Search Our Scientific Publications & Authors

Domest Anim Endocrinol 2021 Mar 23;76:106625. Epub 2021 Mar 23.

Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, Pirassununga, São Paulo, Brazil. Electronic address:

The effects of 17β-estradiol (E2) or estradiol benzoate (EB) on PGF2α release were studied in bred-non-pregnant and pregnant Nelore beef heifers. The day of timed artificial insemination (TAI) was designated day 0 (D0), and a single treatment was given on D14. All heifers also received an intravaginal P4 device on D14, and were randomly assigned to three groups: Control (C, P4 device only, n = 12); E2 (1 mg E2 + 9 mg P4, n = 10); or EB (1 mg, n = 10). Read More

PLoS One 2021 20;16(4):e0250044. Epub 2021 Apr 20.

Project San Francisco, Rwanda Zambia HIV Research Group, Kigali, Rwanda.

Introduction: The longstanding inadequacies of syndromic management for genital ulceration and inflammation are well-described. The Rwanda National Guidelines for sexually transmitted infection (STI) syndromic management are not yet informed by the local prevalence and correlates of STI etiologies, a component World Health Organization guidelines stress as critical to optimize locally relevant algorithms.

Methods: Radio announcements and pharmacists recruited symptomatic patients to seek free STI services in Kigali. Read More

Environ Health Perspect 2021 Apr 20;129(4):47012. Epub 2021 Apr 20.

Water Institute at the University of North Carolina at Chapel Hill (UNC), UNC, Chapel Hill, North Carolina, USA.

Background: Exposure to toxic metals (TMs) such as lead can cause lifelong neurodevelopmental impairment and other adverse outcomes. TMs enter drinking water from human activity, geogenic contamination, and corrosion of water system components. Several studies report TM contamination in piped systems and private wells in high-income countries (HICs). Read More

Blood Adv 2021 Apr;5(8):2079-2086

Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA.

Data on infants and toddlers (ITs) with von Willebrand disease (VWD) are lacking. We used data collected in the US Hemophilia Treatment Center Network (USHTCN) to describe birth characteristics, bleeding episodes, and complications experienced by 105 patients with VWD who were <2 years of age. In 68% of the patients, the reason for diagnostic testing was a family history of a bleeding disorder. Read More

Lab Chip 2021 Apr 24;21(7):1318-1332. Epub 2021 Mar 24.

Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health & Science University, USA.

Tumor-secreted exosomes and other extracellular vesicles (EVs) in circulation contain valuable biomarkers for early cancer detection and screening. We have previously demonstrated collection of cancer-derived nanoparticles (NPs) directly from whole blood and plasma with a chip-based technique that uses a microelectrode array to generate dielectrophoretic (DEP) forces. This technique enables direct recovery of NPs from whole blood and plasma. Read More

eNeuro 2021 Apr 15. Epub 2021 Apr 15.

Department of Psychiatry, University of California, San Diego, La Jolla CA 92093, USA

Substance use disorders are pervasive in our society and have substantial personal and socio-economical costs. A critical hurdle in identifying biomarkers and novel targets for medication development is the lack of resources for obtaining biological samples with a detailed behavioral characterization of substance use disorder. Moreover, it is nearly impossible to find longitudinal samples. Read More

Antimicrob Agents Chemother 2021 Apr 19. Epub 2021 Apr 19.

Spero Therapeutics, Inc., Cambridge, MA.

Tebipenem pivoxil hydrobromide (TBP-PI-HBr) is an orally available prodrug of TBP, a carbapenem with activity against multidrug-resistant gram-negative pathogens. This study evaluated the effects of single therapeutic and supratherapeutic doses of TBP-PI-HBr on the heart rate corrected QT interval (QTc) by assessing the concentration-QT (C-QT) relationship using exposure-response modeling. This was a randomized, double-blind, placebo- and active-controlled, single dose, 4-way, crossover study. Read More

Crit Care 2021 04 19;25(1):148. Epub 2021 Apr 19.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, 325 9th Avenue, Seattle, WA, 98104, USA.

Background: Analyses of blood biomarkers involved in the host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection can reveal distinct biological pathways and inform development and testing of therapeutics for COVID-19. Our objective was to evaluate host endothelial, epithelial and inflammatory biomarkers in COVID-19.

Methods: We prospectively enrolled 171 ICU patients, including 78 (46%) patients positive and 93 (54%) negative for SARS-CoV-2 infection from April to September, 2020. Read More

Ann Clin Biochem 2021 Apr 19:45632211013870. Epub 2021 Apr 19.

University of Southern Denmark, Clinical Research, Odense, Syddanmark, Denmark.

Background: As part of the Survey of Health, Ageing and Retirement in Europe (SHARE) study, dried blood spot (DBS) samples were obtained for measurement of potential biological biomarkers, among those vitamin D. Unfortunately, no studies describe the impact of high temperatures on DBS samples and vitamin D measurements.

Materials And Methods: Capillary samples were collected on DBS cards from 40 outpatients (median age 78 years) along with venous blood samples. Read More

Mol Immunol 2021 Apr 16;135:84-94. Epub 2021 Apr 16.

Molecular Recognition Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST-School, Korea University of Science and Technology (UST), Seoul, 02792, Republic of Korea. Electronic address:

The immune system plays a critical role not only in homeostasis of the body but also in pathogenesis. Autoimmunity and dysregulation of the immune balance are closely related to age. To examine the influence of age on autoimmunity, the pathophysiological features of experimental autoimmune encephalomyelitis (EAE) induced at different ages were elucidated on the basis of plasma-level metabolic changes. Read More

Horm Behav 2021 Apr 16;131:104980. Epub 2021 Apr 16.

Department of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland.

This study aimed to examine the hypothesis that BDNF modulates the activity of the gonadotrophic axis in sheep. Central infusions of BDNF were administered to sexually mature Polish Merino sheep. The sheep were randomly divided into three groups: the control group received intracerebroventricular (ICV) infusions of the vehicle, the BDNF 10 group received ICV infusions of BDNF at 10 μg/480 μL/day, and the BDNF 60 group was infused with BDNF at 60 μg/480 μL/day. Read More

Arthroscopy 2021 Apr 16. Epub 2021 Apr 16.

Hospital for Special Surgery, New York, NY, USA.

Purpose: The aim of this study was to describe the complications that occur following biologic therapeutic injections.

Methods: We queried physician members of the Biologic Association™, a multidisciplinary organization dedicated to providing a unified voice for all matters related to musculoskeletal biologics and regenerative medicine. Patients included in this study must have (a) received a biologic injection, (b) sustained an adverse reaction, and (c) had a minimum of 1 year follow up after the injection. Read More

Am J Med 2021 Apr 16. Epub 2021 Apr 16.

Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland OH; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland OH. Electronic address:

Background: Choline is a dietary precursor to the gut microbial generation of the pro-thrombotic and pro-atherogenic metabolite trimethylamine-N-oxide (TMAO). Eggs are rich in choline, yet the impact of habitual egg consumption on TMAO levels and platelet function in human subjects remains unclear.

Methods: Healthy volunteers (41% male, 81% Caucasian, median age 28) with normal renal function (eGFR>60) were recruited and assigned to one of five daily interventions for four weeks: (i) hardboiled eggs (N=18); (ii) choline bitartrate supplements (N=20); (iii) hardboiled eggs + choline bitartrate supplements (N=16); (iv) egg whites + choline bitartrate supplements (N=18); (v) phosphatidylcholine supplements (N=10). Read More

Int J Clin Pract 2021 Apr 19:e14223. Epub 2021 Apr 19.

Istanbul University-Cerrahpasa, Biochemistry, Turkey.

Aims: Amelogenesis Imperfecta and Generalized Enamel Hypoplasia are developmental dental anomalies that affect dental enamel. While Amelogenesis imperfecta results from various gene mutations, the exact underlying mechanisms of the etiopathogenesis of both remain unclear. This study aims to evaluate Ghrelin hormone levels in children with generalized enamel hypoplasia to establish whether Ghrelin might have a potential role in enamel hypoplasia's etiology. Read More

Clin Infect Dis 2021 Apr 19. Epub 2021 Apr 19.

Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Background: Standard testing fails to identify a pathogen in most patients with febrile neutropenia (FN). We evaluated the ability of the Karius microbial cell-free DNA (mcfDNA) sequencing Test (KT) to identify infectious etiologies of FN and its impact on antimicrobial management.

Methods: This prospective study (ClinicalTrials. Read More

Front Res Metr Anal 2020 22;5:586992. Epub 2021 Jan 22.

Max Planck Institute for Physics, Munich, Germany.

Open science (OS) is of paramount importance for the improvement of science worldwide and across research fields. Recent years have witnessed a transition toward open and transparent scientific practices, but there is still a long way to go. Early career researchers (ECRs) are of crucial relevance in the process of steering toward the standardization of OS practices, as they will become the future decision makers of the institutional change that necessarily accompanies this transition. Read More

Res Pract Thromb Haemost 2021 Mar 8;5(3):395-402. Epub 2021 Mar 8.

Mayo Clinic Rochester MN USA.

Introduction: Plasma thrombin generation kinetics as measured by the calibrated automated thrombogram (CAT) assay is a predictor of symptomatic venous thromboembolism after trauma. We hypothesized that data from a new prototype assay for measurement of thrombin generation kinetics in fresh whole blood (near patient testing of thrombin generation), will correlate with the standard CAT assay in the same patients, making it a potential tool in the future care of trauma patients.

Methods: Patients were enrolled from June 2018 to February 2020. Read More

Gene Rep 2021 Jun 13;23:101140. Epub 2021 Apr 13.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: As the daily number of coronavirus infection disease 19 (COVID19) patients increases, the necessity of early diagnosis becomes more obvious. In this respect, we aimed to develop a serological test for specifically detecting anti-SARS-CoV2 antibodies.

Methods: We collected serum and saliva samples from 609 individuals who work at TBZMED affiliated hospitals in Tabriz, Iran, from April to June of 2020. Read More

Open Med (Wars) 2021 3;16(1):367-374. Epub 2021 Mar 3.

Department of Cardiovascular, Changshou people's Hospital, Chongqing 401220, China.

Background: SARS-CoV-2 has spread worldwide and poses a great threat to human health. Among COVID-19 patients, those with hypertension have been reported to have higher morbidity and mortality. This study was conducted to provide the international community with a deeper understanding of COVID-19 with hypertension. Read More

Data Brief 2021 Jun 26;36:106998. Epub 2021 Mar 26.

Department of Animal Science, South Dakota State University, Brookings, South Dakota, USA.

This is isobaric tags for a relative and absolute quantification (iTRAQ)-Based Proteomic Data on bovine plasma (PL) and follicular fluid (FF) containing high and low pre-ovulatory circulating concentration of estradiol (E2). The PL and FF were collected from nine beef cows that were identified to initiate a new follicular wave on day -4 during synchronization. Follicular dynamics and ovulatory response were monitored using transrectal ultrasonography. Read More

Toxicol Rep 2021 23;8:668-675. Epub 2021 Mar 23.

Department of Pharmacology, Saveetha Dental College and Hospitals, SIMATS, Chennai, 600077, Tamil Nadu, India.

The risk of heavy metals contamination in meat and meat products is of great concern for both food safety and from human health point of view. The present study was carried out to assess the heavy metal residues such as Pb, Cd, As and Hg in broiler chicken meat, neck and edible organs (liver and kidney). In the present study, 150 samples were randomly collected from major cities (Chennai, Coimbatore, Madurai, Trichy, and Salem) of Tamil Nadu state, India and analyzed for Pb, Cd, As and Hg residues (mg/kg) using inductively coupled plasma-mass spectrometry (ICP-MS) technique. Read More

Plast Reconstr Surg Glob Open 2021 Apr 15;9(4):e3379. Epub 2021 Apr 15.

Department of Plastic Surgery, Baylor College of Medicine, Houston, Tex.

Background: Despite the increased popularity of platelet-rich plasma (PRP) in plastic surgery, there is no detailed analysis on the level of evidence on PRP use in plastic surgery. As the number of applications of PRP in plastic surgery increases, it is important for plastic surgeons to understand the scientific and validated evidence behind its use. Therefore, we performed a literature review to identify current level of evidence on platelet-rich plasma in plastic surgery. Read More

Front Endocrinol (Lausanne) 2021 30;12:536018. Epub 2021 Mar 30.

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang, China.

Objective: Skeletal muscle fat content is one of the important contributors to insulin resistance (IR), but its diagnostic value remains unknown, especially in the Chinese population. Therefore, we aimed to analyze differences in skeletal muscle fat content and various functional MRI parameters between diabetic patients and control subjects to evaluate the early indicators of diabetes. In addition, we aimed to investigate the associations among skeletal muscle fat content, magnetic resonance parameters of skeletal muscle function and IR in type 2 diabetic patients and control subjects. Read More

Front Neurol 2021 1;12:648702. Epub 2021 Apr 1.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

High plasma levels of trimethylamine N-oxide (TMAO) and its precursor choline have been linked to stroke; however, their association with cerebral small vessel disease remains unclear. Here we evaluated the association of plasma levels of TMAO and choline with imaging markers of cerebral small vessel disease, including white matter hyperintensities, lacunes, and cerebral microbleeds. We performed a baseline cross-sectional analysis of a multicenter hospital-based cohort study from 2015 to 2018. Read More

Pak J Pharm Sci 2020 Nov;33(6):2543-2546

The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

In this work, the aim of our study was to assess whether sesamin could influence the pharmacokinetics of ivabradine and its active metabolite N-desmethylivabradine in rats. At the begining, 12 healthy male Sprague-Dawley rats were randomly divided into two groups: The rats were received an oral administration of 1.0mg/kg ivabradine alone (the control group), and the rats were given 1. Read More

J Dairy Sci 2021 Apr 14. Epub 2021 Apr 14.

Department of Animal and Dairy Sciences, University of Wisconsin-Madison 53706. Electronic address:

Objectives were to evaluate the effect of feeding rumen-protected methionine (RPM) in pre- and postpartum total mix ration (TMR) on lactation performance and plasma AA concentrations in dairy cows. A total of 470 multiparous Holstein cows [235 cows at University of Wisconsin (UW) and 235 cows at Cornell University (CU)] were enrolled approximately 4 wk before parturition, housed in close-up dry cow and replicated lactation pens. Pens were randomly assigned to treatment diets (pre- and postpartum, respectively): UW control (CON) diet = 2. Read More

J Dairy Sci 2021 Apr 14. Epub 2021 Apr 14.

Davies Livestock Research Centre, School of Animal and Veterinary Sciences, University of Adelaide, Roseworthy Campus, Roseworthy, SA 5371, Australia.

Colostrum is essential for good neonate health; however, it is not known whether different calves absorb the nutrients from colostrum equally well. In this study, the absorption of protein, IgG, and γ-glutamyl transferase was compared in newborn dairy bull calves for 1 wk after feeding colostrum from different sources. Thirty-five Holstein-Friesian bull calves were randomly allocated into 3 groups and fed colostrum within 4 h after birth. Read More

Clin Lab 2021 Apr;67(4)

Background: Venous thromboembolism (VTE) is a common complication in orthopedic trauma patients. Accurate prediction of individual thrombosis risk is important in determining whether prophylactic treatment with anticoagulants is necessary. In this study, we screened for biomarkers that could be used as predictors of VTE risk and evaluated their efficacy and benefit in treating orthopedic traumatic patients. Read More

Pharmacology 2021 Apr 16:1-8. Epub 2021 Apr 16.

Phase I clinical trial ward, GCP center, Affiliated Hospital of Liaoning, University of Traditional Chinese Medicine, Shenyang, China.

Introduction: Nateglinide or N-(trans-4-isopropylcyclohexyl-1-carbonyl)-D-phenylalanine is a drug with a rapid hypoglycemic effect that is mainly used in the treatment of type 2 diabetes. Very few studies have assessed bioequivalence based on feeding status. This study aimed to assess the pharmacokinetic bioequivalence and safety of nateglinide-containing tablets (0. Read More

Toxicol Lett 2021 Apr 15. Epub 2021 Apr 15.

Department of Pharmacy, The First Affiliated Hospital of Harbin Medical University, 23 You-Zheng Street, Harbin, China. Electronic address:

Background: Arsenic trioxide (ATO) has been successfully applied in the treatment of acute promyelocytic leukemia (APL). Arsenic metabolites including inorganic arsenic and methylated arsenic lead to different toxicity and curative effect. This study aims to establish a method to determine arsenic species in red blood cells (RBCs), clarify the distribution characteristics of arsenic species in RBCs. Read More