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Spectrum of Electroencephalography Findings in Newly Diagnosed Epilepsy.

Cureus 2021 Jun 26;13(6):e15938. Epub 2021 Jun 26.

Department of Pediatric Neurology, The Children's Hospital and The Institute Of Child Health, Lahore, PAK.

Background Epilepsy is a neurological disorder that presents with recurrent seizures associated with erratic brain activity which can be measured through EEG in addition to other neurological investigations. However, EEG may show abnormal patterns and waveforms while the patient is having a seizure which is crucial for making an accurate diagnosis. Objective This study aims to evaluate the spectrum of EEG findings in newly diagnosed epileptic patients as part of a neurological investigation. Read More

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Geographic barriers to achieving universal health coverage: evidence from rural Madagascar.

Health Policy Plan 2021 Jul 31. Epub 2021 Jul 31.

NGO PIVOT, BP23 Ranomafana, 312 Ifanadiana, Madagascar.

Poor geographic access can persist even when affordable and well-functioning health systems are in place, limiting efforts for universal health coverage (UHC). It is unclear how to balance support for health facilities and community health workers in UHC national strategies. The goal of this study was to evaluate how a health system strengthening (HSS) intervention aimed towards UHC affected the geographic access to primary care in a rural district of Madagascar. Read More

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Trends in Medicare Part D coverage of generics with equivalent brand-name drugs.

Am J Manag Care 2021 Jul;27(7):283-288

Department of Health Policy, Vanderbilt University School of Medicine, 2525 West End Ave, Ste 1203, Nashville, TN 37203. Email:

Objectives: To evaluate whether increased placement of generic drugs on higher cost-sharing tiers in Medicare Part D is associated with coverage of multisource brand-name drugs, plan type, or product characteristics.

Study Design: Descriptive study of Medicare Prescription Drug Formulary Files.

Methods: We analyzed plan coverage and tiering of brand-name drugs and matched generics from 2013-2019. Read More

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Total Knee Arthroplasty in the Valgus Knee: Can New Operative Technologies Affect Surgical Technique and Outcomes?

Surg Technol Int 2021 Jul 26;39. Epub 2021 Jul 26.

Northwell Health, Department of Orthopaedic Surgery, Lenox Hill Hospital, New York, New York.

Introduction: Valgus knee deformities can sometimes be challenging to address during total knee arthroplasties (TKAs). While appropriate surgical technique is often debated, the role of new operative technologies in addressing these complex cases has not been clearly established. The purpose of this study was to analyze the usefulness of computed tomography scan (CT)-based three-dimensional (3D) modeling operative technology in assisting with TKA planning, execution of bone cuts, and alignment. Read More

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The usability and applicability of knowledge translation theories, models, and frameworks for research in the context of a national health service.

Health Res Policy Syst 2021 Jul 26;19(1):105. Epub 2021 Jul 26.

Research and Evidence, Strategy and Research, Health Service Executive, Dublin 8, Ireland.

Background: Translating research findings into service improvements for patients and/or policy changes is a key challenge for health service organizations. The Health Service Executive (HSE) in Ireland launched the Action Plan for Health Research 2019-2029, as reported by Terrés (HSE, Dublin, 2019), one of the goals of which is to maximize the impact of the research that takes place within the service to achieve improvements in patient care, services, or policy change. The purpose of this research is to review the literature on knowledge translation theories, models, and frameworks (TMFs) and to assess the suitability of the TMFs for HSE use, selecting one or more for this purpose. Read More

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A dynamic, convenient and accurate method for assessing the flood risk of people and vehicle.

Sci Total Environ 2021 Jul 18;797:149036. Epub 2021 Jul 18.

Beijing Capital Co Ltd, Beijing 100028, China.

With the increase of extreme rainstorm caused by climate change, and the development of urbanization and the improvement of people's living standard, there is an urgent need to draw a dynamic, convenient and accurate flood risk map for different disaster bearing bodies, so as to protect people's lives and properties, as well as improve people's risk awareness and facilitate people's lives. This study mainly researched a method of drawing a dynamic, convenient and accurate flood risk map for people and vehicle. In this study, the surface runoff is simulated by GPU (Graphics Processing Unit) Accelerated Surface Water Flow and Transport model (GAST model), meanwhile, the flood risk of people and vehicle is graded base on the incipient velocity formulas, the most unfavorable principle and grading method, finally, the method is applied in two application cases. Read More

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Payer budget impact of an artificial intelligence diagnostic to modify diabetic kidney disease progression.

J Med Econ 2021 Jul 26. Epub 2021 Jul 26.

Boston Healthcare Associates Inc., 33 Arch Street, 17th Floor, Boston, MA 02110, U.S.A.

To evaluate the U.S. payer budget-impact of KidneyIntelX, an artificial intelligence-enabled diagnostic to predict kidney function decline in Type 2 Diabetic Kidney Disease (T2DKD) patients, stages 1-3b. Read More

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The University Münster model surgery system for orthognathic surgery - The digital update.

Head Face Med 2021 Jul 23;17(1):31. Epub 2021 Jul 23.

Head of Department, Department of Cranio-Maxillofacial Surgery, University Hospital Münster, Albert-Schweitzer-Campus 1, Gebäude W 30, Münster, D-48149, Germany.

Aim: The aim of this work is to present a digital methodology of a conventional articulator based planning protocol.

Methods: The digital counterpart consists of intra-oral scans (3Shape) and a free available 3D mesh software (Meshmixer, Autodesk). The maxillary position in relation to the reference plane used and the arbitrary hinge axis were determined mathematically from landmarks on cephalometric x-rays and frontal photographs. Read More

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Etoposide and Camptothecin Reduce Growth, Viability, the Generation of Mutants, and Recognize the Active Site of DNA Topoisomerase I and II Enzymes in .

Indian J Microbiol 2021 Sep 5;61(3):306-314. Epub 2021 May 5.

Departamento de Química Orgánica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prol. de Carpio Y Plan de Ayala. Col. Sto. Tomás, 11340 México City, México.

Candidemia, one of the most common invasive fungal infections in hospitalized patients, can lead to death and huge financial losses. is the main causative agent of this disorder and occupies the second or third place, for which new therapeutic alternatives must be found. The objective of the present study was to evaluate the inhibitory effect of etoposide and camptothecin (inhibitors of deoxyribonucleic acid (DNA) topoisomerase) on the CBS138 strain. Read More

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September 2021

Influence of agricultural activities on atmospheric pollution during post-monsoon harvesting seasons at a rural location of Indo-Gangetic Plain.

Sci Total Environ 2021 Jul 7;796:148903. Epub 2021 Jul 7.

Department of Environment Studies, Panjab University, Chandigarh 160014, India. Electronic address:

The emissions from agricultural activities significantly impact the air quality at local (rural) and regional scales. The study monitored the near real-time concentrations of emission from agrarian activities, i.e. Read More

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Civilian walking blood bank emergency preparedness plan.

Transfusion 2021 07;61 Suppl 1:S313-S325

University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Background: The current global pandemic has created unprecedented challenges in the blood supply network. Given the recent shortages, there must be a civilian plan for massively bleeding patients when there are no blood products on the shelf. Recognizing that the time to death in bleeding patients is less than 2 h, timely resupply from unaffected locations is not possible. Read More

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The effects of the COVID-19 lockdown on adolescents with an eating disorder and identifying factors predicting disordered eating behaviour.

Early Interv Psychiatry 2021 Jul 15. Epub 2021 Jul 15.

Ihsan Dogramaci Children's Hospital, Department of Pediatrics, Division of Adolescent Medicine, Hacettepe University, Ankara, Turkey.

Aim: To evaluate the impact of the COVID-19 lockdown on adolescents with eating disorders (ED) and identify factors predicting ED behaviour.

Method: This study took place during an age-stratified lockdown for those under 20 years in Turkey. Participants completed a survey developed to evaluate the effects of the lockdown on ED behaviour, well-being and quality of life (QoL) and additionally the eating disorder examination questionnaire (EDE-Q), and scales for depression, anxiety and obsessive-compulsive behaviour. Read More

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Assessment of Variation in Care Following Hospital Discharge for Children with Acute Asthma.

J Asthma Allergy 2021 5;14:797-808. Epub 2021 Jul 5.

Discipline of Paediatrics, School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, 2031, Australia.

Purpose: To evaluate potential variation in care management pathways following hospital discharge for children with asthma in New South Wales, Australia.

Methods: A cross-sectional web-based survey was conducted in emergency departments (EDs) and paediatric units of public hospitals with more than five paediatric beds within New South Wales, Australia, between July 2018 and March 2019. Nursing and medical staff in EDs and paediatric units who had cared for children aged under 18 years with asthma in the preceding 12 months were invited to participate in this study. Read More

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[Current status and intention to change indoor smoking rules by enforcing smoke-free legislation in Japan].

Nihon Koshu Eisei Zasshi 2021 Jul 15. Epub 2021 Jul 15.

Department of Medical Statistics, Research & Development Center, Osaka Medical College.

Objective In Japan, the revised Health Promotion Act and the Tokyo Metropolitan Ordinance to Prevent Exposure to Second-hand Smoke have been in place since April 1, 2020. However, regional differences in the prohibition of smoking in restaurants have raised concerns that some restaurants are not regulated by the smoke-free legislation. In addition, outdoor smoking rules have been in place in municipalities prior to the smoke-free legislation, so smoking outside restaurants may occur, and this may obstruct progress in the prohibition of smoking. Read More

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Active robotic technologies for total knee arthroplasty.

Arch Orthop Trauma Surg 2021 Jul 14. Epub 2021 Jul 14.

St. Vincent Charity Medical Center, 33001 Solon Rd., Suite 112, Solon, OH, 44139, USA.

Introduction: When active robotic technologies for Total Knee Arthroplasty (TKA) were introduced over 20 years ago, broad usage of robotic technology was not felt to be needed as early data suggested no clear improvement in clinical outcomes compared to conventional techniques of implantation. Only recently has there been renewed enthusiasm for use of robotic technologies for implantation.

Materials And Methods: Active robotic technology specifically refers to the use of a robot for planning and executing the surgical procedure-with surgeon guidance and control. Read More

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The psychological distress and mental health disorders from COVID-19 stigmatization in Ghana.

Soc Sci Humanit Open 2021 6;4(1):100186. Epub 2021 Jul 6.

Educational Innovations in Science and Technology, Kwame Nkrumah University of Science and Technology, PMB, University Post Office, Ghana.

The emergence of the COVID-19 global pandemic in Ghana has resulted in various degrees of stigmatization. Previous studies have stressed the need for developing policies to curb the stigma towards COVID-19 survivors and healthcare workers. Some have investigated the knowledge and willingness of people to accept COVID-19 survivors. Read More

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How prepared are Canadian trauma centres for mass casualty incidents?

Injury 2021 Jun 25. Epub 2021 Jun 25.

Department of Medicine, University of Toronto, Toronto, ON, Canada; Division of Emergency Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. Electronic address:

Objectives: Mass Casualty Incidents (MCIs) are rare but devastating events that require extensive planning in order to minimize morbidity and mortality. There are two broad categories limiting a hospital's response: physical assets (e.g. Read More

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Testing the effects of a prenatal depression preventive intervention on parenting and young children's self-regulation and functioning (EPIC): protocol for a longitudinal observational study.

BMC Public Health 2021 Jul 10;21(1):1368. Epub 2021 Jul 10.

Institute for Public Health and Medicine, Center for Community Health, Northwestern University Feinberg School of Medicine, 750 N Lake Shore Drive, Suite 680, Chicago, IL, 60611, USA.

Background: Perinatal depression is a pervasive public health concern that disproportionately affects low-income women and can have negative impacts on parenting and child developmental outcomes. Few interventions focus on preventing perinatal depression. Previous studies suggest that Mothers and Babies is efficacious in preventing the worsening of depressive symptoms and the onset of postpartum depression. Read More

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Balanced carbohydrate ratios are associated with improved diet quality in Australia: A nationally representative cross-sectional study.

PLoS One 2021 9;16(7):e0253582. Epub 2021 Jul 9.

Nutrition Research Australia, Sydney, New South Wales, Australia.

Background: Carbohydrate quality influences major health outcomes; however, the best criteria to assess carbohydrate quality remain unknown.

Objective: The objectives were to: i) evaluate whether a diet that meets a carbohydrate ratio (simple, modified or dual ratio) is associated with higher nutrient intakes and diet quality, and ii) model the impact of substituting carbohydrate foods that meet the proposed ratios in place of foods that do not, on nutrient intakes.

Design: A secondary analysis of cross-sectional data from the 2011-12 Australian National Nutrition and Physical Activity Survey. Read More

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[Biomechanics of mini-implants : analysis of the adverse effects of four clinical situations and proposed resolutions].

Orthod Fr 2021 Jun;92(2):195-214

Unité Fonctionnelle d'Orthopédie Dento-Faciale, Centre de Traitements Dentaires, Hospices Civils de Lyon, 6-8 place Depéret, 69365 Lyon cedex 03, France, Faculté d'Odontologie, Université Claude Bernard Lyon 1, 11 rue Guillaume Paradin, 69372 Lyon Cedex 08, France.

The biomechanical adverse effects generated by our treatments must be considered among the failures of mini-implants, certainly excellent means of anchorage. The aim of this article was to illustrate and comment on mechanical adverse effects and to propose solutions. Four common clinical situations in vestibular technique are analyzed, decomposed three-dimensionally and solved. Read More

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Identification of inflammatory subgroups of schizophrenia and bipolar disorder patients with HERV-W ENV antigenemia by unsupervised cluster analysis.

Transl Psychiatry 2021 07 6;11(1):377. Epub 2021 Jul 6.

AP-HP, Hôpital Henri Mondor, Département Médico-Universitaire de Psychiatrie et d'Addictologie (DMU IMPACT), Fédération Hospitalo-Universitaire de Médecine de Précision (FHU ADAPT), Créteil, France.

Human endogenous retroviruses (HERVs) are remnants of infections that took place several million years ago and represent around 8% of the human genome. Despite evidence implicating increased expression of HERV type W envelope (HERV-W ENV) in schizophrenia and bipolar disorder, it remains unknown whether such expression is associated with distinct clinical or biological characteristics and symptoms. Accordingly, we performed unsupervised two-step clustering of a multivariate data set that included HERV-W ENV protein antigenemia, serum cytokine levels, childhood trauma scores, and clinical data of cohorts of patients with schizophrenia (n = 29), bipolar disorder (n = 43) and healthy controls (n = 32). Read More

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Epidemiology of SARS-CoV2 in Qatar's primary care population aged 10 years and above.

BMC Infect Dis 2021 Jul 5;21(1):645. Epub 2021 Jul 5.

Department of Clinical Research, Primary Health Care Corporation, P.O. Box 26555, Doha, Qatar.

Background: There is an urgent need to elucidate the epidemiology of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and characterize its potential impact. Investing in characterising the SARS-CoV2 will help plan and improve the response to the pandemic. Furthermore, it will help identify the most efficient ways of managing the pandemic, avoiding public health policies and interventions that may be unduly restrictive of normal activity or unnecessarily costly. Read More

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The potential for person-centred planning to support the community participation of adults with an intellectual disability.

J Intellect Disabil 2021 Jul 5:17446295211022125. Epub 2021 Jul 5.

Temple University, USA.

Person-centred planning (PCP) puts individuals with an intellectual disability at the centre of service and support planning, identifying how individuals wish to live their lives and what is needed to make that possible. PCP has been identified as having the potential to facilitate improved social inclusion and community participation. A mixed-methods approach combined quantitative analyses with qualitative case studies of individuals with severe-profound intellectual disability to assess the impact of PCP on community participation for adults with an intellectual disability at a disability service in Dublin. Read More

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Building a sustainable rural physician workforce.

Med J Aust 2021 07;215 Suppl 1:S5-S33

CHAPTER 1: CHARACTERISING AUSTRALIA'S RURAL SPECIALIST PHYSICIAN WORKFORCE: THE PROFESSIONAL PROFILE AND PROFESSIONAL SATISFACTION OF JUNIOR DOCTORS AND CONSULTANTS: Objective: To assess differences in the demographic characteristics, professional profile and professional satisfaction of rural and metropolitan junior physicians and physician consultants in Australia.

Design, Setting And Participants: Cross-sectional, population level national survey of the Medicine in Australia: Balancing Employment and Life longitudinal cohort study (collected 2008-2016). Participants were specialist physicians from four career stage groups: pre-registrars (physician intent); registrars; new consultants (< 5 years since Fellowship); and consultants. Read More

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COVID-19 and cancer screening in Scotland: A national and coordinated approach to minimising harm.

Prev Med 2021 10 30;151:106606. Epub 2021 Jun 30.

Public Health Scotland, Edinburgh, Gyle Square, 1 South Gyle Crescent, Edinburgh EH12 9EB, UK.

Screening is an important component of cancer control internationally. In Scotland, the National Health Service Scotland provides screening programmes for cervical, bowel and breast cancers. The COVID-19 pandemic resulted in the suspension of these programmes in March 2020. Read More

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October 2021

[How to deal with an unexpected event that could alter the normal activity of cellular therapy? Recommendations of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].

Bull Cancer 2021 Jun 29. Epub 2021 Jun 29.

Hôpitaux Universitaires de Genève et Faculté de Médecine, Université de Genève, Service d'hématologie, département d'oncologie, Genève, Suisse.

The SARS-CoV-2 (COVID-19) pandemic has rapidly impacted cell therapy activities across the globe. Not only was this, unexpected event, a threat to patients who had previously received hematopoietic cell transplantation or other cell therapy such as CAR-T cells, but also, it was responsible for a disruption of cell therapy activities due to the danger of the virus and to the lack of solid scientific data on the management of patients and donors. The Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) devoted a workshop to issue useful recommendations in such an unexpected event in order to harmonize the actions of all the actors involved in cellular therapy programs so that we can collectively face, in the future, the challenges that could threaten our patients. Read More

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Who are the beneficiaries and what are the reasons for non-utilization of care respite and support services? A cross-sectional study on family caregivers.

BMC Health Serv Res 2021 Jul 2;21(1):637. Epub 2021 Jul 2.

Swiss Paraplegic Research, Guido A. Zäch Strasse 4, 6207, Nottwil, Switzerland.

Background: Family caregivers assume substantial caregiving responsibilities for persons with chronic conditions, such as individuals with spinal cord injury, which leads to negative impacts on their lives. Respite care and other services are provided as a temporary relief and support for them. Design of appropriate respite care programs depends on identification of beneficiary subgroups for the different types of service. Read More

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[White plan and the organisation of emergency response services in France].

Soins 2021 Jun;66(856):20-24

Hôpital d'instruction des armées Legouest, 27 avenue de Plantières, BP 90001, 57077 Metz cedex, France. Electronic address:

The Eemergency plans for outside hospitals (ORSEC) and inside hospitals (white plan) are often linked and must be well structured in order to respond to the tensions created by exceptional health situations. They must be designed, used and updated like toolboxes. How is the chain of care organised? What is the role of the samu (emergency medical assistance service) in the preparation, activation and coordination of the white plan? Read More

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[Emergency response plans in France].

Soins 2021 Jun;66(856):16-19

Hôpital d'instruction des armées Legouest, 27 avenue de Plantières, BP 90001, 57077 Metz cedex, France.

Disaster is a risk which health professionals must learn to manage without ever being sure that they will be confronted with it. A health crisis will have potentially significant repercussions within healthcare facilities. Emergency response plans as well as a shared culture enable healthcare workers to face a crisis by being organised. Read More

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The Implementation of Entrustable Professional Activities in Postgraduate Medical Education in the Netherlands: Rationale, Process, and Current Status.

Acad Med 2021 Jul;96(7S):S29-S35

O. ten Cate is professor of medical education and senior scientist, Center for Research and Development of Education, University Medical Center Utrecht, Utrecht, the Netherlands; ORCID: https://orcid.org/0000-0002-6379-8780.

Postgraduate medical education in the Netherlands has adopted competency-based education since the turn of the century. In 2006, the CanMEDS competency framework was introduced. A 2013 government plan to reduce the length and budgets of training programs led the Dutch Association of Medical Specialists (DAMS) to respond with a proposal to create more flexibility and individualization rather than a blunt cut in the length across all training programs. Read More

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