1,094 results match your criteria pluronic f127®


Comparison of cubosomes and hexosomes for the delivery of phenytoin to the brain.

J Colloid Interface Sci 2021 Jul 18;605:146-154. Epub 2021 Jul 18.

School of Pharmacy, University of Otago, Dunedin, New Zealand. Electronic address:

The ability to formulate cubosomes and hexosomes with a single lipid by changing only the colloidal stabiliser presents a unique opportunity to directly compare the biological performance of these uniquely structured nanoparticles. This was explored here via the encapsulation and brain delivery of a model anti-seizure drug, phenytoin, in selachyl alcohol cubosomes and hexosomes. Nanoparticles were prepared with Pluronic® F127 or Tween 80® as the stabiliser and characterised. Read More

View Article and Full-Text PDF

Development of rivaroxaban microemulsion-based hydrogel for transdermal treatment and prevention of venous thromboembolism.

Colloids Surf B Biointerfaces 2021 Jul 16;206:111978. Epub 2021 Jul 16.

Department of Drugs and Pharmaceutics, Faculty of Pharmacy, Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, 373, CCS, Cidade Universitária, Rio de Janeiro, 21.941-902, Brazil. Electronic address:

We have developed a microemulsion (ME)-based hydrogel, containing propylene glycol, Azone®, Labrasol®, isobutanol and water (20:3:18:3:56), for the transdermal delivery of rivaroxaban (RVX). Formulation ME-1:RVX, which was loaded with 0.3 mg/g of RVX, presented as a clear, homogenous fluid with a droplet size of 82. Read More

View Article and Full-Text PDF

Rheumatoid arthritis treatment using hydroxychloroquine and methotrexate co-loaded nanomicelles: In vivo results.

Colloids Surf B Biointerfaces 2021 Jun 29;206:111952. Epub 2021 Jun 29.

Brazilian Nuclear Energy Commission, Nuclear Engineering Institute, Laboratory of Nanoradiopharmaceuticals and Synthesis of Novel Radiopharmaceuticals, Rio de Janeiro, Brazil; Zona Oeste State University, Laboratory of Radiopharmacy and Nanoradiopharmaceuticals, Rio de Janeiro, Brazil. Electronic address:

Rheumatoid arthritis (RA) is the most common inflammatory rheumatic disease, affecting almost 1% of the world population. It is a long-lasting autoimmune disease, which mainly affects the joints causing inflammation and swelling of the synovial joint. RA has a significant impact on the ability to perform daily activities including simple work and household chores. Read More

View Article and Full-Text PDF

Brain targeting efficiency of intranasal clozapine-loaded mixed micelles following radio labeling with Technetium-99m.

Drug Deliv 2021 Dec;28(1):1524-1538

Labeled Compounds Department, Hot Labs Center, Egyptian Atomic Energy Authority, Cairo, Egypt.

The research objective is to design intranasal (IN) brain targeted CLZ-loaded polymeric nanomicellar systems (PNMS) aiming to improve central systemic CLZ bioavailability. Direct equilibrium method was used to prepare CLZ-PNMS using two hydrophobic poloxamines; Tetronic 904 (T904) and Tetronic 701 (T701) and one hydrophilic poloxamer; Synperonic PE/F127 (F127). Optimization is based on higher percent transmittance, solubilizing efficiency, and release after 24 h with smaller particle size was achieved using Design-Expert software. Read More

View Article and Full-Text PDF
December 2021

Injectable supramolecular hydrogels based on custom-made poly(ether urethane)s and α-cyclodextrins as efficient delivery vehicles of curcumin.

Mater Sci Eng C Mater Biol Appl 2021 Aug 20;127:112194. Epub 2021 May 20.

Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.

A strategy to enhance drug effectiveness while minimizing controversial effects consists in exploiting host-guest interactions. Moreover, these phenomena can induce the self-assembly of physical hydrogels as effective tools to treat various pathologies (e.g. Read More

View Article and Full-Text PDF

Topical Nanoemulgel for the Treatment of Skin Cancer: Proof-of-Technology.

Pharmaceutics 2021 Jun 18;13(6). Epub 2021 Jun 18.

Nanomedicine Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology-Bombay, Mumbai 400076, Maharashtra, India.

The present study is a mechanistic validation of 'proof-of-technology' for the effective topical delivery of chrysin nanoemulgel for localized, efficient treatment of melanoma-affected skin.

Background: Currently available treatments for skin cancer are inefficient due to systemic side effects and poor transcutaneous permeation, thereby presenting a formidable challenge for the development of novel nanocarriers.

Methods: We opted for a novel approach and formulated a nanocomplex system composed of hydrophobic chrysin dissolved in a lipid mix, which was further nanoemulsified in Pluronic F-127 gel to enhance physicochemical and biopharmaceutic characteristics. Read More

View Article and Full-Text PDF

Enhanced Oral Absorption of Icaritin by Using Mixed Polymeric Micelles Prepared with a Creative Acid-Base Shift Method.

Molecules 2021 Jun 6;26(11). Epub 2021 Jun 6.

College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.

The purpose of this study was to develop mixed polymeric micelles with high drug loading capacity to improve the oral bioavailability of icaritin with Soluplus and Poloxamer 407 using a creative acid-base shift (ABS) method, which exhibits the advantages of exclusion of organic solvents, high drug loading and ease of scaling-up. The feasibility of the ABS method was successfully demonstrated by studies of icaritin-loaded polymeric micelles (IPMs). The prepared IPMs were characterized to have a spherical shape with a size of 72. Read More

View Article and Full-Text PDF

An "all-in-one" strategy based on the organic molecule DCN-4CQA for effective NIR-fluorescence-imaging-guided dual phototherapy.

J Mater Chem B 2021 Jul;9(29):5785-5793

State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Qianjin Street, Changchun 130012, P. R. China.

Dual phototherapy combining photodynamic therapy (PDT) and photothermal therapy (PTT) is considered to be a more effective therapeutic method against cancer than single treatment. Therefore, the development of a single material with both near-infrared (NIR)-laser-triggered PDT and PTT abilities is highly desirable but remains a great challenge. A design philosophy for photosensitizers for integrated PDT and PTT treatment has been put forward: (1) a high molar extinction coefficient in the NIR region; (2) suitable LUMO and T1 energy levels to regulate intersystem crossing for effective singlet oxygen (1O2) generation for PDT; and (3) the suppression of fluorescence emission to enhance the process of nonradiative transition with appropriate chemical modifications. Read More

View Article and Full-Text PDF

Mesostructuring layered materials: self-supported mesoporous layered double hydroxide nanotubes.

Nanoscale 2021 Jul;13(27):11781-11792

Instituto de Física da Universidade de São Paulo, 05508-090, São Paulo, SP, Brazil.

Synthesis of layered materials exhibiting hierarchical porosity remains challenging, but nevertheless worthwhile because it turns such solids into functional materials with high specific surface area. Using a soft-templating strategy in combination with the incorporation of 8-fold coordinated Eu3+, self-assembly of self-supported layered double hydroxide (LDH) nanotubes has been achieved. Heteromorphic equimolar substitution of Al3+ by Eu3+ in Zn2+/Al3+ LDH solids intercalated with 1,3,5-benzenetricarboxylate anions (BTC) assists precipitation of the double hydroxide layers onto the convex surface of Pluronic® P-123 worm-like micelles, yielding multilayer cylinders of BTC-intercalated LDHs. Read More

View Article and Full-Text PDF

Pluronic F127 micelles improve the stability and enhance the anticancer stem cell efficacy of citral in breast cancer.

Nanomedicine (Lond) 2021 Jul 23;16(17):1471-1485. Epub 2021 Jun 23.

Drug Delivery & Targeting, CIBBIM-Nanomedicine, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona (UAB), 08035, Barcelona, Spain.

Improving the stability and anti-cancer stem cell (CSC) activity of citral, a natural ALDH1A inhibitor. Citral-loaded micelles (CLM) were obtained using Pluronic F127 and its efficacy tested on the growth of four breast cancer cell lines. The impact of the CLM on the growth and functional hallmarks of breast CSCs were also evaluated using mammosphere and CSC reporter cell lines. Read More

View Article and Full-Text PDF

Surfactant-Stripped Micelles with Aggregation-Induced Enhanced Emission for Bimodal Gut Imaging In Vivo and Microbiota Tagging Ex Vivo.

Adv Healthc Mater 2021 Jun 23:e2100356. Epub 2021 Jun 23.

School of Chemical Engineering and Technology, Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin University, Tianjin, 300350, P. R. China.

Aggregation-induced emission luminogens (AIEgens) hold promise for biomedical imaging and new approaches facilitating their aggregation state are desirable for fluorescence enhancement. Herein, a series of surfactant-stripped AIEgen micelles (SSAMs) with improved fluorescence are developed by a low-temperature surfactant-stripping method to encapsulate AIEgens in temperature-sensitive Pluronic block copolymer. After stripping excessive surfactant, SSAMs exhibit altered optical properties and significantly higher fluorescence quantum yield. Read More

View Article and Full-Text PDF

Nitroxides as Building Blocks for Nanoantioxidants.

ACS Appl Mater Interfaces 2021 Jul 22;13(27):31996-32004. Epub 2021 Jun 22.

Department of Chemistry "Giacomo Ciamician", University of Bologna, via Selmi 2, 40126 Bologna, Italy.

Nitroxides are an important class of radical trapping antioxidants whose promising biological activities are connected to their ability to scavenge peroxyl (ROO) radicals. We have measured the rate constants of the reaction with ROO () for a series of 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) derivatives as 5.1 × 10, 1. Read More

View Article and Full-Text PDF

One-Pot Fabrication of Hierarchically Bicontinuous Polystyrene Monoliths with Homogeneous Skeletons and Glycopolymer Surfaces.

Macromol Rapid Commun 2021 Jul 17;42(14):e2100154. Epub 2021 Jun 17.

College of Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, P. R. China.

The hierarchically bicontinuous polystyrene monoliths (HBPMs) with homogeneous skeletons and glycopolymer surfaces are fabricated for the first time based on the medium internal phase emulsion (MIPE) templating method via activator generated by electron transfer for atom transfer radical polymerization (AGET ATRP). The synergistic self-assembly of amphiphilic diblock glycopolymer (ADG) and Pluronic F127 (PF127) at the oil/water interface via hydrogen bonding interaction contributes to the formation of bicontinuous MIPE with deformed neighboring water droplets, resulting in the highly interconnected HBPM after polymerization. There is a bimodal pore size distribution in the HBPM, that is, through pores (150-5000 nm) and mesopores (10-150 nm). Read More

View Article and Full-Text PDF

Micellar Nanocarriers of Hydroxytyrosol Are Protective against Parkinson's Related Oxidative Stress in an In Vitro hCMEC/D3-SH-SY5Y Co-Culture System.

Antioxidants (Basel) 2021 May 31;10(6). Epub 2021 May 31.

Centre for Nutraceuticals, School of Life Sciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, UK.

Hydroxytyrosol (HT) is a natural phenolic antioxidant which has neuroprotective effects in models of Parkinson's disease (PD). Due to issues such as rapid metabolism, HT is unlikely to reach the brain at therapeutic concentrations required for a clinical effect. We have previously developed micellar nanocarriers from Pluronic F68 (P68) and dequalinium (DQA) which have suitable characteristics for brain delivery of antioxidants and iron chelators. Read More

View Article and Full-Text PDF

Development and In Vitro Evaluation of Controlled Release Viagra Containing Poloxamer-188 Using Gastroplus PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments.

Pharmaceuticals (Basel) 2021 May 18;14(5). Epub 2021 May 18.

Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 17666, United Arab Emirates.

Sildenafil is the active substance in Viagra tablets, which is approved by the FDA to treat sexual dysfunction in men. Poor solubility and short half-life, however, can limit the span of its effectiveness. Therefore, this study focused on an oral controlled release matrix system with the aim to improve solubility, control the drug release, and sustain the duration of drug activity. Read More

View Article and Full-Text PDF

Combination Chemotherapy with Cisplatin and Chloroquine: Effect of Encapsulation in Micelles Formed by Self-Assembling Hybrid Dendritic-Linear-Dendritic Block Copolymers.

Int J Mol Sci 2021 May 14;22(10). Epub 2021 May 14.

Grupo de Terapia Génica y Celular, Instituto Aragonés de Ciencias de la Salud (IACS/IIS-Aragon), 50009 Zaragoza, Spain.

Clinical outcomes of conventional drug combinations are not ideal due to high toxicity to healthy tissues. Cisplatin (CDDP) is the standard component for many cancer treatments, yet its principal dose-limiting side effect is nephrotoxicity. Thus, CDDP is commonly used in combination with other drugs, such as the autophagy inhibitor chloroquine (CQ), to enhance tumor cell killing efficacy and prevent the development of chemoresistance. Read More

View Article and Full-Text PDF

EtoGel for Intra-Articular Drug Delivery: A New Challenge for Joint Diseases Treatment.

J Funct Biomater 2021 May 16;12(2). Epub 2021 May 16.

Department of Health Science, Campus Universitario-Germaneto, "Magna Græcia" University of Catanzaro, Viale Europa, I-88100 Catanzaro, Italy.

Ethosomes have been proposed as potential intra-articular drug delivery devices, in order to obtain a longer residence time of the delivered drug in the knee joint. To this aim, the conventional composition and preparation method were modified. Ethosomes were prepared by using a low ethanol concentration and carrying out a vesicle extrusion during the preparation. Read More

View Article and Full-Text PDF

Atomic Force Microscopy Study of Non-DLVO Interactions between Drops and Bubbles.

Langmuir 2021 Jun 27;37(22):6830-6837. Epub 2021 May 27.

Beijing Key Laboratory of Urban Oil and Gas Distribution Technology, State Key Laboratory of Natural Gas Hydrates, MOE Key Laboratory of Petroleum Engineering, China University of Petroleum, Beijing, No. 18 Fuxue Road, Changping District, 102249 Beijing, P. R. China.

The heterointeraction between liquid drops and air bubbles dispersed in another immiscible liquid is studied with the application of the atomic force microscopy (AFM) probe techniques. The tetradecane drops and air bubbles readily coalescence to form a lens-like structure in 100 mM sodium chloride aqueous solution, demonstrating strong hydrophobic (HB) attraction. The interaction range and strength of this hydrophobic attraction between oil drops and air bubbles is investigated by fine control of electrical double layer thicknesses related to specific electrolyte concentrations, and a midrange term in combination with a short-range term is found to present a proper characterization of this hydrophobic attraction. Read More

View Article and Full-Text PDF

Heterotypic tumor models through freeform printing into photostabilized granular microgels.

Biomater Sci 2021 Jun;9(12):4496-4509

School of Materials Science and Engineering, University of New South Wales, Sydney, NSW 2052, Australia. and School of Chemistry, Australian Centre for Nanomedicine, University of New South Wales, Sydney, NSW 2052, Australia.

The tissue microenvironment contains a complex assortment of multiple cell types, matrices, and vessel structures, which is difficult to reconstruct in vitro. Here, we demonstrate model tumor microenvironments formed through direct writing of vasculature channels and tumor cell aggregates, within a cell-laden microgel matrix. Photocrosslinkable microgels provide control over local and global mechanics, while enabling the integration of virtually any cell type. Read More

View Article and Full-Text PDF

Effect of pH adjustment and ratio of oppositely charged polymers on the mechanistic performance and sustained release of volatile perfume in interpolyelectrolyte complex microcapsules.

Int J Pharm 2021 Jul 5;604:120672. Epub 2021 May 5.

College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea. Electronic address:

In this study, volatile perfume was encapsulated in microcapsules (MCs) via interpolyelectrolyte complexes (IPECs) of oppositely charged polymers, with high encapsulation efficiency, to be delivered in a sustained manner. Positively charged chitosan (CTS) and negatively charged Eudragit® S100 (ES100) were used as eco-friendly biopolymers. Limonene (LMN) was selected as the model perfume. Read More

View Article and Full-Text PDF

Sustained delivery of MMP-9 siRNA via thermosensitive hydrogel accelerates diabetic wound healing.

J Nanobiotechnology 2021 May 5;19(1):130. Epub 2021 May 5.

Department of Endocrinology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, P. R. China.

Excessive expression of matrix metalloproteinase 9 (MMP-9) impedes healing of diabetic chronic wounds, thus wound dressing that could effectively inhibit the expression of MMP-9 offers significant clinical translation for diabetic wound healing. Herein, a hybrid hydrogel dressing was developed for localized and sustained delivery of MMP-9 siRNA (siMMP-9). siMMP-9 was complexed with Gly-TETA (GT), the GT/siMMP9 complex was then loaded into a thermosensitive hydrogel based on Pluronic F-127 (PF) and methylcellulose (MC). Read More

View Article and Full-Text PDF

PK/PD Analysis of Marbofloxacin by Monte Carlo Simulation against in Plasma and Milk of Lactating Goats after IV, SC and SC-Long Acting Formulations Administration.

Animals (Basel) 2021 Apr 12;11(4). Epub 2021 Apr 12.

Department of Animal Health, Faculty of Veterinary Sciences, Regional Campus of International Excellence "Campus Mare Nostrum", Campus de Espinardo s/n., University of Murcia, 30100 Murcia, Spain.

Contagious agalactia is a mycoplasmosis affecting small ruminants that have become an important issue in many countries. However, PK/PD studies of antibiotics to treat this problem in lactating goats affected by , the main CA-causing mycoplasma are almost non-existent. The aims of this study were to evaluate the plasma and milk disposition of marbofloxacin in lactating goats after intravenous (IV), subcutaneous (SC) and subcutaneous poloxamer P407 formulations with and without carboxy-methylcellulose (SC-P407-CMC and SC-P407) administration. Read More

View Article and Full-Text PDF

Use of Pluronic Surfactants in Gel Formulations of Photosensitive 1,4-Dihydropyridine Derivatives: A Potential Approach in the Treatment of Neuropathic Pain.

Pharmaceutics 2021 Apr 10;13(4). Epub 2021 Apr 10.

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, Italy.

1,4-Dihydropyridines (DHPs) are the most important class of L-type calcium channel blockers that are employed for the treatment of cardiovascular diseases, particularly hypertension. Various modifications on this scaffold lead to the discovery of new DHPs blocking different types of calcium channels. Among them, the T-type calcium channel has recently attracted great interest due to its role in chronic pain conditions. Read More

View Article and Full-Text PDF

PLGA Nanoparticle-Based Formulations to Cross the Blood-Brain Barrier for Drug Delivery: From R&D to cGMP.

Pharmaceutics 2021 Apr 6;13(4). Epub 2021 Apr 6.

Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 881 Madison Ave, Memphis, TN 38163, USA.

The blood-brain barrier (BBB) is a natural obstacle for drug delivery into the human brain, hindering treatment of central nervous system (CNS) disorders such as acute ischemic stroke, brain tumors, and human immunodeficiency virus (HIV)-1-associated neurocognitive disorders. Poly(lactic--glycolic acid) (PLGA) is a biocompatible polymer that is used in Food and Drug Administration (FDA)-approved pharmaceutical products and medical devices. PLGA nanoparticles (NPs) have been reported to improve drug penetration across the BBB both in vitro and in vivo. Read More

View Article and Full-Text PDF

Evaluation of In Vitro Neuronal Protection by Postconditioning with Poloxamer 188 Following Simulated Traumatic Brain Injury.

Life (Basel) 2021 Apr 6;11(4). Epub 2021 Apr 6.

Anesthesiology, TVHS VA Medical Center, Nashville, TN 37212, USA; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.

Traumatic brain injury (TBI) leads to morbidity and mortality worldwide. Reperfusion after ischemia adds detrimental injury to cells. Ischemia/reperfusion (I/R) injures cells in a variety of ways including cell membrane disruption. Read More

View Article and Full-Text PDF

General Synthesis of Ultrafine Monodispersed Hybrid Nanoparticles from Highly Stable Monomicelles.

Adv Mater 2021 Jun 29;33(23):e2100820. Epub 2021 Apr 29.

Department of Chemistry, Laboratory of Advanced Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, iChEM and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433, P. R. China.

Ultrafine nanoparticles with organic-inorganic hybridization have essential roles in myriad applications. Over the past three decades, although various efforts on the formation of organic or inorganic ultrasmall nanoparticles have been made, ultrafine organic-inorganic hybrid nanoparticles have scarcely been achieved. Herein, a family of ultrasmall hybrid nanoparticles with a monodisperse, uniform size is synthesized by a facile thermo-kinetics-mediated copolymer monomicelle approach. Read More

View Article and Full-Text PDF

Simultaneous Optimization of Oral and Transdermal Nanovesicles for Bioavailability Enhancement of Ivabradine Hydrochloride.

Int J Nanomedicine 2021 21;16:2917-2931. Epub 2021 Apr 21.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Purpose: Ivabradine hydrochloride is selective pacemaker current (I) ion channel inhibitor used in case of chronic heart failure (CHF) with superior efficacy and lower side effects than most β-blockers. However, the drug suffers from low bioavailability (≈40%) due to extensive first-pass metabolism. Hence, this work aims to formulate nanovesicular platforms to enhance their bioavailability both orally and transdermally. Read More

View Article and Full-Text PDF

Thermosensitive and mucoadhesive in situ ocular gel for effective local delivery and antifungal activity of itraconazole nanocrystal in the treatment of fungal keratitis.

Int J Pharm 2021 Jun 21;602:120623. Epub 2021 Apr 21.

School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK.

Itraconazole is a lipophilic drug, which limits its absorption for ocular administration. This study focused on the incorporation of itraconazole into nanocrystalline carrier system with stabilizer Pluronic® F127 and was further formulated into thermosensitive in situ ocular gel. Itraconazole nanocrystals (ITZ-NCs) were fabricated using media milling method with ultra-small-scale device. Read More

View Article and Full-Text PDF

Curcumin-loaded Pluronic F-127 Micelles as a Drug Delivery System for Curcumin-mediated Photodynamic Therapy for Oral Application.

Photochem Photobiol 2021 Apr 19. Epub 2021 Apr 19.

Department of Restorative Dentistry, School of Dentistry, São Paulo State University - UNESP, Araraquara, São Paulo, Brazil.

Antimicrobial photodynamic therapy (aPDT) is promising for oral decontamination. Curcumin has been used as photosensitizer; however, the hydrophobic properties can negatively affect aPDT. This study evaluated the aPDT efficacy using Cur-loaded Pluronic F-127 micelles against Streptococcus mutans and Candida albicans biofilms. Read More

View Article and Full-Text PDF

Acarbose presents in vitro and in vivo antileishmanial activity against Leishmania infantum and is a promising therapeutic candidate against visceral leishmaniasis.

Med Microbiol Immunol 2021 Jun 18;210(2-3):133-147. Epub 2021 Apr 18.

Laboratório de Pesquisa do Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Avenida Prof. Alfredo Balena, 190, 30.130-100, Belo Horizonte, Minas Gerais, Brazil.

Treatment against visceral leishmaniasis (VL) is mainly hampered by drug toxicity, long treatment regimens and/or high costs. Thus, the identification of novel and low-cost antileishmanial agents is urgent. Acarbose (ACA) is a specific inhibitor of glucosidase-like proteins, which has been used for treating diabetes. Read More

View Article and Full-Text PDF