37,632 results match your criteria plants inhibitory


Correlational nutritional relationships and interactions between expansive holoparasite Orobanche laxissima and woody hosts on metal-rich soils.

Phytochemistry 2021 Jul 23;190:112844. Epub 2021 Jul 23.

Center for Research and Conservation of Biodiversity, Department of Enviromental Biology, Institute of Biology, Jan Kochanowski University, Uniwersytecka 7 Street, PL-25-406, Kielce, Poland. Electronic address:

Plant parasitism by other plants, combined with abiotic environmental stress, offers a unique opportunity to study correlational nutritional relationships in terms of parasite-host interactions and their functional roles in nutrient cycling in ecosystems. Our study analysed the transfer of selected mineral elements, including heavy metals, from soil to different organs in hosts (Punica granatum and Fraxinus angustifolia) and from hosts to the expansive holoparasite (Orobanche laxissima) in cinnamonic soil habitats in Georgia (Caucasus). We also identified other correlated trophic and bioactive effects in the parasite-host relationship. Read More

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Exploring Phytochemicals of Traditional Medicinal Plants Exhibiting Inhibitory Activity Against Main Protease, Spike Glycoprotein, RNA-dependent RNA Polymerase and Non-Structural Proteins of SARS-CoV-2 Through Virtual Screening.

Front Pharmacol 2021 8;12:667704. Epub 2021 Jul 8.

Tamil Nadu Agricultural University, Coimbatore, India.

Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) being a causative agent for global pandemic disease nCOVID'19, has acquired much scientific attention for the development of effective vaccines and drugs. Several attempts have been made to explore repurposing existing drugs known for their anti-viral activities, and test the traditional herbal medicines known for their health benefiting and immune-boosting activity against SARS-CoV-2. In this study, efforts were made to examine the potential of 605 phytochemicals from 37 plant species (of which 14 plants were endemic to India) and 139 antiviral molecules (Pubchem and Drug bank) in inhibiting SARS-CoV-2 multiple protein targets through a virtual screening approach. Read More

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Cadinane-type sesquiterpenes with potential anti-inflammatory and anti-HIV activities from the stems and leaves of .

Nat Prod Res 2021 Jul 24:1-7. Epub 2021 Jul 24.

Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China.

Eight cadinane-type sesquiterpenes, including a new cadinane-type sesquiterpene, named as mappianiodene (), and seven known analogues (-), were isolated and identified from the stems and leaves of . The chemical structure and absolute configurations of was elucidated by extensive spectral methods and the known compounds were identified by comparing their experimental spectral data with the reported spectral data in the literature. The anti-inflammatory and anti-HIV activities of those isolated cadinane-type sesquiterpenes were tested. Read More

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Resveratrol Production from Hydrothermally Pretreated Eucalyptus Wood Using Recombinant Industrial Strains.

ACS Synth Biol 2021 Jul 24. Epub 2021 Jul 24.

Centre of Biological Engineering, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal.

Resveratrol is a phenolic compound with strong antioxidant activity, being promising for several applications in health, food, and cosmetics. It is generally extracted from plants or chemically synthesized, in both complex and not sustainable processes, but microbial biosynthesis of resveratrol can counter these drawbacks. In this work, resveratrol production by microbial biosynthesis from lignocellulosic materials was assessed. Read More

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Active constituents of Zanthoxylum nitidium from Yunnan Province against leukaemia cells in vitro.

BMC Chem 2021 Jul 23;15(1):44. Epub 2021 Jul 23.

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, China.

Zanthoxylum nitidium (Roxb.) DC (Rutaceae) is well known for inhibiting the proliferation of human gastric, liver, kidney and lung cancer cells, though research on its potential use in treating leukaemia is relatively rare. Twenty-six compounds were isolated from the chloroform and petroleum ether extracts of the roots and leaves of Z. Read More

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Physicochemical and Biological Properties of Polysaccharides from Prepared by Different Extraction Techniques.

Polymers (Basel) 2021 Jul 19;13(14). Epub 2021 Jul 19.

Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering & Technology Research Center of Coarse Cereal Industralization, School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China.

In this study, different extraction techniques, including traditional hot water extraction (HWE), microwave-assisted extraction (MAE), pressurized assisted extraction (PAE), and ultrasonic-assisted extraction (UAE), were used to extract polysaccharides (DFPs), and their physicochemical and biological properties were compared. Results revealed that extraction yields of polysaccharides prepared by different extraction techniques ranged from 5.62% to 6. Read More

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Chemical Profile, Antioxidant Capacity, and Antimicrobial Activity of Essential Oils Extracted from Three Different Varieties (Moldoveanca 4, Vis Magic 10, and Alba 7) of .

Molecules 2021 Jul 20;26(14). Epub 2021 Jul 20.

Faculty of Food Engineering, Tourism and Environmental Protection, "Aurel Vlaicu" University of Arad, 310330 Arad, Romania.

Chemical composition, antioxidant capacity, and antimicrobial activity of lavender essential oils (LEOs) extracted from three different varieties of Mill. (1-Moldoveanca 4, 2-Vis magic 10, and 3-Alba 7) have been determined. These plants previously patented in the Republic of Moldova were cultivated in an organic agriculture system in the northeastern part of Romania and then harvested in 3 consecutive years (2017-2019) to obtain the essential oils. Read More

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Bioguided Isolation of Active Compounds from against Methicillin-Resistant (MRSA) and Panton-Valentine Leucocidin Positive Strains (MSSA-PVL).

Molecules 2021 Jul 19;26(14). Epub 2021 Jul 19.

Laboratory of Microbial Biotechnology and Bioactive Molecules, Department of Biology, Faculty of Sciences and Techniques, Sidi Mohamed Ben Abdellah University, Fez 2202, Morocco.

Despite intensified efforts to develop an effective antibiotic, is still a major cause of mortality and morbidity worldwide. The multidrug resistance of bacteria has considerably increased the difficulties of scientific research and the concomitant emergence of resistance is to be expected. In this study we have investigated the in vitro activity of 15 ethanol extracts prepared from Moroccan medicinal plants traditionally used for treatment of skin infections. Read More

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Two New Iridoid Glucosides from the Whole Plant of Link.

Molecules 2021 Jul 10;26(14). Epub 2021 Jul 10.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

As a traditional Chinese medicine, Link has been used to treat various inflammatory-related diseases, and recent studies have shown that it possesses potent anti-inflammatory activity. Therefore, phytochemical investigation on whole plants of were carried out, which led to the isolation of two new iridoid glucosides, patriniscabiosides A () and B (), together with six known compounds (-). The structural elucidation of all compounds was performed by HRESIMS and extensive spectroscopic analyses including IR, 1D, 2D NMR, and electronic circular dichroism (ECD). Read More

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HopA1 Effector from pv Strain 61 Affects NMD Processes and Elicits Effector-Triggered Immunity.

Int J Mol Sci 2021 Jul 12;22(14). Epub 2021 Jul 12.

Laboratory of Signal Transduction and Plant Resistance, UNESCO-Regional Centre for Biotechnology (RCB), NCR Biotech Science Cluster, 3rd Milestone, Faridabad-Gurgaon Expressway, Faridabad 121 001, Haryana, India.

-secreted HopA1 effectors are important determinants in host range expansion and increased pathogenicity. Their recent acquisitions via horizontal gene transfer in several non-pathogenic Pseudomonas strains worldwide have caused alarming increase in their virulence capabilities. In , () gene confers effector-triggered immunity (ETI) against HopA1 derived from pv. Read More

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Whole Genome Sequence of Strain GUMT319: A Potential Biocontrol Agent Against Tobacco Black Shank Disease.

Front Microbiol 2021 6;12:658113. Epub 2021 Jul 6.

Guizhou Academy of Agricultural Sciences, Guiyang, China.

causes black shank, a serious soil-borne disease, in tobacco. In this study, the strain GUMT319 was isolated from the rhizosphere of healthy tobacco plants grown in a field in Guizhou with a high incidence of tobacco black shank. Genome sequencing revealed that GUMT319 contained a single circular chromosome 3,940,023 bp in length, with 4,053 predicted genes and an average GC content of 46. Read More

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Effect of polyphenols extracted from and plants on glutathione S-transferase of the cattle tick () (Acari: Ixodidae).

J Parasit Dis 2021 Jun 5;45(2):524-538. Epub 2021 Jan 5.

Department of Molecular Biology, Genetic Engineering and Biotechnology Research Division, National Research Centre, 33 El Buhouth St, Ad Doqi, Dokki, Cairo, 12622 Cairo Governorate Egypt.

Ticks are hematophageal ectoparasites that transport major pathogens around the world. Glutathione S-transferases (GST) are involved in resistance to acaricide and redox balancing during the life cycle of the tick. The inhibition of tick GST enzymes by certain phenolic compounds, such as phenolic acids and tannins, can be a promising approach to tick control. Read More

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Phytochemical and antimicrobial investigation of the leaves of five Egyptian mango cultivars and evaluation of their essential oils as preservatives materials.

J Food Sci Technol 2021 Aug 1;58(8):3130-3142. Epub 2020 Oct 1.

Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Giza, 12622 Egypt.

The sterols, hydrocarbons and fatty acids constituents of the leaves of five mango cultivars locally implanted in Egypt were identified. The effect of their essential oils (EOs) against food borne microorganisms was studied as preservative materials. The chemical constituents of the EOs isolated from mango leaves were identified by Gas Chromatography-Mass spectrometry (GC-MS) technique. Read More

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Development of edible Thai rice film fortified with ginger extract using microwave-assisted extraction for oral antimicrobial properties.

Sci Rep 2021 Jul 21;11(1):14870. Epub 2021 Jul 21.

Division of Product Development Technology, Faculty of Agro-Industry, Chiang Mai University, Chiang Mai, 50100, Thailand.

This study aimed to investigate microwave-assisted extraction (MAE) of dried ginger and to develop a rice-based edible film incorporating ginger extract. The optimal MAE conditions of 400 W microwave power and an extraction time of 1 min were determined using a 3 full factorial design. The optimized extract showed total phenolic compounds (TPC, 198. Read More

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Environmental responsiveness of flowering time in cassava genotypes and associated transcriptome changes.

PLoS One 2021 21;16(7):e0253555. Epub 2021 Jul 21.

Section of Soil and Crop Sciences, School of Integrative Plant Science, Cornell University, Ithaca, New York, United States of America.

Cassava is an important food security crop in tropical regions of the world. Cassava improvement by breeding is limited by its delayed and poor production of flowers, such that cassava flowering under field conditions indirectly lengthens the breeding cycle. By studying genotype and environment interaction under two Nigerian field conditions (Ubiaja and Ibadan) and three controlled temperature conditions (22°C/18°C, 28/24°C and 34/30°C (day/night)), we found that while early flowering genotypes flowered at similar times and rates under all growing conditions (unfavorable and favorable field and controlled-temperature environments), late flowering genotypes were environmentally sensitive such that they were substantially delayed in unfavorable environments. Read More

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Anti-angiogenic, apoptotic and matrix metalloproteinase inhibitory activity of Withania somnifera (ashwagandha) on lung adenocarcinoma cells.

Phytomedicine 2021 Jun 30;90:153639. Epub 2021 Jun 30.

Yenepoya Research Centre, Yenepoya (Deemed to be University), Deralakatte, Mangalore 575018, India. Electronic address:

Introduction: Withania somnifera belongs to the family Solanaceae, known as Queen of medicinal plants for its enormous use in the medicinal field. Traditionally ashwagandha is used to treat several neurological disorders. This study evaluates the cytotoxic, apoptotic, antiangiogenic and matrix metalloproteinase (MMP) inhibitory activity of W. Read More

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Inhibitory Potential of Dietary Nutraceuticals on Cellular PI3K/Akt Signaling: Implications in Cancer Prevention and Therapy.

Curr Top Med Chem 2021 Jul 16. Epub 2021 Jul 16.

Division of Cell and Molecular Biology, Post Graduate & Research Department of Zoology, St. Joseph's College (Autonomous), Devagiri, Calicut, Kerala, India.

Background: The phosphatidyl inositol-3 kinase (PI3K)/protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) signaling have been associated with many cellular physiological events such as proliferation, maturation, survival, and metabolism. Besides their roles in normal cells, the pathway is often upregulated in various cancers. Due to their prominent roles in the cancer progression events, it is now being considered a target for cancer therapy and cancer chemoprevention. Read More

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Endomembrane-Targeting Effectors Modulate PAMP Triggered Immune Responses in Plants.

Front Microbiol 2021 1;12:651279. Epub 2021 Jul 1.

Department of Biology, University of Saskatchewan, Saskatoon, SK, Canada.

is a devastating obligate, intracellular, biotrophic pathogen that causes clubroot disease in crucifer plants. Disease progression is regulated by effector proteins secreted by . Twelve putative effectors (PEs), expressed at various stages of disease development [0, 2, 5, 7, 14, 21, and 28 days post inoculation (DPI)] in Arabidopsis and localizing to the plant endomembrane system, were studied for their roles in pathogenesis. Read More

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Development of Synergy-Based Combination for Learning and Memory Using , and TLC-MS-Bioautographic Studies.

Front Pharmacol 2021 2;12:678611. Epub 2021 Jul 2.

Bioactive Natural Product Laboratory, Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.

The present study is aimed at developing a synergistic combination to enhance learning and memory in Alzheimer's patients with the help of eight common medicinal plants used in the AYUSH system. Aqueous and hydroalcoholic extracts of eight medicinal plants from the AYUSH system of medicine were prepared. These were subjected to anticholinesterase activity, to find out the combination index of synergistic combination. Read More

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Appraisal of hypotensive effect of natural monoterpene: Bornyl acetate and in-silico molecular docking analysis.

Pak J Pharm Sci 2021 Mar;34(2(Supplementary)):731-735

Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan.

The modern trend of research is highly focused on finding new bioactive molecules from medicinal plants. As a functional bicyclic monoterpene, Bornyl acetate (BA) has displayed antioxidant and anti-inflammatory properties in different types of cells and tissues. The purpose of this research was to evaluate the probable hypotensive effect of BA, an underlying mechanism(s) backboned by in-silico studies. Read More

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Identification of potential plant bioactive as SARS-CoV-2 Spike protein and human ACE2 fusion inhibitors.

Comput Biol Med 2021 Jul 8;136:104631. Epub 2021 Jul 8.

Structural Bioinformatics Lab, CSIR-Institute of Himalayan Bioresource Technology (CSIR-IHBT), Palampur, HP, 176061, India; Biotechnology Division, CSIR-IHBT, Palampur, HP, 176061, India; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, 201002, India. Electronic address:

The Spike receptor binding domain (S-RBD) from SARS-CoV-2, a crucial protein for the entrance of the virus into target cells is known to cause infection by binding to a cell surface protein. Hence, reckoning therapeutics for the S-RBD of SARS-CoV-2 may address a significant way to target viral entry into the host cells. Herein, through in-silico approaches (Molecular docking, molecular dynamics (MD) simulations, and end-state thermodynamics), we aimed to screen natural molecules from different plants for their ability to inhibit S-RBD of SARS-CoV-2. Read More

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Synthesis and evaluation of novel arylisoxazoles linked to tacrine moiety: in vitro and in vivo biological activities against Alzheimer's disease.

Mol Divers 2021 Jul 17. Epub 2021 Jul 17.

Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Alzheimer's disease (AD) is now ranked as the third leading cause of death after heart disease and cancer. There is no definite cure for AD due to the multi-factorial nature of the disease, hence, multi-target-directed ligands (MTDLs) have attracted lots of attention. In this work, focusing on the efficient cholinesterase inhibitory activity of tacrine, design and synthesis of novel arylisoxazole-tacrine analogues was developed. Read More

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Kolaflavanone, a biflavonoid derived from medicinal plant Garcinia, is an inhibitor of mitotic kinesin Eg5.

J Biochem 2021 Jul 15. Epub 2021 Jul 15.

Department of Bioinformatics, Graduate School of Engineering, Soka University, 1-236 Tangi-cho, Hachioji, Tokyo 192-8577, Japan.

Mitotic kinesin Eg5 remains a validated target in antimitotic therapy because of its essential role in the formation and maintenance of bipolar mitotic spindles. Although numerous Eg5 inhibitors of synthetic origin are known, only a few inhibitors derived from natural products have been reported. In our study, we focused on identifying novel Eg5 inhibitors from medicinal plants, particularly Garcinia species. Read More

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Antimicrobial Activity of Natural Plant Compound Carvacrol Against Soft Rot Disease Agent Dickeya zeae.

Curr Microbiol 2021 Jul 14. Epub 2021 Jul 14.

Key Laboratory of New Techniques for Plant Protection in Guangdong, Plant Protection Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, 510640, China.

Dickeya zeae is a globally important bacterial pathogen that has been reported to cause severe soft rot diseases in several essential food crops, including bananas, rice, maize, and potatoes. Carvacrol, a hydrophobic terpene component, is found in aromatic plants of the Labiatae family and various essential oils. However, little work has been done on its antimicrobial potential against D. Read More

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Castaneroxy A From the Leaves of Inhibits Virulence in .

Front Pharmacol 2021 28;12:640179. Epub 2021 Jun 28.

Center for the Study of Human Health, Emory University, Atlanta, GA, United States.

Methicillin-resistant (MRSA) represents one of the most serious infectious disease concerns worldwide, with the CDC labeling it a "serious threat" in 2019. The current arsenal of antibiotics works by targeting bacterial growth and survival, which exerts great selective pressure for the development of resistance. The development of novel anti-infectives that inhibit quorum sensing and thus virulence in MRSA has been recurrently proposed as a promising therapeutic approach. Read More

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Profiles of spp. Isolated from the Rhizosphere of and Their Potential to Promote Plant Growth and Suppress Fungal Phytopathogens.

J Microbiol Biotechnol 2021 Jul 15;31(8):1-10. Epub 2021 Jul 15.

Zhejiang Province Key Laboratory of Plant Secondary Metabolism and Regulation, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, P.R. China.

Members of the genus are known to play an important role in promoting plant growth and protecting plants against phytopathogenic microorganisms. In this study, 21 isolates of spp. were obtained from the root micro-ecosystem of . Read More

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Optimized microwave-assisted extraction of polyphenols and tannins from Syzygium cumini (L.) Skeels leaves through an experimental design coupled to a desirability approach.

An Acad Bras Cienc 2021 7;93(2):e20190632. Epub 2021 Jul 7.

Universidade Federal de Pernambuco/UFPE, Centro de Ciências da Saúde, Departamento de Ciências Farmacêuticas, Av. Prof. Arthur de Sá, s/n, 50740-525 Recife, PE, Brazil.

The present study consisted in optimizing the extractive method of polyphenols and total tannins of leaves of Syzygium cumini (L) Skeels assisted by microwaves to potentiate the antimicrobial activity of the dried extract of S. cumini against sensitive and resistant strains. A Box-Behnken design that consisted of 27 experimental runs coupled with a desirability function for multiple response optimization was employed to optimize the total polyphenols content and total tannins content. Read More

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Antimalarial, Antioxidant, and Toxicological Evaluation of Extracts of , , , and .

Biochem Res Int 2021 22;2021:9971857. Epub 2021 Jun 22.

Department of Chemistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

In many parts of the world, malaria undoubtedly poses a serious threat to health care systems. Malaria treatment has increasingly become complicated, primarily due to the emergence of widespread resistance of the malaria parasites to cheap and affordable malaria therapeutics. The use of herbal remedies to treat various ailments, including malaria and malaria-like ailments in Ghana is common. Read More

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Anticholinesterase Activity of Eight Medicinal Plant Species: and Studies in the Search for Therapeutic Agents against Alzheimer's Disease.

Evid Based Complement Alternat Med 2021 25;2021:9995614. Epub 2021 Jun 25.

Department of Science, University of Basilicata, Viale Dell'Ateneo Lucano 10, Potenza 85100, Italy.

Many Bangladeshi medicinal plants have been used to treat Alzheimer's disease and other neurodegenerative diseases. In the present study, the anticholinesterase effects of eight selected Bangladeshi medicinal plant species were investigated. Species were selected based on the traditional uses against CNS-related diseases. Read More

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Natural flavone tricin exerted anti-inflammatory activity in macrophage via NF-κB pathway and ameliorated acute colitis in mice.

Phytomedicine 2021 Jun 21;90:153625. Epub 2021 Jun 21.

Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong; Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong; State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants (CUHK), The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. Electronic address:

Background: Ulcerative colitis is a subtype of inflammatory bowel disease, characterized by relapsing inflammation in the gastrointestinal tract with limited treatment options. Previous studies suggested that the natural compound tricin, a flavone isolated from rice bran, could suppress chemically-induced colitis in mice, while our recent study also demonstrated the anti-metastatic effect of tricin in colon tumor-bearing mice.

Hypothesis/purpose: Here we further investigated the underlying mechanism of the inhibitory effects of tricin on lipopolysaccharides-activated macrophage RAW264. Read More

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