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Association of Delivery Outcomes With the Number of Childbirth Education Sessions.

J Perinat Neonatal Nurs 2021 Jul-Sep 01;35(3):228-236

University of Nevada Las Vegas School of Nursing (Dr Vanderlaan); University of St Thomas School of Nursing, Houston, Texas (Ms Sadler); and Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania (Dr Kjerulff).

The objective of this study was to determine whether childbirth education conducted over 3 or more sessions is more effective than courses conducted over 1 or 2 sessions. This was a secondary analysis of 2853 participants in a longitudinal study of women recruited during their first pregnancy. Data on childbirth education attendance were collected during the 1-month postpartum interview. Read More

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Toward a transitional care from childhood and adolescence to adulthood in surgical neurooncology? A lesson from the Necker-Enfants Malades and the Sainte-Anne Hospitals collaboration.

J Neurosurg Pediatr 2021 Jul 30:1-7. Epub 2021 Jul 30.

1Service de Neurochirurgie, GHU Paris-Hôpital Sainte-Anne, Paris.

Objective: Transitional care in surgical neurooncology is poorly studied. However, this period is pivotal, since it allows the patient to be empowered in his or her disease management. Here, the authors describe the experience of the Necker-Enfants Malades and the Sainte-Anne Hospital collaboration. Read More

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Utilization of ECMO in vascular surgery: A presentation of two cases.

Int J Surg Case Rep 2021 Jun 29;85:106141. Epub 2021 Jun 29.

Department of Surgery, Division of Vascular Surgery, Mayo Clinic, Jacksonville, FL, USA. Electronic address:

Introduction: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a form of temporary mechanical circulatory support commonly used during cardiothoracic interventions. Malperfusion during complex vascular procedures remains a significant risk that may potentially lead to multiple complications. Here, we report two cases highlighting the efficacy of VA-ECMO in both planned and emergent vascular interventions. Read More

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Implementation of a text-based postpartum blood pressure monitoring program at three different academic sites.

Am J Obstet Gynecol MFM 2021 Jul 27:100446. Epub 2021 Jul 27.

Division of Maternal Fetal Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA.

Background: Up to 30% of patients with hypertensive disorders of pregnancy continue to have elevated blood pressures after delivery, often necessitating medication titration or hospital evaluation in the weeks following hospital discharge. A previous randomized controlled trial demonstrated that remote blood pressure monitoring program resulted in more blood pressures and increased compliance with clinical guidelines in monitoring patients for persistent or worsening postpartum hypertension.

Objective: To measure program participant response rate during the first 10 days after hospital discharge, to assess replicability and scalability of the program, and to evaluate patient satisfaction at 3 distinct sites. Read More

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Prescription opioid fills following surgical abortion.

Contraception 2021 Jul 27. Epub 2021 Jul 27.

Science, Aetion, Inc.; 50 Congress St., Boston, MA 02109, United States. Electronic address:

Objective: To characterize opioid fills after surgical abortion among US commercially-insured women.

Study Design: We identified women aged 15-50 years with an outpatient claim for dilation and curettage or evacuation surgical abortion (D&C/D&E) in IBM MarketScan 2015-2018 and excluded patients with >1 opioid fill in the prior 90 days, evidence of opioid dependence or abuse in the prior 180 days (baseline), miscarriage in 7 days prior, or mifepristone use in 3-7 days prior. We describe the frequency of an oral opioid fill within 7 days after abortion, refill within 42 days of initial fill, and chronic use (≥6 fills) in 1 year after abortion. Read More

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Clinical and service delivery implications of omitting ultrasound before medication abortion provided via direct-to-patient telemedicine and mail.

Contraception 2021 Jul 27. Epub 2021 Jul 27.

Gynuity Health Projects, 220 East 42nd Street #710, New York, NY 10017. Electronic address:

Objectives: To compare outcomes among patients who did or did not have pre-abortion ultrasound or pelvic exam before obtaining medication abortion (MA) via direct-to-patient telemedicine and mail.

Study Design: We analyzed data from participants screened for enrollment into the TelAbortion study at five sites from March 25-September 15, 2020. We compared participants who had pre-abortion ultrasound or pelvic exam ("test-MA") to those who did not ("no-test MA"). Read More

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Cortical Motor Planning and Biomechanical Stability During Unplanned Jump-Landings in Males With ACL-Reconstruction.

J Athl Train 2021 Jul 30. Epub 2021 Jul 30.

*Goethe University, Frankfurt am Main, Germany.

Context: Athletes with anterior cruciate ligament (ACL) reconstruction exhibit increased cortical motor planning during simple sensorimotor tasks compared to healthy controls. This may interfere with proper decision-making during time-constrained movements elevating the re-injury risk.

Objective: To compare cortical motor planning and biomechanical stability during jump-landings between participants with ACL-reconstruction and healthy individuals. Read More

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Contemporary patterns of the management of truncus arteriosus (primary versus staged repair): outcomes from the Japanese National Cardiovascular Database.

Eur J Cardiothorac Surg 2021 Jul 30. Epub 2021 Jul 30.

Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Ehime, Japan.

Objectives: Although primary repair in early infancy has for decades been the prevalent strategy for management of truncus arteriosus (TA), recent concerns about the levels of morbidity and mortality have led to consideration of a staged surgical approach. Our goal was to describe recent patterns of management, to characterize patients who underwent primary or staged repair and to evaluate risk factors associated with operative mortality in a contemporary multicentre cohort.

Methods: In the Japanese Cardiovascular Surgery Database, we identified all cases of TA undergoing an initial surgical procedure from 2008 to 2018. Read More

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A review of constraints and solutions for collecting raptor samples and contextual data for a European Raptor Biomonitoring Facility.

Sci Total Environ 2021 Jun 24;793:148599. Epub 2021 Jun 24.

UK Centre for Ecology & Hydrology, Lancaster Environment Centre, Library Avenue, Bailrigg, Lancaster LA1 4AP, UK. Electronic address:

The COST Action 'European Raptor Biomonitoring Facility' (ERBFacility) aims to develop pan-European raptor biomonitoring in support of better chemicals management in Europe, using raptors as sentinel species. This presents a significant challenge involving a range of constraints that must be identified and addressed. The aims of this study were to: (1) carry out a comprehensive review of the constraints that may limit the gathering in the field of raptor samples and contextual data, and assess their relative importance across Europe; and (2) identify and discuss possible solutions to the key constraints that were identified. Read More

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Navigation of iliac crest graft harvest using markerless augmented reality and cutting guide technology: A pilot study.

Int J Med Robot 2021 Jul 30:e2318. Epub 2021 Jul 30.

Department of Oral and Maxillofacial Surgery, University Hospital RWTH Aachen, Pauwelsstraße 30, D-52074, Aachen, Germany.

Background: Defects of the facial skeleton often require complex reconstruction with vascularized grafts. This trial elucidated the usability, visual perception and accuracy of a markerless augmented reality (AR)-guided navigation for harvesting iliac crest transplants.

Methods: Random CT scans were used to virtually plan two common transplant configurations on ten iliac crest models, each printed four times. Read More

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Polyetheretherketone patient-specific implants (PPSI) for the reconstruction of two different mandibular contour deformities.

Oral Maxillofac Surg 2021 Jul 30. Epub 2021 Jul 30.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Beni-Suef University, East Nile educational compound, Beni-Suef, 62764, Egypt.

Background: This study aims to prospect the soft and hard tissue changes after augmentation of two different local mandibular contour defects using polyetheretherketone (PEEK) patient-specific onlay implants.

Methods: Six patients with disfiguring local mandibular deformities were included in this study (five males and one female) and received seven PEEK patient-specific implants (PSI), virtually designed and surgically settled to augment seven mandibular defects, three deficient chins, and four mandibular angels. The analysis of the soft and hard tissue changes utilized the superimposition of the preoperative and the 6-month postoperative sagittal and coronal CT views, after standardizing the radiographic interpretation. Read More

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Use of Social Media for Cancer Prevention Through Neighborhood Social Cohesion: Protocol for a Feasibility Study.

JMIR Res Protoc 2021 Jul 30;10(7):e28147. Epub 2021 Jul 30.

Department of Communication Studies, The University of Iowa, Iowa City, IA, United States.

Background: Social cohesion is associated with healthier behaviors and better health outcomes, and therefore may offer a mechanism for promoting better health. Low socioeconomic status (SES) communities face higher rates of chronic disease due to both community- and individual-level factors.

Objective: The aim of this study is to leverage social cohesion to promote healthier behaviors and prevent chronic disease in a low SES community. Read More

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Recursive Partitioning vs Computerized Adaptive Testing to Reduce the Burden of Health Assessments in Cleft Lip and/or Palate: Comparative Simulation Study.

J Med Internet Res 2021 Jul 30;23(7):e26412. Epub 2021 Jul 30.

Warwick Clinical Trials Unit, University of Warwick, Coventry, United Kingdom.

Background: Computerized adaptive testing (CAT) has been shown to deliver short, accurate, and personalized versions of the CLEFT-Q patient-reported outcome measure for children and young adults born with a cleft lip and/or palate. Decision trees may integrate clinician-reported data (eg, age, gender, cleft type, and planned treatments) to make these assessments even shorter and more accurate.

Objective: We aimed to create decision tree models incorporating clinician-reported data into adaptive CLEFT-Q assessments and compare their accuracy to traditional CAT models. Read More

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An Avatar-Led Digital Smoking Cessation Program for Sexual and Gender Minority Young Adults: Intervention Development and Results of a Single-Arm Pilot Trial.

JMIR Form Res 2021 Jul 30;5(7):e30241. Epub 2021 Jul 30.

University of Cyprus, Nicosia, Cyprus.

Background: Sexual and gender minority young adults have a high prevalence of smoking and unique barriers to accessing tobacco treatment.

Objective: To address these challenges as well as their preferences for sexual and gender minority-targeted interventions and digital programs, we developed and evaluated the acceptability, preliminary efficacy, and impact on theory-based change processes of an acceptance and commitment therapy-based digital program called Empowered, Queer, Quitting, and Living (EQQUAL).

Methods: Participants (n=22) of a single-arm trial conducted to evaluate the program were young adults, age 18 to 30 years, who self-identified as sexual and gender minority individuals and smoked at least one cigarette per day. Read More

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Prognostic value of DCE-CT-derived blood volume and flow compared to core biopsy microvessel density in patients with metastatic renal cell carcinoma.

Eur Radiol Exp 2021 Jul 30;5(1):32. Epub 2021 Jul 30.

Department of Oncology, Aarhus University Hospital (AUH), Palle Juul-Jensens Blvd. 99, 8200, Aarhus N, Denmark.

Background: Angiogenesis is prominent in metastatic renal cell carcinoma (mRCC). We compared two angiogenesis assessment methods: dynamic contrast-enhanced computed tomography (DCE-CT)-derived blood volume (BV) and blood flow (BF) and core biopsy microvessel density (MVD).

Methods: As planned in DaRenCa Study-1 study, DCE-CT and core biopsy were performed from the same tumour/metastasis at baseline. Read More

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Association of Clinical Severity With Family Affluence-Based Socioeconomic Status Among Hospitalized Pediatric Hand, Foot, and Mouth Disease Patients in Henan, China: A Single Hospital-Based Case Series Study.

Open Forum Infect Dis 2021 Jul 26;8(7):ofab150. Epub 2021 Mar 26.

School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai, China.

Background: The association between the clinical severity of hand, foot, and mouth disease (HFMD) inpatients and socioeconomic status (SES) is important for quantifying SES inequality in HFMD disease burden and informing decision-makers regarding medical subsidy and reimbursement policies. Here, this association was investigated using a quantitative SES measurement.

Methods: Laboratory-confirmed HFMD cases hospitalized at Henan Children's Hospital from February 15, 2017, to February 15, 2018, were invited. Read More

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An Unusual Case of Recurrent Migration of the Peritoneal Dialysis Catheter into the Inguinal Hernia Sac.

Case Rep Nephrol Dial 2021 May-Aug;11(2):152-157. Epub 2021 Jun 28.

Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan.

We herein report the first case of a patient with recurrent migration of the peritoneal dialysis (PD) catheter into the inguinal hernia sac. A 58-year-old man suffered from end-stage renal disease due to polycystic kidney disease (PKD). A year before starting PD, a PD catheter was implanted with stepwise initiation of PD using the Moncrief-Popovich technique. Read More

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Indian Paradigm of Orthopedic Care in Post-COVID-19 Era.

J Orthop Case Rep 2021 Apr;11(4):110-116

Indian Orthopaedic Research Group (IORG). Thane. Maharashtra. India.

Introduction: COVID-19 pandemic caused by the newly emerged strain of coronavirus (SARS-CoV-2) has had phenomenally casted its impact on the health-care systems globally. The rampant spread of contagiosity has challenged the solidarity of the medical fraternity of the developed and developing world. The rising turmoil enforces to trudge with stoicism and expresses the need for planning because of subjugating the prevailing conditions with judicial channelization of available resources. Read More

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Congenital Dislocation of the Patella - Surgical Treatment Rationale and Literature Review.

J Orthop Case Rep 2021 Apr;11(4):59-64

Department of Clinical Surgical, Diagnostic and Pediatric Sciences, Locomotor System Diseases Unit, University of Pavia, Pavia, Italy.

Introduction: Congenital dislocation of the patella (CDP) is a rare condition and its treatment is not well defined. In CDP, patella is dislocated on the lateral aspect of the distal femur, laterally from the trochlear groove, it cannot be reduced manually and it is almost always associated with genu valgum, lateral torsion of the proximal tibia, and flexion contracture of the knee. This condition is present at birth, but the clinical findings can be subtle at birth due to the size and character of the structures being examined; early diagnosis is essential, but it may be delayed to late childhood or adulthood. Read More

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Risk factors for antenatal depression: A review.

World J Psychiatry 2021 Jul 19;11(7):325-336. Epub 2021 Jul 19.

Department of Clinical Psychology and Psychobiology, Faculty of Psychology, University of Santiago de Compostela, Santiago de Compostela 15782, Spain.

Depression is the most prevalent mental disorder in pregnancy, and yet it is less studied than postpartum depression despite the consequences it may have on both the pregnant woman and her offspring. Therefore, it would be important to know which risk factors may favour the appearance of antenatal depression in order to carry out appropriate prevention interventions. The aim of the present review was to identify the main risk factors of antenatal depression. Read More

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/Madre de Dios Birth Cohort to Study Effects of in-utero Trace Metals Exposure in the Southern Peruvian Amazon.

Ann Glob Health 2021 19;87(1):69. Epub 2021 Jul 19.

School of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru.

Background: In-utero exposure to mercury and other trace metals pose a significant threat to child health and development, but exposures and health impacts in artisanal and small-scale gold mining (ASGM) environments are poorly defined.

Objectives: We describe the CONAMAD study design, a prospective birth cohort consisting of multiparous women (18 and over) living in rural and peri-urban Peruvian Amazon communities exposed to ASGM.

Methods: Pregnant women are enrolled from health posts across four zones of Madre de Dios, Peru. Read More

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Asleep Speech Mapping Using Orofacial Muscles as Surrogates for Motor Speech in Patients Who Cannot Tolerate Awake Surgery: A Case Series.

Cureus 2021 Jun 23;13(6):e15861. Epub 2021 Jun 23.

Neurological Surgery, Northwell Health, New York, USA.

Background Bi-polar electrical cortical stimulation during awake craniotomy has been the gold standard for mapping eloquent cortex to preserve speech. Unfortunately, not all patients can tolerate awake surgery. Monopolar hi-frequency electrical stimulation can be conducted while a patient is under general anesthesia. Read More

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Huge Intraosseous Tibial Haemangioma Managed with Embolisation, Excision and Fibular Ilizarov Reconstruction: A Case Report.

Strategies Trauma Limb Reconstr 2021 Jan-Apr;16(1):60-63

Department of Orthopedics, Tumor Section, University of the Philippines - Philippine General Hospital, Manila, Philippines.

Aim: Our aim is to report the successful treatment of an intraosseous haemangioma of tibia with an atypical presentation through a multidisciplinary approach of preoperative embolisation, a subtotal resection of the tibia and subsequent reconstruction with the Ilizarov medial fibular translation technique.

Background: En bloc excision is the treatment of choice for large tumours of the tibia. However, there is no single recommended method for the reconstruction of the resulting bony defect. Read More

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Comparison of Clinical and Radiographic Success of Rotary with Manual Instrumentation Techniques in Primary Teeth: A Systematic Review.

Int J Clin Pediatr Dent 2021 Jan-Feb;14(1):8-13

Department of Pediatric and Preventive Dentistry, KSR Institute of Dental Science and Research, Tiruchengode, Namakkal, Tamil Nadu, India.

Aim And Objective: A systematic review was planned to compare the clinical and radiographic success rate of pulpectomy in primary molars using a rotary system and hand files system.

Study Design: The literature search was undertaken in electronic databases from January 2000 to December 2019 using keywords. Four hundred and forty-two studies were identified after applying limits. Read More

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Tryptophan potentiates CD8 T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation.

J Immunother Cancer 2021 Jul;9(7)

State Key Laboratory of Genetic Engineering, School of Life Sciences and Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China

Background: Tryptophan catabolites suppress immunity. Therefore, blocking tryptophan catabolism with indoleamine 2,3-dioxygenase (IDO) inhibitors is pursued as an anticancer strategy.

Methods: The intracellular level of tryptophan and kynurenine was detected by mass spectrum analysis. Read More

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Does an innovative paper-based health information system (PHISICC) improve data quality and use in primary healthcare? Protocol of a multicountry, cluster randomised controlled trial in sub-Saharan African rural settings.

BMJ Open 2021 Jul 29;11(7):e051823. Epub 2021 Jul 29.

BCGI LLC / pivot-23.5°, Chapel Hill, North Carolina, USA.

Introduction: Front-line health workers in remote health facilities are the first contact of the formal health sector and are confronted with life-saving decisions. Health information systems (HIS) support the collection and use of health related data. However, HIS focus on reporting and are unfit to support decisions. Read More

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A feasibility trial of an intervention in alcohol dependence for structured preparation before detoxification versus usual care: the SPADe trial results.

Pilot Feasibility Stud 2021 Jul 29;7(1):148. Epub 2021 Jul 29.

University of Sussex, School of Psychology, Falmer, Brighton, BN1 9RH, UK.

Background: Individuals who are 'moderately' or 'severely' dependent consume alcohol at levels that are likely to have a severe impact on their own health and mortality, the health and behaviours of others (family members) and to have economic and social implications. Treatment guidelines suggest that treatment needs to be planned with medically assisted withdrawal (also referred to as detoxification), and aftercare support but outcomes are poor with low proportions engaging in after care and high relapse rates. An approach of structured preparation before alcohol detoxification (SPADe) puts an emphasis on introducing lifestyle changes, development of coping strategies for cravings, stress and emotions as well as introducing changes to the immediate family and social environment in advance of alcohol cessation. Read More

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Oral Misoprostol alone versus oral misoprostol followed by oxytocin for labour induction in women with hypertension in pregnancy (MOLI): protocol for a randomised controlled trial.

BMC Pregnancy Childbirth 2021 Jul 29;21(1):537. Epub 2021 Jul 29.

Department of Women's and Children's Health, Liverpool Women's Hospital, University of Liverpool, Crown Street, Liverpool, L8 7SS, UK.

Background: Every year approximately 30,000 women die from hypertensive disease in pregnancy. Magnesium sulphate and anti-hypertensives reduce morbidity, but delivery is the only cure. Low dose oral misoprostol, a prostaglandin E1 analogue, is a highly effective method for labour induction. Read More

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COVID-19 vaccine hesitancy in adults with multiple sclerosis in the United States: A follow up survey during the initial vaccine rollout in 2021.

Mult Scler Relat Disord 2021 Jul 22;54:103163. Epub 2021 Jul 22.

Department of Rehabilitation Medicine, University of Washington, Seattle, WA, United States; Department of Neurology, University of Washington, Seattle, WA, United States.

Background: Multiple sclerosis (MS) organizations have recommended that adults with MS obtain the COVID-19 vaccination. Vaccine hesitancy is a barrier to full COVID-19 inoculation in the general population. Whether vaccine hesitancy is also a barrier towards optimizing vaccination rates in the MS community is unknown. Read More

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Advancing Fellowship Training in Selective Pathology: Design and Implementation of the Milestones 2.0.

Arch Pathol Lab Med 2021 Jul 29. Epub 2021 Jul 29.

the Department of Pathology, University of Oklahoma, Oklahoma City (Peterson).

Context.—: Program requirements for Selective Pathology fellowships in the United States were established by the Accreditation Council for Graduate Medical Education (ACGME) in 2011 to govern fellowships providing advanced training in surgical pathology, focused anatomic pathology, or focused clinical pathology. Selective Pathology entered the ACGME's Next Accreditation System in 2015 with the introduction of the Selective Pathology Milestones 1. Read More

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