2,054 results match your criteria plasmonic cell

Lithographic Processes for the Scalable Fabrication of Micro- and Nanostructures for Biochips and Biosensors.

ACS Sens 2021 Apr 8. Epub 2021 Apr 8.

Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, United Kingdom.

Since the early 2000s, extensive research has been performed to address numerous challenges in biochip and biosensor fabrication in order to use them for various biomedical applications. These biochips and biosensor devices either integrate biological elements (e.g. Read More

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Dual polarized engineering the extinction cross-section of a dielectric wire using graphene-based oligomers.

Sci Rep 2021 Apr 6;11(1):7544. Epub 2021 Apr 6.

Department of Electrical and Computer Engineering, Tarbiat Modares University, Tehran, Iran.

In this paper, graphene-coated spherical nanoparticles are arranged around an infinite length dielectric cylinder to enhance its extinction cross-section. Initially, a single longitudinal one-dimensional periodic array is considered in different loci concerning the transverse electric (TE) incident plane wave. It is observed that regardless of the position of the particles, the extinction cross-section of the dielectric cylinder is considerably enhanced with respect to the bare one. Read More

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A photoanode with hierarchical nanoforest TiO structure and silver plasmonic nanoparticles for flexible dye sensitized solar cell.

Sci Rep 2021 Apr 6;11(1):7552. Epub 2021 Apr 6.

Department of Chemistry, PERL-Photonic and Energy Research Laboratory, The University of Texas Rio Grande Valley, 1201 West University Dr, Edinburg, TX, 78539, USA.

Due to unique photovoltaic properties, the nanostructured morphologies of TiO on flexible substrate have been studied extensively in the recent years for applications in dye sensitized solar cells (DSSCs). Microstructured electrode materials with high surface area can facilitate rapid charge transport and thus improve the light-to-current conversion efficiency. Herein we present an improved photoanode with forest like photoactive TiO hierarchical microstructure using a simple and facile hydrothermal route. Read More

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Light-Scattering Simulations from Spherical Bimetallic Core-Shell Nanoparticles.

Micromachines (Basel) 2021 Mar 26;12(4). Epub 2021 Mar 26.

Dipartimento di Fisica e Astronomia "Ettore Majorana", Università di Catania, and CNR-IMM, via S. Sofia 64, 95123 Catania, Italy.

Bimetallic nanoparticles show novel electronic, optical, catalytic or photocatalytic properties different from those of monometallic nanoparticles and arising from the combination of the properties related to the presence of two individual metals but also from the synergy between the two metals. In this regard, bimetallic nanoparticles find applications in several technological areas ranging from energy production and storage to sensing. Often, these applications are based on optical properties of the bimetallic nanoparticles, for example, in plasmonic solar cells or in surface-enhanced Raman spectroscopy-based sensors. Read More

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Plasmon-Enhanced Sunlight Harvesting in Thin-Film Solar Cell by Randomly Distributed Nanoparticle Array.

Materials (Basel) 2021 Mar 12;14(6). Epub 2021 Mar 12.

Physics Department, University of Jeddah, Jeddah 23218, Saudi Arabia.

In this paper, a randomly distributed plasmonic aluminum nanoparticle array is introduced on the top surface of conventional GaAs thin-film solar cells to improve sunlight harvesting. The performance of such photovoltaic structures is determined through monitoring the modification of its absorbance due to changing its structural parameters. A single Al nanoparticle array is integrated over the antireflective layer to boost the absorption spectra in both visible and near-infra-red regimes. Read More

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COVID-19 Pandemic: What about the Safety of Anti-Coronavirus Nanoparticles?

Nanomaterials (Basel) 2021 Mar 19;11(3). Epub 2021 Mar 19.

Department of Virology, Faculty of Medicine, University of Helsinki, P.O. Box 21, 00014 Helsinki, Finland.

Every day, new information is presented with respect to how to best combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This manuscript sheds light on such recent findings, including new co-factors (i.e. Read More

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Dark Field and Coherent Anti-Stokes Raman (DF-CARS) Imaging of Cell Uptake of Core-Shell, Magnetic-Plasmonic Nanoparticles.

Nanomaterials (Basel) 2021 Mar 9;11(3). Epub 2021 Mar 9.

Department of Physics and Bernal Institute, University of Limerick, V94 T9PX Limerick, Ireland.

Magnetic-plasmonic, FeO-Au, core-shell nanoparticles are popular in many applications, most notably in therapeutics and diagnostics, and thus, the imaging of these nanostructures in biological samples is of high importance. These nanostructures are typically imaged in biological material by dark field scatter imaging, which requires an even distribution of nanostructures in the sample and, therefore, high nanoparticle doses, potentially leading to toxicology issues. Herein, we explore the nonlinear optical properties of magnetic nanoparticles coated with various thicknesses of gold using the open aperture z-scan technique to determine the nonlinear optical properties and moreover, predict the efficacy of the nanostructures in nonlinear imaging. Read More

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Gold Nanostars Bioconjugation for Selective Targeting and SERS Detection of Biofluids.

Nanomaterials (Basel) 2021 Mar 8;11(3). Epub 2021 Mar 8.

European Laboratory for non-linear Spectroscopy (LENS), University of Florence, 50019 Sesto Fiorentino, Florence, Italy.

Gold nanoparticles (AuNPs) show physicochemical and optical functionalities that are of great interest for spectroscopy-based detection techniques, and especially for surface enhanced Raman spectroscopy (SERS), which is capable of providing detailed information on the molecular content of analysed samples. Moreover, the introduction of different moieties combines the interesting plasmonic properties of the AuNPs with the specific and selective recognition capabilities of the antibodies (Ab) towards antigens. The conjugation of biomolecules to gold nanoparticles (AuNPs) has received considerable attention for analysis of liquid samples and in particular biological fluids (biofluids) in clinical diagnostic and therapeutic field. Read More

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High-Q quadrupolar plasmonic lattice resonances in horizontal metal-insulator-metal gratings.

Opt Lett 2021 Apr;46(7):1546-1549

We propose a plasmonic platform for achieving out-of-plane quadrupolar plasmonic surface lattice resonances (SLRs) with large quality factors. The proposed platform is composed of a horizontal metal-insulator-metal (MIM) grating embedded in a homogeneous dielectric environment. Numerical results based on rigorous coupled-wave analysis show that under oblique incidences, high-Q out-of-plane quadrupolar SLRs can be excited at wavelengths of 1242 nm over a wide range of insulator widths, and the quality factor can reach 1036. Read More

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1/f-noise-free optical sensing with an integrated heterodyne interferometer.

Nat Commun 2021 03 30;12(1):1973. Epub 2021 Mar 30.

State Key Laboratory for Artificial Microstructure and Mesoscopic Physics, School of Physics, Peking University, Beijing, 100871, China.

Optical evanescent sensors can non-invasively detect unlabeled nanoscale objects in real time with unprecedented sensitivity, enabling a variety of advances in fundamental physics and biological applications. However, the intrinsic low-frequency noise therein with an approximately 1/f-shaped spectral density imposes an ultimate detection limit for monitoring many paramount processes, such as antigen-antibody reactions, cell motions and DNA hybridizations. Here, we propose and demonstrate a 1/f-noise-free optical sensor through an up-converted detection system. Read More

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Saturable plasmonic metasurfaces for laser mode locking.

Light Sci Appl 2020 Mar 31;9(1):50. Epub 2020 Mar 31.

Laboratoire Interdisciplinaire Carnot de Bourgogne, Université Bourgogne Franche-Comté, 9 avenue Alain Savary, 21078, Dijon, France.

Metamaterials are artificial materials made of subwavelength elementary cells that give rise to unexpected wave properties that do not exist naturally. However, these properties are generally achieved due to 3D patterning, which is hardly feasible at short wavelengths in the visible and near-infrared regions targeted by most photonic applications. To overcome this limitation, metasurfaces, which are the 2D counterparts of metamaterials, have emerged as promising platforms that are compatible with planar nanotechnologies and thus mass production, which platforms the properties of a metamaterial into a 2D sheet. Read More

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Antibody-Functionalized Gold Nanostar-Mediated On-Resonance Picosecond Laser Optoporation for Targeted Delivery of RNA Therapeutics.

Small 2021 Mar 30:e2007577. Epub 2021 Mar 30.

Department of Engineering Physics, Polytechnique Montreal, Montreal, QC, H3C3A7, Canada.

The rapid advances of genetic and genomic technology indicate promising therapeutic potential of genetic materials for regulating abnormal gene expressions causing diseases and disorders. However, targeted intracellular delivery of RNA therapeutics still remains a major challenge hindering the clinical translation. In this study, an elaborated plasmonic optoporation approach is proposed to efficiently and selectively transfect specific cells. Read More

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Plasmonic sensing, imaging, and stimulation techniques for neuron studies.

Biosens Bioelectron 2021 Mar 8;182:113150. Epub 2021 Mar 8.

Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, 46241, Republic of Korea; Department of Optics and Mechatronics Engineering, Pusan National University, Busan, 46241, Republic of Korea. Electronic address:

Studies to understand the structure, functions, and electrophysiological properties of neurons have been conducted at the frontmost end of neuroscience. Such studies have led to the active development of high-performance research tools for exploring the neurobiology at the cellular and molecular level. Following this trend, research and application of plasmonics, which is a technology employed in high-sensitivity optical biosensors and high-resolution imaging, is essential for studying neurons, as plasmonic nanoprobes can be used to stimulate specific areas of cells. Read More

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Virus-like mesoporous silica-coated plasmonic ag nanocube with strong bacteria adhesion for diabetic wound ulcer healing.

Nanomedicine 2021 Mar 23:102381. Epub 2021 Mar 23.

Shengli Clinical Medical College of Fujian Medical University, Fuzhou 350001, PR China; Department of Gastrointestinal Surgery, Fujian, Provincial Hospital, Fuzhou 350001, PR China. Electronic address:

The Gram-positive bacterium Staphylococcus aureus (MRSA) and the Gram-negative bacillus Escherichia coli (E. coli) can be commonly found in diabetic foot ulcers. However, the multi-drug resistant pathogenic bacteria infection is often difficult to eradicate by the conventional antibiotics and easy to spread which can lead to complications such as gangrene or sepsis. Read More

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Asymmetric Core-shell Gold Nanoparticles and Controllable Assemblies for SERS Ratiometric Detection of MicroRNA.

Angew Chem Int Ed Engl 2021 Mar 26. Epub 2021 Mar 26.

Fuzhou University, Qi Shan Campus of Fuzhou University, 2 Xue Yuan Road, University Town, 350108, Fuzhou, CHINA.

Owing to their unique optical properties that depend on shape, morphology, and orientation, diverse plasmonic nanostructures have been the focus of vigorous development and study. Herein, we present a series of Janus nanogap gold nanoparticles (JAuNNPs) with varying proportions of Au shell coverage of approximately 100%, 75%, 50%, and 25%. The internal nanogap between the partial Au shell and core caused asymmetric optical behavior, in addition to their tunability being highly dependent on the degree of Au shell coverage and structural asymmetry. Read More

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Extra- and Intracellular Monitoring of TGF-β Using Single Immunoplasmonic Nanoprobes.

ACS Sens 2021 Mar 23. Epub 2021 Mar 23.

Department of Life Science, University of Seoul, Seoul 02054, South Korea.

Transforming growth factor-β (TGF-β) is a well-known disease-related biomarker associated with fibrotic diseases, and initiation and progression of cancer in many organs. Therefore, quantitative and sensitive detection of TGF-β and similar biomarkers is crucial for patient treatment in the early stages of diagnosis. In many studies, the detection of TGF-β, an important profibrotic and cancer promoting cytokine, has been generally conducted by fluorescence or absorbance-based immunoassays. Read More

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Recent progress of surface-enhanced Raman spectroscopy for subcellular compartment analysis.

Theranostics 2021 4;11(10):4872-4893. Epub 2021 Mar 4.

State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, College of Chemistry, Jilin University, Changchun 130012, People's Republic of China.

Organelles are involved in many cell life activities, and their metabolic or functional disorders are closely related to apoptosis, neurodegenerative diseases, cardiovascular diseases, and the development and metastasis of cancers. The explorations of subcellular structures, microenvironments, and their abnormal conditions are conducive to a deeper understanding of many pathological mechanisms, which are expected to achieve the early diagnosis and the effective therapy of diseases. Organelles are also the targeted locations of drugs, and they play significant roles in many targeting therapeutic strategies. Read More

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Accessing BCG in infected macrophages by antibody-mediated drug delivery system and tracking by surface-enhanced Raman scattering spectroscopy.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Mar 9;255:119660. Epub 2021 Mar 9.

Laboratório de Nanoestruturas Plasmônicas, Universidade Federal de Juiz de Fora, 36036-900, Brazil. Electronic address:

Gold nanoparticles (AuNP) modified with antibody and rifampicin (RP) were tested against Mycobacterium bovis Bacillus Calmette-Guérin (BCG), which previously generated in vitro infection of macrophages from mice. Such a drug delivery system works as nanocarrier for RP and presented lower toxicity for macrophages cells than each separated component. Surface-enhanced Raman scattering (SERS) spectroscopy and fluorescence microscopy were used as analytical tools for the characterization of the internalization of gold nanocarriers into macrophage cells. Read More

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Plasmonic Alloys Reveal a Distinct Metabolic Phenotype of Early Gastric Cancer.

Adv Mater 2021 Mar 20:e2007978. Epub 2021 Mar 20.

State Key Laboratory for Oncogenes and Related Genes, Shanghai Key Laboratory of Gynecologic Oncology, Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P. R. China.

Gastric cancer (GC) is a multifactorial process, accompanied by alterations in metabolic pathways. Non-invasive metabolic profiling facilitates GC diagnosis at early stage leading to an improved prognostic outcome. Herein, mesoporous PdPtAu alloys are designed to characterize the metabolic profiles in human blood. Read More

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Observation and Control of Unidirectional Ballistic Dynamics of Nanoparticles at a Liquid-Gas Interface by 4D Electron Microscopy.

ACS Nano 2021 Mar 18. Epub 2021 Mar 18.

Condensed Matter Physics and Material Science Department, Brookhaven National Laboratory, Upton, New York 11973, United States.

Understanding and controlling the dynamics of active Brownian objects far from equilibrium are fundamentally important for emerging technologies such as artificial micro/nanomotors for drug deliveries and noninvasive microsurgery. However, direct observation and control of unidirectional propulsion of individual nanoscale objects are technically challenging due to the required spatiotemporal resolution. Here, we report visualization and manipulation of unidirectional superfast ballistic dynamics of a single-photon-activated gold nanoparticle (NP) along the liquid-gas interface by four-dimensional electron microscopy (4D EM) at nanometer and nanosecond scales. Read More

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Probing Dynamic Features of Phagosome Maturation in Macrophage using Au@MnO @SiO Nanoparticles as pH-Sensitive Plasmonic Nanoprobes.

Chem Asian J 2021 Mar 16. Epub 2021 Mar 16.

Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.

Phagosome maturation in macrophage is essential to the clearance of pathogenic materials in host defence but the dynamic features remain difficult to be measured in real time. Herein, we reported the multilayered Au@MnO @SiO nanoparticle as a robust pH-sensitive plasmonic nanosensor for monitoring the dynamic acidification features over the phagosome maturation process in macrophage under darkfield microscopy. For this multilayered nanosensor, the gold nanoparticle core plays a role of signal reporter, the MnO shell and the outmost SiO act as the sensing layer and the protecting layer, respectively. Read More

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Treatment of Hepatic Fibrosis in Mice Based on Targeted Plasmonic Hyperthermia.

ACS Nano 2021 Mar 15. Epub 2021 Mar 15.

Biochemistry and Molecular Genetics Department, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08008 Barcelona, Spain.

Liver fibrosis is a major health problem with multiple associated complications, which, to date, has no effective treatment. Hepatic stellate cells are the main responsible cells for fibrosis formation; upon their activation, excess accumulation of extracellular matrix and collagen deposits occurs. The mitogen platelet-derived growth factor (PDGF) and its receptor β (PDGFRβ) play a major role in hepatic stellate cells activation and are, therefore, promising targets for antifibrotic therapies. Read More

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Improving reliability and reducing costs of cardiotoxicity assessments using laser-induced cell poration on microelectrode arrays.

Toxicol Appl Pharmacol 2021 May 6;418:115480. Epub 2021 Mar 6.

Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy. Electronic address:

Drug-induced cardiotoxicity is a major barrier to drug development and a main cause of withdrawal of marketed drugs. Drugs can strongly alter the spontaneous functioning of the heart by interacting with the cardiac membrane ion channels. If these effects only surface during in vivo preclinical tests, clinical trials or worse after commercialization, the societal and economic burden will be significant and seriously hinder the efficient drug development process. Read More

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Probing nucleus-enriched proteins in single living cells a subcellular-resolved plasmonic immunosandwich assay.

Analyst 2021 Mar 9. Epub 2021 Mar 9.

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, 163 Xianlin Avenue, Nanjing 210023, P. R. China.

Nuclear proteins are crucial in cells and are greatly linked to various biological functions. Abnormal expression of nuclear proteins is associated with many diseases ranging from inflammation to cancer. However, it remains challenging to detect nuclear proteins in single cells because of their low abundance and complex subcellular environment. Read More

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Extracellular vesicle drug occupancy enables real-time monitoring of targeted cancer therapy.

Nat Nanotechnol 2021 Mar 8. Epub 2021 Mar 8.

Institute for Health Innovation & Technology, National University of Singapore, Singapore, Singapore.

Current technologies to measure drug-target interactions require complex processing and invasive tissue biopsies, limiting their clinical utility for cancer treatment monitoring. Here we develop an analytical platform that leverages circulating extracellular vesicles (EVs) for activity-based assessment of tumour-specific drug-target interactions in patient blood samples. The technology, termed extracellular vesicle monitoring of small-molecule chemical occupancy and protein expression (ExoSCOPE), utilizes bio-orthogonal probe amplification and spatial patterning of molecular reactions within matched plasmonic nanoring resonators to achieve in situ analysis of EV drug dynamics. Read More

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Smart Electrospun Hybrid Nanofibers Functionalized with Ligand-Free Titanium Nitride (TiN) Nanoparticles for Tissue Engineering.

Nanomaterials (Basel) 2021 Feb 18;11(2). Epub 2021 Feb 18.

Faculty of Technology and Bionics, Rhine-Waal University of Applied Science, Marie-Curie-Straße 1, 47533 Kleve, Germany.

Herein, we report the fabrication and characterization of novel polycaprolactone (PCL)-based nanofibers functionalized with bare (ligand-free) titanium nitride (TiN) nanoparticles (NPs) for tissue engineering applications. Nanofibers were prepared by a newly developed protocol based on the electrospinning of PCL solutions together with TiN NPs synthesized by femtosecond laser ablation in acetone. The generated hybrid nanofibers were characterised using spectroscopy, microscopy, and thermal analysis techniques. Read More

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February 2021

Plasmonically Calibrated Label-Free Surface-Enhanced Raman Spectroscopy for Improved Multivariate Analysis of Living Cells in Cancer Subtyping and Drug Testing.

Anal Chem 2021 03 5;93(10):4601-4610. Epub 2021 Mar 5.

Department of Electrical and Computer Engineering, Virginia Tech, Blacksburg, Virginia 24061, United States.

Plasmonic nanostructure-enabled label-free surface-enhanced Raman spectroscopy (SERS) emerges as a rapid nondestructive molecular fingerprint characterization technique for complex biological samples. However, label-free SERS bioanalysis faces challenges in reliability and reproducibility due to SERS signals' high susceptibility to local optical field variations at plasmonic hotspots, which can bias correlations between the measured spectroscopic features and the actual molecular concentration profiles of complex biochemical matrices. Herein, we report that plasmonically enhanced electronic Raman scattering (ERS) signals from metal nanostructures can serve as a SERS calibration internal standard to improve multivariate analysis of living biological systems. Read More

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Photothermal-triggered system for oligonucleotides delivery from cationic gold nanorods surface: A molecular dynamic investigation.

Colloids Surf B Biointerfaces 2021 May 23;201:111654. Epub 2021 Feb 23.

Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, University of Messina, Viale Ferdinando Stagno d'Alcontres, 31 - 98168 Messina, Italy.

Bioconjugate gold-based nanostructures combining the plasmonic photothermal effect with photothermal-triggered DNA delivery are appealing materials for medical diagnostic and therapy for cell-based disease. In this study, we demonstrate the use of surface hybridization to prepare DNA-modified gold nanorods to be used as photo-delivery system for single stranded oligonucleotides. The as prepared DNA modified gold nanorods have strong absorption bands in the visible and near-infrared regions in which the absorbed light through photothermal effect, induces a surface temperature increasing up to the melting temperature with consequent DNA release. Read More

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Versatile Mesoporous Nanoparticles for Cell Applications.

J Nanosci Nanotechnol 2021 May;21(5):2824-2833

Department of Applied Physics, Nanotechnology and Magnetism Laboratory (NANOMAG), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Mesoporous silica nanostructures are emerging as a promising platform able to deal with challenges of many different applications in fields such as biomedicine and nanotechnology. The versatile physical and functional properties of these materials like high specific surface area, ordered porosity, chemical stability under temperature and pH variations, and biocompatible performance, offers new approaches to many biomedical applications ranging from drug delivery systems to biosensing, cell applications and tissue engineering. Their morphology, size and textural properties can be easily tailored by means of chemical control, giving rise to a variety of nanostructures with hexagonal (SBA15, MCM41) or cubic (SBA16) arrangement of channels and pore size ranging from 1. Read More

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Magical Mathematical Formulas for Nanoboxes.

Nanoscale Res Lett 2021 Mar 1;16(1):39. Epub 2021 Mar 1.

Department of Computer Science, KU Leuven, Celestijnenlaan 200A, 3001, Heverlee, Belgium.

Hollow nanostructures are at the forefront of many scientific endeavors. These consist of nanoboxes, nanocages, nanoframes, and nanotubes. We examine the mathematics of atomic coordination in nanoboxes. Read More

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