3,955 results match your criteria plasma ablation

Spatially and size-resolved analysis of gold nanoparticles in rat spleen after intratracheal instillation by laser ablation-inductively coupled plasma-mass spectrometry.

Metallomics 2021 May 12. Epub 2021 May 12.

University of Münster, Institute of Inorganic and Analytical Chemistry, Corrensstraße 30, 48149 Münster, Germany.

In a dual approach, laser ablation-inductively coupled plasma-mass spectrometry was applied to investigate spleen samples of rats after intratracheal instillation of polyvinylpyrrolidone-coated gold nanoparticles. First, spatially resolved imaging analysis was deployed to investigate gold translocation from the lungs to the spleen and to investigate the distribution pattern of gold in the spleen parenchyma itself. Using the same instrumental setup, laser ablation-inductively coupled plasma-mass spectrometry in single particle mode was applied to determine the species of translocated gold. Read More

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Stroke due to Left Atrial Appendage Thrombus after Pulmonary Vein Isolation despite Novel Oral Anticoagulant: A Case Report.

Case Rep Neurol 2021 Jan-Apr;13(1):225-232. Epub 2021 Apr 12.

Department of Neurology, University Hospital Essen, Essen, Germany.

In patients with atrial fibrillation, catheter ablation is suggested to reduce the mortality rate and is thus frequently performed. However, peri- and postprocedural thromboembolic complications as well as high recurrence rates of atrial fibrillation limit its advantages and require concomitant anticoagulation. With the advent of novel oral anticoagulants (NOACs), fixed dosing without routine laboratory monitoring became feasible. Read More

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Vapor-phase production of nanomaterials.

Chem Soc Rev 2021 May 11. Epub 2021 May 11.

Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA. and RENEW Institute, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA.

The synthesis of nanomaterials, with characteristic dimensions of 1 to 100 nm, is a key component of nanotechnology. Vapor-phase synthesis of nanomaterials has numerous advantages such as high product purity, high-throughput continuous operation, and scalability that have made it the dominant approach for the commercial synthesis of nanomaterials. At the same time, this class of methods has great potential for expanded use in research and development. Read More

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Ghrelin-Induced Food Intake, But not GH Secretion, Requires the Expression of the GH Receptor in the Brain of Male Mice.

Endocrinology 2021 May 11. Epub 2021 May 11.

Universidade de Sao Paulo, Instituto de Ciencias Biomedicas, Departamento de Fisiologia e Biofísica, São Paulo, SP, Brazil.

Ghrelin stimulates both growth hormone (GH) secretion and food intake. The orexigenic action of ghrelin is mainly mediated by neurons that co-express agouti-related protein (AgRP) and neuropeptide Y (NPY) in the arcuate nucleus (ARH). GH also stimulates food intake and, importantly, ARH AgRP/NPY neurons express GH receptor (GHR). Read More

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Large-scale growth of few-layer two-dimensional black phosphorus.

Nat Mater 2021 May 10. Epub 2021 May 10.

Department of Applied Physics, The Hong Kong Polytechnic University, Hong Kong, People's Republic of China.

Two-dimensional materials provide opportunities for developing semiconductor applications at atomistic thickness to break the limits of silicon technology. Black phosphorus (BP), as a layered semiconductor with controllable bandgap and high carrier mobility, is one of the most promising candidates for transistor devices at atomistic thickness. However, the lack of large-scale growth greatly hinders its development in devices. Read More

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Toll-Like Receptor 3 Ablation Prevented High-fat Diet-induced Obesity and Metabolic Disorder.

J Nutr Biochem 2021 May 6:108761. Epub 2021 May 6.

School of Basic Medical Sciences and Joint China-US Research Center for Environment and Pulmonary Diseases, Zhejiang Chinese Medical University, Hangzhou, China. Electronic address:

Inflammation in insulin-sensitive tissues (eg, liver, visceral adipose tissue (VAT)) plays a major role in obesity and insulin resistance. Recruitment of innate immune cells drives the dysregulation of glucose and lipid metabolism. We aimed to seek the role of Toll like receptor 3 (TLR3), a pattern recognition receptor involved in innate immunity, obesity and the metabolic disorder. Read More

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Assessing multiproxy approaches (Sr/Ca, U/Ca, Li/Mg, and B/Mg) to reconstruct sea surface temperature from coral skeletons throughout the Great Barrier Reef.

Sci Total Environ 2021 Apr 29;786:147393. Epub 2021 Apr 29.

Australian Institute of Marine Science, PMB No 3, Townsville MC, Qld 4810, Australia.

Due to the increasing concerns of global warming and short instrumental records of sea surface temperature (SST), coral-based proxies, such as δO, Sr/Ca, U/Ca, and Li/Mg have been developed and applied to reconstruct SST in paleoclimate studies. However, these proxies are not universally applicable in different environments, because they are affected by coral physiology and various environmental factors. In this study, seven long-lived Porites corals were collected from the southern sector of the Great Barrier Reef (GBR) off the coast of Gladstone and the central sector of the GBR within the Whitsunday Islands in 2017 and 2018. Read More

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Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance.

PLoS One 2021 7;16(5):e0246358. Epub 2021 May 7.

Department of Ophthalmology and Visual Sciences, The University of Iowa Carver College of Medicine, Iowa City, IA, United States of America.

Nephrocystin (NPHP1) is a ciliary transition zone protein and its ablation causes nephronophthisis (NPHP) with partially penetrant retinal dystrophy. However, the precise requirements of NPHP1 in photoreceptors are not well understood. Here, we characterize retinal degeneration in a mouse model of NPHP1 and show that NPHP1 is required to prevent infiltration of inner segment plasma membrane proteins into the outer segment during the photoreceptor maturation. Read More

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Micro-droplet-based calibration for quantitative elemental bioimaging by LA-ICPMS.

Anal Bioanal Chem 2021 May 5. Epub 2021 May 5.

Institute of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Strasse 38, 1090, Vienna, Austria.

In this work, a novel standardization strategy for quantitative elemental bioimaging is evaluated. More specifically, multi-element quantification by laser ablation-inductively coupled plasma-time-of-flight mass spectrometry (LA-ICP-TOFMS) is performed by multi-point calibration using gelatin-based micro-droplet standards and validated using in-house produced reference materials. Fully automated deposition of micro-droplets by micro-spotting ensured precise standard volumes of 400 ± 5 pL resulting in droplet sizes of around 200 μm in diameter. Read More

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Determination of spatial mercury concentration by laser ablation-inductively coupled plasma mass spectrometry.

J Toxicol Sci 2021 ;46(5):193-198

Graduate School of Pharmaceutical Sciences, Chiba University.

Laser ablation-inductively coupled plasma mass spectrometry (LA-ICP-MS) is capable of metal imaging by acquiring local spatial information. However, the preparation of an appropriate standard for quantitative analysis is difficult because the matrices between the standard and the sample should match, and homogeneity of metal concentration in the standard is required. Hence, the aim of this study was to establish a highly quantitative mercury imaging method that utilizes LA-ICP-MS and an appropriate mercury standard consisting of rat tissue. Read More

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January 2021

Radiofrequency ablation for intraductal extension of ampullary adenomatous lesions: proposal for a standardized protocol.

Endosc Int Open 2021 May 22;9(5):E749-E755. Epub 2021 Apr 22.

Digestive Endoscopy Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Intraductal extension of ampullary adenoma represents a challenging endoscopic issue. Intraductal radiofrequency ablation (RFA) has been recently suggested, but evidence and standardization of this technique are still lacking. This study aimed to provide a long-term evaluation of clinical efficacy and safety of intraductal RFA ablation with a standardized algorithm of treatment. Read More

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Characterization of Four Copper Materials for Application as Reference Materials for High Precision Copper Isotope Analysis by Laser Ablation Inductively Coupled Plasma Multi-Collector Mass Spectrometry.

Front Chem 2021 15;9:617205. Epub 2021 Apr 15.

Geological Survey of Canada (GSC), Natural Resources Canada, Ottawa, ON, Canada.

Laser ablation inductively coupled plasma multi-collector mass spectrometry (LA-MC-ICP-MS) allows rapid, highly precise measurements of Cu isotope ratios of native Cu and Cu-bearing minerals. However, the National Institute of Standards and Technology Cu-metal isotope standard NIST SRM976 that is commonly used to calibrate LA-MC-ICP-MS Cu isotope measurements of native Cu is no longer available. We have investigated the suitability of four Cu metal materials, SSC-1, SSC-3 and SSC-4 (cathode Cu metal rods) and CUPD-1 (Cu anode sawings), originally developed by the Canada Centre for Mineral and Energy Technology (CANMET) as certified reference materials for trace element analysis, as Cu isotope reference materials for LA-MC-ICP-MS analysis and solution nebulization (SN) of Cu. Read More

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Human Blood Plasma Shapes Distinct Neonatal TLR-Mediated Dendritic Cell Activation via Expression of the MicroRNA Let-7g.

Immunohorizons 2021 Apr 30;5(4):246-256. Epub 2021 Apr 30.

Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA;

The newborn innate immune system is characterized as functionally distinct, resulting in impaired proinflammatory responses to many stimuli and a bias toward Th2 development. Although the magnitude of impairment can be partially overcome, for instance through activation of TLR7/8 in newborn dendritic cells, the newborn innate response remains distinct from that of adults. Using human in vitro modeling of newborn and adult dendritic cells, we investigated the role of extracellular and intracellular regulators in driving age-specific responses to TLR7/8 stimulation. Read More

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Silver nanoparticles protect against arsenic induced genotoxicity via attenuating arsenic bioaccumulation and elevating antioxidation in mammalian cells.

J Hazard Mater 2021 Jul 5;413:125287. Epub 2021 Feb 5.

Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Chinese Academy of Sciences; Anhui Province Key Laboratory of Environmental Toxicology and Pollution Control Technology, High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, PR China. Electronic address:

Arsenic (As) and its compounds have been classified as Group I carcinogenic agents by the International Agency for Research on Cancer (IARC); however, there is few specific and efficient antidotes used for As detoxification. The present study aimed to investigate the protective effects of silver nanoparticles (AgNPs) at non-toxic concentrations on As(Ⅲ) induced genotoxicity and the underlying mechanism. Our data showed that AgNPs pretreatment significantly inhibited the generation of phosphorylated histone H2AX (γ-H2AX, marker of nuclear DNA double strand breaks) and the mutation frequencies induced by As(Ⅲ) exposure. Read More

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High spatial resolution imaging of cisplatin and Texas Red cisplatin in tumour spheroids using laser ablation isotope dilution inductively coupled plasma mass spectrometry and confocal fluorescence microscopy.

Anal Chim Acta 2021 Jun 20;1162:338424. Epub 2021 Mar 20.

Department of Environmental Sciences, Jožef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia; Jožef Stefan International Postgraduate School, Jamova 39, 1000, Ljubljana, Slovenia. Electronic address:

Oncology research uses different imaging techniques to provide information about the spatial distribution of the chemotherapy drugs used for the targeted tissues. Among them, laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is increasingly being used to track the spatial distribution of metal-based chemotherapeutics in different tissue samples. In this investigation, instrumental parameters were optimized for the bioimaging of Pt in HT29 tumour spheroids treated with cisplatin (CDDP) or Texas Red cisplatin (TR-CDDP) using LA-ICP-MS. Read More

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LDPE Transformation by Exposure to Sequential Low-Pressure Plasma and TiO/UV Photocatalysis.

Molecules 2021 Apr 26;26(9). Epub 2021 Apr 26.

Investigador Independiente, Bogotá, DC, Colombia.

Low-density polyethylene (LDPE) sheets (3.0 ± 0.1 cm) received sequential treatment, first by the action of direct-current low-pressure plasma (DC-LPP) with a 100% oxygen partial pressure, 3. Read More

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Backward Flux Re-Deposition Patterns during Multi-Spot Laser Ablation of Stainless Steel with Picosecond and Femtosecond Pulses in Air.

Materials (Basel) 2021 Apr 27;14(9). Epub 2021 Apr 27.

Laser Group, School of Engineering, University of Liverpool, Brownlow Street, Liverpool L69 3GH, UK.

We report on novel observations of directed re-deposition of ablation debris during the ultrafast laser micro-structuring of stainless steel in the air with multi-beams in close proximity on the surface. This interesting phenomenon is observed with both 10 ps and 600 fs NIR laser pulses at 5 kHz repetition rate. Ablation spot geometries could be altered with the use of beam splitting optics or a phase-only Spatial Light modulator. Read More

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Listening with Curiosity - Tracking the Acoustic Response of Portable Laser Ablation.

Chimia (Aarau) 2021 Apr;75(4):300-304

Laboratory of Inorganic Chemistry, ETH Zurich, Vladimir-Prelog-Weg 1, Zurich, Switzerland.

Nowadays, one of the methods of choice for minimal invasive sampling of solid matter is laser ablation (LA). Routine LA sampling is performed commonly in the laboratory and the amount of ablated mass can directly be monitored and analysed. By contrast laser-based sampling in the field, using a portable laser ablation system (pLA), still remains challenging concerning low-absorbing or NIR-transparent samples. Read More

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Laser-Induced Breakdown Spectroscopy Combined with Temporal Plasma Analysis of C Molecular Emission for Carbon Analysis in Coal.

Appl Spectrosc 2021 May 13:37028211012399. Epub 2021 May 13.

Department of Applied Mechanics, 37268Indian Institute of Technology Madras, Chennai, India.

A benchtop laser-induced breakdown spectroscopy is demonstrated to determine the elemental carbon content present in raw coal used for combustion in power plants. The spectral intensities of molecular CN and C emission are measured together with the atomic carbon (C) and other inorganic elements (Si, Fe, Mg, Al, Ca, Na, and K) in the laser-induced breakdown spectroscopy spectrum of coal. The emission persistence time of C molecule emission is measured from the coal plasma generated by a nanosecond laser ablation with a wavelength of 266 nm in the Ar atmosphere. Read More

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Modeling of short-pulse laser-metal interactions in the warm dense matter regime using the two-temperature model.

Phys Rev E 2021 Mar;103(3-1):033204

Naval Research Laboratory, Plasma Physics Division, 4555 Overlook Avenue SW, Washington, DC 20375, USA.

A numerical model for laser-matter interactions in the warm dense matter regime is presented with broad applications, e.g., ablation, thermionic emission, and radiation. Read More

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Analysis of electrostimulation and electroporation by high repetition rate bursts of nanosecond stimuli.

Bioelectrochemistry 2021 Apr 1;140:107811. Epub 2021 Apr 1.

Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508, USA. Electronic address:

Exposures to short-duration, strong electric field pulses have been utilized for stimulation, ablation, and the delivery of molecules into cells. Ultrashort, nanosecond duration pulses have shown unique benefits, but they require higher field strengths. One way to overcome this requirement is to use trains of nanosecond pulses with high repetition rates, up to the MHz range. Read More

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Attenuated β-adrenergic response in calcium/calmodulin-dependent protein kinase IV-knockout mice.

PLoS One 2021 15;16(4):e0249932. Epub 2021 Apr 15.

Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Japan.

In the present study, we examined the importance of Ca2+/calmodulin-dependent protein kinase IV (CaMKIV) in the regulation of cardiac function using genetically modified CaMKIV-null mice. RT-PCR analysis revealed decreased expression of voltage-dependent calcium channels in the cardiac myocytes of CaMKIV-null mice compared with wild-type mice. CaMKIV-null mice showed shortened QT time on electrocardiograms. Read More

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Analysis of lead distribution in avian organs by LA-ICP-MS: Study of experimentally lead-exposed ducks and kites.

Environ Pollut 2021 Apr 5;283:117086. Epub 2021 Apr 5.

Laboratory of Toxicology, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo, Hokkaido, 060-0818, Japan.

Lead poisoning of wild birds by ingestion of lead ammunition occurs worldwide. Histopathological changes in organs of lead-intoxicated birds are widely known, and lead concentration of each organ is measurable using mass spectrometry. However, detailed lead localization at the suborgan level has remained elusive in lead-exposed birds. Read More

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Treatment of Recurrent Respiratory Papillomatosis: Case Series and Review of Technique.

Surg Technol Int 2021 04 9;38. Epub 2021 Apr 9.

Fox Chase Cancer Center, Philadelphia, PA.

Adult Recurrent Respiratory Papillomatosis (RRP) is a rare disease caused by the human papilloma virus in which papilloma grows from the respiratory epithelium. Patients can suffer from significant respiratory distress secondary to tracheal or bronchial obstruction by papilloma and the mainstay of treatment is bronchoscopic debridement. There are a variety of techniques to resect the endoluminal tumor, including CO2 or YAG laser, argon plasma coagulation, microdebrider and cold forceps. Read More

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Neuroplastin expression is essential for hearing and hair cell PMCA expression.

Brain Struct Funct 2021 Jun 12;226(5):1533-1551. Epub 2021 Apr 12.

Neurogenetics Laboratory, Leibniz Institute for Neurobiology, Brenneckestr. 6, 39118, Magdeburg, Germany.

Hearing deficits impact on the communication with the external world and severely compromise perception of the surrounding. Deafness can be caused by particular mutations in the neuroplastin (Nptn) gene, which encodes a transmembrane recognition molecule of the immunoglobulin (Ig) superfamily and plasma membrane Calcium ATPase (PMCA) accessory subunit. This study investigates whether the complete absence of neuroplastin or the loss of neuroplastin in the adult after normal development lead to hearing impairment in mice analyzed by behavioral, electrophysiological, and in vivo imaging measurements. Read More

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Biomarkers of Inflammation and Risk of Hospitalization for Heart Failure in Patients With Atrial Fibrillation.

J Am Heart Assoc 2021 Apr 10;10(8):e019168. Epub 2021 Apr 10.

Population Health Research Institute McMaster University Hamilton Canada.

Background Hospitalization for heart failure (HF) is very common in patients with atrial fibrillation (AF). We hypothesized that biomarkers of inflammation can identify patients with AF at increased risk of this important complication. Methods and Results Patients with established AF were prospectively enrolled. Read More

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Chronic hip pain in adults: Current knowledge and future prospective.

J Anaesthesiol Clin Pharmacol 2020 Oct-Dec;36(4):450-457. Epub 2020 Sep 26.

Consultant Orthopaedics, Orthomax Hospital, Panchkula, Haryana, India.

Chronic hip pain is distressing to the patient as it not only impairs the daily activities of life but also affects the quality of life. Chronic hip pain is difficult to diagnose as patients often present with associated chronic lumbar spine and/or knee joint pain. Moreover, nonorthopaedic causes may also present as chronic hip pain. Read More

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September 2020

Hepatocyte Neogenin Is Required for Hemojuvelin-Mediated Hepcidin Expression and Iron Homeostasis in Mice.

Blood 2021 Apr 6. Epub 2021 Apr 6.

Oregon Health and Science University, Portland, Oregon, United States.

Neogenin (NEO1) is a ubiquitously expressed multi-functional transmembrane protein. It interacts with hemojuvelin (HJV), a BMP co-receptor that plays a pivotal role in hepatic hepcidin expression. Earlier studies suggest that the function of HJV relies on its interaction with NEO1. Read More

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Immunological memory in rheumatic inflammation - a roadblock to tolerance induction.

Nat Rev Rheumatol 2021 May 6;17(5):291-305. Epub 2021 Apr 6.

Deutsches Rheuma-Forschungszentrum Berlin, a Leibniz Institute, Berlin, Germany.

Why do we still have no cure for chronic inflammatory diseases? One reason could be that current therapies are based on the assumption that chronic inflammation is driven by persistent 'acute' immune reactions. Here we discuss a paradigm shift by suggesting that beyond these reactions, chronic inflammation is driven by imprinted, pathogenic 'memory' cells of the immune system. This rationale is based on the observation that in patients with chronic inflammatory rheumatic diseases refractory to conventional immunosuppressive therapies, therapy-free remission can be achieved by resetting the immune system; that is, by ablating immune cells and regenerating the immune system from stem cells. Read More

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LRG1 Mitigates Renal Interstitial Fibrosis through Alleviating Capillary Rarefaction and Inhibiting Inflammatory and Pro-Fibrotic Cytokines.

Am J Nephrol 2021 6;52(3):228-238. Epub 2021 Apr 6.

Division of Internal Medicine, Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Introduction: Increasing evidence has demonstrated that loss of peritubular capillaries plays a critical role in renal interstitial fibrosis. Leucine-rich α2-glycoprotein-1 (LRG1) has been observed promoting angiogenesis in the ocular disease mouse model and myocardial infarction model. We aimed to explore the role of LRG1 in renal interstitial fibrosis. Read More

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