25,302 results match your criteria plasma potassium

Missed critical value callbacks due to middleware flaw.

Clin Biochem 2021 Jul 26. Epub 2021 Jul 26.

Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN, United States. Electronic address:

Objectives: In 2018, our clinical laboratory was alerted to back-to-back plasma sodium critical value callback failures on the same patient, occurring on different shifts and involving different technologists. Therefore, we set forth to investigate the root cause for the critical value callback failures.

Design And Methods: We conducted a thorough investigation focused on the processes associated with critical value identification and notification for plasma sodium measurement performed on the Siemens Vista. Read More

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Use of a Portable Point-of-Care Instrumentation to Measure Human Milk Sodium and Potassium Concentrations.

Breastfeed Med 2021 Jul 28. Epub 2021 Jul 28.

School of Molecular Science, The University of Western Australia, Perth, Australia.

Human milk (HM) sodium (Na) and potassium (K) concentrations, as well as the Na and K ratio (Na:K), are associated with stages of lactation and breast health. Portable point-of-care instruments to measure HM biomarkers related to secretory activation or tight junction disturbances would supply clinicians immediate information for individualized lactation care. This study compared HM concentrations of Na and K and Na:K measured by a biochemist with inductively coupled plasma optical emission spectrometry (ICP-OES) and measured by a clinician with ion-selective electrode probes (ISEPs). Read More

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Reference Intervals for Selected Hematology and Clinical Chemistry Measurands in Temminck's Pangolin ().

Front Vet Sci 2021 8;8:654529. Epub 2021 Jul 8.

Department of Paraclinical Sciences and Centre for Veterinary Wildlife Research, Faculty of Veterinary Science, University of Pretoria, Pretoria, South Africa.

Pangolins are the world's most trafficked non-human mammals. A significant number of Temminck's pangolins () are presented for veterinary care and rehabilitation in southern Africa. Little is known about the physiology and normal health of this species, making diagnosis and medical management difficult. Read More

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Effects of Roxadustat on the Anemia and Iron Metabolism of Patients Undergoing Peritoneal Dialysis.

Front Med (Lausanne) 2021 7;8:667117. Epub 2021 Jul 7.

Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Saitama, Japan.

We investigated the effects of roxadustat on the anemia, iron metabolism, peritoneal membrane function, and residual renal function; and determined the factors associated with the administration of roxadustat in patients who were undergoing peritoneal dialysis. We retrospectively analyzed the changes in hemoglobin, serum ferritin, transferrin saturation (TSAT), 4-h dialysate/plasma creatinine, and renal weekly urea clearance over the 24 weeks following the change from an erythropoiesis-stimulating agent (ESA) to roxadustat in 16 patients who were undergoing peritoneal dialysis and had anemia (Roxadustat group). Twenty-three peritoneal dialysis patients who had anemia and continued ESA served as a control group (ESA group). Read More

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Smartphone-Enabled Quantification of Potassium in Blood Plasma.

Sensors (Basel) 2021 Jul 12;21(14). Epub 2021 Jul 12.

Shibaura Institute of Technology, Graduate School of Engineering and Science, 3-7-5 Koto-ku, Tokyo 135-8548, Japan.

This work describes a new method for determining K concentration, [K], in blood plasma using a smartphone with a custom-built optical attachment. The method is based on turbidity measurement of blood plasma solutions in the presence of sodium tetraphenylborate, a known potassium precipitating reagent. The images obtained by a smartphone camera are analyzed by a custom image-processing algorithm which enables the transformation of the image data from RGB to HSV color space and calculation of a mean value of the light-intensity component (V). Read More

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Supplementation of taurine improves ionic homeostasis and mitochondrial function in the rats exhibiting post-traumatic stress disorder-like symptoms.

Eur J Pharmacol 2021 Jul 21;908:174361. Epub 2021 Jul 21.

Neurotherapeutics Laboratory, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi, 221 005, U.P., India. Electronic address:

Rationale: Current pharmacotherapy for post-traumatic stress disorder (PTSD) is limited to few antidepressants. Mitochondrial dysfunction is observed in PTSD, along with altered potassium homeostasis. Nutritional supplementation of taurine can improve ionic homeostasis and thereby treat PTSD-like symptoms in rats. Read More

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Stability of lactate in venous blood gas and sodium fluoride-potassium oxalate plasma: a 6-year retrospective database analysis.

Clin Chem Lab Med 2021 Jul 21. Epub 2021 Jul 21.

Service de Biochimie et Biologie Moléculaire, Laboratoire de Biologie Médicale Multi-Sites (LBMMS), Hospices Civils de Lyon (HCL), Lyon, France.

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Combined effect of silicon and non-thermal plasma treatments on yield, mineral content, and nutraceutical proprieties of edible flowers of Begonia cucullata.

Plant Physiol Biochem 2021 Jul 11;166:1014-1021. Epub 2021 Jul 11.

CREA Research Centre for Vegetable and Ornamental Crops, Via dei Fiori 8, 51017, Pescia (PT), Italy.

Edible flowers are becoming popular as a nutraceutical and functional food that can contribute to human nutrition with high antioxidant molecules and mineral elements. While comparative studies between different flower species have been performed, less is known about the best agronomical practices to increase yield and nutraceutical proprieties of blooms. Silicon stimulates plant resistance against stress and promotes plant growth while non-thermal plasma (NTP) technology has been applied for the disinfection and decontamination of water, as well as for increasing plant production and quality. Read More

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In vitro characteristics and in vivo platelet quality of whole blood treated with riboflavin and UVA/UVB light and stored for 24 hours at room temperature.

Transfusion 2021 07;61 Suppl 1:S101-S110

Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen, Norway.

Background: There is a global increase in whole blood usage and at the same time, emerging pathogens give cause for pathogen reduction technology (PRT). The Mirasol PRT has shown promising results for plasma and platelet concentrate products. Treatment of whole blood with subsequent platelet survival and recovery analysis would be of global value. Read More

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Effects of Season, Location, Species, and Sex on Hematologic and Plasma Biochemical Values and Body Mass in Free-ranging Grebes ( species).

J Avian Med Surg 2021 Jul;35(2):135-154

Department of Public Health Sciences, Davis, CA 95616, USA.

The effects of season, location, species, and sex on body weight and a comprehensive array of blood chemistry and hematology analytes were compared for free-ranging western () and Clark's () grebes. Birds (n = 56) were collected from Puget Sound, WA, and Monterey Bay and San Francisco Bay, CA, from February 2007 to March 2011. The data supported generalization of observed ranges for most analytes across s grebe metapopulations wintering on the Pacific coast. Read More

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Combined evaluation of plasma B-type natriuretic peptide and urinary liver-type fatty acid-binding protein/creatinine ratio is related to worsening renal function in patients undergoing elective percutaneous coronary intervention.

Clin Exp Nephrol 2021 Jul 13. Epub 2021 Jul 13.

Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, Osaka, 564-8565, Japan.

Background: There are few reports on the significance for the combined evaluation of blood humoral factors and urinary biomarkers in terms of worsening renal function (WRF) after coronary angiography (CAG)/percutaneous coronary arterial intervention (PCI).

Method And Results: Urinary liver type-fatty acid-binding protein (L-FABP), neutrophil gelatinase associated lipocalin (NGAL), and adrenomedullin (AM) were measured less than 24 h before and 3 h, 6 h, 1 day, and 2 days after CAG/PCI. WRF was defined as a > 20% decrease in the estimated GFR. Read More

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Specific disruption of calcineurin-signaling in the distal convoluted tubule impacts the transcriptome and proteome, and causes hypomagnesemia and metabolic acidosis.

Kidney Int 2021 Jul 9. Epub 2021 Jul 9.

Institute of Anatomy, University of Zurich, Zurich, Switzerland;; Swiss National Centre for Competence in Research "Kidney Control of Homeostasis", Zurich, Switzerland. Electronic address:

Adverse effects of calcineurin inhibitors (CNI), such as hypertension, hyperkalemia, acidosis, hypomagnesemia and hypercalciuria, have been linked to dysfunction of the distal convoluted tubule (DCT). To test this, we generated a mouse model with an inducible DCT-specific deletion of the calcineurin regulatory subunit B alpha (CnB1-KO). Three weeks after CnB1 deletion, these mice exhibited hypomagnesemia and acidosis, but no hypertension, hyperkalemia or hypercalciuria. Read More

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Pre-loading large volume oral electrolytes: Tracing fluid and ion fluxes in horses during rest, exercise, and recovery.

J Physiol 2021 Jul 12. Epub 2021 Jul 12.

Research and Development, The Nutraceutical Alliance Inc., Burlington, ON, L7N 2Z9, Canada.

Key Points: Exercise results in rapid and large extracellular to intracellular fluid shifts, as well as significant sweating losses of water and ions. It is unknown if ions within oral electrolyte supplements are taken up by muscle (and other soft tissues) and if oral supplementation can effectively offset sweating losses Pre-loading with 8 L of a balanced hypotonic electrolyte supplement attenuated extracellular fluid losses, increased exercise duration, and increased sweating fluid and ion losses during submaximal exercise. Supplemented electrolytes appear in skeletal muscle within one hour after administration. Read More

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A novel nonsense mutation in the β-subunit of the epithelial sodium channel causing Liddle syndrome.

Blood Press 2021 Jul 5:1-9. Epub 2021 Jul 5.

Second Department of Internal Medicine, University Hospital, Pilsen, Czech Republic.

Purpose: Liddle syndrome is a hereditary form of arterial hypertension caused by mutations in the genes coding of the epithelial sodium channel - SCNN1A, SCNN1B and SCNN1G. It is characterised by early onset of hypertension and variable biochemical features such as hypokalaemia and low plasma concentrations of renin and aldosterone. Phenotypic variability is large and, therefore, LS is probably underdiagnosed. Read More

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Effect of the KCa3.1 blocker, senicapoc, on cerebral edema and cardiovascular function after cardiac arrest - A randomized experimental rat study.

Resusc Plus 2021 Jun 2;6:100111. Epub 2021 Apr 2.

Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Blvd. 82, 8200 Aarhus N, Denmark.

Aim: Formation of cerebral edema and cardiovascular dysfunction may worsen brain injury following cardiac arrest. We hypothesized that administration of the intermediate calcium-activated potassium (KCa3.1) channel blocker, senicapoc, would reduce cerebral edema and augment mean arterial pressure in the early post-resuscitation period. Read More

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Melatonin Alleviated Potassium Dichromate-Induced Oxidative Stress and Reprotoxicity in Male Rats.

Biomed Res Int 2021 15;2021:3565360. Epub 2021 Jun 15.

Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

Melatonin (ML) is a potent antioxidant that reduces oxidative stress. This study was designed to examine the protective effect of melatonin on potassium dichromate- (PDC-) induced male reproductive toxicity. Forty rats were divided into five groups: the control group, rats administered PDC orally (10 mg/kg body weight) for eight weeks, rats administered ML intraperitoneally at doses of either 2. Read More

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Prediction model of emergency mortality risk in patients with acute upper gastrointestinal bleeding: a retrospective study.

PeerJ 2021 24;9:e11656. Epub 2021 Jun 24.

Department of Respiratory Medicine, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua Municipal Central Hospital, Jinhua, ZheJiang, China.

Background: Upper gastrointestinal bleeding is a common presentation in emergency departments and carries significant morbidity worldwide. It is paramount that treating physicians have access to tools that can effectively evaluate the patient risk, allowing quick and effective treatments to ultimately improve their prognosis. This study aims to establish a mortality risk assessment model for patients with acute upper gastrointestinal bleeding at an emergency department. Read More

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Evaluation of potential drug interactions with sodium zirconium cyclosilicate: a single-center, open-label, one sequence crossover study in healthy adults.

Clin Kidney J 2021 Jul 29;14(7):1808-1816. Epub 2020 Dec 29.

Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, Research and Development, AstraZeneca, Gaithersburg, MD, USA.

Background: Sodium zirconium cyclosilicate (SZC; formerly ZS-9) is an oral potassium binder for the treatment of hyperkalemia in adults. SZC acts in the gastrointestinal tract and additionally binds hydrogen ions in acidic environments like the stomach, potentially transiently increasing gastric pH and leading to drug interactions with pH-sensitive drugs. This study assessed potential pharmacokinetic (PK) interactions between SZC and nine pH-sensitive drugs. Read More

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Reverse pseudohyperkalemia is more than leukocytosis: a retrospective study.

Clin Kidney J 2021 May 7;14(5):1443-1449. Epub 2020 Sep 7.

Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: Hyperkalemia is a potentially life-threatening electrolyte abnormality that often requires urgent treatment. Clinicians should distinguish true hyperkalemia from pseudohyperkalemia and reverse pseudohyperkalemia (RPK). RPK has exclusively been described in case reports of patients with hematologic malignancies (HMs) and extreme leukocytosis [white blood cell (WBC) count >200 × 10/mL]. Read More

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Clinical Profile and Treatment Response in Patients with CASPR2 Antibody-Associated Neurological Disease.

Ann Indian Acad Neurol 2021 Mar-Apr;24(2):178-185. Epub 2021 Mar 31.

Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, Karnataka, India.

Background: The clinical spectrum of contactin-associated protein-like 2 (CASPR2) antibody-associated disease is wide and includes Morvan syndrome. Studies describing treatment and long-term outcome are limited.

Aims: We report the clinical profile and emphasize response to treatment and long-term outcome in eight patients with CASPR2-antibody-associated disease. Read More

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0.9% Sodium chloride solution versus Plasma-Lyte 148 versus compound sodium lacTate solution in children admitted to PICU-a randomized controlled trial (SPLYT-P): study protocol for an intravenous fluid therapy trial.

Trials 2021 Jul 3;22(1):427. Epub 2021 Jul 3.

Paediatric Critical Care Research Group, Child Health Research Centre, The University of Queensland, 62 Graham Street, South Brisbane, QLD, 4101, Australia.

Background: Intravenous fluid therapy represents the most common intervention critically ill patients are exposed to. Hyperchloremia and metabolic acidosis associated with 0.9% sodium chloride have been observed to lead to worse outcomes, including mortality. Read More

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Methodology to Quantify and Screen the Demineralization of Teeth by Immersing Them in Acidic Drinks (Orange Juice, Coca-Cola™, and Grape Juice): Evaluation by ICP OES.

Molecules 2021 Jun 1;26(11). Epub 2021 Jun 1.

Group of Spectroscopy and Bioinformatics Applied Biodiversity and Health (GEBABS), Post-Graduate Program in Health and Development in the Midwest Region, School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, Brazil.

Oral health problems may occur as a result of the ingestion of acid drinks. The objective of this in vitro study was to quantify and screen the concentration of potassium (K), phosphorus (P), calcium (Ca), magnesium (Mg), manganese (Mn), zinc (Zn), iron (Fe), copper (Cu), barium (Ba), lead (Pb), arsenic (As), cadmium (Cd), aluminum (Al), cobalt (Co), chromium (Cr), molybdenum (Mo), sodium (Na), nickel (Ni), selenium (Se), and vanadium (V) released from bovine incisors during an erosive challenge at different times of exposure when immersed in Coca-Cola™, orange juice, and grape juice. A total of 240 samples of bovine incisor teeth were used for the erosive challenge and allocated in groups. Read More

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With-No-Lysine Kinase 1 (WNK1) Augments TRPV4 Function in the Aldosterone-Sensitive Distal Nephron.

Cells 2021 Jun 12;10(6). Epub 2021 Jun 12.

Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA.

Kidneys play a central role in regulation of potassium homeostasis and maintenance of plasma K levels within a narrow physiological range. With-no-lysine (WNK) kinases, specifically WNK1 and WNK4, have been recognized to regulate K balance, in part, by orchestrating maxi K channel (BK)-dependent K secretion in the aldosterone-sensitive distal nephron (ASDN), which includes the connecting tubule and collecting duct. We recently demonstrated that the Ca-permeable TRPV4 channel is essential for BK activation in the ASDN. Read More

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The Content of Minerals in the PCOS Group and the Correlation with the Parameters of Metabolism.

Nutrients 2021 Jun 28;13(7). Epub 2021 Jun 28.

Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland.

Polycystic ovary syndrome (PCOS) is a common disease in women of childbearing age. It is characterized by excessive androgen production, ovulation disorders, and developing metabolic syndrome. The aim of the study was to check whether selected minerals were related to the pathophysiological mechanisms of PCOS. Read More

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Molecular and Electrophysiological Role of Diabetes-Associated Circulating Inflammatory Factors in Cardiac Arrhythmia Remodeling in a Metabolic-Induced Model of Type 2 Diabetic Rat.

Int J Mol Sci 2021 Jun 25;22(13). Epub 2021 Jun 25.

Departament of Physiology, Facultad de Farmacia, Universidad del País Vasco UPV/EHU, 01006 Vitoria-Gasteiz, Spain.

Background: Diabetic patients have prolonged cardiac repolarization and higher risk of arrhythmia. Besides, diabetes activates the innate immune system, resulting in higher levels of plasmatic cytokines, which are described to prolong ventricular repolarization.

Methods: We characterize a metabolic model of type 2 diabetes (T2D) with prolonged cardiac repolarization. Read More

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The Effect of the PCSK9 Inhibitor Evolocumab on Aldosterone Secretion among High Cardiovascular Risk Patients: A Pilot Study.

J Clin Med 2021 Jun 5;10(11). Epub 2021 Jun 5.

School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Elevated low-density lipoprotein (LDL) cholesterol is one of the leading causes of cardiovascular disease. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors reduce LDL cholesterol levels with subsequent reductions in cardiovascular morbidity. Elevated aldosterone levels are also associated with a greater risk of cardiovascular morbidity. Read More

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A novel mitochondrial Kv1.3-caveolin axis controls cell survival and apoptosis.

Elife 2021 07 1;10. Epub 2021 Jul 1.

Molecular Physiology Laboratory, Dpt. de Bioquímica i Biomedicina Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, Spain.

The voltage-gated potassium channel Kv1.3 plays an apparent dual physiological role by participating in activation and proliferation of leukocytes as well as promoting apoptosis in several types of tumor cells. Therefore, Kv1. Read More

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Stopping mineralocorticoid receptor antagonists after hyperkalaemia: trial emulation in data from routine care.

Eur J Heart Fail 2021 Jul 1. Epub 2021 Jul 1.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Aims: Whether to continue or stop mineralocorticoid receptor antagonists (MRA) after an episode of hyperkalaemia is a challenge in clinical practice. While stopping MRA may prevent recurrent hyperkalaemias, it deprives patients of their cardioprotection. We here assessed the association between stopping vs. Read More

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The Genetics of Adverse Drug Outcomes in Type 2 Diabetes: A Systematic Review.

Front Genet 2021 14;12:675053. Epub 2021 Jun 14.

Division of Population Health and Genomics, Ninewells Hospital and School of Medicine, University of Dundee, Dundee, United Kingdom.

Adverse drug reactions (ADR) are a major clinical problem accounting for significant hospital admission rates, morbidity, mortality, and health care costs. One-third of people with diabetes experience at least one ADR. However, there is notable interindividual heterogeneity resulting in patient harm and unnecessary medical costs. Read More

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Developing a research database of primary aldosteronism: rationale and baseline characteristics.

BMC Endocr Disord 2021 Jun 29;21(1):137. Epub 2021 Jun 29.

Department of Endocrinology and Metabolism, Adrenal Center, West China Hospital, Sichuan University, Chengdu, 610041, China.

Background: Management of primary aldosteronism (PA) has become a research hotspot in the field of endocrinology. To obtain reliable research evidence, it is necessary to establish a high-quality PA research database.

Methods: The establishment of PA research database involved two steps. Read More

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