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Knowledge, barriers and facilitators regarding COVID-19 vaccine and vaccination programme among the general population: A cross-sectional survey from one thousand two hundred and forty-nine participants.

Diabetes Metab Syndr 2021 May 1;15(3):987-992. Epub 2021 May 1.

Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.

Background And Aims: The success of the COVID-19 vaccination program is dependent on people's knowledge and attitude regarding the vaccination program. Higher vaccine acceptance can be ensured by strengthening the facilitators and limiting the barriers being observed among the general population.

Material And Methods: Indexed study is a cross-sectional web-based survey using a pre-validated questionnaire to assess knowledge, barriers and facilitators of COVID-19 vaccine and vaccination programme administered on adults across India using a Google online survey platform. Read More

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A novel tool for the adsorption of dsDNA: Electrochemical reduction of Pd nanoparticles onto reduced-keratin particles extracted from wool wastes.

Bioelectrochemistry 2021 May 5;140:107835. Epub 2021 May 5.

Ankara University, Faculty of Science, Department of Chemistry, Ankara, Turkey. Electronic address:

This work outlines the fabrication of a novel electrochemical platform for the dsDNA adsorption, using one of the most sustainable materials, wool fabric waste, and Pd ions. To develop a functional material with a significant adsorption capability, the waste wool was subjected to the chemical reduction process, and the keratin-SH (KerSH) particles were extracted in powder form. These particles were used in the adsorption of Pd ions by monitoring with the UV-vis spectra. Read More

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Therapeutic effects of an aspalathin-rich green rooibos extract, pioglitazone and atorvastatin combination therapy in diabetic db/db mice.

PLoS One 2021 13;16(5):e0251069. Epub 2021 May 13.

Biomedical Research and Innovation Platform (BRIP), South African Medical Research Council (MRC), Tygerberg, South Africa.

Oral therapeutics used to treat type 2 diabetes and cardiovascular disease often fail to prevent the progression of disease and their comorbidities. Rooibos (Aspalathus linearis), an endemic South African plant used as an herbal tea, has demonstrated positive effects on glycemia and hypercholesterolemia. However, the treatment efficacy of rooibos extract in combination with conventional hypoglycemic and hypolipidemic medications on blood glucose and lipid profiles has not been established. Read More

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Late-stage ligand functionalization the Staudinger reaction using phosphine-appended 2,2'-bipyridine.

Chem Commun (Camb) 2021 May 13. Epub 2021 May 13.

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.

The ability of a phosphine-appended-2,2'-bipyridine ligand ((Ph2P)2bpy) to serve as a platform for late-stage ligand modifications was evaluated using tetrahedral (Ph2P)2bpyFeCl2. We employed a post-metalation Staudinger reaction to install a series of functionalized arenes, including those containing Brønsted and Lewis acidic groups. This reaction sequence represents a versatile strategy to both tune the ligand donor properties as well as directly incorporate appended functionality. Read More

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Effects of extract on learning and memory ability, brain tissue morphology, and immune function of aging mice.

Open Life Sci 2021 23;16(1):399-407. Epub 2021 Apr 23.

Department of Pharmacy, Luohe Medical College, Luohe 462000, China.

In this study, we aimed to observe the effects of (LC) extract on learning and memory ability, brain tissue morphology, and immune function of aging mice. Kunming mice were selected and randomly divided into a control group, a positive control group, an aging group, and three dose groups. Three dose groups were administered 187. Read More

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A Qualitative Analysis of Ostomy-Related Patient Education Videos on YouTube.

Adv Skin Wound Care 2021 Jun;34(6):314-320

At Medipol University in Istanbul, Turkey, Pelin Basim, MD, is Faculty, Department of General Surgery; and Derya Argun, MD, is Faculty, Department of Internal Medicine. The authors have disclosed no financial relationships related to this article. Submitted October 9, 2020; accepted in revised form December 7, 2020.

Objective: To analyze the content, reliability, and quality of the most viewed YouTube videos targeting patients with ostomies intending to learn about ostomy care (OC).

Methods: Using the keywords "stoma care," "colostomy care," and "ileostomy care," researchers assessed the publicly visible English-language ostomy patient education videos available on YouTube. A total of 84 videos were independently analyzed by two physicians experienced in OC. Read More

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Genomic Analysis of Antibiotic-Resistant and -Susceptible Isolated from Bovine Sources in Maputo, Mozambique.

Foodborne Pathog Dis 2021 May 11. Epub 2021 May 11.

Environmental Microbial and Food Safety Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, Maryland, USA.

This study reports a genomic analysis of isolates recovered from 25 bovine fecal composite samples collected from four different production units in Maputo city and around Maputo Province, Mozambique. The genomes were analyzed to determine the presence of antibiotic resistance genes (ARGs), genetic relatedness, and virulence factors known to cause diseases in humans. Whole-genome sequencing was conducted on 28 isolates using an Illumina NextSeq 500 sequencing platform. Read More

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CT imaging-based machine learning model: a potential modality for predicting low-risk and high-risk groups of thymoma: "Impact of surgical modality choice".

World J Surg Oncol 2021 May 11;19(1):147. Epub 2021 May 11.

Department of Radiology, Ankara University Faculty of Medicine, 06100, Sıhhiye, Ankara, Turkey.

Introduction: Radiomics methods are used to analyze various medical images, including computed tomography (CT), magnetic resonance, and positron emission tomography to provide information regarding the diagnosis, patient outcome, tumor phenotype, and the gene-protein signatures of various diseases. In low-risk group, complete surgical resection is typically sufficient, whereas in high-risk thymoma, adjuvant therapy is usually required. Therefore, it is important to distinguish between both. Read More

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MethylDetectR: a software for methylation-based health profiling.

Wellcome Open Res 2020 13;5:283. Epub 2021 Apr 13.

Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Midlothian, EH4 2XU, UK.

DNA methylation is an important biological process that involves the reversible addition of chemical tags called methyl groups to DNA and affects whether genes are active or inactive. Individual methylation profiles are determined by both genetic and environmental influences. Inter-individual variation in DNA methylation profiles can be exploited to estimate or predict a wide variety of human characteristics and disease risk profiles. Read More

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Molecular identification and subtyping of Blastocystis sp. in hospital patients in Central China.

Eur J Protistol 2021 Apr 23;79:125796. Epub 2021 Apr 23.

College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China. Electronic address:

Blastocystis is a common enteric protist that inhabits the gastrointestinal tract of approximately 1 billion people worldwide. In this study, a total of 1,070 patients from two hospitals in Zhengzhou, Central China were enrolled to know molecular characteristics of Blastocystis sp. The microorganism was identified and subtyped with a PCR amplification and sequencing of the small subunit ribosomal deoxyribonucleic acid (SSU-rDNA). Read More

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Evaluation of the ERA5 reanalysis-based Universal Thermal Climate Index on mortality data in Europe.

Environ Res 2021 May 8;198:111227. Epub 2021 May 8.

Department of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, United Kingdom; The Centre on Climate Change and Planetary Health, London School of Hygiene & Tropical Medicine, London, United Kingdom; Centre for Statistical Methodology, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Air temperature has been the most commonly used exposure metric in assessing relationships between thermal stress and mortality. Lack of the high-quality meteorological station data necessary to adequately characterize the thermal environment has been one of the main limitations for the use of more complex thermal indices. Global climate reanalyses may provide an ideal platform to overcome this limitation and define complex heat and cold stress conditions anywhere in the world. Read More

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Treatment of epilepsy for people with Alzheimer's disease.

Cochrane Database Syst Rev 2021 May 11;5:CD011922. Epub 2021 May 11.

Department of Geriatric Neurology, Chinese PLA General Hospital, Beijing, China.

Background: Any type of seizure can be observed in Alzheimer's disease. Antiepileptic drugs seem to prevent the recurrence of epileptic seizures in most people with Alzheimer's disease. There are pharmacological and non-pharmacological treatments for epilepsy in people with Alzheimer's disease, however there are no current systematic reviews to evaluate the efficacy and tolerability of these treatments. Read More

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Tunable Multiplexed Whole-Cell Biosensors as Environmental Diagnostics for ppb-Level Detection of Aromatic Pollutants.

ACS Sens 2021 May 11. Epub 2021 May 11.

Department of Chemistry, Indian Institute of Technology Bombay Powai, Mumbai 400076, India.

Aromatics such as phenols, benzene, and toluene are carcinogenic xenobiotics which are known to pollute water resources. By employing synthetic biology approaches combined with a structure-guided design, we created a tunable array of whole-cell biosensors (WCBs). The MopR genetic system that has the natural ability to sense and degrade phenol was adapted to detect phenol down to ∼1 ppb, making this sensor capable of directly detecting phenol in permissible limits in drinking water. Read More

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Bacterial composition, function and the enrichment of plant growth promoting rhizobacteria (PGPR) in differential rhizosphere compartments of Al-tolerant soybean in acidic soil.

Yi Chuan 2021 May;43(5):487-500

Institute for Plant Molecular Biology, State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China.

Low pH with aluminum (Al) toxicity are the main limiting factors affecting crop production in acidic soil. Selection of legume crops with acid tolerance and nitrogen-fixation ability should be one of the effective measures to improve soil quality and promote agricultural production. The role of the rhizosphere microorganisms in this process has raised concerns among the research community. Read More

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Treatments for unruptured intracranial aneurysms.

Cochrane Database Syst Rev 2021 May 10;5:CD013312. Epub 2021 May 10.

Department of Surgery, Division of Vascular and Endovascular Surgery, Universidade Federal de São Paulo, São Paulo, Brazil.

Background: Unruptured intracranial aneurysms are relatively common lesions in the general population, with a prevalence of 3.2%, and are being diagnosed with greater frequency as non-invasive techniques for imaging of intracranial vessels have become increasingly available and used. If not treated, an intracranial aneurysm can be catastrophic. Read More

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Ferroptosis-related gene signature predicts prognosis and immunotherapy in glioma.

CNS Neurosci Ther 2021 May 10. Epub 2021 May 10.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, China.

Aims: Glioma is a highly invasive brain tumor, which makes prognosis challenging and renders patients resistant to various treatments. Induction of cell death is promising in cancer therapy. Ferroptosis, a recently discovered regulated cell death, can be induced for killing glioma cells. Read More

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Microbial fuel cells: a comprehensive review for beginners.

A S Vishwanathan

3 Biotech 2021 May 1;11(5):248. Epub 2021 May 1.

WATER Laboratory, Department of Biosciences, Sri Sathya Sai Institute of Higher Learning, Prasanthi Nilayam, Puttaparthi, 515134 Andhra Pradesh India.

Microbial fuel cells (MFCs) have shown immense potential as a one-stop solution for three major sustainability issues confronting the world today-energy security, global warming and wastewater management. MFCs represent a cross-disciplinary platform for research at the confluence of the natural and engineering sciences. The diversity of variables influencing performance of MFCs has garnered research interest across varied scientific disciplines since the beginning of this century. Read More

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One-Year Prospective Study of Plasma Biomarkers From CNS in Patients With Mild Traumatic Brain Injury.

Front Neurol 2021 21;12:643743. Epub 2021 Apr 21.

Department of Radiology and Nuclear Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.

To investigate the longitudinal evolution of three blood biomarkers: neurofilament light (NFL), glial fibrillary acidic protein (GFAP) and tau, in out-patients and hospitalized patients with mild traumatic brain injury (mTBI) compared to controls, along with their associations-in patients-with clinical injury characteristics and demographic variables, and ability to discriminate patients with mTBI from controls. A longitudinal observation study including 207 patients with mTBI, 84 age and sex-matched community controls (CCs) and 52 trauma controls (TCs). Blood samples were collected at 5 timepoints: acute (<24 h), 72 h (24-72 h post-injury), 2 weeks, 3 and 12 months. Read More

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Telehealth Can Be Implemented Across a Musculoskeletal Service Line Without Compromising Patient Satisfaction.

HSS J 2021 Feb 21;17(1):36-45. Epub 2021 Feb 21.

Department of Orthopaedic Surgery, Emory University, Atlanta, GA, USA.

The COVID-19 pandemic has led to changes to in-office orthopedic care, with a rapid shift to telemedicine. Institutions' lack of established infrastructure for these types of visits has posed challenges requiring attention to confidentiality, safety, and patient satisfaction. : The aim of this study was to analyze the feasibility of telemedicine in orthopedics during the pandemic and its effect on efficiency and patient satisfaction. Read More

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February 2021

Transcriptome analysis of mild hypothermia protection against radiationinduced rat lung injury based on RNAseq.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Apr;46(4):345-350

Drug Safety Evaluation Center of China Institute for Radiation Protection; Shanxi Key Laboratory of Drug Toxicology and Drug for Radiation Injury; Key Laboratory on Radiotoxicology and Radiopharmaceutical Preclinical Evaluation, China National Nuclear Corporation, Taiyuan 030006, China.

Objectives: To analyze the differentially expressed genes (DEGs) with radiation-induced rat lung injury, and to reveal the protective mechanism for mild hypothermia in the radiation-induced lung injury in rats at the transcriptome level.

Methods: A total of 10 male SD rats aged 6-8 weeks were randomly divided into 2 groups to establish a rat model of radiation-induced lung injury, and one group was treated with mild hypothermia. RNA was extracted from left lung tissue of each group, and sequenced by BGISEQ-500 platform. Read More

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Dynamic Needle Tip Positioning versus Palpation and Ultrasound for Arteriovenous Puncture: A Meta-analysis.

Ultrasound Med Biol 2021 May 6. Epub 2021 May 6.

Department of Orthopaedics, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine (Cangzhou No. 2 Hospital), Hebei, Cangzhou, China.

At present, dynamic needle-tip positioning (DNTP) technology is applied in arteriovenous puncture, challenging the use of ultrasound technology alone and palpation. Our goals were to extract data from experimental DNTP, ultrasound and palpation studies, using Review Manager, Version 5.3, for data analysis, and to evaluate whether DNTP has certain advantages in puncture. Read More

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[Dexmedetomidine-mediated Wnt Pathway Inhibits Sevoflurane-induced Cognitive Impairment in Neonatal Rats].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2021 Apr;43(2):235-246

Department of Anesthesiology,Wuhan No.1 Hospital,Wuhan Hospital of Integrated Traditional Chinese and Western Medicine,Wuhan 430022,China.

Objective To explore the effect of dexmedetomidine(Dex)on sevoflurane-induced cognitive impairment in neonatal rats through Wnt signaling pathway. Methods Sixty 7-day-old SD rats were assigned into five groups:control group(without any intervention),Dex group(intraperitoneal injection of 25 μg/kg Dex),sevoflurane group(3% sevoflurane treatment for 4 hours),sevoflurane+Dex group(inhalation of 3% sevoflurane after injection of 25 μg/kg Dex for 4 hours),and sevoflurane+Dex+Wnt inhibitor group(Wnt inhibitor XAV393 and 25 μg/kg Dex were injected and 3% sevoflurane was inhaled for 4 hours).Three weeks later,Morris water maze was used to detect the cognitive function;TdT-mediated dUTP nick end labeling(TUNEL)staining was performed to detect the apoptosis of hippocampal neurons;neuronal nuclei (NeuN) staining was conducted to detect the survival of hippocampal neurons;Western blot was carried out to detect the expression of apoptosis-related proteins. Read More

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Observation of the curative effect of intraocular lens in patients with cataract and establishment of the intraocular lens database.

Ann Palliat Med 2021 Apr;10(4):4716-4720

Department of Nursing, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Background: Intraocular lenses are widely used in the treatment of cataract patients, but currently clinical, procedural and product information is incomplete in many hospitals and there is an urgent need for a database to improve surgical safety, and outcomes.

Methods: Data on the brand and specifications of the intraocular lens, and the postoperative outcome of cataract patients after intraocular lens implantation from January 2017 to June 2018 were collected to create an intraocular lens database as an online public platform.

Results: A total of 96 cataract patients were divided into groups A and B based on preoperative corrected visual acuity. Read More

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Impact of COVID-19 on the outreach strategy of cancer social service agencies in Singapore: A pre-post analysis with Facebook data.

J Biomed Inform 2021 May 6:103798. Epub 2021 May 6.

Department of Pharmacy, National University of Singapore, Singapore 117559; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117549. Electronic address:

The Singapore government implemented multiple restrictive measures as the novel coronavirus infection (COVID-19) spread through the community, thereby affecting the support service of cancer-related social service agencies (cancer-SSAs). We are interested to understand how Singapore's cancer-SSAs utilized the social media platform Facebook to overcome the restrictions which were introduced due to COVID-19. Facebook posts from two prominent cancer-SSAs 365 Cancer Prevention Society (365CPS) and Singapore Cancer Society (SCS) between comparable periods in 2019 and 2020 were extracted. Read More

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Conducting polymer hydrogels as a sustainable platform for advanced energy, biomedical and environmental applications.

Sci Total Environ 2021 Apr 30;786:147430. Epub 2021 Apr 30.

Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University, Nanchang 330063, PR China; National-Local Joint Engineering Research Center of Heavy Metals Pollutants Control and Resource Utilization, Nanchang Hangkong University, Nanchang 330063, PR China. Electronic address:

Environmentally friendly polymeric materials and derivative technologies play increasingly important roles in the sustainable development of our modern society. Conducting polymer hydrogels (CPHs) synergizing the advantageous characteristics of conventional hydrogels and conducting polymers are promising to satisfy the requirements of environmental sustainability. Beyond their use in energy and biomedical applications that require exceptional mechanical and electrical properties, CPHs are emerging as promising contaminant adsorbents owing to their porous network structure and regulable functional groups. Read More

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Fourier-transform infrared microspectroscopy of pulmonary edema fluid for postmortem diagnosis of diabetic ketoacidosis.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 26;258:119882. Epub 2021 Apr 26.

Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Ministry of Justice, No. 1347 West Guangfu Rd., Shanghai 200063, China. Electronic address:

Determination of the cause of death for diabetic ketoacidosis (DKA), a common and fatal acute complication of diabetes mellitus, is a challenging forensic task owing to the lack of characteristic morphological findings at autopsy. In this study, Fourier-transform infrared (FTIR) microspectroscopy coupled with chemometrics was employed to characterize biochemical differences in pulmonary edema fluid from different causes of death to supplement conventional methods and provide an efficient postmortem diagnosis of DKA. With this aim, FTIR spectra in three different situations (DKA-caused death, other causes of death with diabetes history, and other causes of death without diabetes history) were measured. Read More

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Circulating Epstein-Barr virus DNA level post induction chemotherapy contributes to prognostication in advanced-stage nasopharyngeal carcinoma.

Eur J Cancer 2021 May 5;151:63-71. Epub 2021 May 5.

Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-Sen University Cancer Center, No. 651 Dongfeng Eastern Road, Guangzhou, 510060, China. Electronic address:

Background: To investigate the value of post-induction chemotherapy (IC) cell-free Epstein-Barr virus DNA (cfEBV DNA) for prognostication in locally advanced nasopharyngeal carcinoma (LA-NPC).

Methods: A total of 910 histologically proven LA-NPC undergoing radical IC + concurrent chemo-radiotherapy (CCRT) or targeted radiotherapy (CTRT) or both (CTCRT) were involved. The concentration of cfEBV DNA was measured by quantitative polymerase chain reaction pre-IC (cfEBV DNA) and at IC completion. Read More

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ProteoSign v2: a faster and evolved user-friendly online tool for statistical analyses of differential proteomics.

Nucleic Acids Res 2021 May 8. Epub 2021 May 8.

Division of Basic Sciences, University of Crete Medical School, Heraklion 71110, Greece.

Bottom-up proteomics analyses have been proved over the last years to be a powerful tool in the characterization of the proteome and are crucial for understanding cellular and organism behaviour. Through differential proteomic analysis researchers can shed light on groups of proteins or individual proteins that play key roles in certain, normal or pathological conditions. However, several tools for the analysis of such complex datasets are powerful, but hard-to-use with steep learning curves. Read More

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Single-Crystalline Silicon Frameworks: A New Platform for Transparent Flexible Optoelectronics.

Adv Mater 2021 May 8:e2008171. Epub 2021 May 8.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu, 215123, P. R. China.

Single-crystalline silicon (sc-Si) is the dominant semiconductor material for the modern electronics industry. Despite their excellent photoelectric and electronic properties, the rigidity, brittleness, and nontransparency of commonly used silicon wafers limit their application in transparent flexible optoelectronics. In this study, a new type of Si microstructure, named single-crystalline Si frameworks (sc-SiFs), is developed, through a combination of wet-etching and microfabrication technologies. Read More

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A new type of pictorial database: The Bicolor Affective Silhouettes and Shapes (BASS).

Behav Res Methods 2021 May 7. Epub 2021 May 7.

Department of Cognition, Emotion, and Methods in Psychology, University of Vienna, Vienna, Austria.

We introduce the Bicolor Affective Silhouettes and Shapes (BASS): a set of 583 normed black-and-white silhouette images that is freely available via https://osf.io/anej6/ . Valence and arousal ratings were obtained for each image from US residents as a Western population (n = 777) and Chinese residents as an Asian population (n = 869). Read More

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