166 results match your criteria piroxicam pirox®

Patient-reported outcomes of topical therapies in actinic keratosis: A systematic review.

Dermatol Ther 2021 Mar 21;34(2):e14833. Epub 2021 Feb 21.

Clinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

Patients' perspectives on actinic keratosis treatments may have an impact on treatment adherence and, therefore, therapeutic outcomes. We performed a systematic review to assess patients' perspectives of topical, field-directed treatments for actinic keratoses. A literature search was conducted, and 14 studies were identified encompassing 4433 patients. Read More

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Nanovesicle formulation enhances anti-inflammatory and safe use of piroxicam.

Pharm Nanotechnol 2021 Jan 29. Epub 2021 Jan 29.

Drug Delivery and Nanotechnology Research Unit (RUNDD), Department of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, 410001, Enugu State. Nigeria.

Background: Enhanced utilization of certain drugs may be possible through the development of alternative delivery forms. Adverse gastrointestinal tract effects such as irritation and ulceration have limited wider applications of NSAIDs in antiiflammatory therapy. This challenge may be overcome through nano topical formulations. Read More

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January 2021

Bilosomes as Promising Nanovesicular Carriers for Improved Transdermal Delivery: Construction, in vitro Optimization, ex vivo Permeation and in vivo Evaluation.

Int J Nanomedicine 2020 8;15:9783-9798. Epub 2020 Dec 8.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Purpose: The goal of this research was to enhance the transdermal delivery of lornoxicam (LX), using nanovesicular carriers composed of the bile salt sodium deoxycholate (SDC), soybean phosphatidyl choline (SPC) and a permeation enhancer limonene.

Methods: Thin-film hydration was the technique employed for the fabrication using a Box-Behnken design with three central points. The investigated factors were SPC molar concentration, SDC amount in mg and limonene percentage (%). Read More

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December 2020

Role of bone marrow derived-mesenchymal stem cells against gastric ulceration: Histological, immunohistochemical and ultrastructural study.

Saudi J Biol Sci 2020 Dec 26;27(12):3456-3464. Epub 2020 Sep 26.

Zoology and Entomology Department, Faculty of Science, Helwan University, Egypt.

The current study aimed to assess the antiulcerogenic impact of mesenchymal bone marrow stem cells (BMMSCs) against gastric ulcer induced by the use of piroxicam in rats and to compare this effect with the antiulcer drug "Pantoloc ®" proton pump inhibitors. The study included histological, histochemical, immunohistochemical and ultrastructural examination in stomach of rats in different study groups. In the ulcerated group, the glandular region of the stomach displayed clear mucosal lesions occurring as perforations along the stomach axis. Read More

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December 2020

Biomimetic Artificial Membrane Permeability Assay over Franz Cell Apparatus Using BCS Model Drugs.

Pharmaceutics 2020 Oct 19;12(10). Epub 2020 Oct 19.

Laboratory of Biopharmacy and Pharmacokinetics (BioPK), Faculty of Pharmacy, Federal University of Goiás, Goiânia, Goiás 74175-100, Brazil.

A major parameter controlling the extent and rate of oral drug absorption is permeability through the lipid bilayer of intestinal epithelial cells. Here, a biomimetic artificial membrane permeability assay (Franz-PAMPA Pampa) was validated using a Franz cells apparatus. Both high and low permeability drugs (metoprolol and mannitol, respectively) were used as external standards. Read More

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October 2020

NSAIDs as a Drug Repurposing Strategy for Biofilm Control.

Antibiotics (Basel) 2020 Sep 10;9(9). Epub 2020 Sep 10.

LEPABE-Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal.

Persistent infections, usually associated with biofilm-producing bacteria, are challenging for both medical and scientific communities. The potential interest in drug repurposing for biofilm control is growing due to both disinvestment in antibiotic R&D and reduced efficacy of the available panel of antibiotics. In the present study, the antibacterial and antibiofilm activities of four non-steroidal anti-inflammatory drugs (NSAIDs), piroxicam (PXC), diclofenac sodium (DCF), acetylsalicylic acid (ASA) and naproxen sodium (NPX) were evaluated against and . Read More

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September 2020

Estragole prevents gastric ulcers via cytoprotective, antioxidant and immunoregulatory mechanisms in animal models.

Biomed Pharmacother 2020 Oct 1;130:110578. Epub 2020 Aug 1.

Postgraduate Program in Natural and Synthetic Bioactive Products, Health Sciences Center, Federal University of Paraíba (UFPB), João Pessoa, PB, Brazil. Electronic address:

Background: Estragole is an aromatic organic compound belonging to the class of phenylpropanoids derived from cinnamic aldehydes and present in essential oils of plant species, such asRavensara anisata (madeira), Ocimum basilicum (manjericão/alfavaca) and Croton zehntneri (canelinha). Pharmacological studies report its anti-inflammatory, antioxidant and vasorelaxant activity.

Hypothesis/purpose: This study aimed to evaluate the acute non-clinical toxicity, gastroprotective activity and the related mechanisms of action. Read More

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October 2020

Investigation of in vivo anti-inflammatory and anti-angiogenic attributes of coumarin-rich ethanolic extract of Melilotus indicus.

Inflammopharmacology 2021 Feb 15;29(1):281-293. Epub 2020 Apr 15.

Department of Pathology, Prince Faisal Oncology Centre, Buraydah Al Qassim, 51431, Saudi Arabia.

Inflammation and angiogenesis are two major contributors to tumourigenesis. Melilotus indicus is traditionally used as an anti-inflammatory agent. The current study was designed to investigate the anti-inflammatory and anti-angiogenic properties of ethanolic extract of M. Read More

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February 2021

Lornoxicam controlled release transdermal gel patch: Design, characterization and optimization using co-solvents as penetration enhancers.

PLoS One 2020 27;15(2):e0228908. Epub 2020 Feb 27.

Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.

The aim of the current study was to develop membrane-based transdermal patches of lornoxicam gel using oleic acid (OA)and propylene glycol (PG) as penetration enhancers to improve drug delivery across the skin and to evaluate in vivo analgesic and anti-inflammatory activity. For this purpose, nine formulations were developed in accordance with 32 factorial design using Design Expert® 11. The concentration of propylene glycol (X1) and oleic acid (X2) were selected as independent variable whereas Q10 (Y1), flux (Y2) and lag time (Y3) were considered as the response variables. Read More

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Development and Validation of an In-Line API Quantification Method Using AQbD Principles Based on UV-Vis Spectroscopy to Monitor and Optimise Continuous Hot Melt Extrusion Process.

Pharmaceutics 2020 Feb 12;12(2). Epub 2020 Feb 12.

Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.

A key principle of developing a new medicine is that quality should be built in, with a thorough understanding of the product and the manufacturing process supported by appropriate process controls. Quality by design principles that have been established for the development of drug products/substances can equally be applied to the development of analytical procedures. This paper presents the development and validation of a quantitative method to predict the concentration of piroxicam in Kollidon VA 64 during hot melt extrusion using analytical quality by design principles. Read More

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February 2020

Effectiveness of Phonophoresis Treatment in Carpal Tunnel Syndrome: A Randomized Double-blind, Controlled Trial.

PM R 2020 01 6;12(1):8-15. Epub 2019 Jun 6.

Department of Rehabilitation Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Objective: To determine the effects of phonophoresis of piroxicam (PH-P) and phonophoresis of dexamethasone sodium phosphate (PH-Dex) on mild to moderate carpal tunnel syndrome (CTS), and to compare each of them with the control group of nondrug ultrasound (US) therapy.

Design: A randomized, double-blind controlled trial.

Setting: Department of rehabilitation medicine, university hospital. Read More

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January 2020

Versatile reconfigurable glass capillary microfluidic devices with Lego® inspired blocks for drop generation and micromixing.

J Colloid Interface Sci 2019 Apr 29;542:23-32. Epub 2019 Jan 29.

Department of Chemical Engineering, Loughborough University, Loughborough LE11 3TU, United Kingdom. Electronic address:

Novel cost effective, versatile, reconfigurable, reusable and easy to assemble glass capillary microfluidic devices were developed and used to generate micro/nano-materials with controlled size and morphology. The devices are composed of coaxial assemblies of glass capillaries held between two interchangeable plastic blocks fabricated from chemically inert polyoxymethylene copolymer using computer numerical control (CNC) machining. Three different blocks were combined and locked together using Lego® inspired stud-and-hole coupling system to achieve different flow configurations. Read More

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Application of a Refined Developability Classification System.

J Pharm Sci 2019 03 30;108(3):1090-1100. Epub 2018 Oct 30.

Institute of Pharmaceutical Technology, Goethe University Frankfurt, Frankfurt am Main, Germany. Electronic address:

In 2010, the Developability Classification System was proposed as an extension of the Biopharmaceutics Classification System to align the classification system with the need for early evaluation of drug candidates according to their developability as oral formulations. Recent work on the Developability Classification System has resulted in the refined developability classification system (rDCS), consisting of standard investigations to estimate drug candidate solubility and permeability and offering customized investigations that are triggered when there is a potential for supersaturation/precipitation (e.g. Read More

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Risk of acute myocardial infarction during use of individual NSAIDs: A nested case-control study from the SOS project.

PLoS One 2018 1;13(11):e0204746. Epub 2018 Nov 1.

Julius Global Health, Utrecht, The Netherlands.

Background: Use of selective COX-2 non-steroidal anti-inflammatory drugs (NSAIDs) (coxibs) has been associated with an increased risk of acute myocardial infarction (AMI). However, the risk of AMI has only been studied for very few NSAIDs that are frequently used.

Objectives: To estimate the risk of AMI for individual NSAIDs. Read More

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A rapid analysis of piroxicam in beagle plasma applying evaporation-free liquid-liquid extraction by supercritical fluid chromatography-tandem mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Nov 3;1100-1101:93-99. Epub 2018 Oct 3.

Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China. Electronic address:

Bioequivalence study is highly prized to piroxicam (PIRO), since its generic products have been widely used worldwide. The present work was undertaken to explore the pharmacokinetic behaviors and bioequivalence of two branded PIRO tablets in beagle dogs using the supercritical fluid chromatography tandem mass spectrometry (SFC-MS/MS) method. Here, a fast evaporation-free liquid-liquid extraction (EF-LLE) method using ethyl acetate was developed for extracting PIRO from beagle dog plasma. Read More

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November 2018

In-Line UV-Vis Spectroscopy as a Fast-Working Process Analytical Technology (PAT) during Early Phase Product Development Using Hot Melt Extrusion (HME).

Pharmaceutics 2018 Sep 23;10(4). Epub 2018 Sep 23.

GMPharma Ltd., Stevenage SG2 8SB, UK.

This paper displays the potential of an in-line PAT system for early phase product development during pharmaceutical continuous manufacturing following a Quality by Design (QbD) framework. Hot melt extrusion (HME) is used as continuous manufacturing process and UV⁻Vis spectroscopy as an in-line monitoring system. A sequential design of experiments (DoE) (screening, optimisation and verification) was used to gain process understanding for the manufacture of piroxicam (PRX)/Kollidon VA64 amorphous solid dispersions. Read More

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September 2018

Risk of ischemic stroke and the use of individual non-steroidal anti-inflammatory drugs: A multi-country European database study within the SOS Project.

PLoS One 2018 19;13(9):e0203362. Epub 2018 Sep 19.

Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.

Background And Purpose: A multi-country European study using data from six healthcare databases from four countries was performed to evaluate in a large study population (>32 million) the risk of ischemic stroke (IS) associated with individual NSAIDs and to assess the impact of risk factors of IS and co-medication.

Methods: Case-control study nested in a cohort of new NSAID users. For each case, up to 100 sex- and age-matched controls were selected and confounder-adjusted odds ratios for current use of individual NSAIDs compared to past use calculated. Read More

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February 2019

Design, Synthesis, Characterization, QSAR, Docking, Anti-inflammatory and Analgesic Evaluation of Some New Phthalazinediones.

Antiinflamm Antiallergy Agents Med Chem 2018 ;17(1):3-15

Department of Chemistry, Faculty of Science and Arts, Ulla, Taibah University, Saudi Arabia.

Background: phthalazine derivatives were reported to possess anticonvulsant , cardiotonic , antibacterial, analgesic , anti-inflammatory, and anti-microbial activity. In the current study, we applied the QSAR for prediction of newly phthalazinediones incorporating thioamide moiety aiming to reach a more potent anti-inflammatory and Analgesic agent.

Methods: Phthalazinediones 10-15 have been synthesized through condensation of dibenzobarallene 3 with thiosemicarbazides 4-8. Read More

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February 2019

Non-ionic Surfactant Based In Situ Forming Vesicles as Controlled Parenteral Delivery Systems.

AAPS PharmSciTech 2018 Apr 6;19(3):1001-1010. Epub 2017 Nov 6.

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, End of 90th street, Fifth settlement, New Cairo, Egypt.

Non-ionic surfactant (NIS) based in situ forming vesicles (ISVs) present an affordable alternative to the traditional systems for the parenteral control of drug release. In this work, NIS based ISVs encapsulating tenoxicam were prepared using the emulsion method. Tenoxicam-loaded ISVs were prepared using a 2. Read More

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Fabrication and evaluation of Eudragit polymeric films for transdermal delivery of piroxicam.

Pharm Dev Technol 2018 Oct 2;23(8):771-779. Epub 2017 May 2.

a Department of Pharmacy, Faculty of Pharmacy , Mahidol University , Bangkok , Thailand.

The aims of this work were to develop and characterize the prolonged release piroxicam transdermal patch as a prototype to substitute oral formulations, to reduce side effects and improve patient compliance. The patches were composed of film formers (Eudragit) as a matrix backbone, with PVC as a backing membrane and PEG200 used as a plasticizer. Results from X-ray diffraction patterns and Fourier transform-infrared spectroscopy indicated that loading piroxicam into films changed the drug crystallinity from needle to an amorphous or dissolved form. Read More

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October 2018

A pharmaceutical study on lornoxicam fast disintegrating tablets: formulation and in vitro and in vivo evaluation.

Drug Deliv Transl Res 2017 06;7(3):450-459

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr el-Aini St, Cairo, 11562, Egypt.

Lornoxicam is an anti-inflammatory drug used to relieve rheumatoid arthritis pain, but the low water solubility and bitter taste of the drug present challenges for formulation as fast disintegrating tablets (FDTs). Complexation of the drug with β-cyclodextrin was initially carried out to increase the drug solubility and to mask its bitter taste. Tablets were prepared by direct compression of drug complex (DC), F-Melt, mannitol, crospovidone, and sodium starch glycolate (SSG). Read More

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Lornoxicam Immediate-Release Tablets: Formulation and Bioequivalence Study in Healthy Mediterranean Volunteers Using a Validated LC-MS/MS Method.

Clin Pharmacol Drug Dev 2017 Nov 8;6(6):564-569. Epub 2017 Feb 8.

Pharmaceutical Research Unit, Amman, Jordan.

This study aimed to demonstrate interchangeability between 2 lornoxicam tablet formulations under fasting conditions among Mediterranean Arabs by using a newly validated high-pressure liquid chromatography-tandem mass spectrometry method. A single-oral solid dosage form (8 mg/tablet), randomized, open-label, 2-way crossover study was conducted on 30 healthy male volunteers. Blood samples were collected prior to dosing and over a 24-hour period, and the washout period was 9 days. Read More

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November 2017

Effects of intravenous ibuprofen and lornoxicam on erythrocyte deformability in rats undergoing hind limb ischemia reperfusion injury.

Bratisl Lek Listy 2016 ;117(12):722-725

Background And Aim: Acute hind limb ischemia reperfusion (I/R) injury is a common consequence of abdominal aorta cross‑clamping during aortic surgery. Erythrocyte deformability is affected by I/R process and may lead to increased tissue and organ injury. Lornoxicam and intravenous ibuprofen are becoming commonly used as non-steroidal anti-inflammatory drugs (NSAID) for postoperative analgesia. Read More

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New Synthesis, Structure and Analgesic Properties of Methyl 1-R-4-Methyl-2,2-Dioxo-1H-2λ⁶,1-Benzothiazine-3-Carboxylates.

Sci Pharm 2017 Jan 12;85(1). Epub 2017 Jan 12.

Department of Pharmaceutical Chemistry, National University of Pharmacy, 53 Pushkinska St., 61002 Kharkiv, Ukraine.

According to the principles of the methodology of bioisosteric replacements a series of methyl 1-R-4-methyl-2,2-dioxo-1-2λ⁶,1-benzothiazine-3-carboxylates has been obtained as potential analgesics. In addition, a fundamentally new strategy for the synthesis of compounds of this chemical class involving the introduction of -alkyl substituent at the final stage in 2,1-benzothiazine nucleus already formed has been proposed. Using nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry and X-ray diffraction analysis it has been proven that in the DMSO/K₂CO₃ system the reaction of methyl 4-methyl-2,2-dioxo-1-2λ⁶,1-benzothiazine-3-carboxylate and alkyl halides leads to formation of -substituted derivatives with good yields regardless of the structure of the alkylating agent. Read More

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January 2017

Therapeutic mechanisms of ibuprofen, prednisone and betamethasone in osteoarthritis.

Mol Med Rep 2017 Feb 22;15(2):981-987. Epub 2016 Dec 22.

Department of Orthopedics, Beijing Rehabilitation Hospital, Capital Medical University, Beijing 100144, P.R. China.

The present study aimed to investigate the therapeutic mechanisms of nonsteroidal anti-inflammatory drugs (NSAIDs) and steroids in osteoarthritis (OA). The CHON‑002 human chondrocyte cell line was used in the study. The levels of the cytokines, interleukin (IL)‑1β, IL‑6, IL‑8 and IL‑10, released by cells treated with tumor necrosis factor‑α (TNF‑α) were determined by ELISA. Read More

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February 2017

The Measurement of Meloxicam and Meloxicam Metabolites in Rat Plasma Using a High-Performance Liquid Chromatography-Ultraviolet Spectrophotometry Method.

Chem Pharm Bull (Tokyo) 2017 Feb 1;65(2):121-126. Epub 2016 Dec 1.

School of Pharmacy, Nihon University.

A high-performance liquid chromatography-ultraviolet spectrophotometry (HPLC-UV) method for the determination of meloxicam (MEL) and meloxicam metabolites (5'-hydroxy meloxicam (5-HMEL) and 5'-carboxy meloxicam (5-CMEL)) has been developed. After extraction of MEL, 5-HMEL, and 5-CMEL from rat plasma using Oasis HLB cartridges, the extracts were separated with a Luna C18 (2) 100 A column (5 µm, 4.6×150 mm, Phenomenex) using a mobile phase of 50 mM phosphate buffer (pH 2. Read More

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February 2017

Nanoemulsifying drug delivery system to improve the bioavailability of piroxicam.

Pharm Dev Technol 2017 May 25;22(3):445-456. Epub 2016 Oct 25.

a Department of Pharmaceutics, Faculty of Pharmacy , Mansoura University , Mansoura , Egypt.

Objective: The aim of this study is to develop and characterize self-nanoemulsifying drug delivery system (SNEDDS) of piroxicam in liquid and solid forms to improve its dissolution, absorption and therapeutic efficacy.

Materials And Methods: The generation of liquid SNEDDS (L-SNEDDS) was composed of soybean or coconut oil/Tween 80/Transcutol HP (12/80/8%w/w) and it was selected as the optimized formulation based on the solubility study and pseudo-ternary phase diagram. Optimized L-SNEDDS and liquid supersaturatable SNEDDS (L-sSNEDDS) preparations were then adsorbed onto adsorbents and formulated as directly compressed tablets. Read More

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Comparative evaluation of the efficacy of two modes of delivery of Piroxicam (Dolonex(®)) for the management of postendodontic pain: A randomized control trial.

J Conserv Dent 2016 Jul-Aug;19(4):301-5

Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, M S Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.

Background: Alleviating pain is of utmost importance when treating patients with endodontic pain.

Aim: To compare and evaluate the efficacy of two modes of delivery of pretreatment Piroxicam (Dolonex(®), Pfizer) for the management of postendodontic pain.

Materials And Methods: Sixty-six patients with symptomatic irreversible pulpitis were randomly divided into three groups of 22 subjects Group I - control group, no pharmacological intervention, Group II - patients received pretreatment oral Piroxicam (40 mg), Group III - patients received pretreatment intraligamentary injections totaling 0. Read More

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Sustained release of piroxicam from solid lipid nanoparticle as an effective anti-inflammatory therapeutics in vivo.

Drug Dev Ind Pharm 2017 Jan 1;43(1):55-66. Epub 2016 Sep 1.

a Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University , Hangzhou , P.R. China.

This study aims to investigate the solid lipid nanoparticle (SLN) as a novel vehicle for the sustained release and transdermal delivery of piroxicam, as well as to determine the anti-inflammation effect of piroxicam-loaded SLN. SLN formulation was optimized and the particle size, polydispersity index, zeta potential (ZP), encapsulation efficiency, drug release, and morphological properties were characterized. The transdermal efficiency and mechanism of the piroxicam-loaded SLNs were investigated in vitro. Read More

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January 2017

Lecithin and PLGA-based self-assembled nanocomposite, Lecithmer: preparation, characterization, and pharmacokinetic/pharmacodynamic evaluation.

Drug Deliv Transl Res 2016 08;6(4):342-53

Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz (E), Mumbai, 400 098, India.

The present study investigates the drug delivery potential of polymer lipid hybrid nanocomposites (Lecithmer®) composed of poly(D,L-lactide-co-glycolide (PLGA) and soya lecithin. Core-shell structure of Lecithmer was evident from cryo-TEM images. Daunorubicin (DNR) and lornoxicam (LNX)-incorporated Lecithmer nanocomposites were evaluated for anticancer and anti-inflammatory activity. Read More

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