187,964 results match your criteria pilot study


Attitudes towards Kratom use, decriminalization and the development of a community-based Kratom control mechanism in Southern Thailand.

Int J Drug Policy 2021 May 12;95:103197. Epub 2021 May 12.

North Substance Abuse Center, Chiangmai University, Thailand.

Kratom (Mitragyna speciosa Korth.) is an indigenous plant of Southeast Asia, which has been used in traditional medicine for centuries. Despite local communities in Southern Thailand viewing Kratom as a traditional remedy and not as an illicit drug, Thailand criminalized Kratom in 1943 which has led to tensions between government authorities and local communities. Read More

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Getting the conclusive lead with investigative genetic genealogy - A successful case study of a 16 year old double murder in Sweden.

Forensic Sci Int Genet 2021 May 8;53:102525. Epub 2021 May 8.

National Forensic Centre, Swedish Police Authority, Linköping, Sweden; Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden. Electronic address:

On the morning of October 19, 2004, an eight-year-old boy and a 56-year-old woman were stabbed to death on an open street in the city of Linköping, Sweden. The perpetrator left his DNA at the crime scene, and after 15 years of various investigation efforts, including more than 9000 interrogations and mass DNA screening of more than 6000 men, there were still no clues about the identity of the unknown murderer. The successful application of investigative genetic genealogy (IGG) in the US raised the interest for this tool within the Swedish Police Authority. Read More

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Pilot-scale two-stage constructed wetlands based on novel solid carbon for rural wastewater treatment in southern China: Enhanced nitrogen removal and mechanism.

J Environ Manage 2021 May 12;292:112750. Epub 2021 May 12.

Department of Environmental Science, College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, PR China. Electronic address:

Constructed wetlands (CWs) have been proved to be an alternative to the treatment of various wastewater. However, there are few studies focused on the removal performance and mechanisms of pollutants in pilot-scale CWs packed with novel solid carbon. In this study, we investigated the effect of poly-3-hydroxybutyrate-co-3-hydroxyvalerate/polyacetic acid (PHBV/PLA) blends as carbon source on pollutant's transformation, microbial communities and functional genes in pilot-scale aeration-anoxic two-stage CWs for polishing rural runoff in southern China. Read More

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Ammonia nitrogen removal from coking wastewater and high quality gypsum recovery by struvite recycling by using calcium hydroxide as decomposer.

J Environ Manage 2021 May 12;292:112712. Epub 2021 May 12.

School of Environment and Civil Engineering, Dongguan University of Technology, Dongguan, 523808, China.

This study deals with the highly significant and cost-effective pretreatment of the high concentration of the Total Ammonia Nitrogen (TAN) in coking wastewater to improve the biodegradability. Struvite crystallization is a promising process for TAN removal, but the high operating cost hinders its application. To solve this problem, a novel struvite recycling process was proposed for pre-treating TAN present in the coking wastewater, within which struvite was decomposed in the solid-liquid system using Ca(OH) as the decomposer. Read More

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Development and validation of knowledge of caring for COVID-19 tool.

Nurs Open 2021 May 15. Epub 2021 May 15.

Oman College of Health Sciences, Muscat, Oman.

Aim: We aimed to examine the validity and reliability of a newly developed tool that measures nursing and allied health students' knowledge of caring for patients with COVID-19.

Method: We developed in five phases (literature review, item development, expert evaluation using content validity index, revisions based on a pilot test, and exploratory factor and reliability analyses on the data from the main study). We administered online surveys (the pilot test & the main study using a cross-sectional design) to students in a governmental health sciences college in Oman. Read More

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Children with ASD: A Pilot Study.

J Autism Dev Disord 2021 May 15. Epub 2021 May 15.

Instituto de Investigación de Enfermedades Raras, Instituto de Salud Carlos III, 28029, Madrid, Spain.

While advances in intensive neonatal care have greatly improved survival rates among preterm infants, incidence of neurodevelopmental disorders in this group is still high, with autism spectrum disorder (ASD) being one of the most frequent. To this end, we conducted a social-communication intervention aimed at investigating efficacy in social-communicative skills. Eighteen children (preterm and full-term with ASD and preterm children) aged 18 through 20 months participated in the study. Read More

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Leap-2/ghrelin interplay in adult growth hormone deficiency: cause or consequence? A pilot study.

IUBMB Life 2021 May 15. Epub 2021 May 15.

Dipartimento di Sicurezza e Bioetica, Sezione di Farmacologia, Università Cattolica del Sacro Cuore - Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.

Ghrelin and its endogenous antagonist liver-expressed antimicrobial peptide-2 (LEAP-2) are involved in GH secretion and glucose/lipids metabolism. LEAP-2 expression in conditions of metabolic impairment may be upregulated, usually pairing with a concomitant reduction in ghrelin secretion. Adult growth hormone deficiency (aGHD) is characterized by insulin resistance, weight gain and increased fat mass. Read More

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Fatigue Perpetuating Factors as Mediators of Change in a Cognitive Behavioral Intervention for Targeted Therapy-Related Fatigue in Chronic Myeloid Leukemia: A Pilot Study.

Ann Behav Med 2021 May 15. Epub 2021 May 15.

Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA.

Background: Cognitive behavioral therapy for targeted-therapy related fatigue (CBT-TTF) has demonstrated preliminary efficacy in reducing fatigue in patients treated with tyrosine kinase inhibitors (TKIs) for chronic myeloid leukemia (CML).

Purpose: The aim of the current analyses was to explore whether fatigue perpetuating factors (disturbed sleep/wake cycle, dysregulated activity patterns, maladaptive cognitions about fatigue and cancer, insufficient processing of cancer and treatment, inadequate social support and interactions, heightened fear of cancer progression) changed over time in patients receiving CBT-TTF, and whether the effect of CBT-TTF on fatigue was mediated by these factors.

Methods: Secondary data analyses were conducted from a pilot randomized controlled trial. Read More

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Feasibility and Acceptability of a Language Concordant Health Coaching Intervention Delivered by Nurses for Latinx With Type 2 Diabetes.

Worldviews Evid Based Nurs 2021 May 14. Epub 2021 May 14.

University of South Florida College of Nursing, Tampa, FL, USA.

Background: Latinx immigrants have high rates of type 2 diabetes (T2D), exhibit out-of-range glycemic control, and have higher rates of diabetes-related complications than non-Latinx whites, with limited English proficiency (LEP) being a major barrier to care.

Aims: We tested the feasibility and acceptability of a language concordant (provider that is proficient in the patient's preferred language) health coaching intervention delivered by nurse and nurse practitioner students in a pilot study of Latinx immigrants with T2D and LEP.

Methods: A sample of 17 Latinx immigrants with T2D and LEP were split into intervention and control groups. Read More

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High-risk individuals for gastric cancer would be missed for surveillance without subtyping of intestinal metaplasia.

Virchows Arch 2021 May 14. Epub 2021 May 14.

Institute of Clinical and Preventive Medicine, Faculty of Medicine, University of Latvia, 19 Raina Blvd, Riga, 1006, Latvia.

The use of Operative Link on Gastritis Assessment (OLGA) and Operative Link on Gastritis Assessment based on Intestinal Metaplasia (OLGIM) staging system is recommended for identifying subjects at risk for developing gastric cancer; usually high-risk lesions are considered only as stages III and IV. Accumulating evidence suggests that incomplete intestinal metaplasia (IM) is important in the development of gastric cancer. Our aim has been to identify the prevalence of incomplete IM in patients with low-risk OLGA/OLGIM stages among a high-risk general population. Read More

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Factors Contributing to Late Cancellation and No-Show for Otolaryngologic Surgery: A Prospective Study.

J Healthc Qual 2021 May 12. Epub 2021 May 12.

Purpose: Late cancellations and no-shows for surgery place a burden on patients, healthcare providers, and the health system. We aim to identify risk factors contributing to this phenomenon.

Methods: Patients who did not arrive for, or canceled within 24 hours of, their surgical appointment between January 2019 and 2020 were identified. Read More

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Translation and Cultural Adaptation of the Ages and Stages Questionnaires (ASQ) Worldwide: A Scoping Review.

J Dev Behav Pediatr 2021 May 12. Epub 2021 May 12.

Department of Psychoeducation, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada; Department of Pediarics, Clinica Alemana-Facultad de Medicina Universidad del Desarrollo, Santiago, Chile.

Objective: This scoping review aims to provide a data mapping and narrative synthesis of the available peer-reviewed scientific literature on the translation and cultural adaptation processes relative to the Ages and Stages Questionnaires (ASQ) as reported by the authors. It also seeks to paint an overall portrait of the implementation of the translated and culturally adapted ASQ worldwide.

Methods: Articles published between 1995 and May 11, 2018, were identified via systematic searches of peer-reviewed literature carried out using CINAHL, Scopus, MEDLINE, Education Source, PsycINFO, and ERIC. Read More

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A strategy to improve expert technology forecasts.

Proc Natl Acad Sci U S A 2021 May;118(21)

Department of Engineering and Public Policy, Carnegie Mellon University, Pittsburgh, PA 15213

Forecasts of the future cost and performance of technologies are often used to support decision-making. However, retrospective reviews find that many forecasts made by experts are not very accurate and are often seriously overconfident, with realized values too frequently falling outside of forecasted ranges. Here, we outline a hybrid approach to expert elicitation that we believe might improve forecasts of future technologies. Read More

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Association of gestational diabetes mellitus with changes in gut microbiota composition at the species level.

BMC Microbiol 2021 May 14;21(1):147. Epub 2021 May 14.

Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: Gestational diabetes mellitus (GDM), a common endocrine disorder with rising prevalence in pregnancy, has been reported to be associated with alteration of gut microbiota in recent years. However, the role of gut microbiome in GDM physiopathology remains unclear. This pilot study aims to characterize the alteration of gut microbiota in GDM on species-level resolution and evaluate the relationship with occurrence of GDM. Read More

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Development of a bedside tool kit for assessing sensitization in patients with chronic osteoarthritis knee pain or chronic knee pain after total knee replacement.

Pain 2021 May 10. Epub 2021 May 10.

Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany Center for Neuroplasticity and Pain & Sport Sciences - Performance and Technology, Department of Health Science and Technology, School of Medicine, Aalborg University, Aalborg, Denmark Department of Economics and Business Administration, University of Applied Sciences Stralsund, Stralsund, Germany.

Abstract: Different pathophysiological mechanisms contribute to the pain development in osteoarthritis (OA). Sensitization mechanisms play an important role in the amplification and chronification of pain and may predict the therapeutic outcome. Stratification of patients according to their pain mechanisms could help to target pain therapy. Read More

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Supporting Patient-centered Communication on Adolescent Sexual and Reproductive Health-Perspectives to Build an Appointment Planning Tool.

J Pediatr Adolesc Gynecol 2021 May 11. Epub 2021 May 11.

Department of Emergency Medicine, 464 Congress Avenue, Suite 260, Yale School of Medicine, New Haven, CT, 06519, USA.

Study Objective: Input from adolescents and healthcare providers is needed to develop electronic tools that can support patient-centered sexual and reproductive (SRH) care. This study explores facilitators and barriers to patient-centered communication in the context of developing an electronic appointment planning tool to promote SRH communication in clinic settings.

Design: In-depth interviews were conducted to explore what constitutes adolescent-friendly SRH care and communication, as well as on the design of the appointment planning tool. Read More

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Developing a virtual geriatric perioperative medicine clinic: a mixed methods healthcare improvement study.

Age Ageing 2021 May 15. Epub 2021 May 15.

Geriatric Perioperative Care, North Bristol NHS Trust, Bristol, UK.

Background: the Geriatric Perioperative Care clinic at North Bristol NHS Trust was suspended in March 2020 during the COVID-19 pandemic. A virtual clinic was piloted to deliver preoperative health optimisation and shared decision-making for patients undergoing critical elective surgery. No literature existed on virtual preoperative clinics for older people to support the development. Read More

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Implementation of GeneXpert MTB/Rif proficiency testing program: A Case of the Uganda national tuberculosis reference laboratory/supranational reference laboratory.

PLoS One 2021 14;16(5):e0251691. Epub 2021 May 14.

Uganda National Tuberculosis Reference Laboratory, Kampala, Uganda.

Background: Following the WHO's endorsement of GeneXpert MTB/RIF assay for tuberculosis diagnosis in 2010, Uganda's ministry of health introduced the assay in its laboratory network in 2012. However, assessing the quality of the result produced from this technique is one of its major implementation challenges. To bridge this gap, the National tuberculosis reference laboratory (NTRL) introduced the GeneXpert MTB/RIF proficiency testing (PT) Scheme in 2015. Read More

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Family-centered music therapy-Empowering premature infants and their primary caregivers through music: Results of a pilot study.

PLoS One 2021 14;16(5):e0250071. Epub 2021 May 14.

Department of Neonatology, University Children's Hospital, Heidelberg, Germany.

Background: In Neonatal Intensive Care Units (NICUs) premature infants are exposed to various acoustic, environmental and emotional stressors which have a negative impact on their development and the mental health of their parents. Family-centred music therapy bears the potential to positively influence these stressors. The few existing studies indicate that interactive live-improvised music therapy interventions both reduce parental stress factors and support preterm infants' development. Read More

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Exploring Outcomes of an Asynchronous Learning Module on Increasing Cultural Competence for Speech-Language Pathology Graduate Students.

Am J Speech Lang Pathol 2021 May 14:1-9. Epub 2021 May 14.

Department of Speech-Language Pathology, California State University, Long Beach.

Purpose Cultural competence is an essential tool for speech-language pathologists and other allied health care professionals in providing ethical and clinically competent care. Determining pedagogical approaches to teaching cultural competence skills to students training in preprofessional programs is imperative to effectively convey the importance of cultural awareness prior to students embarking on their professional careers. Method Forty-five (45) speech-language pathology graduate students were administered a multicultural knowledge quiz before and after a targeted, asynchronous learning module on cultural competence and again 2 months later. Read More

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Simulation and coaching to prevent aggressive events in aged care: A pilot study.

Australas J Ageing 2021 May 14. Epub 2021 May 14.

College of Nursing and Health Sciences, Flinders University, Bedford Park, SA, Australia.

Objectives: Evaluation of simulation and coaching training to change ​the self-efficacy of aged care workers to prevent and manage workplace aggressive events.

Methods: Seventeen aged care workers from a community and residential aged care service provider completed education modules and two half-days of simulation using actors and real-life scenarios, with real-time coaching. Carer self-efficacy to identify, prevent and manage anxiety and aggression was measured before, following and six months after training. Read More

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Gut colonization in preterm infants supplemented with bovine colostrum in the first week of life: An explorative pilot study.

JPEN J Parenter Enteral Nutr 2021 May 14. Epub 2021 May 14.

Comparative Paediatrics and Nutrition, Department of Veterinary and Animal Sciences.

Background: In the first weeks after birth, enteral feeding and bacterial colonization interact to influence gut maturation in preterm infants. Bovine colostrum (BC) has been suggested as a relevant supplementary diet when own mother's milk (MM) is insufficient or absent. In a pilot trial whether the supplement type, BC or human donor milk (DM), affects gut colonization in preterm infants during the first week of life was tested. Read More

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Stakeholder-Generated Implementation Strategies to Promote Evidence-Based ADHD Treatment in Community Mental Health.

Adm Policy Ment Health 2021 May 14. Epub 2021 May 14.

Florida International University, Miami, FL, USA.

Community implementation of evidence-based practices (EBPs) for Attention Deficit/Hyperactivity Disorder (ADHD) is greatly lacking. A recent randomized community-based trial of an EBP for ADHD (Supporting Teens' Autonomy Daily; STAND) demonstrated suboptimal implementation and effectiveness outcomes. In the present study, we conducted an Innovation Tournament (IT) with agency staff stakeholders (N = 26) to identify barriers to successful implementation of STAND and implementation strategies for a revised service delivery model. Read More

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The Application of 'Elite Interviewing' Methodology in Transdisciplinary Research: a Record of Process and Lessons Learned during a 3-Year Pilot in Urban Planetary Health Research.

J Urban Health 2021 May 14. Epub 2021 May 14.

University of Birmingham, Birmingham, UK.

This paper sets out the rationale and process for the interviewing methodology utilized during a 3-year research pilot, 'Moving Health Upstream in Urban Development' (UPSTREAM). The project had two primary aims: firstly, to attempt to value economically the health cost benefits associated with the quality of urban environments and secondly, to engage with those in control of urban development in the UK in order to determine what are the barriers to and opportunities for creating healthy urban environments, including those identified through the utilisation of economic valuation. Engagement at senior level with those who have most control over key facets of planning and development implementation-such as land disposal, investment, development delivery and planning permission-was central to the approach, which encompassed the adoption of 'elite interviewing', a method developed in the USA in the 1950s and used in the political sciences but relatively unutilized in the health and environmental sciences [1]. Read More

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Nutritional status and volume control in adolescents on chronic hemodialysis.

Pediatr Nephrol 2021 May 14. Epub 2021 May 14.

Pediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122, Milan, Italy.

Background: Pediatric patients on maintenance hemodialysis (HD) are at risk of both malnutrition and fluid overload. This pilot study aimed to assess correlates of normalized protein catabolic rate (nPCR) in adolescents on chronic HD, in particular fluid status markers.

Methods: All patients aged 10-18 years on chronic HD in our center between 2017 and 2019 were enrolled. Read More

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L-Lift Technique Using Poly-L-Lactic Acid: A Pilot Study.

Dermatol Surg 2021 May 11. Epub 2021 May 11.

All authors are affiliated with the Brazilian Center for Studies in Dermatology, Porto Alegre, RS, Brazil.

Background: Minimally invasive procedures that prevent and delay the aging process can be an alternative to more invasive surgical procedures.

Objective: To assess the efficacy and safety of L-Lift technique to improve skin firmness, facial global aesthetics, and the patient and investigator satisfaction.

Methods: Prospective, open, single-center study. Read More

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The Use of SMS Text Messaging to Improve the Hospital-to-Community Transition in Patients With Acute Coronary Syndrome (Txt2Prevent): Results From a Pilot Randomized Controlled Trial.

JMIR Mhealth Uhealth 2021 May 14;9(5):e24530. Epub 2021 May 14.

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.

Background: Acute coronary syndrome (ACS) is a leading cause of hospital admission in North America. Many patients with ACS experience challenges after discharge that impact their clinical outcomes and psychosocial well-being. SMS text messaging has the potential to provide support to patients during this postdischarge period. Read More

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Text Messaging and Home Blood Pressure Monitoring for Patients with Uncontrolled Hypertension: Proposal for a Feasibility Pilot Randomized Controlled Trial.

JMIR Res Protoc 2021 May 14;10(5):e18984. Epub 2021 May 14.

Department of Family and Community Medicine, Wake Forest School of Medicine, Winston-Salem, NC, United States.

Background: A decrease in blood pressure, even modestly (ie, 2 mmHg), lowers cardiovascular morbidity and mortality. Low patient adherence to antihypertensive medication is the most significant modifiable patient-related barrier to achieving controlled blood pressure. Preliminary studies have shown that SMS text messaging and home blood pressure monitoring (HBPM) can be effective in promoting medication adherence and blood pressure control. Read More

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The Adaptive GameSquad Xbox-Based Physical Activity and Health Coaching Intervention for Youth With Neurodevelopmental and Psychiatric Diagnoses: Pilot Feasibility Study.

JMIR Form Res 2021 May 14;5(5):e24566. Epub 2021 May 14.

Pennington Biomedical Research Center, Baton Rouge, LA, United States.

Background: The prevalence of neurodevelopmental and psychiatric diagnoses (NPDs) in youth is increasing, and unhealthy physical activity (PA), diet, screen time, and sleep habits contribute to the chronic disease disparities and behavioral challenges this population experiences.

Objective: This pilot study aims to adapt a proven exergaming and telehealth PA coaching intervention for typically developing youth with overweight or obesity; expand it to address diet, screen, and sleep behaviors; and then test its feasibility and acceptability, including PA engagement, among youth with NPDs.

Methods: Participants (N=23; mean age 15. Read More

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