Mater Sci Eng C Mater Biol Appl 2021 Jan 27;120:111717. Epub 2020 Nov 27.
MEPhI, Institute of Engineering Physics for Biomedicine (PhysBio), Moscow, Russia; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Sciences, Moscow, Russia; Sechenov University, Center of Biomedical Engineering, Moscow, Russia; Tomsk Polytechnic University, Research Centrum for Oncotheranostics, Tomsk, Russia. Electronic address:
Having plasmonic absorption within the biological transparency window, titanium nitride (TiN) nanoparticles (NPs) can potentially outperform gold counterparts in phototheranostic applications, but characteristics of available TiN NPs are still far from required parameters. Recently emerged laser-ablative synthesis opens up opportunities to match these parameters as it makes possible the production of ultrapure low size-dispersed spherical TiN NPs, capable of generating a strong phototherapy effect under 750-800 nm excitation. This study presents the first assessment of toxicity, biodistribution and pharmacokinetics of laser-synthesized TiN NPs. Read More