71,287 results match your criteria placebo control


Therapeutic Effects of Ba-Duan-Jin versus Pregabalin for Fibromyalgia Treatment: Protocol for a Randomized Controlled Trial.

Rheumatol Ther 2021 Jul 22. Epub 2021 Jul 22.

Department of Rheumatology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Introduction: Fibromyalgia is characterized by multi-focal pain and is associated with fatigue, unrefreshing sleep and psychological impairment. Pregabalin is one of the most frequently used agents in fibromyalgia treatment. However, it has failed to demonstrate benefit over placebo for reducing fatigue and psychological impairment, and may cause adverse effects (e. Read More

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Interventions for the treatment of persistent post-COVID-19 olfactory dysfunction.

Cochrane Database Syst Rev 2021 07 22;7:CD013876. Epub 2021 Jul 22.

Cochrane UK, Oxford, UK.

Background: Olfactory dysfunction is an early and sensitive marker of COVID-19 infection. Although self-limiting in the majority of cases, when hyposmia or anosmia persists it can have a profound effect on quality of life. Little guidance exists on the treatment of post-COVID-19 olfactory dysfunction, however several strategies have been proposed from the evidence relating to the treatment of post-viral anosmia (such as medication or olfactory training). Read More

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The Effects of Tranexamic Acid on Bleeding Control During and after Percutaneous Nephrolithotomy (PCNL): A Randomized Clinical Trial.

Urol J 2021 Jul 22:6505. Epub 2021 Jul 22.

3. Department of Urology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Purpose: Tranexamic acid is a fibrinolysis suppressor that is used for a variety of bleeding control procedures such as hematuria, surgery bleeding, and trauma caused bleeding. The advantages of using the tranexamic acid are bleeding control and less need for blood transfusion.

Materials And Methods:  This double blind clinical trial was conducted on 108 patients in Imam Khomeni Hospital, Urmia, Iran 2013-14. Read More

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A double-blind placebo-controlled randomized trial of oral saffron in the treatment of rheumatoid arthritis.

Avicenna J Phytomed 2021 Jul-Aug;11(4):332-342

Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Recently, saffron ( L. from the Iridaceae family) has been characterized by its antioxidant, anti-inflammatory and analgesic effects. This study aimed to evaluate the effect of saffron on disease activity in patients with rheumatoid arthritis (RA). Read More

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December 2019

Clinical outcomes of maitland mobilization in patients with Myofascial Chronic Neck Pain: A randomized controlled trial.

Pak J Med Sci 2021 Jul-Aug;37(4):1172-1178

Dr. Nadia Saleem, MS (Rehab), Assistant Professor, Bakhtawar Amin College of Rehabilitation Sciences, Multan Pakistan.

Background And Objective: Myofascial neck pain is a common musculoskeletal problem caused by presence of trigger points and local and referred pain patterns. Chronic neck pain is responsible for the involvement of joints, ligaments, fascia and connective tissue as well. The objective of this study was to assess the effect of Maitland mobilization in patients with myofascial chronic neck pain. Read More

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January 2021

The effects of auricular acupressure on stress, anxiety, and depression of outpatient nurses in South Korea.

Complement Ther Clin Pract 2021 Jul 16;44:101447. Epub 2021 Jul 16.

College of Nursing, Ewha Womans University, 52, Ewhayeodae-gil, Seodaemun-gu, Seoul 03760, South Korea. Electronic address:

Background And Purpose: Outpatient nursing is an occupation with high emotional labor and job stress. The purpose of this study was to examine the effects of auricular acupressure on stress, anxiety, and depression of outpatient nurses.

Materials And Methods: The study design was a randomized controlled trial. Read More

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Cardiometabolic consequences of maternal hyperandrogenemia in male offspring.

Physiol Rep 2021 Jul;9(14):e14941

Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS, USA.

Polycystic ovary syndrome (PCOS) in women is characterized by hyperandrogenemia, obesity, and oligo- or anovulation. In addition, women with PCOS are often obese, with insulin resistance, hyperlipidemia, and elevated blood pressure. The cardiometabolic consequences for the male offspring of maternal hyperandrogenemia are unclear. Read More

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Stem cell therapy for dilated cardiomyopathy.

Cochrane Database Syst Rev 2021 Jul 21;7:CD013433. Epub 2021 Jul 21.

Interdisciplinary Centre for Health Studies CIESAL, Universidad de Valparaíso, Viña del Mar, Chile.

Background: Stem cell therapy (SCT) has been proposed as an alternative treatment for dilated cardiomyopathy (DCM), nonetheless its effectiveness remains debatable.

Objectives: To assess the effectiveness and safety of SCT in adults with non-ischaemic DCM.

Search Methods: We searched CENTRAL in the Cochrane Library, MEDLINE, and Embase for relevant trials in November 2020. Read More

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Profile of Ipragliflozin, an Oral SGLT-2 Inhibitor for the Treatment of Type 2 Diabetes: The Evidence to Date.

Drug Des Devel Ther 2021 14;15:3057-3069. Epub 2021 Jul 14.

School of Pharmacy, Faculty of Science, University of Waterloo, Kitchener, ON, Canada.

Background: Sodium-glucose cotransporter-2 (SGLT-2) inhibitors are a novel class of pharmacotherapeutics for type 2 diabetes management that work by reducing renal reabsorption of glucose. Ipragliflozin is a potent, selective SGLT-2 inhibitor used for the management of type 2 diabetes.

Objective: The primary aim of this review is to summarize the available evidence on the efficacy and safety of ipragliflozin for the management of type 2 diabetes. Read More

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Efficacy of a Digital Sports Vision Training Program for Improving Visual Abilities in Collegiate Baseball and Softball Athletes.

Optom Vis Sci 2021 Jul 17. Epub 2021 Jul 17.

Pacific University College of Optometry, Forest Grove, Oregon

Significance: Dynamic reactive sports involve visual abilities such as visual acuity, depth perception, contrast sensitivity, and visual-motor reaction speed. This randomized, double-blinded control design showed no significant improvement in the visual parameters among athletes after training on a digital sports vision training program.

Purpose: There is a need for evidence supporting the efficacy of recently developed digital training programs. Read More

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A andomisd, controlled, double blind tudy to assess mechanstic effects of combination therapy of dapagflozin with xenatide QW versus dapagliflozin alone i obese patients with ype 2 diabetes mellitus (RESILIENT): study protocol.

BMJ Open 2021 Jul 20;11(7):e045663. Epub 2021 Jul 20.

Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.

Introduction: The newer glucose-lowering therapies for type 2 diabetes (T2D), the glucagon-like peptide-1 receptor agonists (GLP1-RAs) and the sodium-glucose co-transporter 2 inhibitors (SGLT2i), have additional clinical benefits beyond improving glycaemic control; promoting weight loss, addressing associated cardiovascular risk factors and reducing macrovascular and microvascular complications. Considering their independent mechanisms of actions, there is a potential for significant synergy with combination therapy, yet limited data exist. This 32-week randomised, double-blind, placebo-controlled trial will gain mechanistic insight into the effects of coadministration of exenatide QW, a weekly subcutaneous GLP1-RA, with dapagliflozin, a once daily oral SGLT2i, on the dynamic, adaptive changes in energy balance, total, regional and organ-specific fat mass and multiorgan insulin sensitivity. Read More

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Combination of propofol and nasal sufentanil or intravenous midazolam for colonoscopy: a comparative study.

Anaesthesiol Intensive Ther 2021 ;53(2):146-152

Health Sciences University, Haseki Training and Research Hospital, Turkey.

Introduction: The aim of the study was to compare and evaluate the side effects (SEs) and sedation characteristics of synergistic sedation with doses of 0.25 μg kg-1 or 0.5 μg kg-1 intranasal (IN) sufentanil, and intravenous (IV) midazolam during propofol-based sedation in patients undergoing colonoscopy. Read More

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January 2021

Combination fixed-dose β agonist and steroid inhaler as required for adults or children with mild asthma: a Cochrane systematic review.

BMJ Evid Based Med 2021 Jul 19. Epub 2021 Jul 19.

Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Department of Medicine, University of Oxford, Oxford, UK

Background: In people with mild asthma poor adherence to regular therapy is common and increases the risk of exacerbations, morbidity and mortality. The use of fixed-dose combination inhalers containing an inhaled corticosteroid (ICS) and a fast-acting β-agonist (FABA) is established in moderate asthma, but they may also have potential utility in mild asthma.

Objectives: To evaluate the efficacy and safety of single combined FABA/ICS inhaler only used as needed in people with mild asthma. Read More

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Interventions for treating cavitated or dentine carious lesions.

Cochrane Database Syst Rev 2021 Jul 19;7:CD013039. Epub 2021 Jul 19.

School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.

Background: Traditionally, cavitated carious lesions and those extending into dentine have been treated by 'complete' removal of carious tissue, i.e. non-selective removal and conventional restoration (CR). Read More

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Association between Oral vitamin C supplementation and serum uric acid: A meta-analysis of randomized controlled trials.

Complement Ther Med 2021 Jul 16;60:102761. Epub 2021 Jul 16.

Department of Nutrition and Hygiene, College of Public Health, Zhengzhou University, Henan, 450001, China. Electronic address:

Introduction: Results from recent trials assessing the effect of oral vitamin C supplementation on serum uric acid (SUA) have been inconsistent.

Objectives: The purpose of this study was to explore the association between oral vitamin C supplementation and serum uric acid.

Methods: PUBMED, EMBASE, CNKI, Web of Science, and CENTRAL of Cochrane library databases were searched to identify relevant articles published up to February 2020. Read More

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Acute effect of pseudoephedrine on macular microcirculation in healthy subjects: an optical coherence tomography angiography study.

Jpn J Ophthalmol 2021 Jul 19. Epub 2021 Jul 19.

West Eye Center, Izmir, Turkey.

Purpose: To quantitatively evaluate the acute effects of pseudoephedrine on the macular microvasculature using optical coherence tomography angiography (OCTA).

Study Design: Randomized placebo-controlled clinical study.

Methods: In this study, 60 right eyes of 60 healthy subjects were divided into 2 groups. Read More

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Placebo and Side Effects Confound Clinical Trials on New Antitussives.

Authors:
Ronald Eccles

Lung 2021 Jul 19. Epub 2021 Jul 19.

Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK.

This review discusses how the placebo effect related to treatment side effects may confound clinical trials on antitussives and specifically looks at the implications for trials on ATP antagonists. These new antitussives have distinctive side effects on the sensation of taste, and investigators have expressed concerns that this may unblind the clinical trials. Blinding is an essential component of trial design, but the degree of blinding in trials is rarely assessed. Read More

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Alloreactive Immune Response Associated to Human Mesenchymal Stromal Cells Treatment: A Systematic Review.

J Clin Med 2021 Jul 5;10(13). Epub 2021 Jul 5.

Cell Production and Tissue Engineering Unit, Virgen de las Nieves University Hospital, Andalusian Network of Design and Translation of Advanced Therapies, 18014 Granada, Spain.

The well-known immunomodulatory and regenerative properties of mesenchymal stromal cells (MSCs) are the reason why they are being used for the treatment of many diseases. Because they are considered hypoimmunogenic, MSCs treatments are performed without considering histocompatibility barriers and without anticipating possible immune rejections. However, recent preclinical studies describe the generation of alloantibodies and the immune rejection of MSCs. Read More

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GABAergic modulation of performance in response inhibition and interference control tasks.

J Psychopharmacol 2021 Jul 18:2698811211032440. Epub 2021 Jul 18.

Department of Psychology, University of Bonn, Bonn, Germany.

Background: Inhibitory control is a crucial executive function with high relevance to mental and physical well-being. However, there are still unanswered questions regarding its neural mechanisms, including the role of the major inhibitory neurotransmitter, γ-aminobutyric acid (GABA).

Aims: This study examined the effects of lorazepam (0. Read More

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Role of Cod Liver Oil in Reducing Elevated Lipid Parameters.

Cureus 2021 Jun 9;13(6):e15556. Epub 2021 Jun 9.

Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK.

Introduction The health benefits of cod oil, which includes omega-3 fatty acids, have been of considerable interest to medicine due to its promising results. Studies have shown successful therapeutic effects of a high dietary intake of omega-3 fatty acids by reducing the synthesis of very-low-density lipoprotein, with subsequent low levels of serum triglycerides.  Methods This single-blind placebo-controlled two-arm interventional study was conducted in the internal medicine unit of a tertiary care hospital from October 2020 to April 2021. Read More

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Comparative effectiveness of 5-hydroxytryptamine 3 receptor antagonists in irritable bowel syndrome: a network meta-analysis of randomized controlled studies.

Ann Gastroenterol 2021 Jul-Aug;34(4):535-546. Epub 2021 Apr 2.

Tel Aviv University, Ministry of Health, Israel (Yaron Niv).

Background: There is evidence demonstrating the beneficial effects of 5-hydroxytryptamine 3 receptor antagonists (5-HT) for the treatment of non-constipated irritable bowel syndrome (NC-IBS). We aimed to determine the comparative effectiveness of 5-HT antagonists in NC-IBS, as evidenced by the results of a network meta-analysis (NWM) of published relevant randomized controlled trials (RCTs).

Methods: We searched the PubMed/Medline, EMBASE, and Cochrane Library databases for relevant RCTs through September 2020 and data from each selected RCT were extracted. Read More

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Tocilizumab for Severe and Critical COVID-19 Pneumonia in Queens, NYC.

Infect Dis Clin Pract (Baltim Md) 2021 Jul 15;29(4):e215-e220. Epub 2021 Jan 15.

Elmhurst Hospital Center, NYC Health and Hospitals, Queens.

New York City was hard hit by COVID-19. Elmhurst Hospital is a public hospital in Queens where more than 1500 patients were hospitalized with COVID. During the pandemic, various treatments were used with hopes of reducing the need for mechanical ventilation and death. Read More

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Effects of Dexmedetomidine on Patients Undergoing Laparoscopic Surgery for Colorectal Cancer.

J Surg Res 2021 Jul 15;267:687-694. Epub 2021 Jul 15.

Department of Anesthesiology, The First People's Hospital of Changde City, Changde, China. Electronic address:

Background: Pneumoperitoneum during laparoscopic surgery has a systemic impact on the renal system and might contribute to acute kidney injury or postoperative renal dysfunction. However, effective preventive strategies are still lacking. We aimed to explore the effects of dexmedetomidine (DEX) on kidney and other organ function in patients undergoing elective laparoscopic surgery for colorectal cancer. Read More

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Efficacy of intradermal acupuncture for insomnia: a meta-analysis.

Sleep Med 2021 Jun 29;85:66-74. Epub 2021 Jun 29.

Shaoxing Central Hospital, Zhejiang, China. Electronic address:

Objectives: To provide updated evidence from randomized controlled trials (RCTs) on the efficacy of intradermal acupuncture for insomnia.

Methods: A search of relevant literatures was performed on major medical databases, including the Cochrane Library, PubMed, EMBASE, CBM, CNKI, VIP, Wanfang Data and so on. Risk of bias evaluation, meta-analysis, sensitivity analysis and evidence rating of all extracted information were also conducted. Read More

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Reduction in left frontal alpha oscillations by transcranial alternating current stimulation in major depressive disorder is context-dependent in a randomized clinical trial.

Biol Psychiatry Cogn Neurosci Neuroimaging 2021 Jul 14. Epub 2021 Jul 14.

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC; Carolina Center for Neurostimulation, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC; Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC. Electronic address:

Background: Left frontal alpha oscillations are associated with decreased approach motivation and have been proposed as a target for non-invasive brain stimulation for the treatment of depression and anhedonia. Indeed, transcranial alternating current stimulation (tACS) at the alpha frequency reduced left frontal alpha power and was associated with a higher response rate than placebo stimulation in patients with major depressive disorder (MDD) in a recent double-blind placebo controlled clinical trial.

Methods: In this current study, we aimed to replicate successful target engagement by delineating the effects of a single session of bifrontal tACS at the individualized alpha frequency (IAF-tACS) on alpha oscillations in patients with MDD. Read More

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Efficacy and safety of combined isoniazid-rifampicin-pyrazinamide-levofloxacin dry powder inhaler in treatment of pulmonary tuberculosis: A randomized controlled trial.

Pulm Pharmacol Ther 2021 Jul 15;70:102056. Epub 2021 Jul 15.

Drug Delivery System Excellence Center and Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand. Electronic address:

Objective: To determine the efficacy and safety of add-on dry powder for inhalation (DPI) of combined anti-TB agents prepared as a particulate system (study group) compared with placebo DPI (control group) in patients diagnosed with pulmonary TB.

Methods: This study was a randomized, placebo-controlled, double-blinded parallel design. Subjects were pulmonary TB patients, new or re-treatment, aged 18 years or older. Read More

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Effect of quitting smoking on health outcomes during treatment for tuberculosis: secondary analysis of the TB & Tobacco Trial.

Thorax 2021 Jul 16. Epub 2021 Jul 16.

Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.

Background: Despite treatment, patients with tuberculosis (TB) who smoke have poorer outcomes compared with non-smokers. It is unknown, however, if quitting smoking during the 6 months of TB treatment improves TB outcomes.

Methods: The TB & Tobacco Trial was a double-blind, placebo-controlled randomised trial of cytisine for smoking cessation in 2472 patients with pulmonary TB in Bangladesh and Pakistan. Read More

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Benefit of pazopanib in advanced gastrointestinal stromal tumours: results from a phase II trial (SSG XXI, PAGIST).

ESMO Open 2021 Jul 13;6(4):100217. Epub 2021 Jul 13.

Department of Oncology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

Background: Patients with advanced gastrointestinal stromal tumours (GISTs) resistant to the tyrosine kinase inhibitors imatinib and sunitinib may be treated with regorafenib, which resulted in a median progression-free survival (PFS) of 4.8 months in the GRID trial. Also, pazopanib, another tyrosine kinase inhibitor, has been studied in a randomized, placebo-controlled trial (PAZOGIST) in the third line, which showed a PFS of 45. Read More

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Antiplatelet regimens for Asian patients with ischemic stroke or transient ischemic attack: a systematic review and network meta-analysis.

Ann Transl Med 2021 May;9(9):753

Department of Neurology, Korea University Ansan Hospital, Ansan, Republic of Korea.

Background: The optimal antiplatelet treatment for the secondary prevention of non-cardioembolic stroke or transient ischemic attack (TIA) remains uncertain in Asians.

Methods: We searched for eligible randomized control trials in Medline, Embase, and the Cochrane Library. A Bayesian network meta-analysis (NMA) was performed to assess the efficacy and safety of antiplatelet regimens with placebo as the control. Read More

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The Combination of Stromal Vascular Fraction Cells and Platelet-Rich Plasma Reduces Malondialdehyde and Nitric Oxide Levels in Deep Dermal Burn Injury.

J Inflamm Res 2021 8;14:3049-3061. Epub 2021 Jul 8.

Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia.

Introduction: Thermal burns release reactive oxygen species, which cause profound systemic and local changes. Stromal vascular fraction cells (SVFs) combined with platelet-rich plasma accelerate burn wound healing. This study investigated the effect of a combination of locally injected SVFs and PRP on malondialdehyde (MDA) and nitric oxide (NO) serum and tissue levels in a deep dermal burn model in Wistar rats. Read More

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