquilla, Atlántico, Colombia. Electronic address:

The analysis of marine matter using the Sentinel-3B OLCI (Ocean Land Color Instrument) satellite is the most advanced technique for evaluating: the absorption of colored detrital and dissolved material (ADG_443_NN), total suspended matter concentration (TSM_NN) and of chlorophyll-a (CHL_NN) on a global scale. The objective is to analyze ADG_443_NN, TSM_NN and CHL_NN using the Sentinel-3B OLCI satellite and the presence of Fe-nanoparticles (NPs) + hazardous elements (HEs) in suspended sediments (SSs) in the maritime estuary of the Colombian city of Barranquilla. The study used the unpublished image of the Sentinel-3B OLCI satellite in the evaluation of ADG_443_NN, TSM_NN and CHL_NN in 72 sampled points. Read More

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September 2021

Subclinical myocardial injury and the phenotype of clinical congestion in patients with heart failure and reduced left ventrcular ejection fraction.

J Card Fail 2021 Sep 14. Epub 2021 Sep 14.

Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:

Background: Clinical congestion is associated with adverse outcomes in patients with heart failure. The pathophysiological mediators of this association remain uncertain.

Methods: We prospectively enrolled a cohort of patients with heart failure and reduced left ventricular ejection fraction (LVEF) and performed a detailed clinical examination followed on the same day by an invasive right heart catheterization and blood sampling for biomarkers. Read More

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September 2021

Differential Iron Requirements for Osteoblast and Adipocyte Differentiation.

JBMR Plus 2021 Sep 26;5(9):e10529. Epub 2021 Jul 26.

Department of Medical and Molecular Genetics School of Medicine, Indiana University Indianapolis IN USA.

Bone marrow mesenchymal progenitor cells are precursors for various cell types including osteoblasts, adipocytes, and chondrocytes. The external environment and signals act to direct the pathway of differentiation. Importantly, situations such as aging and chronic kidney disease display alterations in the balance of osteoblast and adipocyte differentiation, adversely affecting bone integrity. Read More

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September 2021

Tracheoesophageal fistula and pharyngoesophageal stenosis repair by double skin paddle radial forearm flap.

Eur Ann Otorhinolaryngol Head Neck Dis 2021 Sep 13. Epub 2021 Sep 13.

Institut Universitaire de la Face et du Cou, Centre Antoine Lacassagne, Université Côte d'Azur, 31, avenue de Valombrose, 06103 Nice Cedex 2, France. Electronic address:

Tracheoesophageal fistula (TEF) constitutes a rare, but serious complication in laryngectomized patients, usually occurring after radiotherapy. TEF may occur spontaneously or may be due to enlargement of the TEF created for placement of a voice prosthesis. Surgical treatment of TEF can be complex, especially in the presence of a concomitant pharyngoesophageal stenosis (PES), and is associated with a high failure rate. Read More

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September 2021

Effects of differential measurement error in self-reported diet in longitudinal lifestyle intervention studies.

Int J Behav Nutr Phys Act 2021 Sep 16;18(1):125. Epub 2021 Sep 16.

Department of Preventive Medicine, Northwestern University, Chicago, Israel.

Background: Lifestyle intervention studies often use self-reported measures of diet as an outcome variable to measure changes in dietary intake. The presence of measurement error in self-reported diet due to participant failure to accurately report their diet is well known. Less familiar to researchers is differential measurement error, where the nature of measurement error differs by treatment group and/or time. Read More

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September 2021

A Rare Presentation of Cryptococcal Meningitis in a Treatment-Naive Patient with Sarcoidosis.

Eur J Case Rep Intern Med 2021 9;8(8):002755. Epub 2021 Aug 9.

McLaren Health Care, Flint/Michigan State University, Flint, Michigan, USA.

is an encapsulated, yeast-like fungus that commonly lives in the environment due to soil contamination by the faeces of birds, especially pigeons. Cryptococcus is an opportunistic fungal infection frequently diagnosed in immunocompromised patients with HIV, steroid use, malignancy, history of organ transplantation, or, rarely, sarcoidosis. There have been only a few reports of cryptococcus infection in sarcoidosis patients who were not on steroid treatment. Read More

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Cut-off points to screening for sarcopenia in community-dwelling older people residents in Brazil.

PeerJ 2021 25;9:e12038. Epub 2021 Aug 25.

Postgraduate Program in Physiotherapy, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil.

Background: At a time when the world's population is aging, one of the most important challenges for the healthcare field is to control the decline of the musculoskeletal system. This decline consists of a reduction in muscle mass and function, which is called sarcopenia and is associated with adverse health outcomes. Although there has been an increase in the number of publications on sarcopenia and its consequences, the reported prevalence varies widely, since these depend on the characteristics of the population studied, the definitions found in the literature and the cut-off points adopted. Read More

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Combined effect of nitrogen-doped functional groups and porosity of porous carbons on electrochemical performance of supercapacitors.

Sci Rep 2021 Sep 15;11(1):18387. Epub 2021 Sep 15.

Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100, Torun, Poland.

In this work, nitrogen-doped porous carbons obtained from chitosan, gelatine, and green algae were investigated in their role as supercapacitor electrodes. The effects of three factors on electrochemical performance have been studied-of the specific surface area, functional groups, and a porous structure. Varying nitrogen contents (from 5. Read More

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September 2021

X-linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection.

Sci Rep 2021 Sep 15;11(1):18397. Epub 2021 Sep 15.

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, 21941-900, Brazil.

Cryptococcosis is an opportunistic disease caused by the fungus Cryptococcus neoformans and Cryptococcus gattii. It starts as a pulmonary infection that can spread to other organs, such as the brain, leading to the most serious occurrence of the disease, meningoencephalitis. The humoral response has already been described in limiting the progression of cryptococcosis where the B-1 cell seems to be responsible for producing natural IgM antibodies, crucial for combating fungal infections. Read More

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September 2021