10,083 results match your criteria point cluster


Manifesto for an ECNP Neuromodulation Thematic Working Group (TWG): Non-invasive brain stimulation as a new Super-subspecialty.

Eur Neuropsychopharmacol 2021 Aug 1;52:72-83. Epub 2021 Aug 1.

Sheba Medical Center at Tel Hashomer, Israel, Sackler Faculty of Medicine, Tel Aviv.

Non-Invasive Brain Stimulation (NIBS) techniques and in particular, repetitive Transcranial Magnetic Stimulation (rTMS), are developing beyond mere clinical application. Although originally purposed for the treatment of resistant neuropsychiatric disorders, NIBS is also contributing to a deeper understanding of psychiatric disorders. rTMS is also changing the model of the disorder itself, from "mental" to one of neural connectivity. Read More

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The utility of clusters and a Hungarian clustering algorithm.

PLoS One 2021 4;16(8):e0255174. Epub 2021 Aug 4.

Department of Mathematics and Department of Statistics & Data Science, University of Texas at Austin, Austin, Texas, United States of America.

Implicit in the k-means algorithm is a way to assign a value, or utility, to a cluster of points. It works by taking the centroid of the points and the value of the cluster is the sum of distances from the centroid to each point in the cluster. The aim in this paper is to introduce an alternative way to assign a value to a cluster. Read More

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Multiwell Raman plate reader for high-throughput biochemical screening.

Sci Rep 2021 Aug 3;11(1):15742. Epub 2021 Aug 3.

Department of Applied Physics, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Although Raman spectroscopy has been used for the quantitative analysis of samples in many fields, including material science, biomedical, and pharmaceutical research, its low sensitivity hindered the application of the analytical capability for high-throughput screening. Here, we developed a high-throughput Raman screening system that can analyze hundreds of specimens in a multiwell plate simultaneously. Multiple high numerical aperture (NA) lenses are assembled under each well in the multiwell plate to detect Raman scattering simultaneously with high sensitivity. Read More

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Genotypic spectrum of 21-hydroxylase deficiency in an endogamous population.

J Endocrinol Invest 2021 Aug 2. Epub 2021 Aug 2.

Department of Pediatrics, Ain Shams University, Children's Hospital, Abbassiah Square, Cairo, Egypt.

Background: Congenital adrenal hyperplasia (CAH) due to autosomal recessive 21-hydroxylase deficiency (21-OHD) is caused by defects in the CYP21 (CYP21A2) gene. Several mutations have been identified in the CYP21 (CYP21A2) gene of patients with 21-OHD. We aimed at determining the frequency of these mutations among a group of Egyptian patients and studying the genotype-phenotype correlation. Read More

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Ecological risk and source analysis of soil heavy metals pollution in the river irrigation area from Baoji, China.

PLoS One 2021 2;16(8):e0253294. Epub 2021 Aug 2.

Shaanxi Key Laboratory of Disaster Monitoring and Mechanism Simulation, Baoji University of Arts and Sciences, Baoji, China.

Due to various human activities, soil quality under different land use patterns is deteriorating all over the world. This deterioration is very complex in the river irrigation area and is caused by multi-point and non-point source pollution and seasonal variation. Therefore, the characteristics and sources of soil metal pollution in river irrigation area of Baoji city were analyzed. Read More

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Investigating the effect of quarantine caused by COVID-19 on mental health and social trust.

Przegl Epidemiol 2021 ;75(1):51-57

Department of Psychiatry, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Purpose: This study was conducted to examine the effect of quarantine caused by COVID-19 on people's mental health and social trust.

Method: In this study, the sample size covers 2919 people in the southwest of Iran that was selected cluster sample method and was evaluated online using tools of social trust and a checklist of mental disorder syndrome.

Results: Due to the results, COVID-19 affected all people's mental health negatively, but there was a significant difference between the rates of COVID-19 caused anxiety and the dimensions of the psychological problems and social trust different between men and women and married and single people, and also the education level. Read More

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High Resolution Patterning of an Organic-Inorganic Photoresin for the Fabrication of Platinum Microstructures.

Adv Mater 2021 Aug 1:e2101992. Epub 2021 Aug 1.

Laboratory of Process Technology, NeptunLab, Department of Microsystems Engineering (IMTEK) University of Freiburg, Georges-Köhler-Allee 103, 79110, Freiburg, Germany.

Platinum (Pt) is an interesting material for many applications due to its high chemical resilience, outstanding catalytic activity, high electrical conductivity, and high melting point. However, microstructuring and especially 3D microstructuring of platinum is a complex process, based on expensive and specialized equipment often suffering from very slow processing speeds. In this work, organic-inorganic photoresins, which can be structured using direct optical lithography as well as two-photon lithography (TPL) with submicrometer resolution and high-throughput is presented. Read More

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Estimation of Isentropic Compressibility of Biodiesel Using ELM Strategy: Application in Biofuel Production Processes.

Biomed Res Int 2021 12;2021:7332776. Epub 2021 Jul 12.

Petroleum Engineering Department, Australian College of Kuwait, West Mishref, Kuwait.

Isentropic compressibility is one of the significant properties of biofuel. On the other hand, the complexity related to the experimental procedure makes the detection process of this parameter time-consuming and hard. Thus, we propose a new Machine Learning (ML) method based on Extreme Learning Machine (ELM) to model this important value. Read More

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Mapping Knowledge Structure and Research Frontiers of Ultrasound-Induced Blood-Brain Barrier Opening: A Scientometric Study.

Front Neurosci 2021 14;15:706105. Epub 2021 Jul 14.

Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.

Among the effective approaches developed for blood-brain barrier (BBB) opening, ultrasound is recognized as a non-invasive technique that can induce localized BBB opening transiently and repeatedly. This technique has aroused broad attention from researchers worldwide, and numerous articles have been published recently. However, no existing study has systematically examined this field from a scientometric perspective. Read More

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SARS-CoV-2 in transit: characterization of SARS-CoV-2 genomes from Venezuelan migrants in Colombia.

Int J Infect Dis 2021 Jul 29. Epub 2021 Jul 29.

Instituto de Investigaciones Biomédicas IDB/Emerging Pathogens Network-Incubadora Venezolana de la Ciencia, Cabudare, 3023, Venezuela.; Department of Pathology, Molecular, and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

Objectives: To evaluate the genomic epidemiology of SARS-CoV-2 from Venezuelan migrants living in Colombia.

Methods: SARS-CoV-2 from 30 clinical specimens collected from Venezuelan migrants were sequenced. Genomes were compared with the Wuhan-reference-genome to identify polymorphisms, reconstruct phylogenetic relationships, and perform comparative genomic analyses. Read More

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Accurate influenza forecasts using type-specific incidence data for small geographic units.

PLoS Comput Biol 2021 Jul 29;17(7):e1009230. Epub 2021 Jul 29.

Infectious Disease Group, Predictive Science Inc., San Diego, California, United States.

Influenza incidence forecasting is used to facilitate better health system planning and could potentially be used to allow at-risk individuals to modify their behavior during a severe seasonal influenza epidemic or a novel respiratory pandemic. For example, the US Centers for Disease Control and Prevention (CDC) runs an annual competition to forecast influenza-like illness (ILI) at the regional and national levels in the US, based on a standard discretized incidence scale. Here, we use a suite of forecasting models to analyze type-specific incidence at the smaller spatial scale of clusters of nearby counties. Read More

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Quit attempts and tobacco abstinence in primary care patients: follow-up of a pragmatic, two-arm cluster randomised controlled trial on brief stop-smoking advice - ABC 5As.

ERJ Open Res 2021 Jul 26;7(3). Epub 2021 Jul 26.

Institute of General Practice (ifam), Centre for Health and Society (chs), Addiction Research and Clinical Epidemiology Unit, Medical Faculty of the Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.

We developed a 3.5-h training for general practitioners (GPs) in delivering brief stop-smoking advice according to different methods (ABC, 5As). In a pragmatic, cluster randomised controlled trial our training proved effective in increasing GP-delivered rates of such advice (from 13% to 33%). Read More

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How Can eHealth Meet the Hearing and Communication Needs of Adults With Hearing Impairment and their Significant Others? A Group Concept Mapping Study.

Ear Hear 2021 Jul 27. Epub 2021 Jul 27.

HEARing CRC, Melbourne, VIC, Australia School of Health and Rehabilitation Sciences, University of Queensland, Brisbane, QLD, Australia Department of Audiology and Speech Pathology, University of Melbourne, Melbourne, VIC, Australia.

Objectives: To seek the perspectives of key stakeholders regarding: (1) how eHealth could help meet the hearing and communication needs of adults with hearing impairment and their significant others; and (2) how helpful each aspect of eHealth would be to key stakeholders personally.

Design: Group concept mapping, a mixed-methods participatory research method, was used to seek the perspectives of key stakeholders: adults with hearing impairment (n = 39), significant others (n = 28), and hearing care professionals (n = 56). All participants completed a short online survey before completing one or more of the following activities: brainstorming, sorting, and rating. Read More

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Sensitivity and Specificity of Cutoff Points of Resting Heart Rate from 6,794 Brazilian Adolescents: A Cross-Sectional Study.

Arq Bras Cardiol 2021 Jul;117(1):74-81

Universidade Nove de Julho - Programa de Pós-Graduação em Ciências da Reabilitação, São Paulo, SP - Brasil.

Background: Resting heart rate (RHR) may be a useful screening tool for cardiovascular risk. However, RHR cutoff points, an interesting clinical approach, have never been described in young populations.

Objective: To establish RHR cutoff points in Brazilian adolescents and to analyze whether cutoff points are associated with cardiovascular risk factors. Read More

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Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community acquired pneumonia.

Am J Physiol Lung Cell Mol Physiol 2021 07 28. Epub 2021 Jul 28.

grid.10423.34Hannover Medical School, Hannover, Germany.

Sex-dependent differences in immunity and coagulation play an active role in the outcome of community-acquired pneumonia (CAP). Contact phase proteins act at the crossroads between inflammation and coagulation thus representing a point of convergence in host defense against infection. Here, we measured the levels of factor XII (FXII), FXIIa-C1 esterase inhibitor (C1INH) complexes, and high molecular weight kininogen (HK) in plasma of CAP patients and correlated them to clinical disease severity. Read More

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Impact evaluation of the Care Tipping Point Initiative in Nepal: study protocol for a mixed-methods cluster randomised controlled trial.

BMJ Open 2021 07 26;11(7):e042032. Epub 2021 Jul 26.

Gender Justice Team, CARE USA, Atlanta, Georgia, USA.

Introduction: Girl child, early and forced marriage (CEFM) persists in South Asia, with long-term consequences for girls. CARE's Tipping Point Initiative (TPI) addresses the causes of CEFM by challenging repressive gender norms and inequalities. The TPI engages different participant groups on programmatic topics and supports community dialogue to build girls' agency, shift inequitable power relations, and change community norms sustaining CEFM. Read More

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Maintaining proteostasis under mechanical stress.

EMBO Rep 2021 Jul 26:e52507. Epub 2021 Jul 26.

Institute of Biology II, Faculty of Biology, and Signalling Research Centres BIOSS and CIBSS, Albert-Ludwigs-University Freiburg, Freiburg, Germany.

Cell survival, tissue integrity and organismal health depend on the ability to maintain functional protein networks even under conditions that threaten protein integrity. Protection against such stress conditions involves the adaptation of folding and degradation machineries, which help to preserve the protein network by facilitating the refolding or disposal of damaged proteins. In multicellular organisms, cells are permanently exposed to stress resulting from mechanical forces. Read More

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Kinship Practices Among Alternative Family Forms in Western Industrialized Societies.

J Marriage Fam 2020 Oct 19;82(5):1403-1430. Epub 2020 Aug 19.

Department of Sociology and Population Studies Center, University of Pennsylvania.

Objective: This paper discusses how kinship is construed and enacted in diverse forms of the family that are now part of the culturally pluralistic family system of Western societies.

Background: The study is the second in a pair documenting changes over the past century in the meaning and practice of kinship in the family system of Western societies with industrialized economies. While the first paper reviewed the history of kinship studies, this companion piece shifts the focus to research explorations of kinship in alternative family forms, those that depart from the standard nuclear family structure. Read More

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October 2020

[Clinical efficacy of the combined diagnosis and management for children with airway allergic diseases].

Zhonghua Yu Fang Yi Xue Za Zhi 2021 Jul;55(7):818-826

Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Otolaryngology Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

To evaluate the clinical efficacy of the combined diagnosis and management in children with airway allergic diseases(bronchial asthma, allergic rhinitis). This observational study belongs to cluster sampling cases, which included the clinical data from children with airway allergic diseases in Allergy Department and Otorhinolaryngology Department of Beijing Children's Hospital from April to December in 2015. They were followed up every three months during 12 months. Read More

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Effect of faecal calprotectin testing on referrals for children with chronic gastrointestinal symptoms in primary care: study protocol for a cluster randomised controlled trial.

BMJ Open 2021 07 23;11(7):e045444. Epub 2021 Jul 23.

General Practice and Elderly Care Medicine, University Medical Centre Groningen, Groningen, The Netherlands.

Introduction: Children with chronic gastrointestinal symptoms are frequently seen in primary care, yet general practitioners (GPs) often experience challenges distinguishing functional gastrointestinal disorders (FGID) from organic disorders. We, therefore, aim to evaluate whether a test strategy that includes point-of-care testing (POCT) for faecal calprotectin (FCal) can reduce the referral rate to paediatric specialist care among children with chronic gastrointestinal symptoms. The study findings will contribute to improving the recommendations on FCal use among children in primary care. Read More

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System Level Informatics to Improve Triage Practices for Sickle Cell Disease Vaso-Occlusive Crisis: A Cluster Randomized Controlled Trial.

J Emerg Nurs 2021 Jul 20. Epub 2021 Jul 20.

Background: National Heart Lung and Blood Institute guidelines for the treatment of vaso-occlusive crisis among people with sickle cell disease in the emergency department recommend assigning an emergency severity index of 2 at triage. However, patients with sickle cell disease often do not receive guideline-concordant care at triage. To address this gap, a decision support tool was developed, in the form of a text banner on the triage page in the electronic health record system, visible to triage nurses. Read More

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Impact of the Childcare Physical Activity (PLAY) Policy on Young Children's Physical Activity and Sedentary Time: A Pilot Clustered Randomized Controlled Trial.

Int J Environ Res Public Health 2021 Jul 13;18(14). Epub 2021 Jul 13.

Health and Rehabilitation Sciences Program, Faculty of Health Sciences, University of Western Ontario, London, ON N6A 3K7, Canada.

: The importance of daily physical activity is crucial for healthy development during the early years. Currently, a formal written physical activity policy is lacking in Canadian childcare centers, but holds promise for offering consistent physical activity opportunities. With eight recommendations, the Childcare PLAY policy is an evidence-informed, institutional-level document, targeting children's physical activity, outdoor play, and sedentary time. Read More

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MitoWave: Spatio-temporal analysis of mitochondrial membrane potential fluctuations during ischemia-reperfusion.

Biophys J 2021 Jul 20. Epub 2021 Jul 20.

The Johns Hopkins University, Division of Cardiology, Department of Medicine Baltimore, MD 21205. Electronic address:

Mitochondria exhibit unstable inner membrane potentials (ΔΨ) when subjected to stress, such as during Ischemia/Reperfusion (I/R). Understanding the mechanism of ΔΨ instability involves characterizing and quantifying this phenomenon in an unbiased and reproducible manner. Here, we describe a simple analytical workflow called 'MitoWave' that combines wavelet transform methods and image segmentation to unravel dynamic ΔΨ changes in the cardiac mitochondrial network during I/R. Read More

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Bayesian modeling of factorial time-course data with applications to a bone aging gene expression study.

J Appl Stat 2021 1;48(10):1730-1754. Epub 2020 Jun 1.

Boston University School of Medicine, Boston, MA, U. S. A.

Many scientific studies, especially in the biomedical sciences, generate data measured simultaneously over a multitude of units, over a period of time, and under different conditions or combinations of factors. Often, an important question of interest asked relates to which units behave similarly under different conditions, but measuring the variation over time complicates the analysis significantly. In this article we address such a problem arising from a gene expression study relating to bone aging, and develop a Bayesian statistical method that can simultaneously detect and uncover signals on three levels within such data: factorial, longitudinal, and transcriptional. Read More

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Coupling Spin Defects in Hexagonal Boron Nitride to Monolithic Bullseye Cavities.

Nano Lett 2021 Jul 21. Epub 2021 Jul 21.

School of Mathematical and Physical Sciences, University of Technology Sydney, Ultimo, New South Wales 2007, Australia.

Color centers in hexagonal boron nitride (hBN) are becoming an increasingly important building block for quantum photonic applications. Herein, we demonstrate the efficient coupling of recently discovered spin defects in hBN to purposely designed bullseye cavities. We show that boron vacancy spin defects couple to the monolithic hBN cavity system and exhibit a 6. Read More

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The Challenges of Partnering to Promote Health through Sport.

Int J Environ Res Public Health 2021 07 5;18(13). Epub 2021 Jul 5.

Centre for Sport and Social Impact, La Trobe Business School, La Trobe University, Bundoora, VIC 3086, Australia.

Interagency partnerships and collaborations underpin a settings-based approach to health promotion in all settings, including sport. This study used an online concept mapping approach to explore the challenges that Regional Sports Assemblies (RSAs) in Victoria, Australia experienced when working in partnerships to develop and deliver physical activity programs in a community sport context. Participants from nine RSAs brainstormed 46 unique partnership-related challenges that they then sorted into groups based on similarity of meaning and rated for importance and capacity to manage (6-point scale; 0 = least, 5 = most). Read More

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Tomographic Study of Mesopore Formation in Ceria Nanorods.

J Phys Chem C Nanomater Interfaces 2021 May 3;125(18):10077-10089. Epub 2021 May 3.

Department of Materials Science and Engineering, University of Sheffield, Sheffield S1 3JD, U.K.

Porosity in functional oxide nanorods is a recently discovered new type of microstructure, which is not yet fully understood and still under evaluation for its impact on applications in catalysis and gas/ion storage. Here we explore the shape and distribution of pores in ceria in three dimensions using a modified algorithm of geometric tomography as a reliable tool for reconstructing defective and strained nanoobjects. The pores are confirmed as "negative-particle" or "inverse-particle" cuboctahedral shapes located exclusively beneath the flat surface of the rods separated via a sub-5 nm thin ceria wall from the outside. Read More

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The "Worktivity" mHealth intervention to reduce sedentary behaviour in the workplace: a feasibility cluster randomised controlled pilot study.

BMC Public Health 2021 07 18;21(1):1416. Epub 2021 Jul 18.

Centre for Exercise Medicine, Physical Activity and Health, Ulster University, Shore Road, Co. Antrim BT37 0QB, Newtownabbey, UK.

Background: Office work generally consists of high amounts of sedentary behaviour (SB) which has been associated with negative health consequences. We developed the "WorktivIty" mobile app to help office workers reduce their SB through self-monitoring and feedback on sedentary time, prompts to break sedentary time, and educational facts. The aim of this paper is to report the feasibility of delivering the Worktivity intervention to desk-based office workers in the workplace setting and describe methodological considerations for a future trial. Read More

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Monte Carlo examination of first-order phase transitions in a system with many independent order parameters: Three-dimensional Ashkin-Teller model.

Phys Rev E 2021 Jun;103(6-1):062124

Faculty of Physics, A. Mickiewicz University, ul. Uniwersytetu Poznańskiego 2, 61-614 Poznań, Poland.

A Monte Carlo (MC) computer experiment for the analysis of first-order temperature-driven phase transitions in a system with one or many independently behaving order parameters is presented using the example of the three-dimensional (3D) Ashkin-Teller model, one of the important reference systems in statistical physics showing a rich and complex phase diagram. The properties of a number of quantities, such as magnetization, three types of cumulants, the internal energy, and its histogram, are exploited. The Lee and Kosterlitz concept proposed for strong first-order phase transitions in systems with one independent order parameter is significantly expanded to obtain results with comparable error bars in reasonable computation times at an arbitrary amount of latent heat. Read More

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Percolation of the two-dimensional XY model in the flow representation.

Phys Rev E 2021 Jun;103(6-1):062131

Hefei National Laboratory for Physical Sciences at Microscale, Department of Modern Physics, University of Science and Technology of China, Hefei 230027, China.

We simulate the two-dimensional XY model in the flow representation by a worm-type algorithm, up to linear system size L=4096, and study the geometric properties of the flow configurations. As the coupling strength K increases, we observe that the system undergoes a percolation transition K_{perc} from a disordered phase consisting of small clusters into an ordered phase containing a giant percolating cluster. Namely, in the low-temperature phase, there exhibits a long-ranged order regarding the flow connectivity, in contrast to the quasi-long-range order associated with spin properties. Read More

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