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Endurance Exercise Training reduces Blood Pressure according to the Wilder's Principle.

Int J Sports Med 2021 Sep 24. Epub 2021 Sep 24.

Universidad de Castilla-La Mancha, Sport Sciences, Toledo, Spain.

The effect of antihypertensive medicine (AHM) is larger the higher the pre-treatment blood pressure level. It is unknown whether this Wilder's principle, also applies for the exercise-training blood pressure (BP) lowering effect. One hundred seventy-eight (n=178) middle-aged individuals (55±8 y) with metabolic syndrome (MetS), underwent high intensity interval training (3 days·week) for 16 weeks. Read More

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September 2021

Psychosocial Impact of Coronal Access Scars in Craniosynostosis Procedures on Patients and Their Families.

J Craniofac Surg 2021 Sep 24. Epub 2021 Sep 24.

Oxford Craniofacial Unit Department of Plastic and Reconstructive Surgery Department of Psychological Medicine, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Headley Way, Oxford, UK.

Abstract: The coronal incision is the mainstay for access in craniosynostosis surgery. Scarring is a common concern of parents whose children are offered an open procedure. To the author's knowledge, there are no previous studies looking at the psychosocial impact of scarring from coronal access incisions for craniosynostosis procedures. Read More

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September 2021

Pessary or Surgery for a Symptomatic Pelvic Organ Prolapse, PEOPLE study: A Multicenter Prospective Cohort Study.

BJOG 2021 Sep 24. Epub 2021 Sep 24.

Department of Obstetrics and Gynaecology, UMCU, University of Utrecht, 3584 CX, Utrecht, the Netherlands.

Objective: To compare the 24-months efficacy of pessary or surgery as primary treatment for symptomatic pelvic organ prolapse (POP).

Design: Multicenter prospective comparative cohort study.

Setting: Twenty-two Dutch hospitals. Read More

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September 2021

YouTube as a source of information on bladder pain syndrome: A contemporary analysis.

Neurourol Urodyn 2021 Sep 24. Epub 2021 Sep 24.

Department of Neurosciences, Reproductive Sciences and Odontostomatology, Urology Unit, University of Naples "Federico II", Naples, Italy.

Aim: To evaluate the quality of YouTube™ videos on bladder pain syndrome (BPS) and to investigate whether they can be used as a reliable source of information.

Methods: The search term "bladder pain syndrome" was used on YouTube platform. The first 100 videos were selected. Read More

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September 2021

Screening Hamstring Injury Risk Factors Multiple Times in a Season Does Not Improve the Identification of Future Injury Risk.

Med Sci Sports Exerc 2021 Sep 20. Epub 2021 Sep 20.

School of Behavioural and Health Sciences, Australian Catholic University, Fitzroy, Victoria, Australia Sports Performance, Recovery, Injury and New Techologies (SPRINT) Research Centre, Australian Catholic University, Fitzroy, Victoria, Australia Vald Performance, Newstead, Queensland, Australia School of Health, Sport and Professional Practice, Faculty of Life Sciences and Education, University of South Wales, Treforest, United Kingdom School of Allied Health Sciences, Griffith University, Gold Coast Campus, Queensland, Australia Griffith Centre for Biomedical and Rehabilitation Engineering, Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia La Trobe Sport and Exercise Medicine Research Centre, La Trobe University, Melbourne, Victoria, Australia.

Purpose: To determine if eccentric knee flexor strength and biceps femoris long head (BFlh) fascicle length were associated with prospective HSI in professional Australian Football players, and if more frequent assessments of these variables altered the association with injury risk.

Methods: Across two competitive seasons, 311 Australian Football players (455 player seasons) had their eccentric knee flexor strength during the Nordic hamstring exercise and BFlh architecture assessed at the start and end of preseason and in the middle of the competitive season. Player age and injury history were also collected in preseason. Read More

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September 2021

Orthopaedic Trauma Research Priorities in Latin America: Developing Consensus Through a Modified Delphi Approach.

J Bone Joint Surg Am 2021 Sep 24. Epub 2021 Sep 24.

University of California San Francisco, San Francisco, California.

Background: Despite a substantial burden of musculoskeletal injury, orthopaedic trauma studies in Latin America are lacking. The purpose of the present study was to identify research priorities among orthopaedic trauma surgeons in Latin America.

Methods: Research questions were solicited from members of the Asociación de Cirujanos Traumatólogos de las Américas. Read More

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September 2021

Using Community-Based Participatory Research to Characterize Health and Lifestyle Behaviors of Montagnards, a Refugee-Origin Asian-American Subgroup.

J Immigr Minor Health 2021 Sep 24. Epub 2021 Sep 24.

School of Social Work, North Carolina State University, 1911 Building 207, Campus Box 7639, Raleigh, NC, 27695-8101, USA.

Montagnards, an indigenous multitribal refugee-origin population concentrated in North Carolina, remain an invisible, medically underserved, and socioeconomically underrepresented Asian American sub-group. Yet this group is resilient, with language diversity, rich cultural traditions and family caregiving in multigenerational households. Using community-based participatory research methods, we developed and administered a two-part survey to 144 Montagnard adults, documenting socioeconomic characteristics, health indicators and lifestyle behaviors. Read More

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September 2021

Potential use of ground brown rice for weanling pigs.

J Anim Sci 2021 Sep 24. Epub 2021 Sep 24.

Division of Animal and Dairy Science, Chungnam National University, Daejeon 34134, Korea.

The current study was to assess the effects of substituting corn with ground brown rice (GBR) on growth performance, immune status, and gut microbiota in weanling pigs. Seventy-two weanling pigs [28-day-old with 6.78 ± 0. Read More

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September 2021

A laboratory-based analysis of rapidly growing mycobacteria in Northwest Paulista, Sao Paulo, Brazil.

Int J Mycobacteriol 2021 Apr-Jun;10(2):170-176

Adolfo Lutz Institute, Central Laboratory of Tuberculosis and Mycobacteriosis Laboratory, São Paulo, Brazil.

Background: Rapidly growing mycobacteria (RGM) are a group of nontuberculous mycobacteria (NTM) implicated in difficult-to-treat pulmonary and extrapulmonary diseases, possibly associated with invasive procedures and failures in sterilization of materials and equipment.

Methods: We report our experience with the laboratory identification of RGM in a routine work and give an overview of the RGM isolated in our setting. Laboratorial data from all RGM mycobacterial isolates received at Adolfo Lutz Institute of São José do Rio Preto were analyzed from January 2000 to December 2015. Read More

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September 2021

Impact of COVID-19 pandemic on bariatric surgery in India: An obesity and metabolic surgery society of India survey of 1307 patients.

J Minim Access Surg 2021 Oct-Dec;17(4):542-547

Wockhardt Hospital, Mumbai, Maharashtra, India.

Background: Although safe practice guidelines were issued by the Obesity and Metabolic Surgery Society of India (OSSI) in the end of May 2020, surgeons have been in a dilemma about risk of subjecting patients to hospitalisation and bariatric surgery. This survey was conducted with the objective to evaluate the risk of coronavirus disease-19 (COVID-19) infection in peri- and post-operative period after bariatric and metabolic surgery (BMS).

Methods: A survey with OSSI members was conducted from 20 July 2020 to 31 August 2020 in accordance with EQUATOR guidelines. Read More

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September 2021

Multifocal visual evoked potential evaluation for diagnosis of acute optic neuritis and for prediction of visual outcome and ganglion cell layer thinning following optic neuritis.

Mult Scler 2021 Oct 2;27(11):1717-1726. Epub 2020 Dec 2.

Clinic of Optic Neuritis and Clinic of Multiple Sclerosis, Department of Neurology, Rigshospitalet - Glostrup, Glostrup, Denmark; University of Copenhagen, Copenhagen, Denmark.

Background:: While damage to the optic nerve following optic neuritis (ON) is readily quantifiable, the evaluation of prognosis for visual function and neuroaxonal loss in the acute ON is challenging.

Objective:: The objective of this study is to investigate the value of multifocal visual evoked potential (mfVEP) in acute ON, diagnostically for acute ON and prognostically for visual outcome and subsequent ganglion cell/inner plexiform layer thickness (GCLIPLt).

Methods:: A prospective cohort study of mfVEP and full-field visual evoked potential (ffVEP) in acute, unilateral ON (onset < 31 days) was conducted. Read More

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October 2021

Effects of multimedia-based fall prevention education on the knowledge, attitudes, or behaviors of patients.

Jpn J Nurs Sci 2021 Sep 24:e12455. Epub 2021 Sep 24.

Health Evaluation Center, St. Martin De Porres Hospital, Chiayi City, Taiwan.

Objectives: Patient safety is regarded as a critical quality monitoring indicator for medical institutions. The effects of a multimedia-based patient education intervention on knowledge, attitudes, and behaviors regarding fall prevention were observed.

Methods: The study had a quasi-experimental research design and enrolled 140 participants. Read More

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September 2021

Prognostic factors for patients with relapsed central nervous system nongerminomatous germ cell tumors.

Pediatr Blood Cancer 2021 Sep 24:e29365. Epub 2021 Sep 24.

The Division of Hematology, Oncology and BMT, The Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio.

We aimed toidentify prognostic factors that may help better understand the behavior of relapsed central nervous system nongerminomatous germ cell tumors. We identified nine studies, including 101 patients; 33 patients (33%) were alive 12 months post-initial relapse. Sixty percent of patients with serum/cerebrospinal fluid (CSF) alpha-fetoprotein (AFP) level ≤25 ng/mL at initial diagnosis were survivors compared with 28% among patients with serum/CSF AFP level >25 ng/mL (P = 0. Read More

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September 2021

Prospective study of fertility-sparing treatment with Chlormadinone acetate for endometrial carcinoma and atypical hyperplasia in young women.

Int J Gynaecol Obstet 2021 Sep 24. Epub 2021 Sep 24.

Department of obstetric and gynecologic Surgery, Hôpital Bichat Claude Bernard, 46 rue Henry Huchard, 75018, Paris, France.

Objective: Fertility-sparing treatment is based on progestin therapy and is known to be safe and effective. International recommendations advise the use of megestrol acetate or medroxyprogesterone acetate. However, chlormadinone acetate has fewer undesirable effects and can be used in patients with a history of thromboembolism who are at high vascular risk. Read More

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September 2021

Redox-Mediated Regulation of Mitochondrial Biogenesis, Dynamics, and Respiratory Chain Assembly in Yeast and Human Cells.

Front Cell Dev Biol 2021 7;9:720656. Epub 2021 Sep 7.

Institute of Molecular Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.

Mitochondria are double-membrane organelles that contain their own genome, the mitochondrial DNA (mtDNA), and reminiscent of its endosymbiotic origin. Mitochondria are responsible for cellular respiration via the function of the electron oxidative phosphorylation system (OXPHOS), located in the mitochondrial inner membrane and composed of the four electron transport chain (ETC) enzymes (complexes I-IV), and the ATP synthase (complex V). Even though the mtDNA encodes essential OXPHOS components, the large majority of the structural subunits and additional biogenetical factors (more than seventy proteins) are encoded in the nucleus and translated in the cytoplasm. Read More

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September 2021

Knowledge and Prevalence of Supplements Used by Brazilian Resistance Training Practitioners Before Coronavirus Outbreak.

Open Access J Sports Med 2021 16;12:139-146. Epub 2021 Sep 16.

Setor de Fisiologia Humana e do Exercício, Faculdade de Educação Física e Dança, Universidade Federal de Goiás, Goiânia, Brasil.

Introduction: The use of dietary supplements and ergogenic aids (DSEA) is popular among physical activity enthusiasts. Particularly, resistance training (RT) practitioners represent important DSEA consumers due to its easy access and the appeal of claims related to muscle hypertrophy, aesthetics, and physical performance improvements.

Methods: Our aim was to study knowledge, prevalence, and profile of DSEA used by Brazilian recreational RT practitioners. Read More

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September 2021

Estimated Prevalence and Number of PiMZ Genotypes of Alpha-1 Antitrypsin in Seventy-Four Countries Worldwide.

Int J Chron Obstruct Pulmon Dis 2021 17;16:2617-2630. Epub 2021 Sep 17.

Pneumology Department, Hospital Universitari Vall d'Hebron/Vall d'Hebron Research Institute (VHIR), Vall d'Hebron Barcelona Hospital Campus, CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain.

Background: The α-1 antitrypsin (AAT) protease inhibitor PiMZ is a moderately deficient genotype, until recently considered of little or negligible risk. However, a growing number of studies show that MZ carriers have an increased risk of developing lung and liver diseases, if exposed to smoking or other airborne or industrial pollutants, and hepatotoxic substances.

Methods: We used the epidemiological studies performed to determine the frequencies of PiM and PiZ worldwide, based on the following criteria: 1) samples representative of the general population; 2) AAT phenotyping or genotyping characterized by adequate methods, including isoelectric focusing and polymerase chain reaction; and 3) studies with reliable results assessed with a coefficient of variation calculated from the sample size and 95% confidence intervals, to measure the precision of the results in terms of dispersion of the data around the mean. Read More

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September 2021

Epidemiology of Staphylococcus pseudintermedius in cats in Poland.

Sci Rep 2021 Sep 23;11(1):18898. Epub 2021 Sep 23.

Department of Immunology of Infectious Diseases, Hirszfeld Institute of Immunology and Experimental Therapy, Weigla 12, 53-114, Wroclaw, Poland.

Staphylococcus pseudintermedius is a well-known coagulase-positive staphylococcus that is mainly associated with the asymptomatic colonization of the skin of pets and mucous membranes. Little is still known about the occurrence of S. pseudintermedius in cats. Read More

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September 2021

Risk of urinary tract infection in patients with hydroureter: An analysis from the Society of Fetal Urology Prenatal Hydronephrosis Registry.

J Pediatr Urol 2021 Sep 21. Epub 2021 Sep 21.

CHOC Children's, Division of Pediatric Urology, Orange, CA, USA; University of California, Irvine, Department of Urology, Irvine, CA, USA.

Background: Prenatal hydronephrosis is one of the most common anomalies detected on prenatal ultrasonography. Patients with prenatal hydronephrosis and ureteral dilation are at increased risk of urinary tract infection (UTI) and continuous antibiotic prophylaxis (CAP) is recommended. However, current guidelines do not define the minimum ureteral diameter that would be considered a dilated ureter in these patients. Read More

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September 2021

Ten-year epidemiological study of ocular and orbital tumors in Chiba University Hospital.

BMC Ophthalmol 2021 Sep 23;21(1):344. Epub 2021 Sep 23.

Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba, 260-8670, Japan.

Background: The purpose of this study is to determine the epidemiology of tumors of the ocular adnexa and orbit in Japan.

Methods: We conducted a retrospective study on the histopathological reports in the medical records of the Chiba University Hospital from April 2009 to March 2019. Three hundred and seventy two records were examined. Read More

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September 2021

Interleukin-35 suppresses the activity of natural killer-like B cells in patients with hepatocellular carcinoma.

Int Immunopharmacol 2021 Sep 20;100:108161. Epub 2021 Sep 20.

Digestive Diseases Center, Department of Hepatopancreatobiliary Medicine, The Second Hospital, Jilin University, Changchun, Jilin Province 130041, People's Republic of China. Electronic address:

Natural killer-like B (NKB) cells are newly identified lymphocyte subset, which present immunomodulatory property in infectious diseases through secretion of interleukin-18 (IL-18). However, the role of NKB cells function and its regulation in hepatocellular carcinoma (HCC) is not elucidated. Seventy-two HCC patients and twenty-five controls were enrolled. Read More

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September 2021

Roles and reimbursement of pharmacists as South Africa transitions towards Universal Health Coverage (UHC): An online survey-based study.

PLoS One 2021 23;16(9):e0257348. Epub 2021 Sep 23.

Discipline of Pharmaceutical Sciences, Westville Campus, University of KwaZulu-Natal, Durban, South Africa.

Background: The implementation of Universal Health Coverage in SA has sought to focus on promoting affordable health care services that are accessible to all citizens. In this regard, pharmacists are expected to play a pivotal function in the revitalization of primary health care (PHC) during this transition by the expansion of their practice roles.

Objectives: To assess the readiness and perceptions of pharmacists to expand their roles in an integrated health care system. Read More

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September 2021

Vegan vs. omnivore diets paradox: A whole-metagenomic approach for defining metabolic networks during the race in ultra-marathoners- a before and after study design.

PLoS One 2021 23;16(9):e0255952. Epub 2021 Sep 23.

Institute of Primary Care, University of Zurich, Zurich, Switzerland.

Background: The effect of vegan diets on metabolic processes in the body is still controversial in ultra endurance athletes. The study aims to determine gut microbiome adaptation to extreme exercise according to vegan or omnivore diet consumed in ultra-marathoners. We also seek to evaluate long-term vegan diets' effects on redox homeostasis, and muscle fatigue, and assess energy availability. Read More

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September 2021

Investigation of Effectiveness of Two Different Kinesiotaping Techniques in Myofascial Pain Syndrome: An Open-Label Randomized Clinical Trial.

Pain Physician 2021 Sep;24(6):E721-E731

Istanbul Faculty of Medicine, Istanbul University, Fatih, Turkey.

Background: Myofascial pain syndrome is a regional musculoskeletal pain syndrome characterized by trigger points. Although there are widely accepted treatment modalities, there is no gold standard treatment. Kinesiotaping represents an interesting modality in the treatment of musculoskeletal disorders and attracts attention with studies emerging in the recent years, but in spite of the proposed benefits of kinesiotaping, its efficacy is still unclear, thus further studies evaluating the effectiveness of kinesiotaping are needed. Read More

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September 2021

Safety and feasibility of implanting a transvenous implantable cardioverter defibrillator (TV-ICD) in the left Axilla.

Pacing Clin Electrophysiol 2021 Sep 23. Epub 2021 Sep 23.

Division of Cardiovascular Medicine, Toho University Ohashi Medical Center.

Background: Transvenous implantable cardioverter defibrillator (TV-ICD) systems are commonly implanted in the left anterior chest because of an easier implantation and better defibrillation threshold. This study aimed to evaluate the safety and feasibility of left axillary implantations of TV-ICD systems.

Methods: We performed left axillary TV-ICD implantations and compared that to the major complication rate and operation time of the conventional TV-ICD implantation site (left anterior chest). Read More

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September 2021

Orocutaneous Fistula After Oral Cavity Resection and Reconstruction: Systematic Review and Meta-Analysis.

Ann Otol Rhinol Laryngol 2021 Sep 23:34894211047463. Epub 2021 Sep 23.

Department of Otolaryngology-Head & Neck Surgery, University of Missouri, Columbia, MO, USA.

Objective: Orocutaneous fistula (OCF) after reconstruction for oral cavity resection can lead to prolonged hospitalization and adjuvant treatment delay. Few studies have examined factors leading to OCF after oral cavity resection. Primary objective: evaluate overall incidence and factors associated with OCF after oral cavity reconstruction. Read More

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September 2021

Regional lung metabolic profile in a piglet model of cardiopulmonary bypass with circulatory arrest.

Metabolomics 2021 Sep 22;17(10):89. Epub 2021 Sep 22.

Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA.

Introduction: Acute lung injury is common following cardiopulmonary bypass and deep hypothermic circulatory arrest for congenital heart surgery with the most severe injury in the dorsocaudal lung. Metabolomics offers promise in deducing mechanisms of disease states, providing risk stratification, and understanding therapeutic responses in regards to CPB/DHCA related organ injury.

Objectives: Using an infant porcine model, we sought to determine the individual and additive effects of CPB/DHCA and lung region on the metabolic fingerprint, metabolic pathways, and individual metabolites in lung tissue. Read More

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September 2021

Influence of oral nutritional agents rich in soluble dietary fiber on intestinal flora of elderly men with malnutrition.

Aging Med (Milton) 2021 Sep 31;4(3):162-168. Epub 2021 Aug 31.

Department of Endocrinology/Department of Health Care The Key Laboratory of Geriatrics Beijing Institution of Geriatrics Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China.

Objective: Observe the influence of oral nutritional agents rich in soluble dietary (enteral nutritional suspension [TPF-DM]) on intestinal flora of elderly male subjects with malnutrition.

Method: Seventy-eight subjects with good nutrition were considered as the healthy control group. Twenty-eight male subjects who had malnutrition and were older than 70 years were included and randomly divided into the short-term (3 months) intervention group (n = 20) and the long-term (12 months) group (n = 8). Read More

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September 2021

Adverse Events as a Potential Clinical Marker of Antitumor Efficacy in Ovarian Cancer Patients Treated With Poly ADP-Ribose Polymerase Inhibitor.

Front Oncol 2021 6;11:724620. Epub 2021 Sep 6.

Department of Gynecologic Oncology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, China.

Background: PARP inhibitor (PARPi) is an important progress in ovarian cancer treatment. The available evidence suggests that BRCA mutation and homologous recombination deficiency (HRD) are effective biological markers for PARPi. Here we investigated the relationship between adverse events (AEs) and efficacy of PARPi in ovarian cancer patients. Read More

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September 2021

The effect of medical and urologic disorders on the survival of patients with metastatic castration resistant prostate cancer treated with abiraterone or enzalutamide.

Ther Adv Urol 2021 Jan-Dec;13:17562872211043341. Epub 2021 Sep 17.

Urology Department, University Hospital Ramon y Cajal, Madrid, Spain.

Introduction: Androgenic deprivation therapies have been linked to the development of metabolic syndrome (MS) and cardiovascular diseases, which may lead to a poorer survival in patients with metastatic Castration-Resistant Prostate Cancer (mCRPC). We aimed to analyze whether some cardiovascular or neurological disorders, together with other medical and urological complications, may have an effect on survival outcomes, at baseline and during treatment from patients treated with androgen pathway inhibitors (API).

Material And Methods: A retrospective study of a consecutive series of patients diagnosed with mCRPC between 2010 and 2018 treated with API in the first line setting in a single center. Read More

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September 2021