170 results match your criteria plants vaginalis

A review study on the anti-trichomonas activities of medicinal plants.

Int J Parasitol Drugs Drug Resist 2021 Feb 12;15:92-104. Epub 2021 Feb 12.

Universidade do Grande Rio (UNIGRANRIO) and UFRJ (Universidade Federal do Rio de Janeiro), Rio de Janeiro, Brazil.

The parasitic diseases represent the most important health risk, especially in underdeveloped countries where they have a deep impact on public health. Trichomoniasis is a prevalent non-viral sexually transmitted disease, and a significant amount of new cases are identified each year globally. Furthermore, the infection is linked with serious concerns such as pregnancy outcomes, infertility, predisposition to cervical and prostate cancer, and increased transmission and acquisition of HIV. Read More

View Article and Full-Text PDF
February 2021

Melaleuca alternifolia (tea tree) oil and its monoterpene constituents in treating protozoan and helminthic infections.

Biomed Pharmacother 2020 Oct 2;130:110624. Epub 2020 Sep 2.

Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; Key Laboratory of Tropical Disease Control of Ministry of Education, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Australian tea tree (Melaleuca alternifolia) oil (TTO) and its monoterpene constituents such as terpinen-4-ol (T4O), 1,8-cineole, limonene, p-cymene, and α-terpinene have been shown to be effective in controlling a wide range of parasitic infections. The anti-parasitic effects of these compounds are mainly due to their anti-histamine and anti-acetylcholinesterase activities as well as their ability to modulate host inflammatory responses. This review attempts to summarize recent advances in the uses of TTO and its 15 major monoterpene constituents in treating parasitic infections in both humans and animals. Read More

View Article and Full-Text PDF
October 2020

Production and Functional Characterization of a Recombinant Predicted Pore-Forming Protein (TVSAPLIP12) of in Plants.

Front Cell Infect Microbiol 2020 30;10:581066. Epub 2020 Sep 30.

Department of Biomedical Sciences, University of Sassari, Sassari, Italy.

Pore-forming proteins (PFPs) are a group of functionally versatile molecules distributed in all domains of life, and several microbial pathogens notably use members of this class of proteins as cytotoxic effectors. Among pathogenic protists, , and display a range of pore-forming toxins belonging to the Saposin-Like Proteins (Saplip) family: Amoebapores and Naegleriapores. Following the genome sequencing of , we identified a gene family of 12 predicted saposin-like proteins (TvSaplips): this work focuses on investigating the potential role of TvSaplips as cytopathogenetic effectors. Read More

View Article and Full-Text PDF
September 2020

Anti-trichomonad activities of different compounds from foods, marine products, and medicinal plants: a review.

BMC Complement Med Ther 2020 Sep 9;20(1):271. Epub 2020 Sep 9.

Department of Biological Sciences, University of the Pacific, Stockton, CA, 95211, USA.

Human trichomoniasis, caused by the pathogenic parasitic protozoan Trichomonas vaginalis, is the most common non-viral sexually transmitted disease that contributes to reproductive morbidity in affected women and possibly to prostate cancer in men. Tritrichomonas foetus strains cause the disease trichomoniasis in farm animals (cattle, bulls, pigs) and diarrhea in domestic animals (cats and dogs). Because some T. Read More

View Article and Full-Text PDF
September 2020

Traditional medicinal plants used by the Mon people in Myanmar.

J Ethnopharmacol 2021 Jan 3;265:113253. Epub 2020 Sep 3.

Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China; Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences, Yezin, Nay Pyi Taw, 05282, Myanmar. Electronic address:

Ethnopharmacological Relevance: Myanmar's Mon people largely depend on a traditional medical system for health care, however, information about their medical plants is rare in the current literature. In this first ethnobotanical study of Mon traditional medicinal plants (MTMs), we attempt to answer three research questions: 1) What species are used as MTMs by the Mon people and what diseases can be treated with these MTMs? 2) What are the general characteristics of these MTMs? 3) Which species and their usages have high consensus of knowledge?

Aim Of The Study: We aimed (1) to document both the diversity of medicinal plants used by the Mon people and their knowledge of the therapeutic usages of these plants; and (2) to quantitatively identify the most well-known medicinal plant species and prevalent diseases treated by these species, and to evaluate the status of scientific research and application for each of these species.

Materials And Methods: Ethnobotanical surveys and interviews were carried out in 10 villages in four townships of Mon State, Myanmar in 2018. Read More

View Article and Full-Text PDF
January 2021

Evaluation of the effect of some medicinal plants on cultured Trichomonas Vaginalis.

J Infect Dev Ctries 2020 07 31;14(7):793-799. Epub 2020 Jul 31.

Department of Medical Parasitology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Introduction: Trichomoniasis is a worldwide sexually transmitted disease caused by Trichomonas vaginalis. It inflicts severe complications to the human genitourinary system. The devastating negative effects and the emergence of resistance to common medication impose the search for safer and effective alternatives. Read More

View Article and Full-Text PDF

L.: A Phytochemical and Pharmacological Overview.

Molecules 2020 Jun 24;25(12). Epub 2020 Jun 24.

Institute of Field and Vegetable Crops Novi Sad, Maksima Gorkog 30, 21000 Novi Sad, Serbia.

is a plant with high bioactive potential. It contains marrubiin, a labdane diterpene that is characteristic for this genus, as well as a complex mixture of phenolic compounds. According to numerous studies, acts as a good antioxidant agent, and due to this, it could potentially be useful in treatments of cancer, diabetes mellitus, and liver diseases. Read More

View Article and Full-Text PDF

Trichomonas vaginalis NTPDase inhibited by lycorine modulates the parasite-neutrophil interaction.

Parasitol Res 2020 Aug 11;119(8):2587-2595. Epub 2020 Jun 11.

Laboratório de Pesquisa em Parasitologia, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, Porto Alegre, RS, 90610-000, Brazil.

Lycorine is an Amaryllidaceae alkaloid that presents anti-Trichomonas vaginalis activity. T. vaginalis causes trichomoniasis, the most common non-viral sexually transmitted infection. Read More

View Article and Full-Text PDF

Characterization of the acetolactate synthase gene family in sensitive and resistant biotypes of two tetraploid Monochoria weeds, M. vaginalis and M. korsakowii.

Pestic Biochem Physiol 2020 May 5;165:104506. Epub 2019 Dec 5.

Faculty of Agriculture, Department of Environmental Bioscience, Tenpaku-ku Shiogamaguchi 1-501, Meijo University, Nagoya 468-8502, Japan.

Monochoria vaginalis and M. korsakowii are allotetraploid noxious weeds in rice cultivation. Occurrences of resistance to acetolactate synthase (ALS)-inhibiting herbicides have been reported in these weeds in Japan since the 1990s. Read More

View Article and Full-Text PDF

In Vitro Activity of and Its Main Essential Oil Component Trans-Anethole on .

Iran J Parasitol 2019 Oct-Dec;14(4):631-638

Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: Trichomoniasis is one of the most common nonviral sexually transmitted infections worldwide which drug-resistant cases of the infection are rising. The aim of the study was to assessment the in vitro activity of and its main essential oil component on . Also phytochemical investigation of essential oil was performed. Read More

View Article and Full-Text PDF
February 2020

In vitro anti-Trichomonas vaginalis activity of Haplophyllum myrtifolium.

J Infect Dev Ctries 2019 03 31;13(3):240-244. Epub 2019 Mar 31.

Department of Microbiology, Faculty of Medicine, İzmir Katip Çelebi University, İzmir, Turkey.

Introduction: In the classic treatment of Trichomonas vaginalis infection, although metronidazole has been used since the 1960s, there has been an increase in MTZ-resistant T. vaginalis strains and failure in the treatment of trichomoniasis causes serious concerns. Therefore, the present study aimed to investigate the in vitro antitrichomonal activities of extracts (ethanol and total alkaloid) and pure compounds (chrysosplenetin, dictamnine, gamma-Fagarine, skimmianine) of H. Read More

View Article and Full-Text PDF

Is there association between Trichomonas vaginalis infection and prostate cancer risk?: A systematic review and meta-analysis.

Microb Pathog 2019 Dec 17;137:103752. Epub 2019 Sep 17.

Toxoplasmosis Research Center, Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

We performed a systematic review and meta-analysis to reveal the association between Trichomonas vaginalis (TV) infection and the risk of prostate cancer (PCa) development. Systematic searching (PubMed/Medline, Scopus, Embase, Web of Science, Cinhal, Wiley, Cochrane, Psychoinfo, ProQuest and Google Scholar) was done, up to March 2018 for case-control studies. Random effects model was applied to define odds ratios and their 95% confidence intervals. Read More

View Article and Full-Text PDF
December 2019

Eucalyptus camaldulensis properties for use in the eradication of infections.

Comp Immunol Microbiol Infect Dis 2019 Aug 25;65:234-237. Epub 2019 Apr 25.

Department of Environment, College of Science, University of Al-Qadisiyah, Ad Diwanyah, Iraq. Electronic address:

Eucalyptus camaldulensis (E. camaldulensis), called the eucalyptus has so many characteristics such as antimicrobial features. Common names include red gum, red chewing gum, river chewing gum, red chewing gum. Read More

View Article and Full-Text PDF

Medicinal Plants with Anti- Activity in Iran: A Systematic Review.

Iran J Parasitol 2019 Jan-Mar;14(1):1-9

Student Research Committee, Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Background: Trichomoniasis, due to , is one of the most common sexually transmitted parasitic diseases in the world such as Iran. This systematic review aimed to explore the studies evaluating the medicinal herbs with anti- activity which used in Iran.

Methods: Articles published in 4 Persian and 4 English databases were obtained between 2000 and 2015 including Google Scholar, PubMed, Science Direct, Scopus, Magiran, Barakatkns (formerly IranMedex), Elm net, and SID (Scientific Information Database). Read More

View Article and Full-Text PDF

Nectandra as a renewable source for (+)-α-bisabolol, an antibiofilm and anti-Trichomonas vaginalis compound.

Fitoterapia 2019 Jul 21;136:104179. Epub 2019 May 21.

Laboratório de Produtos Naturais e Espectrometria de Massas (LaPNEM), Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição (FACFAN), Universidade Federal de Mato Grosso do Sul (UFMS), 79070-900, Campo Grande, MS, Brazil. Electronic address:

Essential oils, mixtures of volatile compounds, are targets of research for new antimicrobial drugs. In order to verify the potential from species of the Nectandra genus, the present study evaluated the essential oils from Nectandra amazonum, Nectandra cuspidata, Nectandra gardineri, Nectandra hihua and Nectandra megapotamica to prospect samples with high concentration of a component and its antibacterial, antibiofilm and anti-Trichomonas vaginalis activities. The essential oils from the leaves and barks were extracted by steam distillation and analyzed by gas chromatography coupled to mass spectrometry (GC-MS). Read More

View Article and Full-Text PDF

Structure-activity relationship and synthetic methodologies of α-santonin derivatives with diverse bioactivities: A mini-review.

Eur J Med Chem 2019 Aug 4;175:215-233. Epub 2019 May 4.

College of Food Science and Technology, Shanghai Ocean University, Shanghai, 201306, China; Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai, 201306, China; Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai), Ministry of Agriculture, Shanghai, 201306, China. Electronic address:

α-Santonin, a sesquiterpene lactone isolated from Artemisia Santonica, possesses diverse bioactivities including antioxidant, anti-inflammation, immunosuppressive, anti-roundworm, anti-malaria, etc. However, its bioactivities are not satisfactory and need to be further optimized. Thus, many α-santonin derivatives were synthesized on the basis of rings A, B and C for the discovery of new analogues with prominent bioactivities. Read More

View Article and Full-Text PDF

Mulberry Leaf Polyphenols and Fiber Induce Synergistic Antiobesity and Display a Modulation Effect on Gut Microbiota and Metabolites.

Nutrients 2019 May 6;11(5). Epub 2019 May 6.

Guangdong Key Laboratory of Agricultural Products Processing, Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China.

The antiobesity molecular mechanisms of mulberry leave components were analyzed based on intestinal micro-ecology and metabolomics. An obesity model was established by feeding rats with a high-calorie diet. Rats were divided into seven groups: the obesity model control (MC), positive control (PC), mulberry leaf powder (MLP), mulberry leaf fiber (MLF), mulberry leaf polyphenols (MLPS), mulberry leaf fiber and polyphenols mixture (MLM), and normal control (NC), and fed daily for 6 consecutive weeks. Read More

View Article and Full-Text PDF

Could targeting neighboring bacterial populations help combat bacterial vaginosis?

Nuno Cerca

Future Microbiol 2019 03 11;14:365-368. Epub 2019 Mar 11.

Centre of Biological Engineering (CEB), Laboratory of Research in Biofilms Rosário Oliveira, University of Minho, Campus de Gualtar, Braga, Portugal.

View Article and Full-Text PDF

Chemotherapeutic options for the treatment of human trichomoniasis.

Int J Antimicrob Agents 2019 Feb 27;53(2):116-127. Epub 2018 Oct 27.

Institute of Specific Prophylaxis and Tropical Medicine, Centre for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, A-1090 Vienna, Austria. Electronic address:

Trichomonas vaginalis is the causative agent of the most common non-viral sexually transmitted disease worldwide. The infection may be associated with severe complications, including infertility, preterm labour, cancer and an increased risk of human immunodeficiency virus (HIV) transmission. Treatment remains almost exclusively based on 5-nitroimidazoles, but resistance is on the rise. Read More

View Article and Full-Text PDF
February 2019

Trichomonicidal activity of a new anthraquinone isolated from the roots of Morinda panamensis Seem.

Drug Dev Res 2019 02 20;80(1):155-161. Epub 2018 Dec 20.

Posgrado de Ciencias Genómicas, Universidad Autónoma de la Ciudad de México, Mexico, D.F., Mexico.

Trichomoniasis, caused by the protozoan parasite Trichomonas vaginalis, is the most common nonviral sexually transmitted infection worldwide. Although drug treatment is available, unpleasant side effects and increased resistance to the nitroimidazole family have been documented. Hence, there is a need for the identification of new and safe therapeutic agents against T. Read More

View Article and Full-Text PDF
February 2019

Targeting of tail-anchored proteins to Trichomonas vaginalis hydrogenosomes.

Mol Microbiol 2019 03 8;111(3):588-603. Epub 2019 Jan 8.

Department of Parasitology, Faculty of Science, Charles University, BIOCEV, Průmyslová 595, Vestec, 25242, Czech Republic.

Tail-anchored (TA) proteins are membrane proteins that are found in all domains of life. They consist of an N-terminal domain that performs various functions and a single transmembrane domain (TMD) near the C-terminus. In eukaryotes, TA proteins are targeted to the membranes of mitochondria, the endoplasmic reticulum (ER), peroxisomes and in plants, chloroplasts. Read More

View Article and Full-Text PDF

Comparative effect of manuka honey on anaerobic parasitic protozoans with standard drug therapy under conditions: A preliminary study.

Indian J Pharmacol 2018 Jul-Aug;50(4):197-203

Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: From the past five decades, metronidazole and tinidazole have been used for treating nonresistant and resistant giardiasis and trichomoniasis. However, due to the occurrence of drug resistance to standard therapy idealizes us to explore some additional therapies which is cost-effective, easy accessibility, and natural which has least side effects. Manuka honey obtained from is well known for its antibacterial and wound healing properties and is thought to be a better option as an additional therapy. Read More

View Article and Full-Text PDF

Tracking leading anti- compounds in plant samples; .

Iran J Microbiol 2018 Jun;10(3):187-193

Department of Biology, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran.

Background And Objectives: Due to the importance of finding new and more effective antifungal and antibacterial compounds against invasive vaginitis strains, this study was conducted for fast screening of plant samples.

Materials And Methods: Thirty Iranian plant samples were successively extracted by -hexane, ethyl acetate and methanol to obtain a total of 90 extracts. Each extract was prepared in six concentrations and evaluated for antifungal activity via a micro-broth dilution method. Read More

View Article and Full-Text PDF

Potato Peels and Their Bioactive Glycoalkaloids and Phenolic Compounds Inhibit the Growth of Pathogenic Trichomonads.

J Agric Food Chem 2018 Aug 24;66(30):7942-7947. Epub 2018 Jul 24.

Department of Biological Sciences , University of the Pacific , Stockton , California 95211 , United States.

Potato peel, a waste product of the potato processing industry, is high in bioactive compounds. We investigated the in vitro antitrichomonad activity of potato peel powders prepared from commercial Russet, red, purple, and fingerling varieties as well as several known potato components, alkaloids and phenolic compounds, against three pathogenic strains of trichomonads. Trichomonas vaginalis is a sexually transmitted protozoan parasite that causes the human disease trichomoniasis. Read More

View Article and Full-Text PDF

Anti-Trichomonas vaginalis activities and apoptotic effects of some Iranian medicinal plants.

Trop Biomed 2018 Jun;35(2):347-353

Bogomolets National Medical University, Kyiv, Ukraine.

richomonas (T.) vaginalis a protozoan parasite that causes trichomoniasis is one of the most widespread sexually transmitted diseases. Aim of the present study is to evaluate the in vitro antitrichomonal properties of plant extracts of Quercus (Q. Read More

View Article and Full-Text PDF

A review of the traditional use of southern African medicinal plants for the treatment of selected parasite infections affecting humans.

J Ethnopharmacol 2018 Jun 3;220:250-264. Epub 2018 Apr 3.

Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Rd, Parktown, Gauteng 2193, South Africa. Electronic address:

Ethnopharmacological Relevance: Worldwide, more than three billion cases of parasitic disease are reported yearly and it is likely that this figure is substantially under-estimated. Approximately one in six people globally are estimated to be infected with at least one parasite species annually. In South Africa, the prevalence of Schistosoma haematobium (bilharzia) and intestinal worms and helminths are particularly high, especially in children and in crowded or poorer rural communities with inadequate sanitation and nutrition. Read More

View Article and Full-Text PDF

Activity of Lactobacilli with Probiotic Potential Isolated from Cocoa Fermentation against .

Biomed Res Int 2017 31;2017:3264194. Epub 2017 Oct 31.

Departamento de Ciências Biológicas, Laboratório de Imunologia, Centro de Biotecnologia e Genética, Universidade Estadual de Santa Cruz (UESC), Campus Soane Nazaré de Andrade, Salobrinho, Rodovia Jorge Amado, Km 16, 45662-900 Ilhéus, BA, Brazil.

Study of the probiotic potential of microorganisms isolated from fermented foods has been increasing, especially studies related to lactobacilli. In intestinal models, lactobacilli have demonstrated beneficial properties, such as anti-inflammatory activity and increased antibody production, but the molecular mechanisms involving probiotic and antagonistic action as well as their effect on human vaginal cells have not yet been fully elucidated. The aim of this study was to evaluate the functional and antagonistic properties of three strains of lactobacilli isolated from cocoa fermentation ( 5. Read More

View Article and Full-Text PDF

Trichomonicidal and parasite membrane damaging activity of bidesmosic saponins from Manilkara rufula.

PLoS One 2017 30;12(11):e0188531. Epub 2017 Nov 30.

Laboratório de Pesquisa em Parasitologia, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.

The infection caused by Trichomonas vaginalis is the most common but overlooked non-viral sexually transmitted disease worldwide. Treatment relies on one class of drugs, the 5-nitroimidazoles, but resistance is widespread. New drugs are urgently needed. Read More

View Article and Full-Text PDF
December 2017

Phytochemical-rich foods inhibit the growth of pathogenic trichomonads.

BMC Complement Altern Med 2017 Sep 13;17(1):461. Epub 2017 Sep 13.

Healthy Processed Foods Research Unit, Agricultural Research Service, United States Department of Agriculture, Albany, CA, 94710, USA.

Background: Plants produce secondary metabolites that often possess widespread bioactivity, and are then known as phytochemicals. We previously determined that several phytochemical-rich food-derived preparations were active against pathogenic foodborne bacteria. Trichomonads produce disease (trichomoniasis) in humans and in certain animals. Read More

View Article and Full-Text PDF
September 2017


Afr J Tradit Complement Altern Med 2016 3;13(4):162-165. Epub 2016 Jul 3.

Facultad de Química, Universidad Autónoma de Yucatán, C. 41 No. 421 Col. Industrial, C.P. 97150, Mérida, Yucatán, México.

Background: Chagas disease, amebiasis, giardiasis and trichomoniasis represent a serious health problem in Latin America. The drugs employed to treat these illnesses produce important side effects and resistant strains have appeared. The present study was aimed to evaluate the antiprotozoal activity of leaves, stem bark and root bark of , a celastraceus, that is used in Mexico as an anti-infective in febrile-type diseases. Read More

View Article and Full-Text PDF
September 2017