11,375 results match your criteria pleural fluid


Xpert MTB/RIF Ultra enhances tuberculous pleurisy diagnosis for patients with unexplained exudative pleural effusion who underwent a pleural biopsy via thoracoscopy: a prospective cohort study.

Int J Infect Dis 2021 Apr 9. Epub 2021 Apr 9.

National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China. Electronic address:

Introduction: To evaluate the performance of Xpert MTB/RIF Ultra (Xpert-Ultra) in testing pleural tissue and fluid collected by medical thoracoscopy among patients with unexplained exudative pleural effusion.

Methods: Patients with an undiagnosed exudative pleural effusion were recruited prospectively and consecutively. Pleural tissue and fluid was collected by medical thoracoscopy and subjected to culture, Xpert MTB/RIF (Xpert) and Xpert-Ultra assays. Read More

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A fatal invasive pulmonary infection in an adult patient with malignant lung adenocarcinoma.

Curr Med Mycol 2020 Sep;6(3):61-64

Department of Infectious Diseases and Clinical Microbiology, Kayseri City Hospital, Kayseri, Turkey.

Background And Purpose: complex as a ubiquitous environmental mold is increasingly reported to cause an invasive fungal infection in immunosuppressive hosts. Herein, we present the case of an immunosuppressive 54 - year-old man who developed complex lung infection and pulmonary adenocarcinoma.

Case Report: The patient had some complaints of dyspnea and cough during a neutropenic episode. Read More

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September 2020

Comparison of programmed death-ligand 1 protein expression between primary and metastatic lesions in patients with lung cancer.

J Immunother Cancer 2021 Apr;9(4)

Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA.

Assessment of programmed cell death-ligand 1 (PD-L1) expression by immunohistochemistry (IHC) is the definite diagnostic test to guide treatment for patients with advanced-stage non-small cell lung cancer. Intratumoral heterogeneity and discrepancy of PD-L1 expression between primary and metastatic lesions may increase the risk of tumor misclassification. We performed a retrospective study of the Foundation Medicine, Inc clinical database on lung cancer cases that were evaluated for PD-L1 expression by IHC in the context of routine care. Read More

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[Descending Necrotizing Mediastinitis with Empyema Necessitated Two Performances of Surgical Drainage for Successful Treatment:Report of a Case].

Kyobu Geka 2021 Apr;74(4):313-316

Department of Surgery, Kagawa Prefectural Shirotori Hospital, Higashikagawa, Japan.

The case was a 57-year-old woman. She visited a local doctor with a chief complaint of sore throat. A retropharyngeal abscess was suspected, and she was referred to our otolaryngology. Read More

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The incidence of pleural effusion in COVID-19 pneumonia: State-of-the-art review.

Heart Lung 2021 Feb 27;50(4):481-490. Epub 2021 Feb 27.

Department of Pulmonary and Critical Care Medicine, Albany Medical Center, Albany, NY, USA.

Background: COVID-19-related pleural effusions are frequently described during the ongoing pandemic.

Objectives: We described the incidence, characteristics, and outcomes of COVID-19-related pleural effusions based on the current evidence available in the literature.

Methods: We searched MEDLINE, Pubmed, and Google Scholar databases using keywords of "coronavirus disease 2019 (COVID-19)," "severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)," "pleural effusion," "pleural fluid," and "pleura" from January 1st, 2020 to January 31st, 2021. Read More

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February 2021

Probiotic intake unmasking a gastro-pleural fistula.

Eur Rev Med Pharmacol Sci 2021 Mar;25(6):2600-2603

Unit of Internal Medicine, UOC Medicina Interna, Fondazione Policlinico Universitario "A. Gemelli", IRCCS, Rome, Italy.

Objective: Gastropleural fistula represents a rare clinical event often resulting in an iatrogenic complication of gastrointestinal surgery. Clinical presentation is insidious, patients complain of chronic and non-specific respiratory symptoms and may be conservatively treated for lung infections for several months until detailed tests finally reveal the correct diagnosis.

Patients And Methods: We describe a case of a healthy patient with an unexpected diagnosis of empyema due to a gastropleural fistula. Read More

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Shock and Diffuse ST-elevation in a Patient with Coronavirus Disease-2019 Disease.

J Cardiovasc Echogr 2020 Oct-Dec;30(4):223-226. Epub 2021 Jan 20.

Department of Medicine, Vascular and Emergency Medicine - Stroke Unit, University of Perugia, Perugia, Italy.

The infection by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is associated with significant cardiovascular morbidity and mortality. Cardiac events require prompt diagnosis and management, also in the SARS-CoV-2 era. A 58-year-old male, heavy smoker and with known SARS-CoV-2 infection, abruptly developed severe hypotension and asthenia. Read More

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January 2021

A rare case of spontaneous haemothorax in patient with haemophilia A.

BMJ Case Rep 2021 Apr 7;14(4). Epub 2021 Apr 7.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

Haemorrhage in patients with haemophilia is common after minor trauma but may occur spontaneously. Despite the diversity of bleeding sites, spontaneous haemothorax, on a non-traumatic basis, is an exceedingly rare event and only a few cases had been reported. We present a case of a 43-year-old man with a history of haemophilia A who had pleuritic chest pain for 1 day without significant history of trauma. Read More

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Recurrent Large Volume Malignant Pleural Effusion in a Patient With Renal Cell Carcinoma.

Cureus 2021 Feb 27;13(2):e13593. Epub 2021 Feb 27.

Internal Medicine, NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, USA.

Malignant pleural effusion (MPE) due to renal cell carcinoma (RCC) is extremely rare, accounting for only 1%-2% of all malignant pleural effusions. This paper presents a case report of a 56-year-old male who presented with a chief complaint of bilateral flank pain with dyspnea and was diagnosed with RCC via immunopathologic pleural fluid analysis and who persistently had recurrent large volume pleural effusion. A 56-year-old male who had a recent admission for dyspnea secondary to a right-sided pleural effusion underwent thoracentesis and returned to the hospital for his worsening shortness of breath. Read More

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February 2021

A 6-Year-Old Boy with COVID-19-Positive Pleural Effusion and Kawasaki-Like Features.

Case Rep Pediatr 2021 17;2021:8832826. Epub 2021 Mar 17.

Department of Pediatrics, Ali Asghar Children's Hospital, Iran University of Medical Sciences, Tehran, Iran.

The ongoing outbreak of the novel coronavirus (SARS-CoV-2) has exposed many pediatric patients from around the world to coronavirus disease. Although pleural effusions are classified as atypical features of COVID-19 infection, we report a 6-year-old boy who had a positive IgG antibody ELISA test for COVID-19 and presented with respiratory distress, bilateral pleural effusions, and signs and symptoms of multisystem inflammatory syndrome. The RT-PCR test of the pleural fluid specimen was positive for novel coronavirus. Read More

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Demystifying penetrating atherosclerotic ulcer of aorta: unrealised tyrant of senile aortic changes.

J Cardiovasc Thorac Res 2021 30;13(1):1-14. Epub 2021 Jan 30.

Department of Cardiothoracic and Vascular Surgery (CTVS), All India Institute of Medical Sciences, Rishikesh, Uttarakhand-249203, India.

This review article describes demographic features, comorbidities, clinical and imaging findings, prognosis, and treatment strategies in penetrating atherosclerotic ulcer (PAU) and closely related entities using google scholar web search. PAU is one of the manifestations of the acute aortic syndrome (AAS) spectrum. The underlying aorta invariably shows atherosclerotic changes or aneurysmal dilatation. Read More

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January 2021

Hemorrhagic Malignant Pleural Effusion: Diagnosis, Survival Rate, and Response to Talc Pleurodesis.

Indian J Surg Oncol 2021 Mar 14;12(1):54-60. Epub 2020 Nov 14.

Department of Thoracic Surgery, western Galilee medical center, Nahariya, Israel.

Hemorrhagic malignant pleural effusion (HMPE) is diagnosed in 47-50% of all malignant pleural effusions (MPE). The aim of this study is to evaluate clinical, radiological, and morphological manifestations of HMPE and results of talc pleurodesis treatment. This is a retrospective review of the medical charts of 135 MPE patients which consists of HMPE group (42 patients) and simple MPE group (63 patients) (median age 67. Read More

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COVID-19 Pneumonia on Post-Operative Day 2 after Esophagectomy: Performing Esophago-Gastric Junction Cancer Surgery during the SARS-Cov-2 Second Wave.

Curr Oncol 2021 Mar 27;28(2):1348-1353. Epub 2021 Mar 27.

2nd Department of General Surgery, Medical University of Lublin, ul. Staszica 16, 20-400 Lublin, Poland.

The coronavirus disease 2019 (COVID-19) pandemic has had a substantial impact on the provision of medical healthcare. Due to an increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) transmission, elective surgical treatment has been suspended in many centers. The effects of COVID-19 in the early post-operative period after esophagectomy remains unknown. Read More

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Quantitative Analysis and Automated Lung Ultrasound Scoring for Evaluating COVID-19 Pneumonia with Neural Networks.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 Apr 2;PP. Epub 2021 Apr 2.

As being radiation-free, portable, and capable of repetitive use, ultrasonography is playing an important role in diagnosing and evaluating the COVID-19 Pneumonia (PN) in this epidemic. By virtue of lung ultrasound scores (LUSS), lung ultrasonography (LUS) was used to estimate the excessive lung fluid which is an important clinical manifestation of COVID-19 PN, with high sensitivity and specificity. However, as a qualitative method, LUSS suffered from large inter-observer variations and requirement for experienced clinicians. Read More

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Re-expansion Pulmonary Edema-A Rare Entity: A Thin Line between Pulmonary and Cardiac Decompensation.

Indian J Crit Care Med 2021 Mar;25(3):343-345

Department of Anaesthesia and Intensive Care, PGIMER, Chandigarh, India.

Re-expansion pulmonary edema (RPE) is a rare complication that may occur after treatment of lung collapse caused by pneumothorax, atelectasis, or pleural effusion. The amount of fluid drained and the degree of pleural suction influence the development of RPE. We present a case of RPE in a critically ill patient of scrub typhus with rheumatic heart disease, after draining only 800 mL of pleural fluid, thereby proving that the complex cardiac and pulmonary interactions play an important role in the development of RPE. Read More

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Clinical Profile of Non-neutropenic Patients with Invasive Candidiasis: A Retrospective Study in a Tertiary Care Center.

Indian J Crit Care Med 2021 Mar;25(3):267-272

Department of Infectious Disease, Apollo Hospitals, Chennai, Tamil Nadu, India.

Invasive candidiasis (IC) is a major cause of morbidity and mortality in critically ill patients in the intensive care unit (ICU). In this study, we aim to analyze the clinical profile, species distribution, and susceptibility pattern of patients with IC. Case records of non-neutropenic patients ≥18 years of age with IC between January 2016 and June 2019 at a tertiary care referral hospital were analyzed. Read More

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Intrapleural Fibrinolytics and Deoxyribonuclease for Treatment of Indwelling Pleural Catheter-Related Pleural Infection: A Multi-Center Observational Study.

Respiration 2021 Mar 30:1-9. Epub 2021 Mar 30.

Sir Charles Gairdner Hospital, Perth, Washington, Australia.

Background: Indwelling pleural catheters (IPC) are increasingly used for management of recurrent (especially malignant) effusions. Pleural infection associated with IPC use remains a concern. Intrapleural therapy with tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) significantly reduces surgical referrals in non-IPC pleural infection, but data on its use in IPC-related pleural infection are scarce. Read More

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Preoperative Cervical Length Predicts the Risk of Delivery within One Week after Pleuroamniotic Shunt in Fetuses with Severe Hydrothorax.

Fetal Diagn Ther 2021 Mar 30:1-7. Epub 2021 Mar 30.

Prenatal Diagnosis and Fetal Surgery Center, Medicina Fetal Mexico, Querétaro, Mexico.

Objective: The objective of this study was to assess the predictive performance of preoperative cervical length (CL) for delivery within 1 week after pleuroamniotic shunting (PAS) in fetuses with severe hydrothorax.

Methods: A prospective cohort of fetuses with severe hydrothorax referred to our fetal surgery center in Querétaro, Mexico from January 2012 to July 2020. Severe fetal hydrothorax was diagnosed as an accumulation of fluid within the fetal pleural space accompanied with severe bilateral lung compression, mediastinal shift, polyhydramnios, and/or hydrops. Read More

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Study protocol of a phase 1 clinical trial establishing the safety of intrapleural administration of liposomal curcumin: curcumin as a palliative treatment for malignant pleural effusion (IPAL-MPE).

BMJ Open 2021 Mar 29;11(3):e047075. Epub 2021 Mar 29.

Anatomical Pathology, Flinders University, Bedford Park, South Australia, Australia.

Introduction: This is a phase 1, open-label, single-centre, uncontrolled, dose-escalation study to evaluate the feasibility, tolerability and pharmacokinetic profiles of a single dose of liposomal curcumin, administered via an existing tunnelled indwelling pleural catheter (TIPC) directly to the tumour site in individuals with diagnoses of malignant pleural effusion. Primarily, we aim to determine a maximum tolerated dose of liposomal curcumin administered via this method.

Methods And Analysis: We will use a 3+3 expanded cohort for predefined dose-escalation levels or until a predefined number of dose-limiting toxicities are reached. Read More

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Incidence and Management of Effusions Before and After CD19-Directed Chimeric Antigen Receptor (CAR) T Cell Therapy in Large B Cell Lymphoma.

Transplant Cell Ther 2021 Mar 27;27(3):242.e1-242.e6. Epub 2020 Dec 27.

Department of Blood and Marrow Transplant and Cellular Immunotherapy, Moffitt Cancer Center, Tampa, Florida; Department of Oncologic Sciences, Morsani College of Medicine, University of South Florida, Tampa, Florida. Electronic address:

In patients with lymphoma, third-space fluid accumulations may develop or worsen during cytokine release syndrome (CRS) associated with chimeric antigen receptor (CAR) T cell therapy. Pre-existing symptomatic pleural effusions were excluded by the ZUMA-1 trial of axicabtagene ciloleucel for large B cell lymphoma (LBCL) and variants. The incidence and management of effusions during CAR T cell therapy for LBCL are unknown. Read More

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Biomarkers of Distinguishing Neutrophil-Predominant Tuberculous Pleural Effusion from Parapneumonic Pleural Effusion.

Am J Med Sci 2021 Apr 24;361(4):469-478. Epub 2020 Oct 24.

Department of Respiratory Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. Electronic address:

Background: Tuberculous pleural effusion (TPE) is usually characterized by lymphocytic predominance and high pleural fluid adenosine deaminase (pfADA), while parapneumonic pleural effusion (PPE) is usually characterized by neutrophilic predominance. However, in some cases, neutrophils can be predominant in TPE. In such cases, the differential diagnosis between TPE and PPE is challenging and has been rarely investigated. Read More

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A pleural ultrasound image of a collapsed lung surrounded by pleural fluid ("jellyfish sign") may correspond to an intrapericardial mass.

J Ultrasound 2021 Mar 25. Epub 2021 Mar 25.

Pediatric Intensive Care Unit, Department of Pediatrics at Reina, Sofia University Hospital, Córdoba University, Avda.Menéndez Pidal s/n, C.P.14004, Córdoba, Spain.

Lung ultrasound has been shown to be a valuable diagnostic tool. It has become the main way to get to the diagnosis of pleural effusion with much more specificity and sensibility than the x-ray. The diagnosis of pleural effusion with ultrasound is easily obtained after the visualization of hypoechoic fluid surrounding the lung. Read More

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Cytologic findings in effusions from patients with SARS-CoV-2 infection.

J Am Soc Cytopathol 2021 Jan 22. Epub 2021 Jan 22.

Department of Pathology, University of Michigan-Michigan Medicine, Ann Arbor, Michigan.

Introduction: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is associated with "flu-like" upper respiratory tract symptoms and pneumonia. Body cavity effusions develop in a subset of patients with advanced disease. Although SARS-CoV-2 is known to be present in certain body fluids (eg, blood) of COVID patients, it remains unclear if body cavity fluids are sites of infection. Read More

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January 2021

Acute myeloid leukemia with leukemic pleural effusion and high levels of pleural adenosine deaminase: A case report and review of literature.

Open Med (Wars) 2021 12;16(1):387-396. Epub 2021 Mar 12.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, No. 2, Yude Road, Taichung 404, Taiwan.

Pleural effusions are rarely observed in association with acute myeloid leukemia (AML), and their true incidence remains unknown. Given the low diagnostic yield from cytopathologic analysis of malignant pleural effusions and the fact that patients with leukemia are often thrombocytopenic and unable to tolerate invasive procedures, the incidence of leukemic effusions may be underestimated. Here, we report a rare case of pleural effusion in a patient with newly diagnosed AML. Read More

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Systemic lupus erythematosus combined with primary hyperfibrinolysis and protein C and protein S deficiency: A case report.

World J Clin Cases 2021 Mar;9(8):2008-2014

Department of Hematology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China.

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by systemic involvement and multiple autoantibodies in the serum. Patients with protein C (PC) and protein S (PS) deficiency are prone to thrombosis. In contrast, patients with primary hyperfibrino-lysis tend to bleed. Read More

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A retrospective study on the combined biomarkers and ratios in serum and pleural fluid to distinguish the multiple types of pleural effusion.

BMC Pulm Med 2021 Mar 19;21(1):95. Epub 2021 Mar 19.

Department of Clinical Laboratory, Peking University People's Hospital, Xizhimen South Avenue No. 11, Beijing, 100044, China.

Purpose: Pleural effusion (PE) is a common clinical manifestation, and millions of people suffer from pleural disease. Herein, this retrospective study was performed to evaluate the biomarkers and ratios in serum and pleural fluid (PF) for the differential diagnosis of the multiple types of PE and search for a new diagnostic strategy for PE.

Methods: In-patients, who developed tuberculous PE (TPE), malignant PE (MPE), complicated parapneumonic effusion (CPPE), uncomplicated PPE (UPPE), or PE caused by connective tissue diseases (CTDs) and underwent thoracentesis at Peking University People's Hospital from November 2016 to April 2019, were included in this study. Read More

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Short- and long-term outcome in cats diagnosed with pyothorax: 47 cases (2009-2018).

J Small Anim Pract 2021 Mar 19. Epub 2021 Mar 19.

Evidensia Small Animal Veterinary Hospital Stommeln, Pulheim, Germany.

Objectives: The aims of this retrospective study were to report the short- and long-term outcome in cats treated for pyothorax and to identify prognostic indicators as well as determine recurrence rate.

Methods: Medical records from April 2009 to August 2018 were retrospectively reviewed. Cases were included if a diagnosis of pyothorax was confirmed via cytology and/or culture of pleural fluid. Read More

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Successful resolution of urothorax secondary to non-traumatic uroabdomen in a cat managed with peritoneal dialysis as a bridge to surgery.

JFMS Open Rep 2021 Jan-Jun;7(1):2055116920984748. Epub 2021 Feb 27.

Intensive Care Unit UCICOOP, CABA, Buenos Aires, Argentina.

Case Summary: A 9-year-old neutered male domestic shorthair cat was presented for evaluation of severe hemodynamic collapse and suspected lower urinary tract disease. On admission, severe metabolic acidosis, hyperkalemia and azotemia, and electrocardiographic findings consistent with cardiotoxicity were identified. The diagnosis of uroabdomen was made based on abdominal fluid to plasma concentration ratios of creatinine and potassium. Read More

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February 2021

Cellular composition research of serous pleural effusion fluids. Conceptual issues of preanalytics.

Klin Lab Diagn 2021 Mar;66(2):95-98

FGAOU VO First MGMU named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University).

The purpose of this work was to show the effectiveness of the cytological method on a small number of observations, excluding all possible errors of the preanalytical stage. The paper presents several simple and easily reproducible algorithms for the cytological study of serous pleural effusions with small cellular content. On the example of 20 observations of the study of the cellular composition of serous exudates, a direct dependence of the research results on the preanalytical stage is shown. Read More

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IgG4-related pleural effusion with high adenosine deaminase levels: A case report and literature review.

Medicine (Baltimore) 2021 Mar;100(11):e25162

Respiratory Disease Center.

Rationale: Levels of pleural fluid adenosine deaminase (ADA), a useful marker for the diagnosis of tuberculous pleurisy, are elevated in some reports of immunoglobulin G4 (IgG4)-related pleural effusion. We describe a patient with IgG4-related pleural effusion who exhibited a high concentration of ADA. Furthermore, we reviewed the literature to compare patients with IgG4-related pleural effusion and tuberculous pleurisy. Read More

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