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Development and Validation of a Nomogram to Predict Frailty Progression in Nonfrail Chinese Community-Living Older Adults.

J Am Med Dir Assoc 2021 Jun 12. Epub 2021 Jun 12.

Department of General Practice, Zhongshan Hospital of Fudan University, Shanghai, China.

Objective: Frailty state progression is common among older adults, so it is necessary to identify predictors to implement individualized interventions. We aimed to develop and validate a nomogram to predict frailty progression in community-living older adults.

Design: Prospective cohort study. Read More

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A new method for broad-scale modeling and projection of plant assemblages under climatic, biotic, and environmental cofiltering.

Conserv Biol 2021 Jun 15. Epub 2021 Jun 15.

Environmental Science Center, Qatar University, Doha, P.O. Box 2713, Qatar.

There is increasing interest in broad-scale analysis, modeling, and prediction of the distribution and composition of plant species assemblages under climatic, environmental, and biotic filtering, particularly for conservation purposes. We devised a method (broad-scale analysis & modeling of plant assemblages under climatic-biotic-environmental co-filtering, BAM-PACC) for reliably predicting the impact of climate change on arbitrarily large assemblages of plant communities, while also considering competing biotic and abiotic factors. When applied to a large set of plant communities in the Swiss Alps, BAM-PACC explained presences/absences of 175 plant species in 608 plots with >87% cross-validated accuracy, predicted decreases in α, β, and γ diversity by 2040 under both moderate and extreme climate scenarios, and identified plant species likely to be favored/disfavored by climate change. Read More

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Temperature Behavior of SAW Resonators Based on LiNbO3/Quartz and LiTaO3/Quartz Substrates.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 Jun 15;PP. Epub 2021 Jun 15.

LiNbO3 (LN) or LiTaO3 (LT) thin plates bonded to quartz are novel types of layered substrates for temperature-compensated surface acoustic wave (TCSAW) devices. In SAW resonators with Al electrodes arranged on LT/quartz and LN/quartz substrates, improved temperature behavior due to opposite signs of temperature coefficients of frequency (TCF) in quartz substrates and LT or LN plates can be combined with high Q-factors if the quartz orientation is optimized. The quartz orientation areas that enabled high Q-factors were deduced from analyzing the quartz anisotropy and the characteristics of shear horizontally polarized (SH) waves were calculated in the optimal orientations as functions of the quartz cut angle and plate thickness. Read More

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Estimate of the prevalence of depression among older people in Africa: a systematic review and meta-analysis.

Aging Ment Health 2021 Jun 15:1-11. Epub 2021 Jun 15.

School of Public Health, Curtin University, Perth, Australia.

Objective: The current systematic review and meta-analysis aimed to estimate the pooled prevalence of depression among elderly people in Africa.

Method: We have searched CINAHIL, PubMed, SCOPUS and Psych-INFO databases to identify important observational studies which reported the prevalence of depression among the elderly. We used a random-effects model due to reported heterogeneity among the included studies. Read More

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Comparison of Joint and Landmark Modeling for Predicting Cancer Progression in Men With Castration-Resistant Prostate Cancer: A Secondary Post Hoc Analysis of the PREVAIL Randomized Clinical Trial.

JAMA Netw Open 2021 Jun 1;4(6):e2112426. Epub 2021 Jun 1.

Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.

Importance: Dynamic prediction models may help predict radiographic disease progression in advanced prostate cancer.

Objective: To assess whether dynamic prediction models aid prognosis of radiographic progression risk, using ongoing longitudinal prostate-specific antigen (PSA) assessments.

Design, Setting, And Participants: This prognostic study used data from the PREVAIL study to compare dynamic models for predicting disease progression. Read More

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Flow-diverting device versus coil embolization for unruptured intracranial aneurysm: A meta-analysis.

Medicine (Baltimore) 2021 Jun;100(24):e26351

Department of Interventional Treatment, Binzhou People's Hospital, Binzhou, China.

Background: Both coil embolization (CE) and flow-diverting device (FDD) placement are widely used for treatment of intracranial aneurysms (IAs). The aim of this meta-analysis is to compare the relative clinical safety and efficacy of FDD and CE for the treatment of unruptured IAs.

Methods: The PubMed, Embase, and Cochrane Library databases were searched for relevant studies from the date of inception through April 2020. Read More

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Development and validation of a prediction model of poor performance status and severe symptoms over time in cancer patients (PROVIEW+).

Palliat Med 2021 Jun 15:2692163211019302. Epub 2021 Jun 15.

Institute for Clinical Evaluative Sciences, Toronto, ON, Canada.

Background: Predictive cancer tools focus on survival; none predict severe symptoms.

Aim: To develop and validate a model that predicts the risk for having low performance status and severe symptoms in cancer patients.

Design: Retrospective, population-based, predictive study. Read More

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Heat transfer intensification of nanomaterial with involve of swirl flow device concerning entropy generation.

Sci Rep 2021 Jun 14;11(1):12504. Epub 2021 Jun 14.

Fixed Point Research Laboratory, Fixed Point Theory and Applications Research Group, Center of Excellence in Theoretical and Computational Science (TaCS-CoE), Faculty of Science, King Mongkut's University of Technology Thonburi (KMUTT), 126 Pracha Uthit Rd., Bang Mod, Thung Khru, Bangkok, 10140, Thailand.

The thermal features of hybrid nano-powder turbulent motion through a pipe employing helical turbulator is numerically simulated via Finite Volume Method (FVM). The hybrid nanofluid (MWCNTs + FeO + HO) is obtained by uniformly dispersing MWCNTs + FeO nanomaterials in HO. The characteristics features of thermal energy transfer of hybrid nanofluid are investigated by varying the pitch ratio (P) of the helical turbulator and Reynolds number (Re) of the fluid. Read More

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Accuracy of Frozen Section Analysis of Urethral and Ureteral Margins During Radical Cystectomy for Bladder Cancer: A Systematic Review and Diagnostic Meta-Analysis.

Eur Urol Focus 2021 Jun 11. Epub 2021 Jun 11.

Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

Context: The question of the ability of frozen section analysis (FSA) to accurately detect malignant pathology intraoperatively has been discussed for many decades.

Objective: We aimed to conduct a systematic review and meta-analysis assessing the diagnostic estimates of FSA of the urethral and ureteral margins in patients treated with radical cystectomy (RC) for bladder cancer (BCa).

Evidence Acquisition: The MEDLINE and EMBASE databases were searched in February 2021 for studies analyzing the association between FSA and the final urethral and ureteral margin status in patients treated with RC for BCa. Read More

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CT ​EvaLuation ​by ​ARtificial ​Intelligence ​For ​Atherosclerosis, Stenosis and Vascular ​MorphologY ​(CLARIFY): ​A ​Multi-center, international study.

J Cardiovasc Comput Tomogr 2021 Jun 12. Epub 2021 Jun 12.

Department of Radiology, The George Washington University School of Medicine, Washington, DC, USA.

Background: Atherosclerosis evaluation by coronary computed tomography angiography (CCTA) is promising for coronary artery disease (CAD) risk stratification, but time consuming and requires high expertise. Artificial Intelligence (AI) applied to CCTA for comprehensive CAD assessment may overcome these limitations. We hypothesized AI aided analysis allows for rapid, accurate evaluation of vessel morphology and stenosis. Read More

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DETECTION OF DENSE, OVERLAPPING, GEOMETRIC OBJECTS.

Int J Artif Intell Appl 2020 ;11(4)

NIST, 100 Bureau Dr., Gaithersburg, MD.

Using a unique data collection, we are able to study the detection of dense geometric objects in image data where object density, clarity, and size vary. The data is a large set of black and white images of scatterplots, taken from journals reporting thermophysical property data of metal systems, whose plot points are represented primarily by circles, triangles, and squares. We built a highly accurate single class U-Net convolutional neural network model to identify 97 % of image objects in a defined set of test images, locating the centers of the objects to within a few pixels of the correct locations. Read More

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January 2020

Structure, composition and diversity of restored forest ecosystems on mine-spoils in South-Western Ghana.

PLoS One 2021 14;16(6):e0252371. Epub 2021 Jun 14.

Department of Forest Resources Technology, FRNR, Kwame Nkrumah University of Science and Technology, PMB, Kumasi, Ghana.

In response to national policy obligations, many mining companies in Ghana have restored/reclaimed degraded mined out sites through revegetation. The area extent of such restored areas is unknown and there is also paucity of data on success of restoration, species diversity and compositional dynamics of such restored landscapes, particularly using mixed species. This study assessed stand structure, diversity and composition dynamics of sites restored with mixed species and models species abundance distribution on these sites. Read More

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A photogrammetric method for the measurement of three-dimensional cervical range of motion.

Authors:
Rui Li Qi Jiang

IEEE J Biomed Health Inform 2021 Jun 14;PP. Epub 2021 Jun 14.

Cervical spondylosis has gradually become a high-incidence disease in today's society. The cervical range of motion (CROM) is widely used as the evaluation criterion of cervical status, whereas the existing methods of CROM measuring are not humanized enough. Consequently, the purpose of this study was to develop a novel photogrammetric method to assess three-dimensional CROM. Read More

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Significant Solvent Effect on Reactivity of Oxoiron(IV) Porphyrin π-Cation Radical Complex: Activation in -Alkane Solvent.

Inorg Chem 2021 Jun 14. Epub 2021 Jun 14.

Department of Chemistry, Graduate School of Humanities and Sciences, Nara Women's University, Kitauoyanishi, Nara 630-8506, Japan.

The solvent effect on the reactivity of high-valent metal oxo complexes has not been studied well, because of their solubility and stability. We synthesize oxoiron(IV) porphyrin π-cation radical complexes ( and ) having the -hexyl side chains. and are soluble in various solvents, even in hexane, at -80 °C, allowing for the study of their reactivity in various organic solvents. Read More

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Towards an Understanding of Oxidative Damage in an α-L-Arabinofuranosidase of Trichoderma reesei: a Molecular Dynamics Approach.

Appl Biochem Biotechnol 2021 Jun 14. Epub 2021 Jun 14.

Plant and Microbial Biology, University of Minnesota, Saint Paul, MN, 55108, USA.

Trichoderma reesei is a "workhorse" fungus that produces glycosyl hydrolases (e.g., cellulases) at high titers for use in industrial bioprocessing. Read More

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Effects of interventions on rumination among individuals with cancer: A systematic review and meta-analysis.

J Adv Nurs 2021 Jun 14. Epub 2021 Jun 14.

Psychiatric Nursing Department, Faculty of Nursing, Hacettepe University, Ankara, Turkey.

Aim: This study aimed to examine the effects of interventions on rumination among individuals with cancer.

Design: A systematic review and meta-analysis.

Data Sources: Six databases (Scopus, Cochrane Central Register of Controlled Trials (CENTRAL), PsyArticles, CINAHL, PubMed and Web of Science) were searched for relevant articles published between January 2000 and April 2020. Read More

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Boron Oxide Nanoparticles Exhibit Minor, Species-Specific Acute Toxicity to North-Temperate and Amazonian Freshwater Fishes.

Front Bioeng Biotechnol 2021 28;9:689933. Epub 2021 May 28.

Department of Chemistry and Biochemistry, Mount Allison University, Sackville, NB, Canada.

Boron oxide nanoparticles (nBO) are manufactured for structural, propellant, and clinical applications and also form spontaneously through the degradation of bulk boron compounds. Bulk boron is not toxic to vertebrates but the distinctive properties of its nanostructured equivalent may alter its biocompatibility. Few studies have addressed this possibility, thus our goal was to gain an initial understanding of the potential acute toxicity of nBO to freshwater fish and we used a variety of model systems to achieve this. Read More

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Identification METTL18 as a Potential Prognosis Biomarker and Associated With Immune Infiltrates in Hepatocellular Carcinoma.

Front Oncol 2021 26;11:665192. Epub 2021 May 26.

Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Methyltransferase-like 18 (METTL18), a METTL family member, is abundant in hepatocellular carcinoma (HCC). Studies have indicated the METTL family could regulate the progress of diverse malignancies while the role of METTL18 in HCC remains unclear. Data of HCC patients were acquired from the cancer genome atlas (TCGA) and gene expression omnibus (GEO). Read More

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Data-powered augmented volcano plots for homogeneous catalysis.

Chem Sci 2020 Sep 21;11(44):12070-12080. Epub 2020 Sep 21.

Laboratory for Computational Molecular Design, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL) 1015 Lausanne Switzerland

Given the computational resources available today, data-driven approaches can propel the next leap forward in catalyst design. Using a data-driven inspired workflow consisting of data generation, statistical analysis, and dimensionality reduction algorithms we explore trends surrounding the thermodynamics of a model hydroformylation reaction catalyzed by group 9 metals bearing phosphine ligands. Specifically, we introduce "augmented volcano plots" as a means to easily visualize the similarity of each catalyst's complete catalytic cycle energy profile to that of a hypothetical ideal reference profile without relying upon linear scaling relationships. Read More

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September 2020

An experimental approach for controlling confinement effects at catalyst interfaces.

Chem Sci 2020 Sep 11;11(40):11024-11029. Epub 2020 Sep 11.

Van 't Hoff Institute for Molecular Sciences, University of Amsterdam Science Park 904 Amsterdam 1098 XH The Netherlands

Catalysts are conventionally designed with a focus on enthalpic effects, manipulating the Arrhenius activation energy. This approach ignores the possibility of designing materials to control the entropic factors that determine the pre-exponential factor. Here we investigate a new method of designing supported Pt catalysts with varying degrees of molecular confinement at the active site. Read More

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September 2020

Chronic E-Cigarette Aerosol Inhalation Alters the Immune State of the Lungs and Increases ACE2 Expression, Raising Concern for Altered Response and Susceptibility to SARS-CoV-2.

Front Physiol 2021 31;12:649604. Epub 2021 May 31.

Pulmonary Critical Care Section, VA San Diego Healthcare System, La Jolla, CA, United States.

Conventional smoking is known to both increase susceptibility to infection and drive inflammation within the lungs. Recently, smokers have been found to be at higher risk of developing severe forms of coronavirus disease 2019 (COVID-19). E-cigarette aerosol inhalation (vaping) has been associated with several inflammatory lung disorders, including the recent e-cigarette or vaping product use-associated lung injury (EVALI) epidemic, and recent studies have suggested that vaping alters host susceptibility to pathogens such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Read More

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Identification of Key Biomarkers and Immune Infiltration in Sciatic Nerve of Diabetic Neuropathy BKS-db/db Mice by Bioinformatics Analysis.

Front Pharmacol 2021 26;12:682005. Epub 2021 May 26.

Graduate School of Anhui University of Chinese Medicine, Hefei, China.

Diabetic neuropathy (DN) is one of the chronic complications of diabetes which can cause severe harm to patients. In order to determine the key genes and pathways related to the pathogenesis of DN, we downloaded the microarray data set GSE27382 from Gene Expression Omnibus (GEO) and adopted bioinformatics methods for comprehensive analysis, including functional enrichment, construction of PPI networks, central genes screening, TFs-target interaction analysis, and evaluation of immune infiltration characteristics. Finally, we examined quantitative real- time PCR (qPCR) to validate the expression of hub genes. Read More

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Interactive effect of nitrogen fertilizer and plant density on photosynthetic and agronomical traits of cotton at different growth stages.

Saudi J Biol Sci 2021 Jun 17;28(6):3578-3584. Epub 2021 Mar 17.

MOA Key Laboratory of Crop Ecophysiology and Farming System in the Middle Reaches of the Yangtze River, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, PR China.

Individual effects of application of nitrogen (N) and plant densities (PD) were reported in various studies; however an interactive effect of N and PD in cotton was not studied. To explore the benefits of interactive effects of N fertilizer and PD to increase the quality of cotton. This study was carried out in randomized complete block design (RCBD) with split plot arrangement. Read More

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Textbook outcome after rectal cancer surgery as a composite measure for quality of care: A population-based study.

Eur J Surg Oncol 2021 Jun 4. Epub 2021 Jun 4.

Reinier de Graaf Groep, Department of Surgery, Reinier de Graafweg 5, 2625 AD, Delft, the Netherlands. Electronic address:

Background: Textbook outcome is a composite measure of combined outcome indicators, which has been suggested to be of additional value over single outcome parameters in clinical auditing of surgical treatment. This study aimed to assess textbook outcome after rectal cancer surgery as short-term marker for quality of care.

Materials And Methods: Patients who underwent elective rectal cancer surgery between 2012 and 2019 and registered in the Dutch ColoRectal Audit were included. Read More

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Evaluation of the Effect of Proton Pump Inhibitors on the Efficacy of Dacomitinib and Gefitinib in Patients with Advanced Non-Small Cell Lung Cancer and EGFR-Activating Mutations.

Oncol Ther 2021 Jun 13. Epub 2021 Jun 13.

Clinical Pharmacology, Pfizer Inc, 10555 Science Center Drive, CB10/002/2533, San Diego, CA, 92121, USA.

Introduction: Dacomitinib and gefitinib are irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) indicated for the first-line treatment of patients with advanced non-small cell lung cancer (NSCLC) and EGFR-activating mutations. Pharmacokinetic (PK) studies in healthy volunteers suggested that acid-reducing drugs such as proton pump inhibitors (PPI) decreased dacomitinib and gefitinib exposure by limiting the pH-dependent absorption. This analysis retrospectively evaluates the effect of concomitant PPI use on dacomitinib exposure and on progression-free survival (PFS) and overall survival (OS) in patients treated with dacomitinib 45 mg QD or gefitinib 250 mg QD in a 1:1 randomized phase 3 study (ARCHER 1050). Read More

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Soil amendments from recycled waste differently affect CO₂ soil emissions in restored mining soils under semiarid conditions.

J Environ Manage 2021 Jun 10;294:112894. Epub 2021 Jun 10.

Department of Agronomy & Center for Intensive Mediterranean Agrosystems and Agri-food Biotechnology (CIAIMBITAL), University of Almeria, E-04120, Almería, Spain. Electronic address:

Drylands affected by serious disturbances such as mining activities lose their vegetation cover and organic soil horizons, becoming CO emissions sources. Applications of organic amendments could be a good restoration solution that favours vegetation establishment and soil carbon sequestration; however, they are also associated with CO₂ emissions. Experimental plots with different organic amendments (sewage sludge, garden and greenhouse vegetable composts, and mixtures of both) and unamended soils were installed in a quarry in southeast Spain. Read More

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Mortality of right ventricular dysfunction in patients with acute respiratory distress syndrome subjected to lung protective ventilation: A systematic review and meta-analysis.

Heart Lung 2021 Jun 9;50(5):730-735. Epub 2021 Jun 9.

Department of ICU, Shaanxi Provincial People's Hospital, Xi'an, China.

Background: The impact of right ventricular dysfunction(RVD) on the prognosis of acute respiratory distress syndrome(ARDS) patients is controversial.

Objectives: The objectives of this systematic review and meta-analysis was to investigate whether RVD or pulmonary vascular dysfunction are associated with increased mortality in patients with ARDS.

Methods: We searched Pubmed, Embase, Cochrane Library, Wanfang Data, CNKI, and the WHO Clinical Trial Registry for studies of RVD or pulmonary vascular dysfunction in patients with ARDS. Read More

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Variability in outcomes and quality-of-care indicators across clinics participating in a large smoking-cessation program.

J Subst Abuse Treat 2021 Apr 14;130:108409. Epub 2021 Apr 14.

Nicotine Dependence Services, Centre for Addiction and Mental Health, 175 College St, Toronto, ON M5T 1P7, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, 60 White Squirrel Way, Toronto, ON M6J 1H4, Canada; Department of Family and Community Medicine, University of Toronto, 500 University Ave, Toronto, ON M5G 1V7, Canada; Dalla Lana School of Public Health, University of Toronto, 155 College, Toronto, ON M5T 3M7, Canada; Department of Psychiatry, University of Toronto, 250 College Street, Toronto, ON M5T 1R8, Canada. Electronic address:

Background: The effectiveness of care for substance-related problems varies across providers. Best-known treatments are rarely universally applied, and various process differences can affect participant outcomes. Measuring and understanding this variability can suggest changes that will improve system performance. Read More

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Performance of nanoScan PET/CT and PET/MR for quantitative imaging of F and Zr as compared with ex vivo biodistribution in tumor-bearing mice.

EJNMMI Res 2021 Jun 12;11(1):57. Epub 2021 Jun 12.

Amsterdam UMC, Vrije Universiteit Amsterdam, Radiology & Nuclear Medicine, Cancer Center Amsterdam, De Boelelaan 1117, Amsterdam 1081 HV, The Netherlands.

Introduction: The assessment of ex vivo biodistribution is the preferred method for quantification of radiotracers biodistribution in preclinical models, but is not in line with current ethics on animal research. PET imaging allows for noninvasive longitudinal evaluation of tracer distribution in the same animals, but systemic comparison with ex vivo biodistribution is lacking. Our aim was to evaluate the potential of preclinical PET imaging for accurate tracer quantification, especially in tumor models. Read More

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ZIF-based boronic acid functionalized metal-organic frameworks for the enrichment of cis-diol-containing luteolin from food samples prior to  HPLC.

Mikrochim Acta 2021 Jun 11;188(7):229. Epub 2021 Jun 11.

Key Laboratory of Photochemical Biomaterials and Energy Storage Materials, Heilongjiang Province, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin, 150025, People's Republic of China.

Zeolite imidazole framework-based boronic acid-functionalized metal-organic frameworks ([email protected]@BA-Zr-MOFs) were developed as an adsorbent for solid phase extraction (SPE) of luteolin (LTL) from peanut shell samples. Herein, ZIF-67 as a support matrix, polydopamine (PDA) as a coating to introduce amino and hydroxyl groups on the matrix surface to fix metal-organic frameworks (MOFs), zirconium tetrachloride (ZrCl) as a precursor, terephthalic acid (TPA), and 3-carboxyphenylboronic acid (3-CPBA) as the mutual organic building blocks, and 3-CPBA was also a boronate affinity functional monomer. The effects of synthesis conditions, SPE conditions, selectivity, competitivity, reproducibility, and reusability were evaluated in detail. Read More

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