Front Immunol 2020 13;11:117. Epub 2020 Feb 13.
Inserm, UMR1152, Laboratoire d'Excellence Inflamex, Département Hospitalo-Universtaire FIRE (Fibrosis, Inflammation and Remodeling), Université de Paris, Paris, France.
Individuals with impaired immune responses, such as ventilated and cystic fibrosis patients are often infected with () bacteria, and a co-infection with the virus (IAV) is often present. It has been known for many years that infection with IAV predisposes the host to secondary bacterial infections (such as or ), and there is an abundance of mechanistic studies, including those studying the role of desensitization of TLR signaling, type I IFN- mediated impairment of neutrophil chemokines and antimicrobial production, attenuation of IL1β production etc., showing this. Read More